Synthetic biology: applications come of age.

RNA-guided human genome engineering via Cas9. Science (2013) 48.29

Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins. Science (2010) 4.78

The Synthetic Biology Open Language (SBOL) provides a community standard for communicating designs in synthetic biology. Nat Biotechnol (2014) 2.63

Programmable single-cell mammalian biocomputers. Nature (2012) 2.56

A modular cloning system for standardized assembly of multigene constructs. PLoS One (2011) 2.39

Genetic programs constructed from layered logic gates in single cells. Nature (2012) 2.35

A synthetic biology framework for programming eukaryotic transcription functions. Cell (2012) 2.32

Designing synthetic regulatory networks capable of self-organizing cell polarization. Cell (2012) 2.28

Using targeted chromatin regulators to engineer combinatorial and spatial transcriptional regulation. Cell (2014) 2.27

Engineering synthetic TAL effectors with orthogonal target sites. Nucleic Acids Res (2012) 2.25

Chemical synthesis of the mouse mitochondrial genome. Nat Methods (2010) 2.15

Engineering modular and orthogonal genetic logic gates for robust digital-like synthetic biology. Nat Commun (2011) 2.06

Emerging biomedical applications of synthetic biology. Nat Rev Genet (2011) 2.05

Genomic mining of prokaryotic repressors for orthogonal logic gates. Nat Chem Biol (2013) 1.98

Disease networks. Uncovering disease-disease relationships through the incomplete interactome. Science (2015) 1.95

Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms. Nat Rev Microbiol (2010) 1.86

Synthetic circuit identifies subpopulations with sustained memory of DNA damage. Genes Dev (2011) 1.81

Engineering biological systems with synthetic RNA molecules. Mol Cell (2011) 1.80

Principles of genetic circuit design. Nat Methods (2014) 1.79

Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells. Nature (2012) 1.73

A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice. Nat Commun (2013) 1.71

Tracking, tuning, and terminating microbial physiology using synthetic riboregulators. Proc Natl Acad Sci U S A (2010) 1.66

Foundations for the design and implementation of synthetic genetic circuits. Nat Rev Genet (2012) 1.65

Genetic switchboard for synthetic biology applications. Proc Natl Acad Sci U S A (2012) 1.60

Contextualizing context for synthetic biology--identifying causes of failure of synthetic biological systems. Biotechnol J (2012) 1.53

Cell-free synthetic biology: thinking outside the cell. Metab Eng (2011) 1.49

In silico feedback for in vivo regulation of a gene expression circuit. Nat Biotechnol (2011) 1.49

Tunable signal processing in synthetic MAP kinase cascades. Cell (2011) 1.45

Mutational analysis of the quorum-sensing receptor LasR reveals interactions that govern activation and inhibition by nonlactone ligands. Chem Biol (2014) 1.45

Computational tools for the synthetic design of biochemical pathways. Nat Rev Microbiol (2012) 1.45

Microbial forensics: predicting phenotypic characteristics and environmental conditions from large-scale gene expression profiles. PLoS Comput Biol (2015) 1.43

Reproducibility of Fluorescent Expression from Engineered Biological Constructs in E. coli. PLoS One (2016) 1.41

Synthetic biology in mammalian cells: next generation research tools and therapeutics. Nat Rev Mol Cell Biol (2014) 1.41

Conditional robustness analysis for fragility discovery and target identification in biochemical networks and in cancer systems biology. BMC Syst Biol (2015) 1.39

Toehold switches: de-novo-designed regulators of gene expression. Cell (2014) 1.32

Engineering of a synthetic electron conduit in living cells. Proc Natl Acad Sci U S A (2010) 1.29

Rise and demise of bioinformatics? Promise and progress. PLoS Comput Biol (2012) 1.25

Do-it-yourself biology: challenges and promises for an open science and technology movement. Syst Synth Biol (2013) 1.24

Fundamental relationship between operon organization and gene expression. Proc Natl Acad Sci U S A (2011) 1.19

Iterative plug-and-play methodology for constructing and modifying synthetic gene networks. Nat Methods (2012) 1.17

Long-term model predictive control of gene expression at the population and single-cell levels. Proc Natl Acad Sci U S A (2012) 1.15

Synthetic biology for translational research. Am J Transl Res (2010) 1.10

Synthetic biology, patenting, health and global justice. Syst Synth Biol (2012) 1.08

Genetic design automation: engineering fantasy or scientific renewal? Trends Biotechnol (2011) 1.08

Automatic design of digital synthetic gene circuits. PLoS Comput Biol (2011) 1.06

Improved predictions of transcription factor binding sites using physicochemical features of DNA. Nucleic Acids Res (2012) 1.06

Synthetic biology: advancing the design of diverse genetic systems. Annu Rev Chem Biomol Eng (2013) 1.06

Masquerading microbial pathogens: capsular polysaccharides mimic host-tissue molecules. FEMS Microbiol Rev (2014) 1.05

Relative potential of biosynthetic pathways for biofuels and bio-based products. Nat Biotechnol (2011) 1.05

Automatic compilation from high-level biologically-oriented programming language to genetic regulatory networks. PLoS One (2011) 1.05

Prophage induction is enhanced and required for renal disease and lethality in an EHEC mouse model. PLoS Pathog (2013) 1.04

Synthetic human cell fate regulation by protein-driven RNA switches. Nat Commun (2011) 1.03

Wide-dynamic-range promoters engineered for cyanobacteria. J Biol Eng (2013) 1.03

Dynamical systems approach to endothelial heterogeneity. Circ Res (2012) 1.03

Engineering ecosystems and synthetic ecologies. Mol Biosyst (2012) 1.02

Combined metabolic engineering of precursor and co-factor supply to increase α-santalene production by Saccharomyces cerevisiae. Microb Cell Fact (2012) 1.02

Transferring a synthetic gene circuit from yeast to mammalian cells. Nat Commun (2013) 0.97

Exploiting social evolution in biofilms. Curr Opin Microbiol (2013) 0.97

Biocatalytic retrosynthesis. Nat Chem Biol (2013) 0.97

Developments in the tools and methodologies of synthetic biology. Front Bioeng Biotechnol (2014) 0.97

Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery. Nat Biotechnol (2015) 0.96

Gene autoregulation via intronic microRNAs and its functions. BMC Syst Biol (2012) 0.96

A retrosynthetic biology approach to metabolic pathway design for therapeutic production. BMC Syst Biol (2011) 0.95

Tandem assembly of the epothilone biosynthetic gene cluster by in vitro site-specific recombination. Sci Rep (2011) 0.95

High-precision, in vitro validation of the sequestration mechanism for generating ultrasensitive dose-response curves in regulatory networks. PLoS Comput Biol (2011) 0.95

Towards a whole-cell modeling approach for synthetic biology. Chaos (2013) 0.95

Embodied artificial evolution: Artificial evolutionary systems in the 21st Century. Evol Intell (2012) 0.94

Regulation of endogenous human gene expression by ligand-inducible TALE transcription factors. ACS Synth Biol (2013) 0.94

The centrality of RNA for engineering gene expression. Biotechnol J (2013) 0.94

Genetic Circuits in Salmonella typhimurium. ACS Synth Biol (2012) 0.93

Artificial repressors for controlling gene expression in bacteria. Chem Commun (Camb) (2012) 0.92

Synthetic nanoelectronic probes for biological cells and tissues. Annu Rev Anal Chem (Palo Alto Calif) (2013) 0.92

Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal. Proc Natl Acad Sci U S A (2014) 0.92

A nucleoside kinase as a dual selector for genetic switches and circuits. Nucleic Acids Res (2010) 0.92

Directed evolution as a powerful synthetic biology tool. Methods (2012) 0.91

Engineered temperature compensation in a synthetic genetic clock. Proc Natl Acad Sci U S A (2014) 0.91

Establishing Chlamydomonas reinhardtii as an industrial biotechnology host. Plant J (2015) 0.91

Biocatalyst development by directed evolution. Bioresour Technol (2012) 0.91

Direct mutagenesis of thousands of genomic targets using microarray-derived oligonucleotides. ACS Synth Biol (2014) 0.91

Synthetic Biology: Bits and pieces come to life. Nature (2012) 0.90

A rapid and simple method for DNA engineering using cycled ligation assembly. PLoS One (2014) 0.90

Pentatricopeptide repeats: modular blocks for building RNA-binding proteins. RNA Biol (2013) 0.90

Genetically encoded sender-receiver system in 3D mammalian cell culture. ACS Synth Biol (2013) 0.90

A designer cell-based histamine-specific human allergy profiler. Nat Commun (2014) 0.89

Synthetic in vitro circuits. Curr Opin Chem Biol (2012) 0.89

A modular cell-based biosensor using engineered genetic logic circuits to detect and integrate multiple environmental signals. Biosens Bioelectron (2012) 0.89

Physical constraints on biological integral control design for homeostasis and sensory adaptation. Biophys J (2013) 0.89

Synthetic biology advances for pharmaceutical production. Curr Opin Biotechnol (2015) 0.89

Synthetic biology devices for in vitro and in vivo diagnostics. Proc Natl Acad Sci U S A (2015) 0.88

Engineering reduced evolutionary potential for synthetic biology. Mol Biosyst (2014) 0.88

Computational design of genomic transcriptional networks with adaptation to varying environments. Proc Natl Acad Sci U S A (2012) 0.88

Rapid construction of insulated genetic circuits via synthetic sequence-guided isothermal assembly. Nucleic Acids Res (2013) 0.88

Entrainment to periodic initiation and transition rates in a computational model for gene translation. PLoS One (2014) 0.88

Rewiring neural circuits by the insertion of ectopic electrical synapses in transgenic C. elegans. Nat Commun (2014) 0.87

Synthetic biology: putting synthesis into biology. Wiley Interdiscip Rev Syst Biol Med (2010) 0.87

Systems and synthetic biology approaches to alter plant cell walls and reduce biomass recalcitrance. Plant Biotechnol J (2014) 0.87

Emerging strategies and integrated systems microbiology technologies for biodiscovery of marine bioactive compounds. Mar Drugs (2014) 0.87

Mammalian synthetic biology: emerging medical applications. J R Soc Interface (2015) 0.86

Rational design of allosteric inhibitors and activators using the population-shift model: in vitro validation and application to an artificial biosensor. J Am Chem Soc (2012) 0.86

Disease gene interaction pathways: a potential framework for how disease genes associate by disease-risk modules. PLoS One (2011) 0.86

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A synthetic multicellular system for programmed pattern formation. Nature (2005) 6.93

A fast, robust and tunable synthetic gene oscillator. Nature (2008) 6.85

Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat Biotechnol (2003) 6.74

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Environmentally controlled invasion of cancer cells by engineered bacteria. J Mol Biol (2005) 4.25

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