Published in Proc Natl Acad Sci U S A on September 12, 2012
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Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer. Proc Natl Acad Sci U S A (2009) 1.13
NMR spectroscopy reveals the solution dimerization interface of p53 core domains bound to their consensus DNA. J Biol Chem (2001) 1.12
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. Proc Natl Acad Sci U S A (2010) 1.08
Ultraslow oligomerization equilibria of p53 and its implications. Proc Natl Acad Sci U S A (2009) 1.07
Interaction of the p53 DNA-binding domain with its n-terminal extension modulates the stability of the p53 tetramer. J Mol Biol (2011) 1.04
Assignment of 1H(N), 15N, 13C(alpha), 13CO and 13C(beta) resonances in a 67 kDa p53 dimer using 4D-TROSY NMR spectroscopy. J Biomol NMR (2000) 0.90
Quaternary structure of the specific p53-DNA complex reveals the mechanism of p53 mutant dominance. Nucleic Acids Res (2011) 0.89
Awakening guardian angels: drugging the p53 pathway. Nat Rev Cancer (2009) 5.12
The complete folding pathway of a protein from nanoseconds to microseconds. Nature (2003) 3.61
The crystal structure of human CD1d with and without alpha-galactosylceramide. Nat Immunol (2005) 3.53
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Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A (2006) 3.35
A transient and low-populated protein-folding intermediate at atomic resolution. Science (2010) 3.08
A role for the ESCRT system in cell division in archaea. Science (2008) 2.94
Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase. EMBO J (2006) 2.89
Is there a unifying mechanism for protein folding? Trends Biochem Sci (2003) 2.63
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A (2008) 2.30
Cooperative binding of tetrameric p53 to DNA. J Mol Biol (2004) 2.26
Unifying features in protein-folding mechanisms. Proc Natl Acad Sci U S A (2003) 2.24
Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain. Proc Natl Acad Sci U S A (2008) 2.14
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. Proc Natl Acad Sci U S A (2007) 2.09
PRIMA-1 reactivates mutant p53 by covalent binding to the core domain. Cancer Cell (2009) 2.09
Molecular mechanism of the interaction between MDM2 and p53. J Mol Biol (2002) 2.03
Comparative binding of p53 to its promoter and DNA recognition elements. J Mol Biol (2005) 1.96
Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. J Biol Chem (2003) 1.94
Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53. Proc Natl Acad Sci U S A (2007) 1.86
The FtsK gamma domain directs oriented DNA translocation by interacting with KOPS. Nat Struct Mol Biol (2006) 1.76
General structural motifs of amyloid protofilaments. Proc Natl Acad Sci U S A (2006) 1.72
Tumor suppressor p53 slides on DNA with low friction and high stability. Biophys J (2008) 1.70
Testing protein-folding simulations by experiment: B domain of protein A. Proc Natl Acad Sci U S A (2004) 1.70
Kinetic instability of p53 core domain mutants: implications for rescue by small molecules. J Biol Chem (2003) 1.68
Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations. J Biol Chem (2005) 1.67
The central region of HDM2 provides a second binding site for p53. Proc Natl Acad Sci U S A (2006) 1.67
Direct observation of barrier-limited folding of BBL by single-molecule fluorescence resonance energy transfer. Proc Natl Acad Sci U S A (2009) 1.65
The tumor suppressor p53: from structures to drug discovery. Cold Spring Harb Perspect Biol (2010) 1.64
The crystal structure of human CD1b with a bound bacterial glycolipid. J Immunol (2004) 1.64
Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains. J Biol Chem (2006) 1.61
Core domain interactions in full-length p53 in solution. Proc Natl Acad Sci U S A (2006) 1.59
A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants. Proc Natl Acad Sci U S A (2002) 1.58
Algorithm for prediction of tumour suppressor p53 affinity for binding sites in DNA. Nucleic Acids Res (2008) 1.58
Solution structure of p53 core domain: structural basis for its instability. Proc Natl Acad Sci U S A (2006) 1.53
Phi-analysis at the experimental limits: mechanism of beta-hairpin formation. J Mol Biol (2006) 1.53
Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor. Proc Natl Acad Sci U S A (2005) 1.52
Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family. J Mol Biol (2005) 1.52
The denatured state of Engrailed Homeodomain under denaturing and native conditions. J Mol Biol (2003) 1.51
Characterization of the p53-rescue drug CP-31398 in vitro and in living cells. Oncogene (2002) 1.51
Halogen-enriched fragment libraries as leads for drug rescue of mutant p53. J Am Chem Soc (2012) 1.50
Structural evolution of p53, p63, and p73: implication for heterotetramer formation. Proc Natl Acad Sci U S A (2009) 1.46
A single-molecule characterization of p53 search on DNA. Proc Natl Acad Sci U S A (2010) 1.43
Sequential unfolding of ankyrin repeats in tumor suppressor p16. Structure (2003) 1.43
Direct observation of ultrafast folding and denatured state dynamics in single protein molecules. Proc Natl Acad Sci U S A (2009) 1.39
14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers. Nucleic Acids Res (2008) 1.36
Distinguishing between cooperative and unimodal downhill protein folding. Proc Natl Acad Sci U S A (2007) 1.35
Rapid amyloid fiber formation from the fast-folding WW domain FBP28. Proc Natl Acad Sci U S A (2003) 1.33
Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53. J Biol Chem (2004) 1.31
Early events in protein folding. Curr Opin Struct Biol (2003) 1.28
Correlation of levels of folded recombinant p53 in escherichia coli with thermodynamic stability in vitro. J Mol Biol (2007) 1.27
Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant. Chem Biol (2010) 1.27
Simulation and experiment conspire to reveal cryptic intermediates and a slide from the nucleation-condensation to framework mechanism of folding. J Mol Biol (2005) 1.27
Modulation of the oligomerization state of p53 by differential binding of proteins of the S100 family to p53 monomers and tetramers. J Biol Chem (2009) 1.25
Small molecule induced reactivation of mutant p53 in cancer cells. Nucleic Acids Res (2013) 1.24
One-state downhill versus conventional protein folding. J Mol Biol (2004) 1.24
The helix-turn-helix motif as an ultrafast independently folding domain: the pathway of folding of Engrailed homeodomain. Proc Natl Acad Sci U S A (2007) 1.23
Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL. J Biol Chem (2007) 1.23
Recognition of DNA by p53 core domain and location of intermolecular contacts of cooperative binding. J Mol Biol (2002) 1.22
Regulation of DNA binding of p53 by its C-terminal domain. J Mol Biol (2004) 1.22
Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation. Proc Natl Acad Sci U S A (2004) 1.21
Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition. Proc Natl Acad Sci U S A (2012) 1.21
Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53. Nucleic Acids Res (2010) 1.20
Carboxyl pK(a) values and acid denaturation of BBL. J Mol Biol (2010) 1.20
Binding of natively unfolded HIF-1alpha ODD domain to p53. Mol Cell (2005) 1.18
Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53. Nucleic Acids Res (2008) 1.18
Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53. Proc Natl Acad Sci U S A (2002) 1.18
CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90. Proc Natl Acad Sci U S A (2002) 1.17
Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration. Proc Natl Acad Sci U S A (2011) 1.16
Conformational entropy of alanine versus glycine in protein denatured states. Proc Natl Acad Sci U S A (2007) 1.13
Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer. Proc Natl Acad Sci U S A (2009) 1.13
Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53. Nucleic Acids Res (2009) 1.13
Sequence-dependent sliding kinetics of p53. Proc Natl Acad Sci U S A (2012) 1.13
Features critical for membrane binding revealed by DivIVA crystal structure. EMBO J (2010) 1.12
An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid. Nat Commun (2012) 1.11
A structural double-mutant cycle: estimating the strength of a buried salt bridge in barnase. Acta Crystallogr D Biol Crystallogr (2002) 1.10
The structure of the major transition state for folding of an FF domain from experiment and simulation. J Mol Biol (2005) 1.10
The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. Structure (2012) 1.09
The kinetic pathway of folding of barnase. J Mol Biol (2003) 1.09
Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. Proc Natl Acad Sci U S A (2010) 1.08
Structural biology of the tumor suppressor p53 and cancer-associated mutants. Adv Cancer Res (2007) 1.07
Ultraslow oligomerization equilibria of p53 and its implications. Proc Natl Acad Sci U S A (2009) 1.07
Structural biology: analysis of 'downhill' protein folding. Nature (2007) 1.07
Modulation of binding of DNA to the C-terminal domain of p53 by acetylation. Structure (2005) 1.06
Solution structure of the C4 zinc finger domain of HDM2. Protein Sci (2005) 1.06
Simulation and experiment at high temperatures: ultrafast folding of a thermophilic protein by nucleation-condensation. J Mol Biol (2005) 1.06
Phi-analysis of the folding of the B domain of protein A using multiple optical probes. J Mol Biol (2006) 1.06
First-order rate-determining aggregation mechanism of p53 and its implications. Proc Natl Acad Sci U S A (2012) 1.06
Mimicking natural evolution in vitro: an N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activity. Proc Natl Acad Sci U S A (2003) 1.05
The role of the turn in beta-hairpin formation during WW domain folding. Protein Sci (2007) 1.05
Determination of the folding transition states of barnase by using PhiI-value-restrained simulations validated by double mutant PhiIJ-values. Proc Natl Acad Sci U S A (2005) 1.05
Interaction of the p53 DNA-binding domain with its n-terminal extension modulates the stability of the p53 tetramer. J Mol Biol (2011) 1.04
Effects of oncogenic mutations and DNA response elements on the binding of p53 to p53-binding protein 2 (53BP2). J Biol Chem (2006) 1.04
Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide. Proc Natl Acad Sci U S A (2003) 1.04
Interaction between the transactivation domain of p53 and PC4 exemplifies acidic activation domains as single-stranded DNA mimics. J Biol Chem (2009) 1.04
Members of the S100 family bind p53 in two distinct ways. Protein Sci (2008) 1.03