Published in Br J Pharmacol on March 01, 2013
Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles. Med Gas Res (2015) 1.13
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Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells. J Bone Miner Metab (2013) 0.83
Molecular hydrogen suppresses activated Wnt/β-catenin signaling. Sci Rep (2016) 0.78
The production of high dose hydrogen gas by the AMS-H-01 for treatment of disease. Med Gas Res (2016) 0.75
Should hydrogen therapy be included in a musculoskeletal medicine routine? F1000Res (2016) 0.75
Hydrogen-rich saline prevents bone loss in diabetic rats induced by streptozotocin. Int Orthop (2017) 0.75
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Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol (2002) 5.57
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Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radic Biol Med (2000) 2.28
Inhibition of osteoblast differentiation by tumor necrosis factor-alpha. Endocrinology (2000) 2.13
Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation. Endocrinology (2004) 1.66
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Assessment of fracture risk. Eur J Radiol (2009) 1.40
Osteoporosis: the role of micronutrients. Am J Clin Nutr (2005) 1.34
Role of antioxidant systems, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis. Mol Cell Biochem (2006) 1.34
Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation. Biochem J (2011) 1.25
Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens. Mol Endocrinol (2010) 1.24
Association of oxidative stress with postmenopausal osteoporosis and the effects of hydrogen peroxide on osteoclast formation in human bone marrow cell cultures. Calcif Tissue Int (2010) 1.22
Lack of a relation between vitamin and mineral antioxidants and bone mineral density: results from the Women's Health Initiative. Am J Clin Nutr (2005) 1.14
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The effect of aging and ovariectomy on the vertebral bone mass and biomechanical properties of mature rats. Bone (1993) 1.09
Ovariectomy-associated changes in bone mineral density and bone marrow haematopoiesis in rats. Int J Exp Pathol (2009) 1.03
Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats. Osteoporos Int (2012) 0.98
Involvement of oxidative stress in age-related bone loss. J Surg Res (2011) 0.96
The combination therapy with alfacalcidol and risedronate improves the mechanical property in lumbar spine by affecting the material properties in an ovariectomized rat model of osteoporosis. BMC Musculoskelet Disord (2009) 0.91
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Effects of ovariectomy and ascorbic acid supplement on oxidative stress parameters and bone mineral density in rats. Libyan J Med (2011) 0.85
Reactive oxygen species on bone mineral density and mechanics in Cu,Zn superoxide dismutase (Sod1) knockout mice. Biochem Biophys Res Commun (2010) 0.84
Inhibitory effect of vitamin K2 (menatetrenone) on bone resorption in ovariectomized rats: a histomorphometric and dual energy X-ray absorptiometric study. Jpn J Pharmacol (1999) 0.84
Effect of nitric oxide donor nitroglycerin on bone mineral density in a rat model of estrogen deficiency-induced osteopenia. Bone (2003) 0.83
Assessing fracture risk and effects of osteoporosis drugs: bone mineral density and beyond. Am J Med (2009) 0.82
Exploiting the antioxidant potential of a common vitamin: could vitamin C prevent postmenopausal osteoporosis? J Obstet Gynaecol Res (2011) 0.78
The diploid genome sequence of an Asian individual. Nature (2008) 46.29
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med (2003) 26.05
The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev (2007) 13.05
Diverse somatic mutation patterns and pathway alterations in human cancers. Nature (2010) 10.83
TEAD mediates YAP-dependent gene induction and growth control. Genes Dev (2008) 9.88
Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol (2008) 8.92
The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19
An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science (2012) 7.94
ZDOCK: an initial-stage protein-docking algorithm. Proteins (2003) 7.52
Gene discovery and annotation using LCM-454 transcriptome sequencing. Genome Res (2006) 7.10
The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol (2010) 7.08
A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly. Hum Mol Genet (2003) 6.82
Epidemiological serosurvey of hepatitis B in China--declining HBV prevalence due to hepatitis B vaccination. Vaccine (2009) 6.30
PlasmoDB: the Plasmodium genome resource. A database integrating experimental and computational data. Nucleic Acids Res (2003) 6.19
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes Dev (2010) 6.05
SNP discovery via 454 transcriptome sequencing. Plant J (2007) 5.92
MicroRNA-mediated conversion of human fibroblasts to neurons. Nature (2011) 5.59
A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev (2010) 5.38
The oyster genome reveals stress adaptation and complexity of shell formation. Nature (2012) 5.30
A porous supramolecular architecture from a copper(II) coordination polymer with a 3D four-connected 8(6) net. Inorg Chem (2003) 5.16
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. Arch Neurol (2007) 5.09
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J Exp Med (2007) 4.95
Stability of the regulatory T cell lineage in vivo. Science (2010) 4.89
Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche. Nat Med (2007) 4.80
The Plasmodium genome database. Nature (2002) 4.36
Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells. Blood (2003) 3.98
Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment. Am J Clin Nutr (2004) 3.96
Germline gain-of-function mutations in SOS1 cause Noonan syndrome. Nat Genet (2006) 3.81
Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial. Genome Biol (2006) 3.75
Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes Dev (2012) 3.48
ToxoDB: accessing the Toxoplasma gondii genome. Nucleic Acids Res (2003) 3.24
Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev (2011) 3.15
A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol (2010) 3.09
Gene density, transcription, and insulators contribute to the partition of the Drosophila genome into physical domains. Mol Cell (2012) 3.08
Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol (2003) 3.02
Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype. Virology (2002) 2.96
Prognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis. Lancet Oncol (2012) 2.91
Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties. Immunity (2004) 2.89
Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. Immunity (2009) 2.84
Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J Hepatol (2009) 2.84
Androgen deprivation causes epithelial-mesenchymal transition in the prostate: implications for androgen-deprivation therapy. Cancer Res (2011) 2.71
A highly sensitive CMOS digital Hall sensor for low magnetic field applications. Sensors (Basel) (2012) 2.69
Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia. Blood (2006) 2.69
Mutations in myosin light chain kinase cause familial aortic dissections. Am J Hum Genet (2010) 2.67
Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers. Mol Cancer Res (2009) 2.65
Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system. Proc Natl Acad Sci U S A (2005) 2.65
Evaluation of the impact of hepatitis B vaccination among children born during 1992-2005 in China. J Infect Dis (2009) 2.62
A review of EPAP nasal device therapy for obstructive sleep apnea syndrome. Sleep Breath (2014) 2.61
Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection. Nat Med (2004) 2.59
The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. Mol Cell Biol (2008) 2.57
Noninvasive characterization of epicardial activation in humans with diverse atrial fibrillation patterns. Circulation (2010) 2.57
A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation. Biochem Biophys Res Commun (2005) 2.55
The mitochondrial inner membrane protein mitofilin controls cristae morphology. Mol Biol Cell (2005) 2.53
Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes. Kidney Int (2011) 2.50
AILUN: reannotating gene expression data automatically. Nat Methods (2007) 2.47
High-resolution genomic and expression analyses of copy number alterations in breast tumors. Genes Chromosomes Cancer (2008) 2.46
1,1'-[(Hexane-1,6-diyldi-oxy)bis-(nitrilo-methyl-idyne)]dinaphthalene. Acta Crystallogr Sect E Struct Rep Online (2008) 2.45
Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression. J Exp Med (2005) 2.42
Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. Am J Physiol Renal Physiol (2006) 2.39
Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification. J Clin Oncol (2011) 2.38
Diethyl 3,8-dimethyl-4,7-diazadeca-2,8-dienedioate. Acta Crystallogr C (2004) 2.38
HIV/STD stigmatization fears as health-seeking barriers in China. AIDS Behav (2006) 2.37
PlasmoDB: the Plasmodium genome resource. An integrated database providing tools for accessing, analyzing and mapping expression and sequence data (both finished and unfinished). Nucleic Acids Res (2002) 2.37
Inflammation in acute kidney injury. Nephron Exp Nephrol (2008) 2.32
Efficacy and safety of dutasteride in patients with spinal and bulbar muscular atrophy: a randomised placebo-controlled trial. Lancet Neurol (2011) 2.27
Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance. Proc Natl Acad Sci U S A (2007) 2.27
Role of interleukin 17 in inflammation, atherosclerosis, and vascular function in apolipoprotein e-deficient mice. Arterioscler Thromb Vasc Biol (2011) 2.27
TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis. Cell (2008) 2.26
2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-yl N-ethyl-carbamate. Acta Crystallogr Sect E Struct Rep Online (2009) 2.24
Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: the role of CD4+ T cells and IFN-gamma. J Immunol (2006) 2.22
Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury. J Am Soc Nephrol (2009) 2.18
The histone acetyltransferase MOF is a key regulator of the embryonic stem cell core transcriptional network. Cell Stem Cell (2012) 2.17
Release of hydrophobic molecules from polymer micelles into cell membranes revealed by Forster resonance energy transfer imaging. Proc Natl Acad Sci U S A (2008) 2.16
Expression of tumor-associated antigens in acute myeloid leukemia: Implications for specific immunotherapeutic approaches. Blood (2006) 2.14
Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice. Biomaterials (2009) 2.13
Differences between left and right ventricular chamber geometry affect cardiac vulnerability to electric shocks. Circ Res (2005) 2.11
Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1. Sci Transl Med (2011) 2.10
Increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas. Int J Urol (2011) 2.07
A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis. Nat Genet (2011) 2.05
Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line. Invest Ophthalmol Vis Sci (2005) 2.02
Atrial fibrillation and acute myocardial infarction: antithrombotic therapy and outcomes. Am J Med (2012) 2.02
Sexually transmitted disease prevalence and characteristics of market vendors in eastern China. Sex Transm Dis (2003) 2.02
Regulation of tetrahydrobiopterin biosynthesis by shear stress. Circ Res (2007) 2.01
Baseline serum lactate dehydrogenase levels for patients treated with intensity-modulated radiotherapy for nasopharyngeal carcinoma: a predictor of poor prognosis and subsequent liver metastasis. Int J Radiat Oncol Biol Phys (2011) 1.99
Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease. J Cell Mol Med (2012) 1.99
Airborne trifluoroacetic acid and its fraction from the degradation of HFC-134a in Beijing, China. Environ Sci Technol (2014) 1.96
Analysis of 50 SNPs in CYP2D6, CYP2C19, CYP2C9, CYP3A4 and CYP1A2 by MALDI-TOF mass spectrometry in Chinese Han population. Forensic Sci Int (2010) 1.96
Ngari virus is a Bunyamwera virus reassortant that can be associated with large outbreaks of hemorrhagic fever in Africa. J Virol (2004) 1.93
Landscape determinants and remote sensing of anopheline mosquito larval habitats in the western Kenya highlands. Malar J (2006) 1.90
A novel GATA6 mutation in patients with tetralogy of Fallot or atrial septal defect. J Hum Genet (2010) 1.89
On the speckle-free nature of photoacoustic tomography. Med Phys (2009) 1.84
Recruiting and training leadership through professional societies: a report from the American Society of Preventive Oncology Junior Members Interest Group. Cancer Epidemiol Biomarkers Prev (2006) 1.81
The cauliflower Or gene encodes a DnaJ cysteine-rich domain-containing protein that mediates high levels of beta-carotene accumulation. Plant Cell (2006) 1.80
Reactivation of latent Epstein-Barr virus by methotrexate: a potential contributor to methotrexate-associated lymphomas. J Natl Cancer Inst (2004) 1.80
Photoacoustic microscopy with 2-microm transverse resolution. J Biomed Opt (2010) 1.79
OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer. Nat Genet (2003) 1.77
Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas. Clin Cancer Res (2012) 1.76