Published in Proc Natl Acad Sci U S A on November 07, 2012
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Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel. Biochemistry (2010) 1.73
An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations. J Gen Physiol (2012) 1.72
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Probing the structure of DNA-carbon nanotube hybrids with molecular dynamics. Nano Lett (2007) 1.65
A novel diagnostic test detects a low frequency of the hemicentin Gln5345Arg variant among Northern Irish age related macular degeneration patients. Mol Vis (2004) 1.64
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In utero onset of long QT syndrome with atrioventricular block and spontaneous or lidocaine-induced ventricular tachycardia: compound effects of hERG pore region mutation and SCN5A N-terminus variant. Heart Rhythm (2008) 1.61
Embedded cholesterol in the nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A (2008) 1.61
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Proteomic investigation of the effect of salicylic acid on Arabidopsis seed germination and establishment of early defense mechanisms. Plant Physiol (2006) 1.43
Identification of a rare coding variant in complement 3 associated with age-related macular degeneration. Nat Genet (2013) 1.39
Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2. J Am Chem Soc (2011) 1.37
Predictors of optical density of lutein and zeaxanthin in retinas of older women in the Carotenoids in Age-Related Eye Disease Study, an ancillary study of the Women's Health Initiative. Am J Clin Nutr (2006) 1.35
A unitary anesthetic binding site at high resolution. J Biol Chem (2009) 1.34
Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus. Proc Natl Acad Sci U S A (2013) 1.34
Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain. Proc Natl Acad Sci U S A (2010) 1.33
Natural history of drusenoid pigment epithelial detachment in age-related macular degeneration: Age-Related Eye Disease Study Report No. 28. Ophthalmology (2010) 1.32
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Identification of a fluorescent general anesthetic, 1-aminoanthracene. Proc Natl Acad Sci U S A (2009) 1.29
Hypomethylation of the IL17RC promoter associates with age-related macular degeneration. Cell Rep (2012) 1.28
Modulation of Nav1.7 and Nav1.8 peripheral nerve sodium channels by protein kinase A and protein kinase C. J Neurophysiol (2003) 1.27
Nontoxic membrane-active antimicrobial arylamide oligomers. Angew Chem Int Ed Engl (2004) 1.26
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Acidic residues on the voltage-sensor domain determine the activation of the NaChBac sodium channel. Biophys J (2007) 1.13
Conformational changes and gating at the selectivity filter of potassium channels. J Am Chem Soc (2008) 1.13
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Polarization effects and charge transfer in the KcsA potassium channel. Biophys Chem (2006) 1.12
Biomimetic facially amphiphilic antibacterial oligomers with conformationally stiff backbones. Chem Biol (2006) 1.11
Expression and intracellular localization of an SCN5A double mutant R1232W/T1620M implicated in Brugada syndrome. Circ Res (2002) 1.11
C-reactive protein and homocysteine are associated with dietary and behavioral risk factors for age-related macular degeneration. Nutrition (2006) 1.10
A novel SCN5A mutation manifests as a malignant form of long QT syndrome with perinatal onset of tachycardia/bradycardia. Cardiovasc Res (2004) 1.10
A recipe for the computation of the free energy barrier and the lowest free energy path of concerted reactions. J Phys Chem B (2005) 1.09
A novel mutation in SCN5A, delQKP 1507-1509, causing long QT syndrome: role of Q1507 residue in sodium channel inactivation. J Mol Cell Cardiol (2003) 1.08
The role of conformation in ion permeation in a K+ channel. J Am Chem Soc (2008) 1.07
A proton leak current through the cardiac sodium channel is linked to mixed arrhythmia and the dilated cardiomyopathy phenotype. PLoS One (2012) 1.07
Modeling membranes under a transmembrane potential. J Phys Chem B (2008) 1.07
Exploring the gating mechanism in the ClC chloride channel via metadynamics. J Mol Biol (2006) 1.06
Congenital heart block: identification of autoantibody binding site on the extracellular loop (domain I, S5-S6) of alpha(1D) L-type Ca channel. J Autoimmun (2009) 1.06
A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration. PLoS One (2011) 1.05
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Initial response of the potassium channel voltage sensor to a transmembrane potential. J Am Chem Soc (2009) 1.03
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Solution NMR structure of a designed metalloprotein and complementary molecular dynamics refinement. Structure (2008) 1.03
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General anesthetics predicted to block the GLIC pore with micromolar affinity. PLoS Comput Biol (2012) 1.02
Probing Membrane Insertion Activity of Antimicrobial Polymers via Coarse-grain Molecular Dynamics. J Chem Theory Comput (2006) 1.02
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Exploring volatile general anesthetic binding to a closed membrane-bound bacterial voltage-gated sodium channel via computation. PLoS Comput Biol (2013) 1.01
A distinct de novo expression of Nav1.5 sodium channels in human atrial fibroblasts differentiated into myofibroblasts. J Physiol (2012) 1.00
Biophysical properties of human Na v1.7 splice variants and their regulation by protein kinase A. J Neurophysiol (2008) 1.00