The Nobel Prize-winning work of Ralph Steinman (1943-2011) and its relevance to transplantation.

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Published in Transplantation on January 15, 2013

Authors

Angus W Thomson, Manikkam Suthanthiran

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(truncated to the top 100)

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Rapamycin inhibits the growth and metastatic progression of non-small cell lung cancer. Clin Cancer Res (2004) 5.40

Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N Engl J Med (2005) 5.02

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Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells. Blood (2004) 3.68

Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest (2010) 3.59

Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations. Transplantation (2005) 3.57

Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. J Exp Med (2007) 2.86

Noninvasive diagnosis of BK virus nephritis by measurement of messenger RNA for BK virus VP1 in urine. Transplantation (2002) 2.86

Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J Immunol (2007) 2.61

Dendritic cells: emerging pharmacological targets of immunosuppressive drugs. Nat Rev Immunol (2004) 2.38

MicroRNA expression profiles predictive of human renal allograft status. Proc Natl Acad Sci U S A (2009) 2.36

Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival. Am J Transplant (2005) 2.32

Organ transplantation--how much of the promise has been realized? Nat Med (2005) 2.26

Rapamycin inhibits IL-4--induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood (2003) 2.12

Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2007) 2.10

Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production. Blood (2002) 2.02

Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm. Cell Stem Cell (2012) 1.99

High PD-L1/CD86 ratio on plasmacytoid dendritic cells correlates with elevated T-regulatory cells in liver transplant tolerance. Transplantation (2008) 1.85

Rapamycin is an effective inhibitor of human renal cancer metastasis. Kidney Int (2003) 1.83

IL-33 expands suppressive CD11b+ Gr-1(int) and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival. J Immunol (2011) 1.72

What does the future hold for cell-based tolerogenic therapy? Nat Rev Immunol (2007) 1.64

Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction. Immunol Rev (2003) 1.61

Gut microbial community structure and complications after kidney transplantation: a pilot study. Transplantation (2014) 1.60

Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells. Blood (2002) 1.53

CD4+ T cell responses elicited by different subsets of human skin migratory dendritic cells. J Immunol (2005) 1.52

Noninvasive prediction of organ graft rejection and outcome using gene expression patterns. Transplantation (2008) 1.50

Noninvasive detection of renal allograft inflammation by measurements of mRNA for IP-10 and CXCR3 in urine. Kidney Int (2004) 1.48

Tolerogenic plasmacytoid DC. Eur J Immunol (2010) 1.48

mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS. Blood (2010) 1.45

Dendritic cell subsets in blood and lymphoid tissue of rhesus monkeys and their mobilization with Flt3 ligand. Blood (2003) 1.43

Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells. J Immunol (2006) 1.40

Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients. J Immunol (2009) 1.35

Rapamycin blocks tumor progression: unlinking immunosuppression from antitumor efficacy. Transplantation (2002) 1.33

The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo. Am J Transplant (2005) 1.32

Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig. J Immunol (2002) 1.32

Adoptive regulatory T-cell therapy protects against cerebral ischemia. Ann Neurol (2013) 1.30

"Alternatively activated" dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig. J Immunol (2006) 1.30

Plasmacytoid dendritic cell precursors induce allogeneic T-cell hyporesponsiveness and prolong heart graft survival. Am J Transplant (2005) 1.26

Tolerogenic dendritic cells and their role in transplantation. Semin Immunol (2011) 1.26

Development of dendritic cell-based immunotherapy for autoimmunity. Int Rev Immunol (2010) 1.24

Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver. Diabetes (2012) 1.22

IL-1beta-driven ST2L expression promotes maturation resistance in rapamycin-conditioned dendritic cells. J Immunol (2008) 1.22

Dendritic cells: key to fetal tolerance? Biol Reprod (2007) 1.21

Dendritic cell subset ratio in peripheral blood correlates with successful withdrawal of immunosuppression in liver transplant patients. Am J Transplant (2003) 1.21

Reduction in the circulating pDC1/pDC2 ratio and impaired function of ex vivo-generated DC1 in chronic hepatitis B infection. Clin Immunol (2002) 1.17

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Low TLR4 expression by liver dendritic cells correlates with reduced capacity to activate allogeneic T cells in response to endotoxin. J Immunol (2005) 1.14

Angiogenic factors in superimposed preeclampsia: a longitudinal study of women with chronic hypertension during pregnancy. Hypertension (2012) 1.14

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Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques. Transplantation (2007) 1.10

Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells. J Hepatol (2008) 1.10

Hypertension, kidney disease, HIV and antiretroviral therapy among Tanzanian adults: a cross-sectional study. BMC Med (2014) 1.10

Ethanol affects the generation, cosignaling molecule expression, and function of plasmacytoid and myeloid dendritic cell subsets in vitro and in vivo. J Leukoc Biol (2006) 1.09

Dendritic cells, the liver, and transplantation. Hepatology (2007) 1.09

Dendritic cell subset ratio in tolerant, weaning and non-tolerant liver recipients is not affected by extent of immunosuppression. Am J Transplant (2005) 1.09

Dendritic cells under the spell of prostaglandins. Trends Immunol (2003) 1.08

Naturally occurring regulatory T cells: recent insights in health and disease. Crit Rev Immunol (2007) 1.08

Hyperexpression of Foxp3 and IDO during acute rejection of islet allografts. Transplantation (2007) 1.08

Immature and mature CD8alpha+ dendritic cells prolong the survival of vascularized heart allografts. J Immunol (2002) 1.07

Enhanced granulysin mRNA expression in urinary sediment in early and delayed acute renal allograft rejection. Transplantation (2004) 1.07

CD103 mRNA levels in urinary cells predict acute rejection of renal allografts. Transplantation (2003) 1.07

Dendritic cells and regulation of graft-versus-host disease and graft-versus-leukemia activity. Blood (2012) 1.06

IL-27 production and STAT3-dependent upregulation of B7-H1 mediate immune regulatory functions of liver plasmacytoid dendritic cells. J Immunol (2012) 1.06

Regulatory dendritic cell therapy in organ transplantation. Transpl Int (2006) 1.06

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Noninvasive diagnosis of acute rejection of renal allografts. Curr Opin Organ Transplant (2010) 0.98

Histone deacetylase inhibition facilitates GM-CSF-mediated expansion of myeloid-derived suppressor cells in vitro and in vivo. J Leukoc Biol (2011) 0.97

Endotoxin modulates the capacity of CpG-activated liver myeloid DC to direct Th1-type responses. Eur J Immunol (2006) 0.97

Serine proteinase inhibitor-9, an endogenous blocker of granzyme B/perforin lytic pathway, is hyperexpressed during acute rejection of renal allografts. Transplantation (2003) 0.96

Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance. J Immunol (2012) 0.96

Influence of immunosuppressive drugs on dendritic cells. Transpl Immunol (2003) 0.96

Induced regulatory T cells: mechanisms of conversion and suppressive potential. Hum Immunol (2012) 0.95

Growth factor-induced mobilization of dendritic cells in kidney and liver of rhesus macaques: implications for transplantation. Transplantation (2007) 0.95

Epidemiology of BK virus in renal allograft recipients: independent risk factors for BK virus replication. Transplantation (2008) 0.95

Genomic biomarkers correlate with HLA-identical renal transplant tolerance. J Am Soc Nephrol (2013) 0.94

Controlled release formulations of IL-2, TGF-β1 and rapamycin for the induction of regulatory T cells. J Control Release (2012) 0.94

Measurement of apoptosis of intact human islets by confocal optical sectioning and stereologic analysis of YO-PRO-1-stained islets. Transplantation (2005) 0.94

Essential role of program death 1-ligand 1 in regulatory T-cell-afforded protection against blood-brain barrier damage after stroke. Stroke (2014) 0.93

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Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO. J Immunol (2012) 0.92

Transgenic galectin-1 induces maturation of dendritic cells that elicit contrasting responses in naive and activated T cells. J Immunol (2006) 0.92

Taming the lions: manipulating dendritic cells for use as negative cellular vaccines in organ transplantation. Curr Opin Organ Transplant (2008) 0.92

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Differential modulation of CD4 and CD8 T-cell proliferation by induction of nitric oxide synthesis in antigen presenting cells. Transplantation (2002) 0.92