Published in Proc Natl Acad Sci U S A on November 14, 2012
Targeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitors. Cancers (Basel) (2015) 0.99
Cdk5 activity in the brain - multiple paths of regulation. J Cell Sci (2014) 0.95
Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein. Cell Rep (2015) 0.82
Peptide TFP5/TP5 derived from Cdk5 activator P35 provides neuroprotection in the MPTP model of Parkinson's disease. Mol Biol Cell (2015) 0.79
Proliferating cell nuclear antigen binds DNA polymerase-β and mediates 1-methyl-4-phenylpyridinium-induced neuronal death. PLoS One (2014) 0.78
p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing. J Neurochem (2015) 0.78
CDK5: A new lead to survival. Cell Cycle (2013) 0.77
TFP5 prevents 1-methyl-4-phenyl pyridine ion-induced neurotoxicity in mouse cortical neurons. Exp Ther Med (2016) 0.75
Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells. Stem Cells Int (2016) 0.75
The interaction of Munc 18 (p67) with the p10 domain of p35 protects in vivo Cdk5/p35 activity from inhibition by TFP5, a peptide derived from p35. Mol Biol Cell (2016) 0.75
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature (1999) 5.53
A decade of CDK5. Nat Rev Mol Cell Biol (2001) 5.24
Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature (2000) 4.31
p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature (1994) 3.95
Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron (2003) 2.97
Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. Neuron (2008) 2.88
A brain-specific activator of cyclin-dependent kinase 5. Nature (1994) 2.71
Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron (2003) 2.17
Controlled elimination of intracellular H(2)O(2): regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modification. Antioxid Redox Signal (2005) 2.00
Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25. J Biol Chem (2000) 1.89
Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A (2003) 1.87
Cdk5 deregulation in the pathogenesis of Alzheimer's disease. Trends Mol Med (2004) 1.76
Cell cycle regulation of neuronal apoptosis in development and disease. Prog Neurobiol (2004) 1.75
Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions. Neuron (2001) 1.68
Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease. Neuron (2007) 1.65
Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2. J Neurosci (2006) 1.61
A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease. Curr Opin Neurobiol (2004) 1.60
Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death. Nat Cell Biol (2009) 1.57
Structure and regulation of the CDK5-p25(nck5a) complex. Mol Cell (2001) 1.57
Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J Neurochem (1993) 1.46
Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments. J Biol Chem (1992) 1.45
Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death. J Neurosci (2005) 1.44
Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2. J Biol Chem (1992) 1.37
Mechanisms of MPTP toxicity. Mov Disord (1998) 1.35
Purification and characterization of a novel proline-directed protein kinase from bovine brain. J Biol Chem (1992) 1.30
A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline-directed protein kinase associated with microtubule. FEBS Lett (1993) 1.27
Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity. EMBO J (2008) 1.26
Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex. J Neurosci (2010) 1.21
Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes. J Neurochem (2008) 1.21
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. J Cell Sci (2007) 1.17
Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells. Biochem Biophys Res Commun (2000) 1.16
Identification of nuclear import mechanisms for the neuronal Cdk5 activator. J Biol Chem (2006) 1.08
Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain. FEBS Lett (1994) 1.07
AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576. J Alzheimers Dis (2002) 1.05
No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro. Proc Natl Acad Sci U S A (2010) 1.05
Cyclin-dependent kinase 5 (cdk5) activation requires interaction with three domains of p35. J Neurosci Res (2002) 1.04
The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator. Neurosignals (2003) 1.02
Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP. Eur J Pharmacol (1984) 0.96
Reconstitution of neuronal Cdc2-like kinase from bacteria-expressed Cdk5 and an active fragment of the brain-specific activator. Kinase activation in the absence of Cdk5 phosphorylation. J Biol Chem (1995) 0.95
Cyclin-dependent kinase 5 and neuronal migration in the neocortex. Neurosignals (2003) 0.95
Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: characterization and localization of receptor binding sites in rat and human brain. Proc Natl Acad Sci U S A (1984) 0.93
Precursor of cdk5 activator, the 23 kDa subunit of tau protein kinase II: its sequence and developmental change in brain. FEBS Lett (1994) 0.92
Cyclin I-Cdk5 governs survival in post-mitotic cells. Cell Cycle (2010) 0.89
Role of cdk5 in the pathogenesis of Alzheimer's disease. Neurosignals (2003) 0.88
Controversies over p25 in Alzheimer's disease. J Alzheimers Dis (2002) 0.84
Mechanism and consequences of nerve cell death in Parkinson's disease. J Neural Transm Suppl (1999) 0.80
When good Cdk5 turns bad. Sci Aging Knowledge Environ (2006) 0.80
Identification of p10 as a neurotoxic product generated from the proteolytic cleavage of the neuronal Cdk5 activator. J Cell Biochem (2010) 0.78
The DNA sequence of the human X chromosome. Nature (2005) 6.97
Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA. Nature (2011) 6.10
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell (2011) 4.26
Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis. Proc Natl Acad Sci U S A (2003) 4.06
Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell (2004) 4.00
Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus. BMC Microbiol (2007) 3.25
Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: a phase I/II study. Lancet Oncol (2009) 2.45
A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nat Biotechnol (2003) 2.41
Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone. J Exp Med (2011) 2.38
Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. Chem Biol (2009) 1.93
Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1. Cancer Res (2008) 1.92
The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus. Mol Cell (2012) 1.83
Heightened epithelial Na+ channel-mediated Na+ absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia. Am J Physiol Cell Physiol (2005) 1.74
Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032. PLoS One (2007) 1.71
Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis. J Am Chem Soc (2007) 1.69
SVRMHC prediction server for MHC-binding peptides. BMC Bioinformatics (2006) 1.59
Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. ACS Chem Biol (2009) 1.56
Strain differences in alcohol-induced neurochemical plasticity: a role for accumbens glutamate in alcohol intake. Alcohol Clin Exp Res (2008) 1.54
Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool. Blood (2011) 1.54
Influence of stroke-related impairments on performance in 6-minute walk test. J Rehabil Res Dev (2007) 1.51
Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells. J Nutr (2002) 1.48
Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism. J Neurosci (2009) 1.47
Rapid displacement of dengue virus type 1 by type 4, Pacific region, 2007-2009. Emerg Infect Dis (2010) 1.47
Anti-cancer drugs targeting fatty acid synthase (FAS). Recent Pat Anticancer Drug Discov (2012) 1.46
Sequence and structure of the extrachromosomal palindrome encoding the ribosomal RNA genes in Dictyostelium. Nucleic Acids Res (2003) 1.46
Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol (2010) 1.45
Complete genome sequence of Enterococcus faecium strain TX16 and comparative genomic analysis of Enterococcus faecium genomes. BMC Microbiol (2012) 1.43
A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis. J Am Chem Soc (2003) 1.42
Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting. Mol Cell Biol (2004) 1.40
Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis. Chem Biol (2006) 1.38
Regulation of cation transport in the distal nephron by mechanical forces. Am J Physiol Renal Physiol (2006) 1.37
Drug development against metastasis-related genes and their pathways: a rationale for cancer therapy. Biochim Biophys Acta (2008) 1.36
A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis. Proc Natl Acad Sci U S A (2008) 1.36
The tumor metastasis suppressor gene Drg-1 down-regulates the expression of activating transcription factor 3 in prostate cancer. Cancer Res (2006) 1.35
Radical-mediated enzymatic methylation: a tale of two SAMS. Acc Chem Res (2011) 1.33
Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties. Drug Alcohol Depend (2006) 1.33
Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20. Mol Cell (2012) 1.29
Abnormal neural activity in the patients with remitted geriatric depression: a resting-state functional magnetic resonance imaging study. J Affect Disord (2008) 1.29
Dietary K+ regulates apical membrane expression of maxi-K channels in rabbit cortical collecting duct. Am J Physiol Renal Physiol (2005) 1.29
Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals. Purinergic Signal (2007) 1.27
Extended daily access to cocaine results in distinct alterations in Homer 1b/c and NMDA receptor subunit expression within the medial prefrontal cortex. Synapse (2009) 1.27
RhoC promotes metastasis via activation of the Pyk2 pathway in prostate cancer. Cancer Res (2008) 1.27
Effect of GRP75/mthsp70/PBP74/mortalin overexpression on intracellular ATP level, mitochondrial membrane potential and ROS accumulation following glucose deprivation in PC12 cells. Mol Cell Biochem (2005) 1.25
Evidence for two distinct binding sites for tau on microtubules. Proc Natl Acad Sci U S A (2004) 1.24
Focal adhesion kinase plays a pivotal role in herpes simplex virus entry. J Biol Chem (2005) 1.24
Differential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P rats. Alcohol Clin Exp Res (2009) 1.23
NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell (2010) 1.22
Effects of antipsychotics on fat deposition and changes in leptin and insulin levels. Magnetic resonance imaging study of previously untreated people with schizophrenia. Br J Psychiatry (2004) 1.21
Chronic ethanol consumption by C57BL/6 mice promotes tolerance to its interoceptive cues and increases extracellular dopamine, an effect blocked by naltrexone. Alcohol Clin Exp Res (2003) 1.20
Mechanism underlying flow stimulation of sodium absorption in the mammalian collecting duct. Am J Physiol Renal Physiol (2006) 1.20
Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells. Cancer Res (2011) 1.20
Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures. Alcohol Clin Exp Res (2012) 1.19
Isolation of temperature-sensitive p53 mutations from a comprehensive missense mutation library. J Biol Chem (2003) 1.16
Posttranscriptional compensation for heterozygous disruption of the kidney-specific NaK2Cl cotransporter gene. J Am Soc Nephrol (2002) 1.16
Effect of aldosterone on BK channel expression in mammalian cortical collecting duct. Am J Physiol Renal Physiol (2008) 1.15
Flow-induced prostaglandin E2 release regulates Na and K transport in the collecting duct. Am J Physiol Renal Physiol (2012) 1.14
Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates. J Am Chem Soc (2005) 1.14
Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke. J Neurosci (2011) 1.13
Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis. Chem Biol (2008) 1.13
Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase. Breast Cancer Res Treat (2010) 1.11
Asymmetric [3+2] cycloadditions of allenoates and dual activated olefins catalyzed by simple bifunctional N-acyl aminophosphines. Angew Chem Int Ed Engl (2010) 1.10
Multiple receptor interactions trigger release of membrane and intracellular calcium stores critical for herpes simplex virus entry. Mol Biol Cell (2007) 1.10
Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain. EMBO Mol Med (2013) 1.10
Enediyne natural products: biosynthesis and prospect towards engineering novel antitumor agents. Curr Med Chem (2003) 1.10
Radical-mediated enzymatic carbon chain fragmentation-recombination. Nat Chem Biol (2011) 1.09
Epoxyeicosatrienoic acid activates BK channels in the cortical collecting duct. J Am Soc Nephrol (2008) 1.09
Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function. J Neurosci (2005) 1.08
Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099. Mol Biosyst (2010) 1.08
The finished DNA sequence of human chromosome 12. Nature (2006) 1.08
Identification and analysis of the biosynthetic gene cluster encoding the thiopeptide antibiotic cyclothiazomycin in Streptomyces hygroscopicus 10-22. Appl Environ Microbiol (2010) 1.08
New insights on neurobiological mechanisms underlying alcohol addiction. Neuropharmacology (2012) 1.07
Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase. Biochem Biophys Res Commun (2006) 1.07
Nanoporous anatase TiO2 mesocrystals: additive-free synthesis, remarkable crystalline-phase stability, and improved lithium insertion behavior. J Am Chem Soc (2010) 1.06
Identification of Tyr504 as an alternative tyrosyl radical site in human prostaglandin H synthase-2. Biochemistry (2004) 1.05
No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro. Proc Natl Acad Sci U S A (2010) 1.05
Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro. J Alzheimers Dis (2009) 1.04
Biosynthetic pathway for high structural diversity of a common dilactone core in antimycin production. Org Lett (2012) 1.04
A soluble oligomer of tau associated with fiber formation analyzed by NMR. Biochemistry (2008) 1.04
The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Proc Natl Acad Sci U S A (2005) 1.03
Glucose deprivation induces mitochondrial dysfunction and oxidative stress in PC12 cell line. J Cell Mol Med (2003) 1.03
Increasing nitric oxide content in Arabidopsis thaliana by expressing rat neuronal nitric oxide synthase resulted in enhanced stress tolerance. Plant Cell Physiol (2011) 1.02
The effectiveness of progressive addition lenses on the progression of myopia in Chinese children. Ophthalmic Physiol Opt (2009) 1.02
A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization. Cell (2013) 1.01
Substrate specificity of CDK2-cyclin A. What is optimal? J Biol Chem (2003) 1.01
Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a nonribosomal peptide synthetase system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. J Bacteriol (2007) 0.99
Activation mechanism of CDK2: role of cyclin binding versus phosphorylation. Biochemistry (2002) 0.99
Regional gray matter changes are associated with cognitive deficits in remitted geriatric depression: an optimized voxel-based morphometry study. Biol Psychiatry (2008) 0.99
Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics. J Bacteriol (2008) 0.99
Distinct neurochemical adaptations within the nucleus accumbens produced by a history of self-administered vs non-contingently administered intravenous methamphetamine. Neuropsychopharmacology (2011) 0.99
Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells. Proc Natl Acad Sci U S A (2009) 0.98
TMAO promotes fibrillization and microtubule assembly activity in the C-terminal repeat region of tau. Biochemistry (2006) 0.98
Improvement of FK506 production in Streptomyces tsukubaensis by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems. Appl Environ Microbiol (2012) 0.97
Biosynthesis of thiopeptide antibiotics and their pathway engineering. Nat Prod Rep (2013) 0.96
r-Shaped hybrid nanogenerator with enhanced piezoelectricity. ACS Nano (2013) 0.96
Bifunctional N-acyl-aminophosphine-catalyzed asymmetric [4+2] cycloadditions of allenoates and imines. Chemistry (2011) 0.94
ThioFinder: a web-based tool for the identification of thiopeptide gene clusters in DNA sequences. PLoS One (2012) 0.94
Crosstalk between Raf/MEK/ERK and PI3K/AKT in suppression of Bax conformational change by Grp75 under glucose deprivation conditions. J Mol Biol (2011) 0.94
Targeting Homer genes using adeno-associated viral vector: lessons learned from behavioural and neurochemical studies. Behav Pharmacol (2008) 0.94