Published in Neurosignals on December 15, 2003
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Balance of calcineurin Aα and CDK5 activities sets release probability at nerve terminals. J Neurosci (2013) 1.09
Cell migration and invasion in human disease: the Tks adaptor proteins. Biochem Soc Trans (2012) 1.04
Selectivity and potency of cyclin-dependent kinase inhibitors. AAPS J (2006) 1.04
p10, the N-terminal domain of p35, protects against CDK5/p25-induced neurotoxicity. Proc Natl Acad Sci U S A (2012) 0.98
The 3' untranslated region of human Cyclin-Dependent Kinase 5 Regulatory subunit 1 contains regulatory elements affecting transcript stability. BMC Mol Biol (2007) 0.91
Mutations and novel polymorphisms in coding regions and UTRs of CDK5R1 and OMG genes in patients with non-syndromic mental retardation. Neurogenetics (2006) 0.89
Cyclin-dependent kinase 5 mediates adult OPC maturation and myelin repair through modulation of Akt and GsK-3β signaling. J Neurosci (2014) 0.85
Signaling in migrating neurons: from molecules to networks. Front Neurosci (2011) 0.83
Maternal separation with early weaning: a rodent model providing novel insights into neglect associated developmental deficits. Dev Psychopathol (2012) 0.83
X-ray irradiation promotes apoptosis of hippocampal neurons through up-regulation of Cdk5 and p25. Cancer Cell Int (2013) 0.82
Docking and 3D-QSAR modeling of cyclin-dependent kinase 5/p25 inhibitors. J Mol Model (2010) 0.80
Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells. Hum Mol Genet (2014) 0.78
Insights into Ligand-Protein Binding from Local Mechanical Response. J Chem Theory Comput (2011) 0.78
Specific serine-proline phosphorylation and glycogen synthase kinase 3β-directed subcellular targeting of stathmin 3/Sclip in neurons. J Biol Chem (2012) 0.76
The interaction of Munc 18 (p67) with the p10 domain of p35 protects in vivo Cdk5/p35 activity from inhibition by TFP5, a peptide derived from p35. Mol Biol Cell (2016) 0.75
Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature (2009) 11.74
HDAC2 negatively regulates memory formation and synaptic plasticity. Nature (2009) 6.96
Recovery of learning and memory is associated with chromatin remodelling. Nature (2007) 6.72
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell (2009) 5.34
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J (2007) 4.66
A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature (2010) 4.39
Trekking across the brain: the journey of neuronal migration. Cell (2007) 3.90
Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2. Nat Protoc (2010) 3.71
Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning. Neuron (2004) 3.33
Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron (2003) 2.97
Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. Neuron (2008) 2.88
Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron (2005) 2.68
An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature (2012) 2.67
G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors. Cell (2005) 2.64
Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science (2013) 2.61
Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell (2010) 2.57
Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool. Neuron (2007) 2.53
Life is a journey: a genetic look at neocortical development. Nat Rev Genet (2002) 2.46
14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nat Genet (2003) 2.27
APP processing is regulated by cytoplasmic phosphorylation. J Cell Biol (2003) 2.21
Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron (2010) 2.08
Cyclin-dependent kinases in brain development and disease. Annu Rev Cell Dev Biol (2011) 2.08
A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons. Nat Cell Biol (2004) 2.06
Functional integration of dopaminergic neurons directly converted from mouse fibroblasts. Cell Stem Cell (2011) 1.95
Targeting the correct HDAC(s) to treat cognitive disorders. Trends Pharmacol Sci (2010) 1.94
Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci (2010) 1.93
Guiding neuronal cell migrations. Cold Spring Harb Perspect Biol (2010) 1.82
Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons. J Neurosci (2004) 1.81
p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo. J Neurosci (2006) 1.80
Cyclin-dependent kinases: a family portrait. Nat Cell Biol (2009) 1.80
Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex. Nat Neurosci (2012) 1.79
Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected]. Cell Stem Cell (2013) 1.77
Histone acetylation: molecular mnemonics on the chromatin. Nat Rev Neurosci (2013) 1.77
Cdk5 deregulation in the pathogenesis of Alzheimer's disease. Trends Mol Med (2004) 1.76
Doublecortin-like kinase controls neurogenesis by regulating mitotic spindles and M phase progression. Neuron (2006) 1.74
Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development. Neuron (2011) 1.67
Epigenetic regulation of gene expression in physiological and pathological brain processes. Physiol Rev (2011) 1.66
Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex. Neuron (2010) 1.60
A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease. Curr Opin Neurobiol (2004) 1.60
Par-4 links dopamine signaling and depression. Cell (2005) 1.58
The potential of HDAC inhibitors as cognitive enhancers. Annu Rev Pharmacol Toxicol (2013) 1.52
Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase. Neuron (2004) 1.51
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci U S A (2010) 1.49
Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to neuronal positioning during early corticogenesis. Neuron (2004) 1.40
A hippocampal Cdk5 pathway regulates extinction of contextual fear. Nat Neurosci (2007) 1.35
Pyramidal neuron polarity axis is defined at the bipolar stage. J Cell Sci (2008) 1.31
Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons. Nat Neurosci (2013) 1.31
The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. J Neurosci (2002) 1.30
Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron (2007) 1.30
The role of Cdk5 in neuroendocrine thyroid cancer. Cancer Cell (2013) 1.30
Cdk5: one of the links between senile plaques and neurofibrillary tangles? J Alzheimers Dis (2003) 1.30
SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons. Nat Neurosci (2013) 1.30
Centrosome motility is essential for initial axon formation in the neocortex. J Neurosci (2010) 1.29
Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Neuron (2010) 1.26
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. J Clin Invest (2014) 1.23
BACE1 suppression by RNA interference in primary cortical neurons. J Biol Chem (2003) 1.19
Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity. Neuropharmacology (2012) 1.18
Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1. J Neurosci (2007) 1.17
Spindle regulation in neural precursors of flies and mammals. Nat Rev Neurosci (2007) 1.16
Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity. Neuron (2009) 1.16
Bridging physiology and pathology in AD. Cell (2009) 1.13
Layering defect in p35 deficiency is linked to improper neuronal-glial interaction in radial migration. Nat Neurosci (2003) 1.13
Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling--a hypothesis on neuronal migration. Cereb Cortex (2006) 1.13
A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration. J Neurosci (2013) 1.12
Mechanism of CDK5/p25 binding by CDK inhibitors. J Med Chem (2005) 1.11
MicroRNAs in learning, memory, and neurological diseases. Learn Mem (2012) 1.09
Cyclin-dependent kinase 5 phosphorylates serine 31 of tyrosine hydroxylase and regulates its stability. J Biol Chem (2004) 1.07
Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity. Neurobiol Learn Mem (2011) 1.07
Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology. Proc Natl Acad Sci U S A (2008) 1.04
Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway. PLoS One (2011) 1.04
A high-throughput screen for Wnt/β-catenin signaling pathway modulators in human iPSC-derived neural progenitors. J Biomol Screen (2012) 1.03
ASPM regulates Wnt signaling pathway activity in the developing brain. Genes Dev (2011) 1.01
Ndel1 controls the dynein-mediated transport of vimentin during neurite outgrowth. J Biol Chem (2008) 1.01
Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. J Neurosci (2004) 1.00
Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. J Biol Chem (2002) 0.99
Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5. Neuron (2012) 0.99
Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles. J Neuropathol Exp Neurol (2002) 0.98
Cdk5 phosphorylation of FAK regulates centrosome-associated miocrotubules and neuronal migration. Cell Cycle (2004) 0.95
Mechanisms of age-related cognitive change and targets for intervention: epigenetics. J Gerontol A Biol Sci Med Sci (2012) 0.93
Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis. J Biol Chem (2010) 0.92
Phosphorylation of the homer-binding domain of group I metabotropic glutamate receptors by cyclin-dependent kinase 5. J Neurochem (2009) 0.92
Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons. Nat Cell Biol (2011) 0.92
GC box-binding transcription factors control the neuronal specific transcription of the cyclin-dependent kinase 5 regulator p35. J Biol Chem (2001) 0.89
Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene. J Neurosci (2003) 0.89
Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1). J Neurosci (2011) 0.88
Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth. PLoS Biol (2009) 0.87
MicroTUB(B3)ules and brain development. Cell (2010) 0.85
Linking cell cycle reentry and DNA damage in neurodegeneration. Ann N Y Acad Sci (2009) 0.84
Control of cortical neuron migration and layering: cell and non cell-autonomous effects of p35. J Neurosci (2004) 0.84
Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models. J Biol Chem (2013) 0.83
Disc1 regulates both β-catenin-mediated and noncanonical Wnt signaling during vertebrate embryogenesis. FASEB J (2011) 0.83
Cdk5 selectively affects the migration of different populations of neurons in the developing spinal cord. J Comp Neurol (2007) 0.81
DNA methylation in cognition comes of age. Nat Neurosci (2012) 0.80
Targeting p35/Cdk5 signalling via CIP-peptide promotes angiogenesis in hypoxia. PLoS One (2013) 0.80
Phosphoproteomic analysis with a solid-phase capture-release-tag approach. Chem Biol (2005) 0.80
Cognitive enhancement: A molecular memory booster. Nature (2011) 0.80
Putting a notch in our understanding of nuclear migration. Cell (2008) 0.80
Forebrain-specific deletion of Cdk5 in pyramidal neurons results in mania-like behavior and cognitive impairment. Neurobiol Learn Mem (2013) 0.79
Chronically implanted hyperdrive for cortical recording and optogenetic control in behaving mice. Conf Proc IEEE Eng Med Biol Soc (2011) 0.79
Axon selection: From a polarized cytoplasm to a migrating neuron. Commun Integr Biol (2011) 0.78