Tipping the lysine methylation balance in disease.

PubWeight™: 0.82‹?›

🔗 View Article (PMC 3826254)

Published in Biopolymers on February 01, 2013

Authors

Joshua C Black1, Johnathan R Whetstine

Author Affiliations

1: Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, 13th Street, Charlestown, MA 02129.

Articles cited by this

Selective inhibition of BET bromodomains. Nature (2010) 18.79

The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature (2002) 18.30

Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature (2000) 18.26

Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev (2006) 14.36

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A (2003) 13.68

Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell (2001) 11.39

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet (2009) 10.21

ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS. Proc Natl Acad Sci U S A (1964) 9.91

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J (2003) 9.55

Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci (2006) 8.24

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev (2007) 6.71

Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer (2010) 6.27

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell (2007) 6.04

hDOT1L links histone methylation to leukemogenesis. Cell (2005) 5.83

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell (2007) 5.49

Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell (2009) 5.26

Dynamic regulation of histone lysine methylation by demethylases. Mol Cell (2007) 5.14

AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. Mol Cell (2010) 4.99

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell (2011) 4.90

The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Nature (2006) 4.74

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nat Genet (2009) 4.52

Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science (2010) 3.97

PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Mol Cell (2007) 3.68

A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification. Blood (2007) 3.60

Molecular mechanisms and potential functions of histone demethylases. Nat Rev Mol Cell Biol (2012) 3.40

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell (2009) 3.34

Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations. J Clin Invest (2006) 3.27

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat Chem Biol (2012) 3.15

The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Genes Dev (2009) 3.04

H3K27 demethylases, at long last. Cell (2007) 3.02

Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation. Am J Hum Genet (2004) 2.99

The super elongation complex (SEC) and MLL in development and disease. Genes Dev (2011) 2.63

Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells. PLoS One (2008) 2.52

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat Struct Mol Biol (2009) 2.50

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. Int J Cancer (2011) 2.42

Histone methylation regulates memory formation. J Neurosci (2010) 2.30

Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex. Neuron (2009) 2.26

Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters. J Neurosci (2007) 2.24

Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature (2010) 2.20

Histone modifying enzymes: structures, mechanisms, and specificities. Biochim Biophys Acta (2008) 2.07

H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM. Cancer Res (2010) 1.98

Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Proc Natl Acad Sci U S A (2010) 1.97

Protein methylation. Science (1971) 1.95

DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis. Blood (2011) 1.88

Total synthesis of (+)-chaetocin and its analogues: their histone methyltransferase G9a inhibitory activity. J Am Chem Soc (2010) 1.80

Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines. Cancer Res (2000) 1.78

Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D. Biochem Biophys Res Commun (2007) 1.75

Roles of the Polycomb group proteins in stem cells and cancer. Cell Death Dis (2011) 1.70

Selective inhibitors of histone methyltransferase DOT1L: design, synthesis, and crystallographic studies. J Am Chem Soc (2011) 1.66

The histone demethylase UTX enables RB-dependent cell fate control. Genes Dev (2010) 1.62

Disruption of the gene Euchromatin Histone Methyl Transferase1 (Eu-HMTase1) is associated with the 9q34 subtelomeric deletion syndrome. J Med Genet (2005) 1.60

Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer. Oncogene (2009) 1.58

Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression. Mol Cell (2010) 1.55

Histone demethylase LSD1 regulates neural stem cell proliferation. Mol Cell Biol (2010) 1.47

Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry (2007) 1.44

Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B. J Neurosci (2010) 1.33

The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase. Antioxid Redox Signal (2009) 1.32

Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. J Med Chem (2010) 1.31

SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation. Mol Cell Biol (2011) 1.30

Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. J Am Chem Soc (2010) 1.29

Epigenetic regulation of cancer growth by histone demethylases. Int J Cancer (2010) 1.23

The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein. J Biol Chem (2011) 1.22

Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment. Hippocampus (2011) 1.20

(-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells. Carcinogenesis (2011) 1.14

Chromatin landscape: methylation beyond transcription. Epigenetics (2011) 1.12

Reduced exploration, increased anxiety, and altered social behavior: Autistic-like features of euchromatin histone methyltransferase 1 heterozygous knockout mice. Behav Brain Res (2009) 1.10

Structural Modifications of Histones and their Possible Role in the Regulation of RNA Synthesis. Science (1964) 1.07

Studies on the origin of epsilon-N-methyl-L-lysine in protein. J Biol Chem (1965) 1.02

Positive association of schizophrenia to JARID2 gene. Am J Med Genet B Neuropsychiatr Genet (2007) 1.01

Analysis of 9p24 and 11p12-13 regions in autism spectrum disorders: rs1340513 in the JMJD2C gene is associated with ASDs in Finnish sample. Psychiatr Genet (2010) 0.94

Effects of RNA interference-mediated gene silencing of JMJD2A on human breast cancer cell line MDA-MB-231 in vitro. J Exp Clin Cancer Res (2011) 0.92

Whole genome association study in a homogenous population in Shandong peninsula of China reveals JARID2 as a susceptibility gene for schizophrenia. J Biomed Biotechnol (2009) 0.89

Polycythemia vera transforming to acute myeloid leukemia and complex abnormalities including 9p homogeneously staining region with amplification of MLLT3, JMJD2C, JAK2, and SMARCA2. Cancer Genet Cytogenet (2008) 0.86

Male rats fed methyl- and folate-deficient diets with or without niacin develop hepatic carcinomas associated with decreased tissue NAD concentrations and altered poly(ADP-ribose) polymerase activity. J Nutr (1997) 0.83

Articles by these authors

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell (2004) 21.30

A histone H3 lysine 27 demethylase regulates animal posterior development. Nature (2007) 6.57

Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature (2003) 6.48

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell (2007) 6.04

Dynamic regulation of histone lysine methylation by demethylases. Mol Cell (2007) 5.14

Histone lysine methylation dynamics: establishment, regulation, and biological impact. Mol Cell (2012) 2.85

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nat Cell Biol (2009) 2.74

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev (2010) 2.55

KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors. Cell (2013) 2.34

Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression. Mol Cell (2010) 1.55

The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein. J Biol Chem (2011) 1.22

RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes. Mol Cell Biol (2012) 1.14

The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span. Proc Natl Acad Sci U S A (2009) 1.14

Chromatin landscape: methylation beyond transcription. Epigenetics (2011) 1.12

Roles of USF, Ikaros and Sp proteins in the transcriptional regulation of the human reduced folate carrier B promoter. Biochem J (2004) 0.94

Detection of impaired homologous recombination repair in NSCLC cells and tissues. J Thorac Oncol (2013) 0.89

LOX out, histones: a new enzyme is nipping at your tails. Mol Cell (2012) 0.84

Transcriptional regulation of the human reduced folate carrier promoter C: synergistic transactivation by Sp1 and C/EBP beta and identification of a downstream repressor. Biochim Biophys Acta (2004) 0.81