PubRank

Christoph Wittmann

Author PubWeight™ 83.15‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Complete genome sequence of the myxobacterium Sorangium cellulosum. Nat Biotechnol 2007 2.43
2 Correcting mass isotopomer distributions for naturally occurring isotopes. Biotechnol Bioeng 2002 1.90
3 Sampling for metabolome analysis of microorganisms. Anal Chem 2007 1.89
4 The yeast Kluyveromyces marxianus and its biotechnological potential. Appl Microbiol Biotechnol 2008 1.61
5 OpenFLUX: efficient modelling software for 13C-based metabolic flux analysis. Microb Cell Fact 2009 1.61
6 Comparative metabolic flux analysis of lysine-producing Corynebacterium glutamicum cultured on glucose or fructose. Appl Environ Microbiol 2004 1.50
7 Systems metabolic engineering of xylose-utilizing Corynebacterium glutamicum for production of 1,5-diaminopentane. Biotechnol J 2013 1.50
8 From zero to hero--design-based systems metabolic engineering of Corynebacterium glutamicum for L-lysine production. Metab Eng 2011 1.47
9 Characterization of the metabolic shift between oxidative and fermentative growth in Saccharomyces cerevisiae by comparative 13C flux analysis. Microb Cell Fact 2005 1.47
10 Amplified expression of fructose 1,6-bisphosphatase in Corynebacterium glutamicum increases in vivo flux through the pentose phosphate pathway and lysine production on different carbon sources. Appl Environ Microbiol 2005 1.44
11 Bio-based production of chemicals, materials and fuels -Corynebacterium glutamicum as versatile cell factory. Curr Opin Biotechnol 2011 1.43
12 Integrated optical sensing of dissolved oxygen in microtiter plates: a novel tool for microbial cultivation. Biotechnol Bioeng 2003 1.41
13 Minibioreactors. Biotechnol Lett 2004 1.37
14 In-depth profiling of lysine-producing Corynebacterium glutamicum by combined analysis of the transcriptome, metabolome, and fluxome. J Bacteriol 2004 1.32
15 In vivo quantification of intracellular amino acids and intermediates of the methionine pathway in Corynebacterium glutamicum. Anal Biochem 2005 1.23
16 Industrial biotechnology of Pseudomonas putida and related species. Appl Microbiol Biotechnol 2012 1.20
17 Systems-wide metabolic pathway engineering in Corynebacterium glutamicum for bio-based production of diaminopentane. Metab Eng 2010 1.17
18 Metabolic flux engineering of L-lysine production in Corynebacterium glutamicum--over expression and modification of G6P dehydrogenase. J Biotechnol 2007 1.12
19 Characterization and control of fungal morphology for improved production performance in biotechnology. J Biotechnol 2012 1.09
20 Systems and synthetic metabolic engineering for amino acid production - the heartbeat of industrial strain development. Curr Opin Biotechnol 2012 1.09
21 Transcriptional and metabolic responses of Bacillus subtilis to the availability of organic acids: transcription regulation is important but not sufficient to account for metabolic adaptation. Appl Environ Microbiol 2006 1.05
22 Response of the central metabolism of Escherichia coli to modified expression of the gene encoding the glucose-6-phosphate dehydrogenase. FEBS Lett 2007 1.01
23 Consequences of phosphoenolpyruvate:sugar phosphotranferase system and pyruvate kinase isozymes inactivation in central carbon metabolism flux distribution in Escherichia coli. Microb Cell Fact 2012 1.01
24 Getting the big beast to work--systems biotechnology of Bacillus megaterium for novel high-value proteins. J Biotechnol 2012 1.00
25 Morphology engineering of Aspergillus niger for improved enzyme production. Biotechnol Bioeng 2010 1.00
26 Theoretical aspects of 13C metabolic flux analysis with sole quantification of carbon dioxide labeling. Comput Biol Chem 2005 1.00
27 Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae. Biotechnol Bioeng 2003 0.99
28 Metabolic fluxes in the central carbon metabolism of Dinoroseobacter shibae and Phaeobacter gallaeciensis, two members of the marine Roseobacter clade. BMC Microbiol 2009 0.99
29 Metabolic pathway analysis for rational design of L-methionine production by Escherichia coli and Corynebacterium glutamicum. Metab Eng 2006 0.99
30 Metabolic responses to pyruvate kinase deletion in lysine producing Corynebacterium glutamicum. Microb Cell Fact 2008 0.98
31 Systems metabolic engineering of Escherichia coli for production of the antitumor drugs violacein and deoxyviolacein. Metab Eng 2013 0.97
32 Improved enzyme production by bio-pellets of Aspergillus niger: targeted morphology engineering using titanate microparticles. Biotechnol Bioeng 2011 0.97
33 Physiology of the yeast Kluyveromyces marxianus during batch and chemostat cultures with glucose as the sole carbon source. FEMS Yeast Res 2007 0.95
34 Metabolic engineering of cellular transport for overproduction of the platform chemical 1,5-diaminopentane in Corynebacterium glutamicum. Metab Eng 2011 0.95
35 Debottlenecking recombinant protein production in Bacillus megaterium under large-scale conditions--targeted precursor feeding designed from metabolomics. Biotechnol Bioeng 2012 0.94
36 Flux Design: In silico design of cell factories based on correlation of pathway fluxes to desired properties. BMC Syst Biol 2009 0.93
37 Microbial production of the drugs violacein and deoxyviolacein: analytical development and strain comparison. Biotechnol Lett 2011 0.93
38 Identification and elimination of the competing N-acetyldiaminopentane pathway for improved production of diaminopentane by Corynebacterium glutamicum. Appl Environ Microbiol 2010 0.93
39 Microparticle based morphology engineering of filamentous microorganisms for industrial bio-production. Biotechnol Lett 2012 0.92
40 Integration of in vivo and in silico metabolic fluxes for improvement of recombinant protein production. Metab Eng 2011 0.92
41 Systems biology of recombinant protein production using Bacillus megaterium. Methods Enzymol 2011 0.92
42 Appropriate sampling for intracellular amino acid analysis in five phylogenetically different yeasts. Biotechnol Lett 2008 0.92
43 Metabolic network simulation using logical loop algorithm and Jacobian matrix. Metab Eng 2004 0.91
44 Advanced biotechnology: metabolically engineered cells for the bio-based production of chemicals and fuels, materials, and health-care products. Angew Chem Int Ed Engl 2015 0.90
45 Filamentous fungi in good shape: microparticles for tailor-made fungal morphology and enhanced enzyme production. Bioeng Bugs 2011 0.90
46 Comparative study on central metabolic fluxes of Bacillus megaterium strains in continuous culture using 13C labelled substrates. Bioprocess Biosyst Eng 2006 0.90
47 Metabolic engineering of industrial platform microorganisms for biorefinery applications--optimization of substrate spectrum and process robustness by rational and evolutive strategies. Bioresour Technol 2012 0.89
48 Optimized bioprocess for production of fructofuranosidase by recombinant Aspergillus niger. Appl Microbiol Biotechnol 2010 0.89
49 Metabolic fluxes and beyond-systems biology understanding and engineering of microbial metabolism. Appl Microbiol Biotechnol 2010 0.89
50 In-silico-driven metabolic engineering of Pseudomonas putida for enhanced production of poly-hydroxyalkanoates. Metab Eng 2012 0.88
51 Reconciling in vivo and in silico key biological parameters of Pseudomonas putida KT2440 during growth on glucose under carbon-limited condition. BMC Biotechnol 2013 0.88
52 Metabolic engineering of Corynebacterium glutamicum for production of 1,5-diaminopentane from hemicellulose. Biotechnol J 2011 0.87
53 Bio-based production of the platform chemical 1,5-diaminopentane. Appl Microbiol Biotechnol 2011 0.87
54 Metabolic engineering of the tricarboxylic acid cycle for improved lysine production by Corynebacterium glutamicum. Appl Environ Microbiol 2009 0.86
55 Increased lysine production by flux coupling of the tricarboxylic acid cycle and the lysine biosynthetic pathway--metabolic engineering of the availability of succinyl-CoA in Corynebacterium glutamicum. Metab Eng 2012 0.86
56 Derivatization of small biomolecules for optimized matrix-assisted laser desorption/ionization mass spectrometry. J Mass Spectrom 2002 0.85
57 Accumulation of homolanthionine and activation of a novel pathway for isoleucine biosynthesis in Corynebacterium glutamicum McbR deletion strains. J Bacteriol 2006 0.85
58 Transposon mutagenesis identified chromosomal and plasmid genes essential for adaptation of the marine bacterium Dinoroseobacter shibae to anaerobic conditions. J Bacteriol 2013 0.84
59 Gene regulatory and metabolic adaptation processes of Dinoroseobacter shibae DFL12T during oxygen depletion. J Biol Chem 2014 0.84
60 Software tool for automated processing of 13C labeling data from mass spectrometric spectra. Biotechniques 2003 0.84
61 Towards methionine overproduction in Corynebacterium glutamicum--methanethiol and dimethyldisulfide as reduced sulfur sources. J Microbiol Biotechnol 2010 0.84
62 Adaptation of Bacillus subtilis carbon core metabolism to simultaneous nutrient limitation and osmotic challenge: a multi-omics perspective. Environ Microbiol 2014 0.84
63 Metabolic flux screening of Saccharomyces cerevisiae single knockout strains on glucose and galactose supports elucidation of gene function. J Biotechnol 2007 0.84
64 Systems metabolic engineering of Corynebacterium glutamicum for production of the chemical chaperone ectoine. Microb Cell Fact 2013 0.83
65 Production of medium chain length polyhydroxyalkanoate in metabolic flux optimized Pseudomonas putida. Microb Cell Fact 2014 0.83
66 Respirometric 13C flux analysis--Part II: in vivo flux estimation of lysine-producing Corynebacterium glutamicum. Metab Eng 2006 0.83
67 High yield production of extracellular recombinant levansucrase by Bacillus megaterium. Appl Microbiol Biotechnol 2012 0.82
68 Analysis of 13C labeling enrichment in microbial culture applying metabolic tracer experiments using gas chromatography-combustion-isotope ratio mass spectrometry. Anal Biochem 2008 0.82
69 Systems-wide analysis and engineering of metabolic pathway fluxes in bio-succinate producing Basfia succiniciproducens. Biotechnol Bioeng 2013 0.82
70 Core fluxome and metafluxome of lactic acid bacteria under simulated cocoa pulp fermentation conditions. Appl Environ Microbiol 2013 0.82
71 Effect of different carbon sources on central metabolic fluxes and the recombinant production of a hydrolase from Thermobifida fusca in Bacillus megaterium. J Biotechnol 2007 0.82
72 Investigation of the central carbon metabolism of Sorangium cellulosum: metabolic network reconstruction and quantification of pathway fluxes. J Microbiol Biotechnol 2009 0.81
73 Physiological response of Corynebacterium glutamicum to oxidative stress induced by deletion of the transcriptional repressor McbR. Microbiology 2008 0.81
74 Systems metabolic engineering of Escherichia coli for gram scale production of the antitumor drug deoxyviolacein from glycerol. Biotechnol Bioeng 2014 0.81
75 Metabolic flux pattern of glucose utilization by Xanthomonas campestris pv. campestris: prevalent role of the Entner-Doudoroff pathway and minor fluxes through the pentose phosphate pathway and glycolysis. Mol Biosyst 2014 0.80
76 Metabolite profiling studies in Saccharomyces cerevisiae: an assisting tool to prioritize host targets for antiviral drug screening. Microb Cell Fact 2009 0.80
77 Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for metabolic flux analyses using isotope-labeled ethanol. Rapid Commun Mass Spectrom 2007 0.80
78 Respirometric 13C flux analysis, Part I: design, construction and validation of a novel multiple reactor system using on-line membrane inlet mass spectrometry. Metab Eng 2006 0.79
79 Oxygen supply in disposable shake-flasks: prediction of oxygen transfer rate, oxygen saturation and maximum cell concentration during aerobic growth. Biotechnol Lett 2013 0.78
80 The key to acetate: metabolic fluxes of acetic acid bacteria under cocoa pulp fermentation-simulating conditions. Appl Environ Microbiol 2014 0.77
81 Membrane fluidity of halophilic ectoine-secreting bacteria related to osmotic and thermal treatment. Bioprocess Biosyst Eng 2013 0.77
82 Editorial: how multiplexed tools and approaches speed up the progress of metabolic engineering. Biotechnol J 2013 0.76
83 Customization of Aspergillus niger morphology through addition of talc micro particles. J Vis Exp 2012 0.75
84 From gene to product. J Biotechnol 2013 0.75
85 Application of cation-exchange membranes for characterisation and imaging ammonia-oxidising bacteria in soils. FEMS Microbiol Ecol 2005 0.75
86 Quantification of S-adenosyl methionine in microbial cell extracts. Biotechnol Lett 2006 0.75
87 Production of non-proteinogenic amino acids from α-keto acid precursors with recombinant Corynebacterium glutamicum. Biotechnol Bioeng 2013 0.75
88 GC-MS-based ¹³C metabolic flux analysis. Methods Mol Biol 2014 0.75
89 Dynamic calibration and dissolved gas analysis using membrane inlet mass spectrometry for the quantification of cell respiration. Rapid Commun Mass Spectrom 2003 0.75
90 Viability characterization of Taxus chinensis plant cell suspension cultures by rapid colorimetric- and image analysis-based techniques. Bioprocess Biosyst Eng 2014 0.75