Published in Nature on May 15, 2003
Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol (2011) 3.36
Ethical issues in funding orphan drug research and development. J Med Ethics (2005) 1.71
Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF. J Bone Miner Res (2009) 1.68
Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth. Hum Mol Genet (2007) 1.56
CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes. J Biochem (2008) 1.55
Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux. Am J Hum Genet (2004) 1.45
Identification of quantitative trait loci affecting murine long bone length in a two-generation intercross of LG/J and SM/J Mice. J Bone Miner Res (2008) 1.26
Wnt signaling in development and disease. Cell Biosci (2012) 1.22
Wnt signaling and skeletal development. Cell Signal (2007) 1.22
Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo. Mol Cell Biol (2005) 1.21
Asymmetric lower-limb malformations in individuals with homeobox PITX1 gene mutation. Am J Hum Genet (2008) 1.21
Global comparative transcriptome analysis of cartilage formation in vivo. BMC Dev Biol (2009) 1.18
Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation. Hum Mol Genet (2007) 1.18
BMP2 is essential for post natal osteogenesis but not for recruitment of osteogenic stem cells. Bone (2009) 1.14
A systematic review of genetic skeletal disorders reported in Chinese biomedical journals between 1978 and 2012. Orphanet J Rare Dis (2012) 1.12
Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation. Cell Metab (2013) 1.09
FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice. J Cell Biol (2005) 1.07
Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection. J Clin Invest (2011) 1.05
Replication of long-bone length QTL in the F9-F10 LG,SM advanced intercross. Mamm Genome (2009) 1.05
Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2. J Biol Chem (2008) 1.04
Atp6v0d2 is an essential component of the osteoclast-specific proton pump that mediates extracellular acidification in bone resorption. J Bone Miner Res (2009) 1.04
C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and -independent pathways. BMC Dev Biol (2007) 1.03
Defective osteoblast function in ICAP-1-deficient mice. Development (2007) 1.03
Hedgehog-dependent proliferation drives modular growth during morphogenesis of a dermal bone. Development (2012) 0.98
Regulation of chondrocyte differentiation by actin-severing protein adseverin. Dev Biol (2006) 0.96
Epiphyseal abnormalities, trabecular bone loss and articular chondrocyte hypertrophy develop in the long bones of postnatal Ext1-deficient mice. Bone (2013) 0.94
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Extracellular phosphate alters cementoblast gene expression. J Dent Res (2006) 0.92
Smad1 plays an essential role in bone development and postnatal bone formation. Osteoarthritis Cartilage (2011) 0.91
Loss of ATRX in chondrocytes has minimal effects on skeletal development. PLoS One (2009) 0.90
Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton. Ann N Y Acad Sci (2014) 0.90
MicroRNA-34a modulates cytoskeletal dynamics through regulating RhoA/Rac1 cross-talk in chondroblasts. J Biol Chem (2012) 0.90
Current concepts of extracellular matrix. J Orthop Sci (2006) 0.88
An improved collagen scaffold for skeletal regeneration. J Biomed Mater Res A (2010) 0.88
Placenta to cartilage: direct conversion of human placenta to chondrocytes with transformation by defined factors. Mol Biol Cell (2012) 0.86
Systems genetics analysis of mouse chondrocyte differentiation. J Bone Miner Res (2011) 0.84
Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation. BMC Dev Biol (2009) 0.83
Alteration of proteoglycan sulfation affects bone growth and remodeling. Bone (2013) 0.83
Vegfa regulates perichondrial vascularity and osteoblast differentiation in bone development. Development (2015) 0.83
Folate modulates Hox gene-controlled skeletal phenotypes. Genesis (2004) 0.82
Frontal nasal prominence expression driven by Tcfap2a relies on a conserved binding site for STAT proteins. Dev Dyn (2006) 0.80
Transcriptional Profiling Identifies the Signaling Axes of IGF and Transforming Growth Factor-b as Involved in the Pathogenesis of Osteosarcoma. Clin Orthop Relat Res (2016) 0.79
Novel mutation of RUNX2 gene in a patient with cleidocranial dysplasia. Int J Clin Exp Pathol (2015) 0.79
Cilia/Ift protein and motor -related bone diseases and mouse models. Front Biosci (Landmark Ed) (2015) 0.78
OPG inhibits gene expression of RANK and CAII in mouse osteoclast-like cell. Rheumatol Int (2011) 0.78
Making no bones about it: Transcription factors in vertebrate skeletogenesis and disease. Trends Dev Biol (2012) 0.78
Defective entry into mitosis 1 (Dim1) negatively regulates osteoclastogenesis by inhibiting the expression of nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATc1). J Biol Chem (2014) 0.78
Evidence of gene-environment interaction for the RUNX2 gene and environmental tobacco smoke in controlling the risk of cleft lip with/without cleft palate. Birth Defects Res A Clin Mol Teratol (2012) 0.78
About the importance of being desulfated. Genes Dev (2008) 0.77
Effects of pulsed electromagnetic fields on the mRNA expression of CAII and RANK in ovariectomized rats. Rheumatol Int (2011) 0.77
C-Nap1 mutation affects centriole cohesion and is associated with a Seckel-like syndrome in cattle. Nat Commun (2015) 0.77
An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos. Biomed Res Int (2017) 0.75
Analysis of the Fgfr2C342Y mouse model shows condensation defects due to misregulation of Sox9 expression in prechondrocytic mesenchyme. Biol Open (2017) 0.75
MESENCHYMAL STROMAL CELLS AND THEIR ORTHOPAEDIC APPLICATIONS. Case Orthop J (2016) 0.75
HIF-1α and growth plate development: what we really know. Bonekey Rep (2015) 0.75
Development of a subset of forelimb muscles and their attachment sites requires the ulnar-mammary syndrome gene Tbx3. Dis Model Mech (2016) 0.75
The Modulatory Effects of Mesenchymal Stem Cells on Osteoclastogenesis. Stem Cells Int (2015) 0.75
All-trans-retinoic acid inhibits chondrogenesis of rat embryo hindlimb bud mesenchymal cells by downregulating p53 expression. Mol Med Rep (2015) 0.75
Vascular Endothelial Growth Factor Control Mechanisms in Skeletal Growth and Repair. Dev Dyn (2016) 0.75
Synergistic activity of polarised osteoblasts inside condensations cause their differentiation. Sci Rep (2015) 0.75
SOX9 directly Regulates CTGF/CCN2 Transcription in Growth Plate Chondrocytes and in Nucleus Pulposus Cells of Intervertebral Disc. Sci Rep (2016) 0.75
Directing the osteoblastic and chondrocytic differentiations of mesenchymal stem cells: matrix vs. induction media. Regen Biomater (2017) 0.75
Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med (2010) 4.88
Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. Nat Med (2008) 3.98
Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. Nat Cell Biol (2008) 2.85
Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3. Mol Biol Cell (2008) 2.78
Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. J Clin Invest (2012) 2.58
Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis. Development (2002) 2.57
Neuronal loss and brain atrophy in mice lacking cathepsins B and L. Proc Natl Acad Sci U S A (2002) 2.54
VEGFA is necessary for chondrocyte survival during bone development. Development (2004) 2.54
Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function. Am J Pathol (2005) 2.38
NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest (2008) 2.29
Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice. Cell (2007) 2.18
Lack of collagen XVIII/endostatin results in eye abnormalities. EMBO J (2002) 2.13
Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation. Curr Biol (2010) 2.08
Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis. Arthritis Rheum (2007) 2.07
Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling. Exp Cell Res (2005) 1.92
Multiple roles of vascular endothelial growth factor (VEGF) in skeletal development, growth, and repair. Curr Top Dev Biol (2005) 1.75
Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations ("glomangiomas"). Am J Hum Genet (2002) 1.66
Knobloch syndrome: novel mutations in COL18A1, evidence for genetic heterogeneity, and a functionally impaired polymorphism in endostatin. Hum Mutat (2004) 1.61
Editorial: Journal of negative results in biomedicine. J Negat Results Biomed (2002) 1.58
Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development (2004) 1.58
Localization of collagen XVIII and the endostatin portion of collagen XVIII in aged human control eyes and eyes with age-related macular degeneration. Invest Ophthalmol Vis Sci (2004) 1.56
Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice. J Biol Chem (2004) 1.53
FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis. J Cell Biol (2008) 1.53
Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney. EMBO J (2003) 1.53
The role of backscattering in SHG tissue imaging. Biophys J (2007) 1.43
Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression. Cancer Res (2004) 1.42
Cherubism: best clinical practice. Orphanet J Rare Dis (2012) 1.42
Physiological role of collagen XVIII and endostatin. FASEB J (2005) 1.40
Differential expression of CD146 in tissues and endothelial cells derived from infantile haemangioma and normal human skin. J Pathol (2003) 1.35
Genome scans provide evidence for keloid susceptibility loci on chromosomes 2q23 and 7p11. J Invest Dermatol (2004) 1.34
Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function. EMBO J (2003) 1.34
Loss of collagen XVIII enhances neovascularization and vascular permeability in atherosclerosis. Circulation (2004) 1.30
Molecular interplay between endostatin, integrins, and heparan sulfate. J Biol Chem (2009) 1.25
Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4. Dev Biol (2003) 1.23
Targeted disruption of Col8a1 and Col8a2 genes in mice leads to anterior segment abnormalities in the eye. FASEB J (2005) 1.18
Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms. Dev Biol (2007) 1.15
Characterization of endostatin binding to heparin and heparan sulfate by surface plasmon resonance and molecular modeling: role of divalent cations. J Biol Chem (2003) 1.07
Growth of cranial synchondroses and sutures requires polycystin-1. Dev Biol (2008) 1.06
Commitment to the osteoblast lineage is not required for RANKL gene expression. J Biol Chem (2009) 1.05
Infantile hemangioma: challenges, new insights, and therapeutic promise. J Craniofac Surg (2009) 1.04
Endogenous endostatin inhibits choroidal neovascularization. FASEB J (2007) 1.03
Two-dimensional nanoscale structural and functional imaging in individual collagen type I fibrils. Biophys J (2010) 1.02
Rapamycin inhibits proliferation of hemangioma endothelial cells by reducing HIF-1-dependent expression of VEGF. PLoS One (2012) 1.01
Second harmonic generation imaging of fascia within thick tissue block. Opt Express (2007) 1.01
Multimodal nonlinear optical imaging of collagen arrays. J Struct Biol (2008) 1.00
Signaling mechanisms in infantile hemangioma. Curr Opin Hematol (2009) 1.00
Risk of vascular anomalies with Down syndrome. Pediatrics (2008) 1.00
Mechanical force-induced midpalatal suture remodeling in mice. Bone (2007) 1.00
Wnt/beta-catenin--a canonical tale of cell-fate choice in the vertebrate skeleton. Dev Cell (2005) 0.99
A novel missense mutation in the paired domain of PAX9 causes non-syndromic oligodontia. Hum Genet (2003) 0.98
The first draft of the endostatin interaction network. J Biol Chem (2009) 0.98
The role of structural genes in the pathogenesis of osteoarthritic disorders. Arthritis Res (2002) 0.97
Age-dependent iris abnormalities in collagen XVIII/endostatin deficient mice with similarities to human pigment dispersion syndrome. Invest Ophthalmol Vis Sci (2003) 0.96
The polycystic kidney disease 1 (Pkd1) gene is required for the responses of osteochondroprogenitor cells to midpalatal suture expansion in mice. Bone (2009) 0.96
The role of SH3BP2 in the pathophysiology of cherubism. Orphanet J Rare Dis (2012) 0.95
The role of endothelial-mesenchymal transition in heterotopic ossification. J Bone Miner Res (2012) 0.95
Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in mice. Dev Biol (2004) 0.94
Transglutaminase-2: a new endostatin partner in the extracellular matrix of endothelial cells. Biochem J (2010) 0.94
Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair. J Clin Invest (2016) 0.94
Increased angiogenic response in aortic explants of collagen XVIII/endostatin-null mice. Am J Pathol (2004) 0.92
Col2-Cre recombinase is co-expressed with endogenous type II collagen in embryonic renal epithelium and drives development of polycystic kidney disease following inactivation of ciliary genes. Matrix Biol (2008) 0.91
Impaired skin and hair follicle development in Runx2 deficient mice. Dev Biol (2008) 0.89
How vascular endothelial growth factor-A (VEGF) regulates differentiation of mesenchymal stem cells. J Histochem Cytochem (2013) 0.88
FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program. Dev Cell (2012) 0.88
Matrix remodeling as stem cell recruitment event: a novel in vitro model for homing of human bone marrow stromal cells to the site of injury shows crucial role of extracellular collagen matrix. Matrix Biol (2010) 0.88
Genetics and experimental models of crystal-induced arthritis. Lessons learned from mice and men: is it crystal clear? Curr Opin Rheumatol (2007) 0.88
Osteoblast-adipocyte lineage plasticity in tissue development, maintenance and pathology. Cell Mol Life Sci (2013) 0.88
Imaging skeletal muscle using second harmonic generation and coherent anti-Stokes Raman scattering microscopy. Biomed Opt Express (2011) 0.86
Growth defect in Grg5 null mice is associated with reduced Ihh signaling in growth plates. Dev Dyn (2002) 0.86
Non-viral endostatin plasmid transfection of mesenchymal stem cells via collagen scaffolds. Biomaterials (2008) 0.86
Treatment with the angiogenesis inhibitor endostatin: a novel therapy in rheumatoid arthritis. J Rheumatol (2002) 0.85
Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment. Matrix Biol (2009) 0.85
Skeletal defects in Osterix-Cre transgenic mice. Transgenic Res (2014) 0.85
Opening peer-review: the democracy of science. J Negat Results Biomed (2014) 0.84
An evolutionarily conserved enhancer regulates Bmp4 expression in developing incisor and limb bud. PLoS One (2012) 0.84
Cherubism gene Sh3bp2 is important for optimal bone formation, osteoblast differentiation, and function. Am J Orthod Dentofacial Orthop (2010) 0.83
Why cellular stress suppresses adipogenesis in skeletal tissue, but is ineffective in adipose tissue: control of mesenchymal cell differentiation via integrin binding sites in extracellular matrices. Matrix Biol (2013) 0.82
Unexpected matrix diseases and novel therapeutic strategies. Cell Tissue Res (2009) 0.82
Retracted Recent progress in studies of infantile hemangioma. J Dermatol (2010) 0.82
A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression. Genesis (2014) 0.82
Endostatin's heparan sulfate-binding site is essential for inhibition of angiogenesis and enhances in situ binding to capillary-like structures in bone explants. Matrix Biol (2004) 0.81
Recent progress in studies of infantile hemangioma. J Dermatol (2010) 0.81
On bone-forming cells and blood vessels in bone development. Cell Metab (2010) 0.81
Engineering endostatin-producing cartilaginous constructs for cartilage repair using nonviral transfection of chondrocyte-seeded and mesenchymal-stem-cell-seeded collagen scaffolds. Tissue Eng Part A (2010) 0.81
Lack of type VIII collagen in mice ameliorates diabetic nephropathy. Diabetes (2009) 0.80
Distinct VEGF functions during bone development and homeostasis. Arch Immunol Ther Exp (Warsz) (2014) 0.79
Type XVIII collagen is essential for survival during acute liver injury in mice. Dis Model Mech (2013) 0.79
Tankyrase loses its grip on SH3BP2 in cherubism. Cell (2011) 0.78
Transforming blood vessels into bone. Cell Cycle (2011) 0.78
Presphenoidal synchondrosis fusion in DBA/2J mice. Mamm Genome (2012) 0.77
Engineering endostatin-expressing cartilaginous constructs using injectable biopolymer hydrogels. Acta Biomater (2012) 0.77
Role of polycystin-1 in bone remodeling: orthodontic tooth movement study in mutant mice. Angle Orthod (2014) 0.75
From the Editor's Desk. Matrix Biol (2005) 0.75
Anthrax toxin receptors and infantile systemic hyalinosis. Matrix Biol (2007) 0.75