Published in J Biol Chem on November 26, 2012
Diacylglycerol kinase delta promotes lipogenesis. Biochemistry (2013) 0.84
Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3β/Fyn kinase axis during oxidative hepatocellular toxicity. Cell Death Dis (2014) 0.84
Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling. Mol Cell Proteomics (2013) 0.81
Arrestins in apoptosis. Handb Exp Pharmacol (2014) 0.75
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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell (2005) 8.22
Perturbations of the AKT signaling pathway in human cancer. Oncogene (2005) 6.64
ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. Proc Natl Acad Sci U S A (2005) 6.35
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev (2001) 6.15
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell (2007) 6.00
Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer. Nat Rev Cancer (2010) 5.82
Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer (2007) 5.71
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr Biol (1998) 5.04
FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell (2009) 4.48
Disruption of diacylglycerol metabolism impairs the induction of T cell anergy. Nat Immunol (2006) 2.43
Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance. Nature (2009) 2.27
Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science (2007) 2.25
The phosphatase PHLPP controls the cellular levels of protein kinase C. J Biol Chem (2007) 2.24
Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy. Oncogene (2010) 2.22
Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. Nat Immunol (2003) 1.98
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance. Cell (2008) 1.97
Essential role of Gab1 for signaling by the c-Met receptor in vivo. J Cell Biol (2000) 1.97
Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell (2011) 1.74
PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma. Oncogene (2011) 1.59
Diacylglycerol kinase epsilon regulates seizure susceptibility and long-term potentiation through arachidonoyl- inositol lipid signaling. Proc Natl Acad Sci U S A (2001) 1.51
Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway. J Biol Chem (2003) 1.51
Regulation and functions of diacylglycerol kinases. Chem Rev (2011) 1.48
Scribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt. EMBO Rep (2011) 1.45
Knockout of PKC alpha enhances insulin signaling through PI3K. Mol Endocrinol (2002) 1.42
Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases. J Biol Chem (1996) 1.40
beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt. Mol Cell Biol (2009) 1.37
Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice. Cancer Res (2006) 1.27
Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling. Proc Natl Acad Sci U S A (2005) 1.21
Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling. Proc Natl Acad Sci U S A (2006) 1.20
Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions. J Biol Chem (2002) 1.19
Tumor-promoting activity of phorbol and four diesters of phorbol in mouse skin. Cancer Res (1971) 1.12
Association of diacylglycerol kinase zeta with protein kinase C alpha: spatial regulation of diacylglycerol signaling. J Cell Biol (2003) 1.11
Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI. Proc Natl Acad Sci U S A (2010) 1.10
mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells. J Biol Chem (2010) 1.09
PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growth. Mol Cell Biol (2011) 1.05
Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization. J Biol Chem (2009) 1.03
Activation of diacylglycerol kinase alpha is required for VEGF-induced angiogenic signaling in vitro. Oncogene (2004) 1.03
S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells. J Biol Chem (2007) 1.02
Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase. Blood (2005) 1.00
Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. PLoS One (2010) 0.94
Cyclooxygenase-2 transactivates the epidermal growth factor receptor through specific E-prostanoid receptors and tumor necrosis factor-alpha converting enzyme. Cell Signal (2007) 0.91
Diacylglycerol kinase delta and protein kinase C(alpha) modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8. J Biol Chem (2010) 0.87
Proteins kinase Cɛ is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes. Oncogene (2011) 0.87
Phorbol ester receptors and the in vitro effects of tumor promoters. Ann N Y Acad Sci (1983) 0.86
A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer. BJU Int (2008) 0.81
Disruption of diacylglycerol metabolism impairs the induction of T cell anergy. Nat Immunol (2006) 2.43
Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science (2007) 2.25
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance. Cell (2008) 1.97
DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GN. J Am Soc Nephrol (2012) 1.93
The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis. Crit Care Med (2002) 1.66
Regulation and functions of diacylglycerol kinases. Chem Rev (2011) 1.48
Differential trafficking of the vesicular monoamine transporter-2 by methamphetamine and cocaine. Eur J Pharmacol (2002) 1.30
The role of cyclooxygenase-2 and prostaglandins in colon cancer. Prostaglandins Other Lipid Mediat (2006) 1.29
Modulation of oxidative stress, inflammation, and atherosclerosis by lipoprotein-associated phospholipase A2. J Lipid Res (2012) 1.28
Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. Mol Biol Cell (2009) 1.28
Diacylglycerol kinases. Cell Signal (2004) 1.25
The emerging roles of PAF acetylhydrolase. J Lipid Res (2008) 1.22
New perspectives on APC control of cell fate and proliferation in colorectal cancer. Cell Cycle (2009) 1.21
Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling. Proc Natl Acad Sci U S A (2005) 1.21
Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling. Proc Natl Acad Sci U S A (2006) 1.20
Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta. J Biol Chem (2002) 1.20
Sol Sherry lecture in thrombosis: molecular events in acute inflammation. Arterioscler Thromb Vasc Biol (2002) 1.16
Association between 5-lipoxygenase expression and plaque instability in humans. Arterioscler Thromb Vasc Biol (2005) 1.15
Function and regulation of retinoic acid-inducible gene-I. Crit Rev Immunol (2010) 1.15
Association of diacylglycerol kinase zeta with protein kinase C alpha: spatial regulation of diacylglycerol signaling. J Cell Biol (2003) 1.11
Diacylglycerol kinase epsilon is selective for both acyl chains of phosphatidic acid or diacylglycerol. J Biol Chem (2009) 1.10
Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. Shock (2006) 1.09
Dramatic differences in the roles in lipid metabolism of two isoforms of diacylglycerol kinase. Biochemistry (2008) 1.08
Identification of a domain that mediates association of platelet-activating factor acetylhydrolase with high density lipoprotein. J Biol Chem (2008) 1.08
Expression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity. Transl Oncol (2010) 1.08
A dangerous venous variation in thoracoscopic right lower lobectomy. Ann Thorac Surg (2009) 1.03
IFN-epsilon mediates TNF-alpha-induced STAT1 phosphorylation and induction of retinoic acid-inducible gene-I in human cervical cancer cells. J Immunol (2007) 1.01
Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta. J Biol Chem (2003) 1.00
Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism. Cell Signal (2004) 1.00
The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid. J Biol Chem (2006) 0.99
Diacylglycerol kinases as sources of phosphatidic acid. Biochim Biophys Acta (2009) 0.99
Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance. EMBO J (2009) 0.98
Diacylglycerol kinase-zeta localization in skeletal muscle is regulated by phosphorylation and interaction with syntrophins. Mol Biol Cell (2003) 0.98
Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression. Cancer Lett (2008) 0.97
Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis. Pediatr Res (2010) 0.97
The impact of Yangtze River discharge, ocean currents and historical events on the biogeographic pattern of Cellana toreuma along the China coast. PLoS One (2012) 0.95
Regulation of neurite outgrowth in N1E-115 cells through PDZ-mediated recruitment of diacylglycerol kinase zeta. Mol Cell Biol (2005) 0.95
Role of the hydrophobic segment of diacylglycerol kinase epsilon. Biochemistry (2007) 0.95
DGKι regulates presynaptic release during mGluR-dependent LTD. EMBO J (2010) 0.94
Determination of the topology of the hydrophobic segment of mammalian diacylglycerol kinase epsilon in a cell membrane and its relationship to predictions from modeling. J Mol Biol (2008) 0.94
Retinoic acid inhibits beta-catenin through suppression of Cox-2: a role for truncated adenomatous polyposis coli. J Biol Chem (2007) 0.94
Nuclear localization of diacylglycerol kinase zeta in neurons. Eur J Neurosci (2003) 0.93
The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta. J Biol Chem (2005) 0.91
Cyclooxygenase-2 transactivates the epidermal growth factor receptor through specific E-prostanoid receptors and tumor necrosis factor-alpha converting enzyme. Cell Signal (2007) 0.91
Substrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinase. Biochemistry (2007) 0.91
Lipid messenger, diacylglycerol, and its regulator, diacylglycerol kinase, in cells, organs, and animals: history and perspective. Tohoku J Exp Med (2008) 0.89
The p38 MAPK pathway mediates transcriptional activation of the plasma platelet-activating factor acetylhydrolase gene in macrophages stimulated with lipopolysaccharide. J Biol Chem (2004) 0.89
Speciation and dispersal along continental coastlines and island arcs in the Indo-West Pacific turbinid gastropod genus Lunella. Evolution (2011) 0.88
Cell biology and pathophysiology of the diacylglycerol kinase family: morphological aspects in tissues and organs. Int Rev Cytol (2007) 0.88
Molecular basis for susceptibility of plasma platelet-activating factor acetylhydrolase to oxidative inactivation. FASEB J (2007) 0.87
Molecular phylogeny and historical biogeography of Nacella (Patellogastropoda: Nacellidae) in the Southern Ocean. Mol Phylogenet Evol (2010) 0.87
Diacylglycerol kinase delta and protein kinase C(alpha) modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8. J Biol Chem (2010) 0.87
Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase. Mem Inst Oswaldo Cruz (2005) 0.87
Measurement of mammalian diacylglycerol kinase activity in vitro and in cells. Methods Enzymol (2007) 0.86
Study of arachidonoyl specificity in two enzymes of the PI cycle. J Mol Biol (2011) 0.86
PAF-acetylhydrolase expressed during megakaryocyte differentiation inactivates PAF-like lipids. Blood (2009) 0.85
Lipid modulation of the activity of diacylglycerol kinase alpha- and zeta-isoforms: activation by phosphatidylethanolamine and cholesterol. Biochemistry (2004) 0.85
The levels of retinoic acid-inducible gene I are regulated by heat shock protein 90-alpha. J Immunol (2009) 0.85
Diacylglycerol kinase and animal models: the pathophysiological roles in the brain and heart. Adv Enzyme Regul (2006) 0.84
Diacylglycerol kinase zeta is associated with chromatin, but dissociates from condensed chromatin during mitotic phase in NIH3T3 cells. J Cell Biochem (2008) 0.84
Deficiency of phospholipase A2 group 7 decreases intestinal polyposis and colon tumorigenesis in Apc(Min/+) mice. Cancer Res (2013) 0.84
Diacylglycerol kinase delta promotes lipogenesis. Biochemistry (2013) 0.84
Molecular species of phosphatidylinositol-cycle intermediates in the endoplasmic reticulum and plasma membrane. Biochemistry (2010) 0.83
Substrate specificity of diacylglycerol kinase-epsilon and the phosphatidylinositol cycle. FEBS Lett (2011) 0.83
Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator. J Biol Chem (2012) 0.83
DGKζ is involved in LPS-activated phagocytosis through IQGAP1/Rac1 pathway. Biochem Biophys Res Commun (2012) 0.82
Membrane interactions of the hydrophobic segment of diacylglycerol kinase epsilon. Biochim Biophys Acta (2007) 0.82
Towards a model of postglacial biogeography in shallow marine species along the Patagonian Province: lessons from the limpet Nacella magellanica (Gmelin, 1791). BMC Evol Biol (2012) 0.82
Ceramide-induced alterations in dopamine transporter function. Eur J Pharmacol (2003) 0.82
[Diaphragmatic hernia complicated with diaphragmatic resection by automatic stapling device]. Kyobu Geka (2014) 0.82
Cytoplasmic localization of DGKζ exerts a protective effect against p53-mediated cytotoxicity. J Cell Sci (2013) 0.81
Enhancement of interleukin-1beta-induced iNOS expression in cultured vascular smooth muscle cells of Goto-Kakizaki diabetes rats. Eur J Pharmacol (2009) 0.81
The alpha isoform of diacylglycerol kinase exhibits arachidonoyl specificity with alkylacylglycerol. Biochemistry (2004) 0.81
Lung production of platelet-activating factor acetylhydrolase in oleic acid-induced acute lung injury. Prostaglandins Leukot Essent Fatty Acids (2007) 0.81
Integrin alphaDbeta2 is dynamically expressed by inflamed macrophages and alters the natural history of lethal systemic infections. J Immunol (2008) 0.81
Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes. Am J Physiol Heart Circ Physiol (2011) 0.80
Regulation of sonic hedgehog expression by integrin β1 and epidermal growth factor receptor in intestinal epithelium. IUBMB Life (2014) 0.79
A human thyroid cancer cell line, DH-14-3, newly established from poorly differentiated thyroid carcinoma. Tohoku J Exp Med (2013) 0.79
An in-silico genomic survey to annotate genes coding for early development-relevant signaling molecules in the pearl oyster, Pinctada fucata. Zoolog Sci (2013) 0.79
Descending necrotizing mediastinitis secondary to retropharyngeal abscess without cervical spread. Gen Thorac Cardiovasc Surg (2008) 0.79
Selective translocation of diacylglycerol kinase zeta in hippocampal neurons under transient forebrain ischemia. Neurosci Lett (2004) 0.79
Protein kinase C inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein. Biochim Biophys Acta (2006) 0.78
Inhibition of thrombin-induced Ca²⁺ influx in platelets by R59949, an inhibitor of diacylglycerol kinase. J Pharm Pharmacol (2012) 0.78
Expression of mRNAs for the diacylglycerol kinase family in immune cells during an inflammatory reaction. Biomed Res (2014) 0.78
Endocannabinoids and diacylglycerol kinase activity. Biochim Biophys Acta (2010) 0.77
Increased blood flow induces oxidative stress through an endothelium- and nitric oxide-independent mechanism. Free Radic Biol Med (2010) 0.77
Correction: Phylogeography of the Rock Shell Thais clavigera (Mollusca): Evidence for Long-Distance Dispersal in the Northwestern Pacific. PLoS One (2015) 0.77
Increased induction of inducible nitric oxide synthase expression in aortae of type 2 diabetes rats. J Pharmacol Sci (2008) 0.77
Novel role for molecular transporter importin 9 in posttranscriptional regulation of IFN-ε expression. J Immunol (2013) 0.77
DGKζ is degraded through the cytoplasmic ubiquitin-proteasome system under excitotoxic conditions, which causes neuronal apoptosis because of aberrant cell cycle reentry. Cell Signal (2012) 0.76
Novel mechanism for regulation of plasma platelet-activating factor acetylhydrolase expression in mammalian cells. Biochem J (2010) 0.76