Published in Nucleic Acids Res on November 27, 2012
The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucleic Acids Res (2015) 10.66
Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resistance. Proc Natl Acad Sci U S A (2013) 0.97
Structural basis for dimerization and catalysis of a novel esterase from the GTSAG motif subfamily of the bacterial hormone-sensitive lipase family. J Biol Chem (2014) 0.93
Key challenges for the creation and maintenance of specialist protein resources. Proteins (2015) 0.88
Interdomain hydrophobic interactions modulate the thermostability of microbial esterases from the hormone-sensitive lipase family. J Biol Chem (2015) 0.86
EzCatDB: the enzyme reaction database, 2015 update. Nucleic Acids Res (2014) 0.84
Expanding the Catalytic Triad in Epoxide Hydrolases and Related Enzymes. ACS Catal (2015) 0.84
Transcriptome analysis in Coffea eugenioides, an Arabica coffee ancestor, reveals differentially expressed genes in leaves and fruits. Mol Genet Genomics (2015) 0.80
Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif. Biochemistry (2016) 0.80
A novel α/β-hydrolase gene IbMas enhances salt tolerance in transgenic sweetpotato. PLoS One (2014) 0.78
Structural insights into the substrate specificity of two esterases from the thermophilic Rhizomucor miehei. J Lipid Res (2015) 0.78
Compositional profile of α / β-hydrolase fold proteins in mangrove soil metagenomes: prevalence of epoxide hydrolases and haloalkane dehalogenases in oil-contaminated sites. Microb Biotechnol (2014) 0.77
Zearalenone lactonohydrolase activity in Hypocreales and its evolutionary relationships within the epoxide hydrolase subset of a/b-hydrolases. BMC Microbiol (2014) 0.77
Est10: A Novel Alkaline Esterase Isolated from Bovine Rumen Belonging to the New Family XV of Lipolytic Enzymes. PLoS One (2015) 0.77
Structural and biochemical characterisation of Archaeoglobus fulgidus esterase reveals a bound CoA molecule in the vicinity of the active site. Sci Rep (2016) 0.77
Diversity in protein domain superfamilies. Curr Opin Genet Dev (2015) 0.77
The first description of a hormone-sensitive lipase from a basidiomycete: Structural insights and biochemical characterization revealed Bjerkandera adusta BaEstB as a novel esterase. Microbiologyopen (2017) 0.76
The alternate AP-1 adaptor subunit Apm2 interacts with the Mil1 regulatory protein and confers differential cargo sorting. Mol Biol Cell (2015) 0.76
BEM46 shows eisosomal localization and association with tryptophan-derived auxin pathway in Neurospora crassa. Eukaryot Cell (2014) 0.76
Independent Evolution of Six Families of Halogenating Enzymes. PLoS One (2016) 0.76
Carboxylic ester hydrolases: Classification and database derived from their primary, secondary, and tertiary structures. Protein Sci (2016) 0.75
A Novel Subfamily Esterase with a Homoserine Transacetylase-like Fold but No Transferase Activity. Appl Environ Microbiol (2017) 0.75
Misclassification of PfEH1 and PfEH2 as Epoxide Hydrolases. MBio (2017) 0.75
Characterization of CpdC, a large-ring lactone-hydrolyzing enzyme from Pseudomonas sp. strain HI-70, and its use as a fusion tag facilitating overproduction of proteins in Escherichia coli. Appl Environ Microbiol (2013) 0.75
Mice Lacking Lipid Droplet-Associated Hydrolase, a Gene Linked to Human Prostate Cancer, Have Normal Cholesterol Ester Metabolism. J Lipid Res (2016) 0.75
Evolution of a Catalytic Mechanism. Mol Biol Evol (2015) 0.75
Activity screening of environmental metagenomic libraries reveals novel carboxylesterase families. Sci Rep (2017) 0.75
Correction: Role of Key Salt Bridges in Thermostability of G. thermodenitrificans EstGtA2: Distinctive Patterns within the New Bacterial Lipolytic Enzyme Family XV. PLoS One (2015) 0.75
Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila. Sci Rep (2017) 0.75
In vivo delivery and activation of masked fluorogenic hydrolase substrates by endogenous hydrolases in C. elegans. Chembiochem (2017) 0.75
Bacillus sp. JR3 esterase LipJ: A new mesophilic enzyme showing traces of a thermophilic past. PLoS One (2017) 0.75
A family of archaea-like carboxylesterases preferentially expressed in the symbiotic phase of the mychorrizal fungus Tuber melanosporum. Sci Rep (2017) 0.75
The structure of a complex of the lactonohydrolase zearalenone hydrolase with the hydrolysis product of zearalenone at 1.60 Å resolution. Acta Crystallogr F Struct Biol Commun (2017) 0.75
Crystal Structure and Substrate Specificity Modification of Acetyl Xylan Esterase from Aspergillus luchuensis. Appl Environ Microbiol (2017) 0.75
The unusual substrate specificity of a virulence associated serine hydrolase from the highly toxic bacterium, Francisella tularensis. Biochem Biophys Rep (2016) 0.75
Ylehd, an epoxide hydrolase with promiscuous haloalkane dehalogenase activity from tropical marine yeast Yarrowia lipolytica is induced upon xenobiotic stress. Sci Rep (2017) 0.75
The Pfam protein families database. Nucleic Acids Res (2011) 33.46
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. Mol Syst Biol (2011) 28.61
The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics. Nucleic Acids Res (2008) 27.83
FastTree 2--approximately maximum-likelihood trees for large alignments. PLoS One (2010) 26.15
Reorganizing the protein space at the Universal Protein Resource (UniProt). Nucleic Acids Res (2011) 18.50
InterPro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res (2011) 13.45
The alpha/beta hydrolase fold. Protein Eng (1992) 9.94
Bacterial lipolytic enzymes: classification and properties. Biochem J (1999) 4.92
MEROPS: the database of proteolytic enzymes, their substrates and inhibitors. Nucleic Acids Res (2011) 4.90
Alpha/beta hydrolase fold enzymes: the family keeps growing. Curr Opin Struct Biol (1999) 4.12
Lipases for biotechnology. Curr Opin Biotechnol (2002) 3.46
Alpha/Beta-hydrolase fold enzymes: structures, functions and mechanisms. Curr Protein Pept Sci (2000) 2.95
aCHEdb: the database system for ESTHER, the alpha/beta fold family of proteins and the Cholinesterase gene server. Nucleic Acids Res (1998) 2.43
Of barn owls and bankers: a lush variety of alpha/beta hydrolases. Structure (1999) 2.27
Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions. J Lipid Res (2008) 1.95
The Lipase Engineering Database: a navigation and analysis tool for protein families. Nucleic Acids Res (2003) 1.67
ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins. Nucleic Acids Res (2004) 1.52
Isolation and characterization of a novel lipase from a metagenomic library of tidal flat sediments: evidence for a new family of bacterial lipases. Appl Environ Microbiol (2006) 1.46
A new type of thermoalkalophilic hydrolase of Paucimonas lemoignei with high specificity for amorphous polyesters of short chain-length hydroxyalkanoic acids. J Biol Chem (2001) 1.39
A cholinesterase genes server (ESTHER): a database of cholinesterase-related sequences for multiple alignments, phylogenetic relationships, mutations and structural data retrieval. Nucleic Acids Res (1996) 1.37
Hormone-sensitive lipase is closely related to several bacterial proteins, and distantly related to acetylcholinesterase and lipoprotein lipase: identification of a superfamily of esterases and lipases. Biochim Biophys Acta (1994) 1.35
The alpha/beta fold family of proteins database and the cholinesterase gene server ESTHER. Nucleic Acids Res (1997) 1.33
Alpha/beta hydrolase fold: an update. Protein Pept Lett (2009) 1.26
Thioesterases: a new perspective based on their primary and tertiary structures. Protein Sci (2010) 1.22
Novel cold-adapted alkaline lipase from an intertidal flat metagenome and proposal for a new family of bacterial lipases. Appl Environ Microbiol (2008) 1.20
Diverse catalytic activities in the alphabeta-hydrolase family of enzymes: activation of H2O, HCN, H2O2, and O2. Bioorg Chem (2004) 1.17
Characterization and structural modeling of a new type of thermostable esterase from Thermotoga maritima. FEBS J (2007) 1.12
The crystal structure of polyhydroxybutyrate depolymerase from Penicillium funiculosum provides insights into the recognition and degradation of biopolyesters. J Mol Biol (2005) 1.08
Proteopedia: a status report on the collaborative, 3D web-encyclopedia of proteins and other biomolecules. J Struct Biol (2011) 1.02
ThYme: a database for thioester-active enzymes. Nucleic Acids Res (2010) 1.01
Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis. J Biol Chem (2012) 0.97
A new esterase showing similarity to putative dienelactone hydrolase from a strict marine bacterium, Vibrio sp. GMD509. Appl Microbiol Biotechnol (2007) 0.96
Catalytic promiscuity in the alpha/beta-hydrolase superfamily: hydroxamic acid formation, C--C bond formation, ester and thioester hydrolysis in the C--C hydrolase family. Chembiochem (2008) 0.95
A new esterase EstD2 isolated from plant rhizosphere soil metagenome. Appl Microbiol Biotechnol (2010) 0.94
A thermostable esterase from Thermoanaerobacter tengcongensis opening up a new family of bacterial lipolytic enzymes. Biochim Biophys Acta (2011) 0.94
Functional and structural studies of a novel cold-adapted esterase from an Arctic intertidal metagenomic library. Appl Microbiol Biotechnol (2012) 0.90
Enzymatic activity and protein interactions in alpha/beta hydrolase fold proteins: moonlighting versus promiscuity. Protein Pept Lett (2012) 0.90
Rhodococcus sp. strain CR-53 LipR, the first member of a new bacterial lipase family (family X) displaying an unusual Y-type oxyanion hole, similar to the Candida antarctica lipase clan. Appl Environ Microbiol (2012) 0.89
Sequence similarities between hormone-sensitive lipase and five prokaryotic enzymes. Trends Biochem Sci (1993) 0.87
New friendly tools for users of ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins. Chem Biol Interact (2005) 0.86
Catalytic activities of a cocaine hydrolase engineered from human butyrylcholinesterase against (+)- and (-)-cocaine. Chem Biol Interact (2012) 0.86
Indication for a new lipolytic enzyme family: isolation and characterization of two esterases from a metagenomic library. J Mol Microbiol Biotechnol (2010) 0.86
Emergent decarboxylase activity and attenuation of α/β-hydrolase activity during the evolution of methylketone biosynthesis in tomato. Plant Cell (2012) 0.85
Proteins with an alpha/beta hydrolase fold: Relationships between subfamilies in an ever-growing superfamily. Chem Biol Interact (2012) 0.82
Links between kinetic data and sequences in the alpha/beta-hydrolases fold database. Brief Bioinform (2001) 0.82
A multi-faceted analysis of RutD reveals a novel family of α/β hydrolases. Proteins (2012) 0.80
Hydrolase-like properties of a cofactor-independent dioxygenase. Chembiochem (2012) 0.79
Enzyme promiscuity in the hormone-sensitive lipase family of proteins. Protein Pept Lett (2012) 0.78
Reaction mechanism of the Co2+-activated multifunctional bromoperoxidase-esterase from Pseudomonas putida IF-3. Arch Biochem Biophys (2002) 0.78
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations. EMBO J (2005) 5.55
Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors. EMBO J (2005) 2.91
Bacterial glycosidases for the production of universal red blood cells. Nat Biotechnol (2007) 2.41
Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion. Neuron (2007) 2.04
Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor. EMBO J (2009) 1.91
A medium-throughput crystallization approach. Acta Crystallogr D Biol Crystallogr (2002) 1.72
Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site. EMBO J (2003) 1.53
ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins. Nucleic Acids Res (2004) 1.52
Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation. Proc Natl Acad Sci U S A (2004) 1.52
Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism. Proc Natl Acad Sci U S A (2010) 1.48
Aspergillus niger protein EstA defines a new class of fungal esterases within the alpha/beta hydrolase fold superfamily of proteins. Structure (2004) 1.46
Acetylcholinesterase is required for neuronal and muscular development in the zebrafish embryo. Nat Neurosci (2002) 1.44
Maspardin is mutated in mast syndrome, a complicated form of hereditary spastic paraplegia associated with dementia. Am J Hum Genet (2003) 1.34
LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis. EMBO J (2006) 1.31
Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding. J Biol Chem (2006) 1.29
High-throughput automated refolding screening of inclusion bodies. Protein Sci (2004) 1.23
Expression and characterization of the protein Rv1399c from Mycobacterium tuberculosis. A novel carboxyl esterase structurally related to the HSL family. Eur J Biochem (2004) 1.20
Crystal structure of Thermotoga maritima alpha-L-fucosidase. Insights into the catalytic mechanism and the molecular basis for fucosidosis. J Biol Chem (2004) 1.20
Mechanism of acetylcholinesterase inhibition by fasciculin: a 5-ns molecular dynamics simulation. J Am Chem Soc (2002) 1.17
Crystal structure of the conserved hypothetical protein Rv1155 from Mycobacterium tuberculosis. FEBS Lett (2005) 1.04
Butyrylcholinesterase and acetylcholinesterase activity and quantal transmitter release at normal and acetylcholinesterase knockout mouse neuromuscular junctions. Br J Pharmacol (2003) 1.02
Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia californica. J Mol Neurosci (2006) 0.94
Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions. EMBO J (2010) 0.92
Glycosyltransferases, glycoside hydrolases: surprise, surprise! Curr Opin Struct Biol (2008) 0.92
The Mtr2-Mex67 NTF2-like domain complex. Structural insights into a dual role of Mtr2 for yeast nuclear export. J Biol Chem (2003) 0.91
Functional characterization of the glycosyltransferase domain of penicillin-binding protein 1a from Thermotoga maritima. Biochim Biophys Acta (2006) 0.90
Respiratory survival mechanisms in acetylcholinesterase knockout mouse. Eur J Neurosci (2003) 0.90
Butyrylcholinesterase and the control of synaptic responses in acetylcholinesterase knockout mice. Life Sci (2007) 0.90
Enzymatic activity and protein interactions in alpha/beta hydrolase fold proteins: moonlighting versus promiscuity. Protein Pept Lett (2012) 0.90
A novel NIPA1 mutation associated with a pure form of autosomal dominant hereditary spastic paraplegia. Neurogenetics (2005) 0.89
Crystal structure of the GalNAc/Gal-specific agglutinin from the phytopathogenic ascomycete Sclerotinia sclerotiorum reveals novel adaptation of a beta-trefoil domain. J Mol Biol (2010) 0.88
Crystal structure of E. coli yddE protein reveals a striking homology with diaminopimelate epimerase. Proteins (2004) 0.88
Distinct oligomeric forms of the Pseudomonas aeruginosa RetS sensor domain modulate accessibility to the ligand binding site. Environ Microbiol (2010) 0.88
Identification of the catalytic nucleophile of the family 29 alpha-L-fucosidase from Thermotoga maritima through trapping of a covalent glycosyl-enzyme intermediate and mutagenesis. J Biol Chem (2003) 0.87
Use of a purified and functional recombinant calcium-channel beta4 subunit in surface-plasmon resonance studies. Biochem J (2002) 0.87
Interaction between the SifA virulence factor and its host target SKIP is essential for Salmonella pathogenesis. J Biol Chem (2009) 0.87
Structural insights into the catalytic mechanism of bacterial guanosine-diphospho-D-mannose pyrophosphorylase and its regulation by divalent ions. J Biol Chem (2010) 0.86
Conformational remodeling of femtomolar inhibitor-acetylcholinesterase complexes in the crystalline state. J Am Chem Soc (2010) 0.86
New friendly tools for users of ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins. Chem Biol Interact (2005) 0.86
Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE. Chem Biol Interact (2005) 0.86
Evolution of cholinesterases in the animal kingdom. Chem Biol Interact (2010) 0.84
Expression of the standard scorpion alpha-toxin AaH II and AaH II mutants leading to the identification of some key bioactive elements. Biochim Biophys Acta (2005) 0.84
The size, shape and specificity of the sugar-binding site of the jacalin-related lectins is profoundly affected by the proteolytic cleavage of the subunits. Biochem J (2002) 0.83
Structure of a polyisoprenoid binding domain from Saccharophagus degradans implicated in plant cell wall breakdown. FEBS Lett (2010) 0.82
Proteins with an alpha/beta hydrolase fold: Relationships between subfamilies in an ever-growing superfamily. Chem Biol Interact (2012) 0.82
Are there non-catalytic functions of acetylcholinesterases? Lessons from mutant animal models. Bioessays (2005) 0.81
Synaptic remodeling at the skeletal neuromuscular junction of acetylcholinesterase knockout mice and its physiological relevance. Chem Biol Interact (2005) 0.80
Acetylcholinesterase activity in Clytia hemisphaerica (Cnidaria). Chem Biol Interact (2008) 0.80
The neuroligins and their ligands: from structure to function at the synapse. J Mol Neurosci (2014) 0.80
Effects of acetylcholinesterase and butyrylcholinesterase inhibition on breathing in mice adapted or not to reduced acetylcholinesterase. Pharmacol Biochem Behav (2004) 0.79
Molecular characterization of monoclonal antibodies that inhibit acetylcholinesterase by targeting the peripheral site and backdoor region. PLoS One (2013) 0.79
A tetrameric acetylcholinesterase from the parasitic nematode Dictyocaulus viviparus associates with the vertebrate tail proteins PRiMA and ColQ. Mol Biochem Parasitol (2011) 0.79
Gene overexpression and biochemical characterization of the biotechnologically relevant chlorogenic acid hydrolase from Aspergillus niger. Appl Environ Microbiol (2007) 0.79
Structural insights into antibody sequestering and neutralizing of Na+ channel α-type modulator from old world scorpion venom. J Biol Chem (2012) 0.78
Behavioral phenotyping of heterozygous acetylcholinesterase knockout (AChE+/-) mice showed no memory enhancement but hyposensitivity to amnesic drugs. Behav Brain Res (2009) 0.77
Structural insights into AChE inhibition by monoclonal antibodies. Chem Biol Interact (2005) 0.77
Structure-function relationships of the alpha/beta-hydrolase fold domain of neuroligin: a comparison with acetylcholinesterase. Chem Biol Interact (2010) 0.77
Structural comparison of three crystalline complexes of a peptidic toxin with a synaptic acetylcholine recognition protein. J Mol Neurosci (2006) 0.77
The structure of human DNase I bound to magnesium and phosphate ions points to a catalytic mechanism common to members of the DNase I-like superfamily. Biochemistry (2012) 0.77
Evolution of acetylcholinesterase and butyrylcholinesterase in the vertebrates: an atypical butyrylcholinesterase from the Medaka Oryzias latipes. PLoS One (2011) 0.76
Acetylcholinesterase from the invertebrate Ciona intestinalis is capable of assembling into asymmetric forms when co-expressed with vertebrate collagenic tail peptide. FEBS J (2008) 0.76
Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases. Acta Neuropathol Commun (2015) 0.76
Localization of butyrylcholinesterase at the neuromuscular junction of normal and acetylcholinesterase knockout mice. J Histochem Cytochem (2010) 0.75
Effect of fluoxetine on neuromuscular function in acetylcholinesterase (AChE) knockout mice. Chem Biol Interact (2008) 0.75
Tracking the origin and divergence of cholinesterases and neuroligins: the evolution of synaptic proteins. J Mol Neurosci (2014) 0.75
Breathing without acetylcholinesterase. Adv Exp Med Biol (2004) 0.75
Effect of locomotor training on muscle performance in the context of nerve-muscle communication dysfunction. Muscle Nerve (2012) 0.75
Hydrolase versus other functions of members of the alpha/beta-hydrolase fold superfamily of proteins. Protein Pept Lett (2012) 0.75
[Bacterial glycosidases for the production of universal blood]. Med Sci (Paris) (2007) 0.75
Hyposensitivity to the amnesic effects of scopolamine or amyloid beta(25-35) peptide in heterozygous acetylcholinesterase knockout (AChE(+/-)) mice. Chem Biol Interact (2008) 0.75
A. niger protein "EstA", perhaps a new electrotactin, defines a new class of fungal esterases within the alpha/beta hydrolase fold superfamily. Chem Biol Interact (2005) 0.75
Special issue on «Toxins: from threats to benefits». Toxicon (2013) 0.75
Genetic ablation of acetylcholinesterase alters muscle function in mice. Chem Biol Interact (2008) 0.75
Cholinesterase activity in human pulmonary arteries and veins: correlation with mRNA levels. Life Sci (2005) 0.75