Published in Arterioscler Thromb Vasc Biol on November 29, 2012
Tgfβ-Smad and MAPK signaling mediate scleraxis and proteoglycan expression in heart valves. J Mol Cell Cardiol (2013) 0.83
Hypervitaminosis A is prevalent in children with CKD and contributes to hypercalcemia. Pediatr Nephrol (2014) 0.75
Growth and maturation of heart valves leads to changes in endothelial cell distribution, impaired function, decreased metabolism and reduced cell proliferation. J Mol Cell Cardiol (2016) 0.75
A review of the effect of diet on cardiovascular calcification. Int J Mol Sci (2015) 0.75
Vitamin A Oral Supplementation Induces Oxidative Stress and Suppresses IL-10 and HSP70 in Skeletal Muscle of Trained Rats. Nutrients (2017) 0.75
Pathogenesis of Zika Virus-Associated Embryopathy. Biores Open Access (2016) 0.75
Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med (1996) 10.09
Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med (1996) 8.57
Mutations in NOTCH1 cause aortic valve disease. Nature (2005) 6.27
Beta-carotene supplementation and incidence of cancer and cardiovascular disease: the Women's Health Study. J Natl Cancer Inst (1999) 4.27
Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies. Circulation (2005) 4.19
Randomised trial of alpha-tocopherol and beta-carotene supplements on incidence of major coronary events in men with previous myocardial infarction. Lancet (1997) 4.19
SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse. Dev Biol (1997) 3.84
RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes Dev (1994) 3.54
Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation. J Am Coll Cardiol (2006) 2.95
Vitamin A deficiency in mice causes a systemic expansion of myeloid cells. Blood (2000) 2.30
Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse. Development (2001) 2.25
Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study. Am J Clin Nutr (2012) 2.14
Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease. Circulation (2009) 2.07
Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway. Circulation (2005) 1.88
Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs). Nucl Recept Signal (2009) 1.80
Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development. Dev Biol (2007) 1.67
Hearts and bones: shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development. Dev Biol (2006) 1.65
Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9. Proc Natl Acad Sci U S A (2005) 1.64
From carrot to clinic: an overview of the retinoic acid signaling pathway. Cell Mol Life Sci (2010) 1.57
WT1 regulates epicardial epithelial to mesenchymal transition through β-catenin and retinoic acid signaling pathways. Dev Biol (2011) 1.53
Retinoic acid deficiency alters second heart field formation. Proc Natl Acad Sci U S A (2008) 1.51
Retinoid metabolism and nuclear receptor responses: New insights into coordinated regulation of the PPAR-RXR complex. FEBS Lett (2007) 1.46
Sox9 and p300 cooperatively regulate chromatin-mediated transcription. J Biol Chem (2005) 1.44
RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice. J Clin Invest (1996) 1.41
Nonclassical action of retinoic acid on the activation of the cAMP response element-binding protein in normal human bronchial epithelial cells. Mol Biol Cell (2005) 1.33
Notch1 represses osteogenic pathways in aortic valve cells. J Mol Cell Cardiol (2009) 1.32
Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo. Circ Res (2008) 1.30
Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice. Proc Natl Acad Sci U S A (2003) 1.30
Reduced sox9 function promotes heart valve calcification phenotypes in vivo. Circ Res (2010) 1.30
Vitamin A deficiency decreases and high dietary vitamin A increases disease severity in the mouse model of asthma. J Immunol (2008) 1.28
Positionally-dependent chondrogenesis induced by BMP4 is co-regulated by Sox9 and Msx2. Dev Dyn (2000) 1.24
Requirement for RAR-mediated gene repression in skeletal progenitor differentiation. J Cell Biol (2002) 1.23
Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage and ear development. Dev Biol (2006) 1.23
Wnt signaling in heart valve development and osteogenic gene induction. Dev Biol (2009) 1.22
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. J Med Chem (1997) 1.20
BMP-9 induced osteogenic differentiation of mesenchymal stem cells: molecular mechanism and therapeutic potential. Curr Gene Ther (2011) 1.18
Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos. Mech Dev (2002) 1.18
Calcific aortic stenosis: from bench to the bedside--emerging clinical and cellular concepts. Heart (2003) 1.18
The neural crest in cardiac congenital anomalies. Differentiation (2012) 1.17
Cartilage link protein 1 (Crtl1), an extracellular matrix component playing an important role in heart development. Dev Biol (2007) 1.15
Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2. Development (2011) 1.14
A high fat/high carbohydrate diet induces aortic valve disease in C57BL/6J mice. J Am Coll Cardiol (2006) 1.14
The RXRalpha gene functions in a non-cell-autonomous manner during mouse cardiac morphogenesis. Development (1998) 1.13
Differential expression of cartilage and bone-related proteins in pediatric and adult diseased aortic valves. J Mol Cell Cardiol (2010) 1.12
Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL. Arterioscler Thromb Vasc Biol (2011) 1.12
Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2. J Thorac Cardiovasc Surg (2009) 1.12
Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart. Dev Biol (2012) 1.10
Insights into the use of biomarkers in calcific aortic valve disease. J Heart Valve Dis (2010) 1.08
Endogenous retinoic acid regulates cardiac progenitor differentiation. Proc Natl Acad Sci U S A (2010) 1.02
Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice. Am J Physiol Heart Circ Physiol (2009) 0.99
Synthetic retinoid Am80 reduces scavenger receptor expression and atherosclerosis in mice by inhibiting IL-6. Arterioscler Thromb Vasc Biol (2006) 0.96
Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes. PLoS One (2011) 0.95
Serum antioxidants and myocardial infarction. Are low levels of carotenoids and alpha-tocopherol risk factors for myocardial infarction? Circulation (1994) 0.95
Decreased levels of embryonic retinoic acid synthesis accelerate recovery from arterial growth delay in a mouse model of DiGeorge syndrome. Circ Res (2010) 0.94
Retinoid metabolism and its effects on the vasculature. Biochim Biophys Acta (2011) 0.93
Molecular and developmental mechanisms of congenital heart valve disease. Birth Defects Res A Clin Mol Teratol (2011) 0.92
ALDH1A2 (RALDH2) genetic variation in human congenital heart disease. BMC Med Genet (2009) 0.92
Vitamin D receptor deficiency and low vitamin D diet stimulate aortic calcification and osteogenic key factor expression in mice. PLoS One (2012) 0.92
Transglutaminase 2-mediated activation of β-catenin signaling has a critical role in warfarin-induced vascular calcification. Arterioscler Thromb Vasc Biol (2011) 0.91
Differential activation of valvulogenic, chondrogenic, and osteogenic pathways in mouse models of myxomatous and calcific aortic valve disease. J Mol Cell Cardiol (2012) 0.90
A 9-cis beta-carotene-enriched diet inhibits atherogenesis and fatty liver formation in LDL receptor knockout mice. J Nutr (2008) 0.90
Transcriptional regulation of heart valve development and disease. Cardiovasc Pathol (2010) 0.88
The role of Lrp5/6 in cardiac valve disease: experimental hypercholesterolemia in the ApoE-/- /Lrp5-/- mice. J Cell Biochem (2011) 0.87
Effect of statin treatment on aortic valve and coronary artery calcification. J Heart Valve Dis (2007) 0.87
Vitamin A differentially regulates RANKL and OPG expression in human osteoblasts. Biochem Biophys Res Commun (2004) 0.87
Enhancement of osteogenic gene expression for the differentiation of human periosteal derived cells. Stem Cell Res (2011) 0.86
Restraint of Fgf8 signaling by retinoic acid signaling is required for proper heart and forelimb formation. Dev Biol (2011) 0.85
Ectopic retinoic acid signaling affects outflow tract cushion development through suppression of the myocardial Tbx2-Tgfβ2 pathway. Development (2012) 0.85
Vitamin A deficiency induces a decrease in EEG delta power during sleep in mice. Brain Res (2007) 0.82
Cardiovascular calcification in rats with hypervitaminosis A. Arch Pathol (1969) 0.80
Vitamin A deficiency does not influence longitudinal growth in mice. Nutrition (2007) 0.79
Vitamin A: too much of a good thing? Obstet Gynecol Surv (2012) 0.78
FGF23 induces left ventricular hypertrophy. J Clin Invest (2011) 7.22
Extracellular matrix remodeling and organization in developing and diseased aortic valves. Circ Res (2006) 2.91
Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo. Circ Res (2008) 1.30
Reduced sox9 function promotes heart valve calcification phenotypes in vivo. Circ Res (2010) 1.30
Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease. J Mol Cell Cardiol (2013) 1.09
Temporal and spatial expression of collagens during murine atrioventricular heart valve development and maintenance. Dev Dyn (2008) 1.04
Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse. Hum Mol Genet (2012) 1.02
Mmp15 is a direct target of Snai1 during endothelial to mesenchymal transformation and endocardial cushion development. Dev Biol (2011) 0.99
Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes. PLoS One (2011) 0.95
Heart valve development, maintenance, and disease: the role of endothelial cells. Curr Top Dev Biol (2012) 0.91
Myocardial alternative RNA splicing and gene expression profiling in early stage hypoplastic left heart syndrome. PLoS One (2012) 0.89
Differential changes in TGF-β/BMP signaling pathway in the right ventricular myocardium of newborns with hypoplastic left heart syndrome. J Card Fail (2010) 0.87
Tgfβ-Smad and MAPK signaling mediate scleraxis and proteoglycan expression in heart valves. J Mol Cell Cardiol (2013) 0.83
Collagen XIV is important for growth and structural integrity of the myocardium. J Mol Cell Cardiol (2012) 0.82
Snai1 is important for avian epicardial cell transformation and motility. Dev Dyn (2013) 0.81
Cost-benefit analysis of robotic versus nonrobotic minimally invasive mitral valve surgery. Innovations (Phila) (2015) 0.79
Genetics of valvular heart disease. Curr Cardiol Rep (2014) 0.77
Genetic basis of aortic valvular disease. Curr Opin Cardiol (2017) 0.77
Is aviation a good model to study human errors in health care? Am J Surg (2011) 0.76
Minimally Invasive Aortic Valve Replacement: Cost-Benefit Analysis of Ministernotomy Versus Minithoracotomy Approach. J Heart Valve Dis (2015) 0.75