Published in Dev Biol on March 01, 1997
The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev (2002) 8.19
A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J (1998) 5.15
Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium. J Cell Biol (2007) 4.52
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors. Proc Natl Acad Sci U S A (2005) 4.25
Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization. Proc Natl Acad Sci U S A (2001) 4.13
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J Cell Biol (2004) 3.24
Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors. Int J Biochem Cell Biol (2007) 2.78
Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc Natl Acad Sci U S A (2003) 2.64
Protein zero gene expression is regulated by the glial transcription factor Sox10. Mol Cell Biol (2000) 2.11
L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer. Mol Cell Biol (2008) 2.07
Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway. Proc Natl Acad Sci U S A (2000) 1.82
The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones. Proc Natl Acad Sci U S A (2001) 1.81
Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A (2004) 1.77
Mesenchymal stem cells and tissue engineering. Methods Enzymol (2006) 1.71
Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development. Dev Biol (2007) 1.67
Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9. Proc Natl Acad Sci U S A (2005) 1.64
Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Mol Cell Biol (2000) 1.63
Mechanism of regulatory target selection by the SOX high-mobility-group domain proteins as revealed by comparison of SOX1/2/3 and SOX9. Mol Cell Biol (1999) 1.62
Interactions between SOX factors and Wnt/beta-catenin signaling in development and disease. Dev Dyn (2010) 1.53
Deletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasia. Proc Natl Acad Sci U S A (1998) 1.51
Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis. Genes Dev (2002) 1.48
Campomelic dysplasia translocation breakpoints are scattered over 1 Mb proximal to SOX9: evidence for an extended control region. Am J Hum Genet (1999) 1.47
Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons. Genesis (2010) 1.46
Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. J Cell Biol (2004) 1.45
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Retracted A zinc finger transcription factor, alphaA-crystallin binding protein 1, is a negative regulator of the chondrocyte-specific enhancer of the alpha1(II) collagen gene. Mol Cell Biol (2000) 1.40
SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex. Nucleic Acids Res (2002) 1.38
S100A1 and S100B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes. EMBO Rep (2007) 1.36
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Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes. Exp Cell Res (2009) 1.21
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An in situ hybridization study of Runx2, Osterix, and Sox9 at the onset of condylar cartilage formation in fetal mouse mandible. J Anat (2006) 1.17
Lamprey type II collagen and Sox9 reveal an ancient origin of the vertebrate collagenous skeleton. Proc Natl Acad Sci U S A (2006) 1.17
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SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression. PLoS Genet (2011) 1.16
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Fibronectin and stem cell differentiation - lessons from chondrogenesis. J Cell Sci (2012) 1.15
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Aryl hydrocarbon receptor-mediated down-regulation of sox9b causes jaw malformation in zebrafish embryos. Mol Pharmacol (2008) 1.10
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Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage. Dev Biol (2010) 1.08
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Sox9 function in craniofacial development and disease. Genesis (2011) 1.07
Regulation of the human SOX9 promoter by Sp1 and CREB. Exp Cell Res (2007) 1.07
GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis. Dev Cell (2012) 1.07
Fine mapping of chromosome 17 translocation breakpoints > or = 900 Kb upstream of SOX9 in acampomelic campomelic dysplasia and a mild, familial skeletal dysplasia. Am J Hum Genet (2005) 1.05
Sonic Hedgehog promotes the development of multipotent neural crest progenitors endowed with both mesenchymal and neural potentials. Proc Natl Acad Sci U S A (2007) 1.05
Distinct roles of Sox5, Sox6, and Sox9 in different stages of chondrogenic differentiation. J Bone Miner Metab (2005) 1.04
Related function of mouse SOX3, SOX9, and SRY HMG domains assayed by male sex determination. Genesis (2001) 1.02
Rho kinase-dependent activation of SOX9 in chondrocytes. Arthritis Rheum (2010) 1.02
Computational identification and functional validation of regulatory motifs in cartilage-expressed genes. Genome Res (2007) 1.01
Cloning and characterisation of the Sry-related transcription factor gene Sox8. Nucleic Acids Res (2000) 1.01
Human circulating fibrocytes have the capacity to differentiate osteoblasts and chondrocytes. Int J Biochem Cell Biol (2009) 1.00
An in situ hybridization study of Runx2, Osterix, and Sox9 in the anlagen of mouse mandibular condylar cartilage in the early stages of embryogenesis. J Anat (2008) 1.00
The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis. Nucleic Acids Res (2015) 0.99
Expression profiling of zebrafish sox9 mutants reveals that Sox9 is required for retinal differentiation. Dev Biol (2009) 0.97
Identification of an evolutionarily conserved regulatory element of the zebrafish col2a1a gene. Dev Biol (2011) 0.96
A homozygous nonsense mutation in SOX9 in the dominant disorder campomelic dysplasia: a case of mitotic gene conversion. Hum Genet (2005) 0.96
Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes. PLoS One (2011) 0.95
Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification. J Biol Chem (2012) 0.94
Survival of Hoxa13 homozygous mutants reveals a novel role in digit patterning and appendicular skeletal development. Dev Dyn (2010) 0.94
Stepwise enforcement of the notochord and its intersection with the myoseptum: an evolutionary path leading to development of the vertebra? J Anat (2006) 0.93
Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin. J Biol Chem (2010) 0.93
Smad3 activates the Sox9-dependent transcription on chromatin. Int J Biochem Cell Biol (2008) 0.92
Bone morphogenetic protein rescues the lack of secondary cartilage in Runx2-deficient mice. J Anat (2007) 0.92
Bridging the Gap: Understanding Embryonic Intervertebral Disc Development. Cell Dev Biol (2012) 0.91
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Characterization of human adipose-derived stem cells and expression of chondrogenic genes during induction of cartilage differentiation. Clinics (Sao Paulo) (2012) 0.90
Expression patterns of cartilage collagens and Sox9 during mouse heart development. Histochem Cell Biol (2003) 0.89
Characterization and functionality of proliferative human Sertoli cells. Cell Transplant (2010) 0.88
Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice. PLoS One (2012) 0.88
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BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter. Histochem Cell Biol (2006) 0.88
Exportin 4 interacts with Sox9 through the HMG Box and inhibits the DNA binding of Sox9. PLoS One (2011) 0.88
The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template. Nucleic Acids Res (2010) 0.87
Tendon-to-bone attachment: from development to maturity. Birth Defects Res C Embryo Today (2014) 0.87
TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. J Cell Sci (2013) 0.86
The multifaceted role of the vasculature in endochondral fracture repair. Front Endocrinol (Lausanne) (2015) 0.85
Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage. Proc Natl Acad Sci U S A (2014) 0.85
Master regulator for chondrogenesis, Sox9, regulates transcriptional activation of the endoplasmic reticulum stress transducer BBF2H7/CREB3L2 in chondrocytes. J Biol Chem (2014) 0.85
E6-AP/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein. J Biol Chem (2013) 0.85
Identification of five developmental processes during chondrogenic differentiation of embryonic stem cells. PLoS One (2010) 0.85
Low oxygen tension during incubation periods of chondrocyte expansion is sufficient to enhance postexpansion chondrogenesis. Tissue Eng Part A (2010) 0.84
Involvement of SOX-9 and FGF-23 in RUNX-2 regulation in osteoarthritic chondrocytes. J Cell Mol Med (2009) 0.84
miR-1247 functions by targeting cartilage transcription factor SOX9. J Biol Chem (2013) 0.84
Increased dietary intake of vitamin A promotes aortic valve calcification in vivo. Arterioscler Thromb Vasc Biol (2012) 0.83
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