Published in Circulation on November 30, 2012
Effects of Nitric Oxide on the Endothelium During Hemolysis. | NCT03748082
A novel minimally-invasive method to sample human endothelial cells for molecular profiling. PLoS One (2015) 1.39
Targeting inflammation using salsalate in patients with type 2 diabetes: effects on flow-mediated dilation (TINSAL-FMD). Diabetes Care (2013) 1.10
Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-β isoform in the endothelium. Circ Res (2013) 1.02
Relation of mitochondrial oxygen consumption in peripheral blood mononuclear cells to vascular function in type 2 diabetes mellitus. Vasc Med (2014) 1.00
New insights into insulin action and resistance in the vasculature. Ann N Y Acad Sci (2014) 0.97
Increased muscle blood supply and transendothelial nutrient and insulin transport induced by food intake and exercise: effect of obesity and ageing. J Physiol (2015) 0.96
Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol (2013) 0.92
Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes. Circ Res (2016) 0.92
Prokineticin receptor-1 is a new regulator of endothelial insulin uptake and capillary formation to control insulin sensitivity and cardiovascular and kidney functions. J Am Heart Assoc (2013) 0.88
Elevated Angiopoietin-2 Level in Patients With Continuous-Flow Left Ventricular Assist Devices Leads to Altered Angiogenesis and Is Associated With Higher Nonsurgical Bleeding. Circulation (2016) 0.86
Molecular mechanisms of vascular dysfunction and cardiovascular biomarkers in type 2 diabetes. Cardiovasc Diagn Ther (2014) 0.85
Visceral adiposopathy: a vascular perspective. Horm Mol Biol Clin Investig (2015) 0.85
Cyclooxygenase inhibition improves endothelial vasomotor dysfunction of visceral adipose arterioles in human obesity. Obesity (Silver Spring) (2013) 0.84
Aberrant phenotype in human endothelial cells of diabetic origin: implications for saphenous vein graft failure? J Diabetes Res (2015) 0.83
Role of oxidative stress in endothelial insulin resistance. World J Diabetes (2015) 0.83
Endothelial Dysfunction in Human Diabetes Is Mediated by Wnt5a-JNK Signaling. Arterioscler Thromb Vasc Biol (2016) 0.83
Ageing, metabolism and cardiovascular disease. J Physiol (2015) 0.82
Insulin Downregulates the Transcriptional Coregulator CITED2, an Inhibitor of Proangiogenic Function in Endothelial Cells. Diabetes (2016) 0.81
Increased Hs-CRP/adiponectin ratio is associated with increase carotid intima-media thickness. Lipids Health Dis (2014) 0.81
Kinase-SUMO networks in diabetes-mediated cardiovascular disease. Metabolism (2016) 0.80
Forkhead box O-1 modulation improves endothelial insulin resistance in human obesity. Arterioscler Thromb Vasc Biol (2015) 0.80
Exercise mediated protection of diabetic heart through modulation of microRNA mediated molecular pathways. Cardiovasc Diabetol (2017) 0.78
Intravenous Lipid Infusion Induces Endoplasmic Reticulum Stress in Endothelial Cells and Blood Mononuclear Cells of Healthy Adults. J Am Heart Assoc (2016) 0.76
Restoration of autophagy in endothelial cells from patients with diabetes mellitus improves nitric oxide signaling. Atherosclerosis (2016) 0.76
Melatonin Pathway and Atenolol-Related Glucose Dysregulation: Is There a Correlation? Clin Transl Sci (2016) 0.76
The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells. Redox Biol (2016) 0.76
Novel therapeutic strategies for adult obese asthmatics. Immunol Allergy Clin North Am (2014) 0.76
Obesity, type 2 diabetes, and impaired insulin stimulated blood flow: role of skeletal muscle NO synthase and endothelin-1. J Appl Physiol (1985) (2016) 0.76
Redox regulation of ischemic limb neovascularization - What we have learned from animal studies. Redox Biol (2017) 0.75
Prokineticin Is a New Linker between Obesity and Cardiovascular Diseases. Front Cardiovasc Med (2017) 0.75
Targeting vascular endothelial cell insulin resistance in type 2 diabetes mellitus: is protein kinase cβ the bullseye for reducing vascular risk in diabetes? Circulation (2012) 0.75
Flow signaling and atherosclerosis. Cell Mol Life Sci (2016) 0.75
Diabetes and cardiovascular disease: let's push forward with translational research. Cardiovasc Diagn Ther (2015) 0.75
Interleukin-1β mediates high glucose induced phenotypic transition in human aortic endothelial cells. Cardiovasc Diabetol (2016) 0.75
Insulin resistance in vascular endothelial cells promotes intestinal tumour formation. Oncogene (2017) 0.75
Inflammation and insulin resistance. J Clin Invest (2006) 18.76
Executive summary: heart disease and stroke statistics--2010 update: a report from the American Heart Association. Circulation (2010) 9.18
Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation (2006) 5.50
Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Proc Natl Acad Sci U S A (1998) 4.94
Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I. Circulation (2003) 4.61
Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation (2002) 3.71
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest (1999) 3.18
Activation of protein kinase C isoforms and its impact on diabetic complications. Circ Res (2010) 2.87
Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science (1996) 2.80
Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance. Arterioscler Thromb Vasc Biol (2008) 2.75
Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosis. Circ Res (1998) 2.70
High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation (1997) 2.51
Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans. Circ Res (2002) 2.37
Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications. Rev Endocr Metab Disord (2010) 2.19
Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy. JAMA (2003) 2.16
Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration. J Immunol (1996) 2.11
NF-kappa B and I kappa B alpha: an inducible regulatory system in endothelial activation. J Exp Med (1994) 2.10
Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab (2010) 2.09
Overweight and obese humans demonstrate increased vascular endothelial NAD(P)H oxidase-p47(phox) expression and evidence of endothelial oxidative stress. Circulation (2007) 1.99
Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans. Circulation (2009) 1.99
Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation (2011) 1.95
Relation of brachial and digital measures of vascular function in the community: the Framingham heart study. Hypertension (2011) 1.90
Selective inhibition of protein kinase Cbeta2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation (2004) 1.88
Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production. J Biol Chem (2003) 1.80
Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes (2006) 1.71
Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: the distinct role of protein kinase C and mitochondrial superoxide production. Atherosclerosis (2005) 1.66
Biopsy coupled to quantitative immunofluorescence: a new method to study the human vascular endothelium. J Appl Physiol (1985) (2002) 1.64
Vascular inflammation in obesity and sleep apnea. Circulation (2010) 1.38
Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low density lipoprotein cholesterol levels. J Am Coll Cardiol (1996) 1.34
Update on nitric oxide-dependent vasodilation in human subjects. Methods Enzymol (2005) 1.34
Smooth muscle dysfunction occurs independently of impaired endothelium-dependent dilation in adults at risk of atherosclerosis. J Am Coll Cardiol (1998) 1.30
Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance. Arterioscler Thromb Vasc Biol (2005) 1.29
Protein expression in vascular endothelial cells obtained from human peripheral arteries and veins. J Vasc Res (2009) 1.22
Insulin resistance and endothelial cell dysfunction: studies in mammalian models. Exp Physiol (2007) 1.15
Preserved glucoregulation but attenuation of the vascular actions of insulin in mice heterozygous for knockout of the insulin receptor. Diabetes (2004) 1.13
Effects of simulated hyperglycemia, insulin, and glucagon on endothelial nitric oxide synthase expression. Am J Physiol Endocrinol Metab (2000) 1.10
Selective PKC beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes mellitus. Cardiovasc Drugs Ther (2008) 1.07
Compromised arterial function in human type 2 diabetic patients. Diabetes (2005) 0.99
Severe obesity is associated with impaired arterial smooth muscle function in young adults. Obesity (Silver Spring) (2010) 0.88
Impaired vascular function during short-term poor glycaemic control in Type 1 diabetic patients. Diabet Med (2005) 0.88
Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation (2010) 9.09
Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension (2004) 8.27
Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol (2003) 7.47
The clinical implications of endothelial dysfunction. J Am Coll Cardiol (2003) 6.71
Aortic stiffness, blood pressure progression, and incident hypertension. JAMA (2012) 6.01
Clinical correlates and heritability of flow-mediated dilation in the community: the Framingham Heart Study. Circulation (2004) 4.73
Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study. Circulation (2008) 4.69
Local shear stress and brachial artery flow-mediated dilation: the Framingham Heart Study. Hypertension (2004) 4.56
Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science (2010) 4.15
Predictive value of reactive hyperemia for cardiovascular events in patients with peripheral arterial disease undergoing vascular surgery. Arterioscler Thromb Vasc Biol (2007) 4.13
Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society. Diabetes Care (2013) 3.89
Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease. J Am Coll Cardiol (2003) 3.87
Endothelial function in HIV-infected persons. Clin Infect Dis (2006) 3.80
Risk stratification for postoperative cardiovascular events via noninvasive assessment of endothelial function: a prospective study. Circulation (2002) 3.67
SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J Biol Chem (2008) 3.66
Endothelial function: a barometer for cardiovascular risk? Circulation (2002) 3.31
Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver. Diabetes (2005) 3.04
Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects. Arterioscler Thromb Vasc Biol (2008) 2.82
Serum myeloperoxidase levels independently predict endothelial dysfunction in humans. Circulation (2004) 2.79
Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem (2009) 2.69
The assessment of endothelial function: from research into clinical practice. Circulation (2012) 2.68
Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes (2002) 2.53
Cross-sectional relations of peripheral microvascular function, cardiovascular disease risk factors, and aortic stiffness: the Framingham Heart Study. Circulation (2005) 2.49
Cross-sectional correlates of increased aortic stiffness in the community: the Framingham Heart Study. Circulation (2007) 2.42
Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications. Rev Endocr Metab Disord (2010) 2.19
Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy. JAMA (2003) 2.16
Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection. Hypertension (2008) 2.14
Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arterioscler Thromb Vasc Biol (2007) 2.07
Hemodynamic correlates of blood pressure across the adult age spectrum: noninvasive evaluation in the Framingham Heart Study. Circulation (2010) 2.07
Intraoperative use of dextran is associated with cardiac complications after carotid endarterectomy. J Vasc Surg (2013) 2.02
Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation (2011) 1.95
Relation of brachial and digital measures of vascular function in the community: the Framingham heart study. Hypertension (2011) 1.90
Genome-wide association with select biomarker traits in the Framingham Heart Study. BMC Med Genet (2007) 1.90
Testing endothelial vasomotor function: nitric oxide, a multipotent molecule. Circulation (2003) 1.85
Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function. Circulation (2006) 1.78
Metabolic syndrome, insulin resistance, and brachial artery vasodilator function in Framingham Offspring participants without clinical evidence of cardiovascular disease. Am J Cardiol (2008) 1.74
Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation. Arterioscler Thromb Vasc Biol (2003) 1.69
Heritability and a genome-wide linkage scan for arterial stiffness, wave reflection, and mean arterial pressure: the Framingham Heart Study. Circulation (2005) 1.68
Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. BMC Med Genet (2007) 1.65
Shouldering the risk factor burden: infection, atherosclerosis, and the vascular endothelium. Circulation (2002) 1.65
Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue. Obesity (Silver Spring) (2008) 1.63
Relations of arterial stiffness and endothelial function to brain aging in the community. Neurology (2013) 1.60
Low-renin hypertension with relative aldosterone excess is associated with impaired NO-mediated vasodilation. Hypertension (2005) 1.60
Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. J Clin Hypertens (Greenwich) (2007) 1.59
Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study: evidence for susceptibility loci on 1q. Atherosclerosis (2005) 1.59
Reduced adipose tissue inflammation represents an intermediate cardiometabolic phenotype in obesity. J Am Coll Cardiol (2011) 1.57
Impact of the learning curve for endoscopic vein harvest on conduit quality and early graft patency. Ann Thorac Surg (2011) 1.56
Circulating vascular growth factors and central hemodynamic load in the community. Hypertension (2012) 1.56
Sickle cell anemia is associated with reduced nitric oxide bioactivity in peripheral conduit and resistance vessels. Am J Hematol (2003) 1.53
Obesity and cardiovascular disease. Circulation (2012) 1.49
Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics. Circ Res (2013) 1.48
Clinical correlates, heritability, and genetic linkage of circulating CD40 ligand in the Framingham Offspring Study. Am Heart J (2008) 1.45
Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients. Am J Cardiol (2005) 1.44
Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group II: pathogenesis of atherosclerosis in diabetes. Circulation (2002) 1.43
Relation of novel echocardiographic measures to invasive hemodynamic assessment in scleroderma-associated pulmonary arterial hypertension. Arthritis Care Res (Hoboken) (2014) 1.43
A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. Diabetes (2004) 1.43
Arterial stiffness in mild-to-moderate CKD. J Am Soc Nephrol (2009) 1.41
Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetes. Transl Res (2010) 1.40
Update on nitric oxide-dependent vasodilation in human subjects. Methods Enzymol (2005) 1.34
Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem Biophys Res Commun (2010) 1.31
Arteriolar function in visceral adipose tissue is impaired in human obesity. Arterioscler Thromb Vasc Biol (2011) 1.30
Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease. J Am Coll Nutr (2007) 1.30
Effect of exercise on upper and lower extremity endothelial function in patients with coronary artery disease. Am J Cardiol (2002) 1.28
Endothelial dysfunction in obesity: etiological role in atherosclerosis. Curr Opin Endocrinol Diabetes Obes (2007) 1.28
Mitochondria and endothelial function. Circ Res (2013) 1.27
Multimarker approach to evaluate correlates of vascular stiffness: the Framingham Heart Study. Circulation (2008) 1.26
Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res (2012) 1.26
Physical activity/exercise and diabetes mellitus. Diabetes Care (2003) 1.24
Effects of systemic inflammation on endothelium-dependent vasodilation. Trends Cardiovasc Med (2006) 1.24
Relations of exercise blood pressure response to cardiovascular risk factors and vascular function in the Framingham Heart Study. Circulation (2012) 1.23
Acute effects of vasoactive drug treatment on brachial artery reactivity. J Am Coll Cardiol (2002) 1.19
Association of fetuin-a with incident diabetes mellitus in community-living older adults: the cardiovascular health study. Circulation (2012) 1.18