Published in Science on December 14, 2012
The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome. Science (2013) 4.12
RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts. Nat Rev Mol Cell Biol (2013) 3.47
Interplay between the cancer genome and epigenome. Cell (2013) 3.05
Xist RNA is a potent suppressor of hematologic cancer in mice. Cell (2013) 2.93
Transcriptional regulation and its misregulation in disease. Cell (2013) 2.92
A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer. Cancer Cell (2014) 2.72
High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation. Nature (2013) 2.00
Regulatory interactions between RNA and polycomb repressive complex 2. Mol Cell (2014) 1.97
Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia. Cell (2014) 1.88
Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA. Arterioscler Thromb Vasc Biol (2014) 1.87
Targeting long non-coding RNA to therapeutically upregulate gene expression. Nat Rev Drug Discov (2013) 1.82
Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet (2015) 1.81
A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation. Mol Cell (2014) 1.78
Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA. Nat Struct Mol Biol (2014) 1.76
The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells. Cell Stem Cell (2015) 1.75
fMiRNA-192 and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma. PLoS Genet (2015) 1.69
A new world of Polycombs: unexpected partnerships and emerging functions. Nat Rev Genet (2013) 1.67
Negative regulation of lncRNA GAS5 by miR-21. Cell Death Differ (2013) 1.60
An evolutionarily conserved long noncoding RNA TUNA controls pluripotency and neural lineage commitment. Mol Cell (2014) 1.55
Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis. Genome Biol (2015) 1.55
Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome. Science (2014) 1.54
Natural antisense transcript for hyaluronan synthase 2 (HAS2-AS1) induces transcription of HAS2 via protein O-GlcNAcylation. J Biol Chem (2014) 1.54
Association of large intergenic noncoding RNA expression with disease activity and organ damage in systemic lupus erythematosus. Arthritis Res Ther (2015) 1.49
Long non-coding RNA HNF1A-AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells. Gut (2013) 1.48
Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks. PLoS Genet (2013) 1.48
Long noncoding RNAs in cell-fate programming and reprogramming. Cell Stem Cell (2014) 1.47
Xist imprinting is promoted by the hemizygous (unpaired) state in the male germ line. Proc Natl Acad Sci U S A (2015) 1.44
Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers. Cancer Cell (2015) 1.43
Regulation of transcription by long noncoding RNAs. Annu Rev Genet (2014) 1.43
Long non-coding RNAs: modulators of nuclear structure and function. Curr Opin Cell Biol (2013) 1.43
Methylation QTLs are associated with coordinated changes in transcription factor binding, histone modifications, and gene expression levels. PLoS Genet (2014) 1.39
ATRX directs binding of PRC2 to Xist RNA and Polycomb targets. Cell (2014) 1.38
A pathophysiological view of the long non-coding RNA world. Oncotarget (2014) 1.36
Comprehensive analysis of RNA-protein interactions by high-throughput sequencing-RNA affinity profiling. Nat Methods (2014) 1.27
linc-HOXA1 is a noncoding RNA that represses Hoxa1 transcription in cis. Genes Dev (2013) 1.27
Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE). J Nutr (2015) 1.20
Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus. J Cell Biol (2014) 1.20
Divergent transcription: a driving force for new gene origination? Cell (2013) 1.20
A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure. Hum Mol Genet (2013) 1.19
Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance. Cell (2013) 1.19
Role of the lncRNA-p53 regulatory network in cancer. J Mol Cell Biol (2014) 1.16
Identification and function of long non-coding RNA. Front Cell Neurosci (2013) 1.15
Long non-coding RNA and alternative splicing modulations in Parkinson's leukocytes identified by RNA sequencing. PLoS Comput Biol (2014) 1.15
Analysing the relationship between lncRNA and protein-coding gene and the role of lncRNA as ceRNA in pulmonary fibrosis. J Cell Mol Med (2014) 1.14
Correlation of long non-coding RNA expression with metastasis, drug resistance and clinical outcome in cancer. Oncotarget (2014) 1.13
The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration. Oncotarget (2015) 1.12
An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription. Mol Ther (2014) 1.11
Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease. Front Genet (2014) 1.11
The presence, role and clinical use of spermatozoal RNAs. Hum Reprod Update (2013) 1.11
Senescence-associated lncRNAs: senescence-associated long noncoding RNAs. Aging Cell (2013) 1.09
Evf2 (Dlx6as) lncRNA regulates ultraconserved enhancer methylation and the differential transcriptional control of adjacent genes. Development (2013) 1.08
A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation. EMBO J (2013) 1.08
Long noncoding RNAs-related diseases, cancers, and drugs. ScientificWorldJournal (2013) 1.07
Non-coding RNAs: multi-tasking molecules in the cell. Int J Mol Sci (2013) 1.07
Long noncoding RNAs in cancer: from function to translation. Trends Cancer (2015) 1.06
Noncoding RNA in age-related cardiovascular diseases. J Mol Cell Cardiol (2015) 1.04
Characterization of long non-coding RNA transcriptome in clear-cell renal cell carcinoma by next-generation deep sequencing. Mol Oncol (2014) 1.04
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. Nat Cell Biol (2016) 1.02
Negative regulation of the interferon response by an interferon-induced long non-coding RNA. Nucleic Acids Res (2014) 1.02
Intrinsic and extrinsic control of oligodendrocyte development. Curr Opin Neurobiol (2013) 1.01
Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex. RNA (2014) 1.00
Long non-coding RNAs and chromatin modifiers: their place in the epigenetic code. Epigenetics (2013) 0.99
Hormone-regulated transcriptomes: lessons learned from estrogen signaling pathways in breast cancer cells. Mol Cell Endocrinol (2013) 0.99
Involvement of extracellular vesicle long noncoding RNA (linc-VLDLR) in tumor cell responses to chemotherapy. Mol Cancer Res (2014) 0.99
Structure and function of the T-loop structural motif in noncoding RNAs. Wiley Interdiscip Rev RNA (2013) 0.99
Independent polled mutations leading to complex gene expression differences in cattle. PLoS One (2014) 0.98
A novel antisense long noncoding RNA within the IGF1R gene locus is imprinted in hematopoietic malignancies. Nucleic Acids Res (2014) 0.98
Genetic and epigenetic regulation of human lincRNA gene expression. Am J Hum Genet (2013) 0.97
A novel RNA motif mediates the strict nuclear localization of a long noncoding RNA. Mol Cell Biol (2014) 0.96
Long non-coding RNAs and their implications in cancer epigenetics. Biosci Rep (2013) 0.95
Head-to-head antisense transcription and R-loop formation promotes transcriptional activation. Proc Natl Acad Sci U S A (2015) 0.95
Something silent this way forms: the functional organization of the repressive nuclear compartment. Annu Rev Cell Dev Biol (2013) 0.95
Translation: screening for novel therapeutics with disease-relevant cell types derived from human stem cell models. Biol Psychiatry (2013) 0.95
The bright side of dark matter: lncRNAs in cancer. J Clin Invest (2016) 0.94
Purifying selection on splice-related motifs, not expression level nor RNA folding, explains nearly all constraint on human lincRNAs. Mol Biol Evol (2014) 0.93
From genotype to phenotype in human atherosclerosis--recent findings. Curr Opin Lipidol (2013) 0.93
Novel long non-coding RNAs are specific diagnostic and prognostic markers for prostate cancer. Oncotarget (2015) 0.93
Long Noncoding RNAs: A New Regulatory Code in Metabolic Control. Trends Biochem Sci (2015) 0.92
The long non-coding RNA Fendrr links epigenetic control mechanisms to gene regulatory networks in mammalian embryogenesis. RNA Biol (2013) 0.92
Upregulation of long non-coding RNA urothelial carcinoma associated 1 by CCAAT/enhancer binding protein α contributes to bladder cancer cell growth and reduced apoptosis. Oncol Rep (2014) 0.92
Long noncoding RNAs(lncRNAs) and the molecular hallmarks of aging. Aging (Albany NY) (2014) 0.92
High expression of CAI2, a 9p21-embedded long noncoding RNA, contributes to advanced-stage neuroblastoma. Cancer Res (2014) 0.91
Emerging epigenetic mechanisms of long non-coding RNAs. Neuroscience (2013) 0.91
The miR-545/374a cluster encoded in the Ftx lncRNA is overexpressed in HBV-related hepatocellular carcinoma and promotes tumorigenesis and tumor progression. PLoS One (2014) 0.91
CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus. Cancer Res (2015) 0.89
Next-generation sequencing and epigenomics research: a hammer in search of nails. Genomics Inform (2014) 0.89
Exploring the secrets of long noncoding RNAs. Int J Mol Sci (2015) 0.89
Over-expression of lncRNA DANCR is associated with advanced tumor progression and poor prognosis in patients with colorectal cancer. Int J Clin Exp Pathol (2015) 0.89
Long noncoding RNAs in biology and hematopoiesis. Blood (2013) 0.88
CruzDB: software for annotation of genomic intervals with UCSC genome-browser database. Bioinformatics (2013) 0.88
Long noncoding RNAs in diseases of aging. Biochim Biophys Acta (2015) 0.88
Single-cell transcriptome analysis reveals dynamic changes in lncRNA expression during reprogramming. Cell Stem Cell (2015) 0.88
Epigenetic layers and players underlying neurodevelopment. Trends Neurosci (2013) 0.88
The interaction of PRC2 with RNA or chromatin is mutually antagonistic. Genome Res (2016) 0.88
All's well that transcribes well: non-coding RNAs and post-stroke brain damage. Neurochem Int (2013) 0.88
New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases. Chem Rev (2015) 0.88
Core promoters in transcription: old problem, new insights. Trends Biochem Sci (2015) 0.87
Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA. BMC Genomics (2015) 0.87
Long Non-Coding RNA NEAT1 Associates with SRp40 to Temporally Regulate PPARγ2 Splicing during Adipogenesis in 3T3-L1 Cells. Genes (Basel) (2014) 0.87