Published in Methods Mol Biol on January 01, 2012
MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination. Proc Natl Acad Sci U S A (2013) 1.60
A systems' biology approach to study microRNA-mediated gene regulatory networks. Biomed Res Int (2013) 0.81
Understanding microRNA-mediated gene regulatory networks through mathematical modelling. Nucleic Acids Res (2016) 0.78
miR-574-3p acts as a tumor promoter in osteosarcoma by targeting SMAD4 signaling pathway. Oncol Lett (2016) 0.75
Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway. Oncotarget (2016) 0.75
Modelling the molecular mechanisms of ageing. Biosci Rep (2017) 0.75
Do simple models lead to generality in ecology? Trends Ecol Evol (2013) 2.88
Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med (2011) 1.78
Minimum Information About a Simulation Experiment (MIASE). PLoS Comput Biol (2011) 1.48
Investigations into the analysis and modeling of the TNF alpha-mediated NF-kappa B-signaling pathway. Genome Res (2003) 1.12
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease. EMBO J (2011) 1.10
Optimal sampling time selection for parameter estimation in dynamic pathway modeling. Biosystems (2004) 1.08
Analysing the impact of nucleo-cytoplasmic shuttling of β-catenin and its antagonists APC, Axin and GSK3 on Wnt/β-catenin signalling. Cell Signal (2013) 1.02
Mathematical modelling of interferon-gamma signalling in pancreatic stellate cells reflects and predicts the dynamics of STAT1 pathway activity. Cell Signal (2009) 1.02
Computational analysis of target hub gene repression regulated by multiple and cooperative miRNAs. Nucleic Acids Res (2012) 1.00
Kinetic modeling-based detection of genetic signatures that provide chemoresistance via the E2F1-p73/DNp73-miR-205 network. Cancer Res (2013) 0.98
MicroRNA-mRNA interactions in colorectal cancer and their role in tumor progression. Genes Chromosomes Cancer (2015) 0.97
Systems biology of JAK-STAT signalling in human malignancies. Prog Biophys Mol Biol (2011) 0.96
Gene expression in low- and high-dose-irradiated human peripheral blood lymphocytes: possible applications for biodosimetry. Radiat Res (2012) 0.94
Approximations and their consequences for dynamic modelling of signal transduction pathways. Math Biosci (2006) 0.93
A systems biology approach to investigate the effect of pH-induced gene regulation on solvent production by Clostridium acetobutylicum in continuous culture. BMC Syst Biol (2011) 0.93
Microarray data clustering based on temporal variation: FCV with TSD preclustering. Appl Bioinformatics (2003) 0.93
14-3-3sigma gene silencing during melanoma progression and its role in cell cycle control and cellular senescence. Mol Cancer (2009) 0.92
Switching feedback mechanisms realize the dual role of MCIP in the regulation of calcineurin activity. FEBS Lett (2006) 0.92
Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Res (2009) 0.92
A frequency-based gene selection method to identify robust biomarkers for radiation dose prediction. Int J Radiat Biol (2012) 0.92
The multikinase inhibitor Sorafenib displays significant antiproliferative effects and induces apoptosis via caspase 3, 7 and PARP in B- and T-lymphoblastic cells. BMC Cancer (2010) 0.91
Studies on mechanisms of interferon-gamma action in pancreatic cancer using a data-driven and model-based approach. Mol Cancer (2011) 0.91
Power-law models of signal transduction pathways. Cell Signal (2007) 0.89
Improving the reuse of computational models through version control. Bioinformatics (2013) 0.89
Investigating dynamics of inhibitory and feedback loops in ERK signalling using power-law models. Mol Biosyst (2010) 0.89
Dynamic energy budget approaches for modelling organismal ageing. Philos Trans R Soc Lond B Biol Sci (2010) 0.89
2-DE profiling of GDNF overexpression-related proteome changes in differentiating ST14A rat progenitor cells. Proteomics (2007) 0.89
Clinico-pathologic function of cerebral ABC transporters - implications for the pathogenesis of Alzheimer's disease. Curr Alzheimer Res (2008) 0.88
Dynamics of biological systems: role of systems biology in medical research. Expert Rev Mol Diagn (2006) 0.88
SBML export interface for the systems biology toolbox for MATLAB. Bioinformatics (2007) 0.87
How Modeling Standards, Software, and Initiatives Support Reproducibility in Systems Biology and Systems Medicine. IEEE Trans Biomed Eng (2016) 0.87
A shift in the dominant phenotype governs the pH-induced metabolic switch of Clostridium acetobutylicumin phosphate-limited continuous cultures. Appl Microbiol Biotechnol (2013) 0.86
Parameter identifiability and sensitivity analysis predict targets for enhancement of STAT1 activity in pancreatic cancer and stellate cells. PLoS Comput Biol (2012) 0.86
A systems biology approach to analyse amplification in the JAK2-STAT5 signalling pathway. BMC Syst Biol (2008) 0.86
Non-coding RNA detection methods combined to improve usability, reproducibility and precision. BMC Bioinformatics (2010) 0.86
Identification of immunogenic consensus T-cell epitopes in globally distributed influenza-A H1N1 neuraminidase. Infect Genet Evol (2010) 0.86
A unified framework for unraveling the functional interaction structure of a biomolecular network based on stimulus-response experimental data. FEBS Lett (2005) 0.86
MicroRNA-regulated networks: the perfect storm for classical molecular biology, the ideal scenario for systems biology. Adv Exp Med Biol (2013) 0.86
PLMaddon: a power-law module for the Matlab SBToolbox. Bioinformatics (2007) 0.85
Association of RHAMM with E2F1 promotes tumour cell extravasation by transcriptional up-regulation of fibronectin. J Pathol (2014) 0.85
Intracellular delay limits cyclic changes in gene expression. Math Biosci (2006) 0.84
Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008). Mol Oncol (2008) 0.84
Modeling the Calvin-Benson cycle. BMC Syst Biol (2011) 0.84
Dynamical effects of epigenetic silencing of 14-3-3sigma expression. Mol Biosyst (2009) 0.83
Coenzyme A-transferase-independent butyrate re-assimilation in Clostridium acetobutylicum-evidence from a mathematical model. Appl Microbiol Biotechnol (2014) 0.83
Analysis of DNA microarray data. Curr Top Med Chem (2004) 0.83
A mathematical analysis of nuclear intensity dynamics for Mig1-GFP under consideration of bleaching effects and background noise in Saccharomyces cerevisiae. Mol Biosyst (2010) 0.83
Biochemical pathway modeling tools for drug target detection in cancer and other complex diseases. Methods Enzymol (2011) 0.83
Integration in action. EMBO Rep (2012) 0.82
Stochastic approaches in systems biology. Wiley Interdiscip Rev Syst Biol Med (2010) 0.82
Inbred mouse strains reveal biomarkers that are pro-longevity, antilongevity or role switching. Aging Cell (2014) 0.82
How mathematical modelling elucidates signalling in Bacillus subtilis. Mol Microbiol (2010) 0.82
Asthma phenotyping, therapy, and prevention: what can we learn from systems biology? Pediatr Res (2013) 0.81
Integrative modelling of pH-dependent enzyme activity and transcriptomic regulation of the acetone-butanol-ethanol fermentation of Clostridium acetobutylicum in continuous culture. Microb Biotechnol (2013) 0.81
Multi-compartmental modeling of SORLA's influence on amyloidogenic processing in Alzheimer's disease. BMC Syst Biol (2012) 0.81
Phosphoglycerate mutases function as reverse regulated isoenzymes in Synechococcus elongatus PCC 7942. PLoS One (2013) 0.81
Glucose de-repression by yeast AMP-activated protein kinase SNF1 is controlled via at least two independent steps. FEBS J (2014) 0.81
Advanced significance analysis of microarray data based on weighted resampling: a comparative study and application to gene deletions in Mycobacterium bovis. Bioinformatics (2004) 0.80
Insights into erlotinib action in pancreatic cancer cells using a combined experimental and mathematical approach. World J Gastroenterol (2012) 0.80
System approaches of Weiss and Bertalanffy and their relevance for systems biology today. Semin Cancer Biol (2011) 0.79
Systems biology and bioinformatics in aging research: a workshop report. Rejuvenation Res (2012) 0.79
Dynamic properties of a delayed protein cross talk model. Biosystems (2007) 0.79
Nucleo-cytoplasmic shuttling of APC can maximize β-catenin/TCF concentration. J Theor Biol (2011) 0.79
Simulations of stressosome activation emphasize allosteric interactions between RsbR and RsbT. BMC Syst Biol (2013) 0.79
Tracing organizing principles: learning from the history of systems biology. Hist Philos Life Sci (2013) 0.79
A system biology approach to understand functional activity of cell communication systems. Methods Cell Biol (2008) 0.78
Systems biology to battle vascular disease. Nephrol Dial Transplant (2010) 0.78
Hybrid modeling of the crosstalk between signaling and transcriptional networks using ordinary differential equations and multi-valued logic. Biochim Biophys Acta (2013) 0.78
A multi-level model accounting for the effects of JAK2-STAT5 signal modulation in erythropoiesis. Comput Biol Chem (2009) 0.78
A model-based strategy to investigate the role of microRNA regulation in cancer signalling networks. Theory Biosci (2010) 0.78
The role of dynamic stimulation pattern in the analysis of bistable intracellular networks. Biosystems (2008) 0.78
A hybrid systems framework for cellular processes. Biosystems (2005) 0.78
Thresholds in transient dynamics of signal transduction pathways. J Theor Biol (2010) 0.77
Principal difference between stability and structural stability (robustness) as used in systems biology. Nonlinear Dynamics Psychol Life Sci (2007) 0.77
The systems biology of mitochondrial fission and fusion and implications for disease and aging. Biogerontology (2014) 0.77
Web resources for microRNA research. Adv Exp Med Biol (2013) 0.77
Proteolysis of beta-galactosidase following SigmaB activation in Bacillus subtilis. Mol Biosyst (2012) 0.76
Analysis of cell adhesion during early stages of colon cancer based on an extended multi-valued logic approach. Mol Biosyst (2012) 0.76
Investigating the two-moment characterisation of subcellular biochemical networks. J Theor Biol (2009) 0.76
Naïve Bayes classifier predicts functional microRNA target interactions in colorectal cancer. Mol Biosyst (2015) 0.76
Tumors as chaotic attractors. Mol Biosyst (2014) 0.76
The RNA world in the 21st century-a systems approach to finding non-coding keys to clinical questions. Brief Bioinform (2015) 0.76
How quantitative measures unravel design principles in multi-stage phosphorylation cascades. J Theor Biol (2008) 0.76
Modeling of cellular processes: methods, data, and requirements. Methods Mol Biol (2011) 0.76
Rough hypercuboid based supervised clustering of miRNAs. Mol Biosyst (2015) 0.76
Personalized cancer immunotherapy using Systems Medicine approaches. Brief Bioinform (2015) 0.76
Baccoside A suppresses epileptic-like seizure/convulsion in Caenorhabditis elegans. Seizure (2010) 0.76