PubRank

Nigel M Hooper

Author PubWeight™ 96.06‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet 2011 9.23
2 ADAMs family members as amyloid precursor protein alpha-secretases. J Neurosci Res 2003 2.29
3 Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein. Proc Natl Acad Sci U S A 2007 2.05
4 Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein. Proc Natl Acad Sci U S A 2003 2.03
5 Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem J 2004 1.98
6 Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). J Biol Chem 2005 1.73
7 The prion protein and lipid rafts. Mol Membr Biol 2006 1.54
8 The angiotensin-converting enzyme gene family: genomics and pharmacology. Trends Pharmacol Sci 2002 1.51
9 Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis. J Cell Sci 2005 1.38
10 Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis. Traffic 2010 1.36
11 Dual mechanisms for shedding of the cellular prion protein. J Biol Chem 2004 1.32
12 Angiotensin-converting enzyme as a GPIase: a critical reevaluation. Nat Med 2005 1.28
13 The involvement of lipid rafts in Alzheimer's disease. Mol Membr Biol 2006 1.26
14 Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease. Trends Mol Med 2005 1.26
15 Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study. Hypertension 2006 1.25
16 The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein. Biochem J 2007 1.25
17 Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor. Biochem J 2009 1.24
18 The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway. J Biol Chem 2010 1.21
19 Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein. J Biol Chem 2009 1.19
20 The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein. Eur J Biochem 2004 1.18
21 Lipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes. Int J Alzheimers Dis 2010 1.17
22 Reactive oxygen species-mediated beta-cleavage of the prion protein in the cellular response to oxidative stress. J Biol Chem 2005 1.12
23 Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells. J Biol Chem 2005 1.10
24 Visualization of detergent solubilization of membranes: implications for the isolation of rafts. Biophys J 2007 1.09
25 alpha-cleavage of the prion protein occurs in a late compartment of the secretory pathway and is independent of lipid rafts. Mol Cell Neurosci 2008 1.08
26 Prion protein facilitates uptake of zinc into neuronal cells. Nat Commun 2012 1.07
27 Prion protein and Alzheimer disease. Prion 2009 1.05
28 Glypican-1 mediates both prion protein lipid raft association and disease isoform formation. PLoS Pathog 2009 1.04
29 The N-terminal region of the prion protein ectodomain contains a lipid raft targeting determinant. J Biol Chem 2003 1.04
30 Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence. Biochemistry 2003 1.04
31 The prion protein and neuronal zinc homeostasis. Trends Biochem Sci 2003 1.04
32 Increased circulating insulin-like growth factor-1 in late-onset Alzheimer's disease. J Alzheimers Dis 2007 1.04
33 PCSK9: an emerging target for treatment of hypercholesterolemia. Expert Opin Ther Targets 2011 1.02
34 Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1. J Biol Chem 2013 1.01
35 A broad-spectrum fluorescence-based peptide library for the rapid identification of protease substrates. Proteomics 2006 1.00
36 Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein. J Biol Chem 2011 1.00
37 The kinetics of phase separation in asymmetric membranes. Biophys J 2005 0.97
38 Surface coat remodeling during differentiation of Trypanosoma brucei. J Biol Chem 2003 0.97
39 Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system. Biochem Pharmacol 2007 0.97
40 The role of lipid rafts in prion protein biology. Front Biosci (Landmark Ed) 2011 0.96
41 ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors. Can J Physiol Pharmacol 2002 0.95
42 Rab GTPase regulation of VEGFR2 trafficking and signaling in endothelial cells. Arterioscler Thromb Vasc Biol 2009 0.95
43 Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain. FEBS Lett 2007 0.95
44 N-glycans, not the GPI anchor, mediate the apical targeting of a naturally glycosylated, GPI-anchored protein in polarised epithelial cells. J Cell Sci 2004 0.94
45 Prion protein is reduced in aging and in sporadic but not in familial Alzheimer's disease. J Alzheimers Dis 2010 0.94
46 The role of zinc in Alzheimer's disease. Int J Alzheimers Dis 2010 0.94
47 Role of lipid rafts in the processing of the pathogenic prion and Alzheimer's amyloid-beta proteins. Semin Cell Dev Biol 2007 0.93
48 Tethering the N-terminus of the prion protein compromises the cellular response to oxidative stress. J Neurochem 2003 0.92
49 The Caenorhabditis elegans orthologue of mammalian puromycin-sensitive aminopeptidase has roles in embryogenesis and reproduction. J Biol Chem 2003 0.90
50 Effect of hydrophobic mismatch on phase behavior of lipid membranes. Biophys J 2006 0.90
51 Alkaline phosphatase is increased in both brain and plasma in Alzheimer's disease. Neurodegener Dis 2011 0.89
52 ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol Sci 2004 0.89
53 Plasma angiotensin-converting enzyme in Alzheimer's disease. J Alzheimers Dis 2009 0.87
54 Secretase-mediated cell surface shedding of the angiotensin-converting enzyme. Protein Pept Lett 2004 0.87
55 Emerging and potential therapies for Alzheimer's disease. Expert Opin Ther Targets 2008 0.87
56 The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill. J Renin Angiotensin Aldosterone Syst 2008 0.86
57 Plasma alkaline phosphatase is elevated in Alzheimer's disease and inversely correlates with cognitive function. Int J Mol Epidemiol Genet 2011 0.85
58 Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha. Biochemistry 2002 0.85
59 Glycosylation efficiency of Asn-Xaa-Thr sequons is independent of distance from the C-terminus in membrane dipeptidase. Glycobiology 2003 0.85
60 Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE. BMC Genomics 2007 0.84
61 Sphingomyelin chain length influences the distribution of GPI-anchored proteins in rafts in supported lipid bilayers. Mol Membr Biol 2007 0.83
62 Prion protein is decreased in Alzheimer's brain and inversely correlates with BACE1 activity, amyloid-β levels and Braak stage. PLoS One 2013 0.83
63 Association of a GPI-anchored protein with detergent-resistant membranes facilitates its trafficking through the early secretory pathway. Exp Cell Res 2008 0.83
64 The C-terminal domain, but not the interchain disulphide, is required for the activity and intracellular trafficking of aminopeptidase A. Biochem J 2002 0.83
65 Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis. FEBS J 2005 0.83
66 Normalized proliferation of normal and psoriatic keratinocytes by suppression of sAPPalpha-release. J Invest Dermatol 2004 0.83
67 BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging. PLoS One 2013 0.83
68 Protective effect of prion protein via the N-terminal region in mediating a protective effect on paraquat-induced oxidative injury in neuronal cells. J Neurosci Res 2008 0.83
69 Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis. Biochim Biophys Acta 2007 0.83
70 Neuronal zinc regulation and the prion protein. Prion 2013 0.82
71 Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C(alpha), src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C. Brain Res Mol Brain Res 2002 0.82
72 A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedema. Hum Mutat 2011 0.81
73 Changes of angiotensin-converting enzyme activity in the pancreas of chronic hypoxia and acute pancreatitis. Int J Biochem Cell Biol 2003 0.81
74 N-glycans as apical targeting signals in polarized epithelial cells. Biochem Soc Symp 2005 0.81
75 Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain. PLoS One 2012 0.81
76 The ectodomain shedding of angiotensin-converting enzyme is independent of its localisation in lipid rafts. J Cell Sci 2003 0.81
77 Distance of sequons to the C-terminus influences the cellular N-glycosylation of the prion protein. Biochem J 2003 0.81
78 Isolation and characterization of glycosylphosphatidylinositol-anchored peptides by hydrophilic interaction chromatography and MALDI tandem mass spectrometry. Anal Chem 2006 0.80
79 Regulation of amyloid-β production by the prion protein. Prion 2012 0.79
80 Emerging therapeutics for Alzheimer's disease. Expert Rev Neurother 2006 0.79
81 Contamination of nuclear fractions with plasma membrane lipid rafts. Proteomics 2007 0.78
82 Nitric oxide inhibits the shedding of the glycosylphosphatidylinositol-anchored dipeptidase from porcine renal proximal tubules. Biochem J 2002 0.78
83 Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening. Bioorg Med Chem Lett 2009 0.78
84 Cellular prion protein protects against reactive-oxygen-species-induced DNA damage. Free Radic Biol Med 2007 0.77
85 An ACE structure. Nat Struct Biol 2003 0.76
86 Glycosyl-phosphatidylinositol (GPI)-anchored renal dipeptidase is released by a phospholipase C in vivo. Kidney Blood Press Res 2002 0.76
87 Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design. J Med Chem 2013 0.75
88 Release of renal dipeptidase from glycosylphosphatidylinositol anchor by insulin-triggered phospholipase C/intracellular Ca2+. Arch Pharm Res 2007 0.75
89 Spontaneous release of glycosylphosphatidylinositol (GPI)-anchored renal dipeptidase from porcine renal proximal tubules. Arch Pharm Res 2002 0.75
90 The Role of Tissue Non-specific Alkaline Phosphatase (TNAP) in Neurodegenerative Diseases: Alzheimer's Disease in the Focus. Subcell Biochem 2015 0.75
91 Presenilin-1 mutations alter K+ currents in the human neuroblastoma cell line, SH-SY5Y. Neuroreport 2002 0.75