Published in J Biol Chem on February 05, 2013
Heat shock response and autophagy--cooperation and control. Autophagy (2015) 0.85
PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression. Autophagy (2015) 0.84
Overexpression of Heat Shock Transcription Factor 1 enhances the resistance of melanoma cells to doxorubicin and paclitaxel. BMC Cancer (2013) 0.81
Autophagy: An Integral Component of the Mammalian Stress Response. J Biochem Pharmacol Res (2013) 0.80
Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia. Blood (2016) 0.80
Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux. Biochem Pharmacol (2013) 0.79
Atg7 in development and disease: panacea or Pandora's Box? Protein Cell (2015) 0.78
Pleiotropic role of HSF1 in neoplastic transformation. Curr Cancer Drug Targets (2014) 0.78
Photothermal therapy of glioblastoma multiforme using multiwalled carbon nanotubes optimized for diffusion in extracellular space. ACS Biomater Sci Eng (2016) 0.77
Heat shock factor 1 induces cancer stem cell phenotype in breast cancer cell lines. Breast Cancer Res Treat (2015) 0.77
Autophagy is not uniformly cytoprotective: a personalized medicine approach for autophagy inhibition as a therapeutic strategy in non-small cell lung cancer. Biochim Biophys Acta (2016) 0.77
Quantitative chemical proteomics profiling of de novo protein synthesis during starvation-mediated autophagy. Autophagy (2016) 0.76
Identification of Personalized Chemoresistance Genes in Subtypes of Basal-Like Breast Cancer Based on Functional Differences Using Pathway Analysis. PLoS One (2015) 0.76
Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans. Nat Commun (2017) 0.75
HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis. Autophagy (2016) 0.75
Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy. Sci Rep (2017) 0.75
Loss of malin, but not laforin, results in compromised autophagic flux and proteasomal dysfunction in cells exposed to heat shock. Cell Stress Chaperones (2016) 0.75
Tomato HsfA1a plays a critical role in plant drought tolerance by activating ATG genes and inducing autophagy. Autophagy (2015) 0.75
mAb MDR1-modified chitosan nanoparticles overcome acquired EGFR-TKI resistance through two potential therapeutic targets modulation of MDR1 and autophagy. J Nanobiotechnology (2017) 0.75
Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature (1999) 23.62
Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell (2005) 17.81
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A (2003) 15.59
Autophagy: process and function. Genes Dev (2007) 15.21
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell (2006) 11.79
Role of autophagy in cancer. Nat Rev Cancer (2007) 10.88
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell (2007) 8.84
Autophagy: molecular machinery for self-eating. Cell Death Differ (2005) 8.46
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev (2007) 6.35
A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res (2001) 5.92
Subversion of cellular autophagosomal machinery by RNA viruses. PLoS Biol (2005) 5.84
Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress. Mol Cell Biol (1993) 5.11
Induction of autophagy by spermidine promotes longevity. Nat Cell Biol (2009) 5.00
Heat shock factors: integrators of cell stress, development and lifespan. Nat Rev Mol Cell Biol (2010) 4.63
Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ (2006) 3.95
Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res (2008) 3.17
Heat shock response modulators as therapeutic tools for diseases of protein conformation. J Biol Chem (2005) 2.95
HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell (2012) 2.94
CHIP activates HSF1 and confers protection against apoptosis and cellular stress. EMBO J (2003) 2.78
Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1. Mol Cell Biol (1993) 2.73
Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells. Oncogene (2009) 2.13
Autophagic survival in resistance to histone deacetylase inhibitors: novel strategies to treat malignant peripheral nerve sheath tumors. Cancer Res (2010) 2.11
High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proc Natl Acad Sci U S A (2011) 2.03
Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab. PLoS One (2009) 1.91
Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth. Oncogene (2009) 1.85
Chromatin landscape dictates HSF binding to target DNA elements. PLoS Genet (2010) 1.82
Induction of autophagy by drug-resistant esophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics. Autophagy (2011) 1.81
Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis. Mol Cell (2002) 1.67
Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization. Breast Cancer Res Treat (2008) 1.64
Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells. Med Oncol (2009) 1.60
Heat shock factor 1 and heat shock proteins: critical partners in protection against acute cell injury. Crit Care Med (2002) 1.58
Genome-wide analysis of human HSF1 signaling reveals a transcriptional program linked to cellular adaptation and survival. Mol Biosyst (2006) 1.47
Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis. Oncogene (2010) 1.45
Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells. Cancer Lett (2011) 1.43
Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1. Oncogene (2007) 1.40
Heat shock transcription factor 1 opens chromatin structure of interleukin-6 promoter to facilitate binding of an activator or a repressor. J Biol Chem (2007) 1.39
Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism. Cancer Res (2011) 1.35
Oestrogen receptor status of breast carcinoma: Allred/H score conversion table. Histopathology (2008) 1.31
DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity. Proc Natl Acad Sci U S A (2004) 1.21
A novel association between the human heat shock transcription factor 1 (HSF1) and prostate adenocarcinoma. Am J Pathol (2000) 1.11
HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression. Cancer Res (2008) 0.94
PRDM1 is required for mantle cell lymphoma response to bortezomib. Mol Cancer Res (2010) 0.86
Carboplatin in combination therapy for metastatic breast cancer. Oncologist (2004) 0.84
Induction of HSF1 expression is associated with sporadic colorectal cancer. World J Gastroenterol (2004) 0.84
Molecular definition of breast tumor heterogeneity. Cancer Cell (2007) 12.67
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell (2004) 10.89
Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55
Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell (2007) 7.60
Angiotensin II blockade and aortic-root dilation in Marfan's syndrome. N Engl J Med (2008) 7.31
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science (2010) 6.04
A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer. JAMA (2011) 4.63
Regulation of in situ to invasive breast carcinoma transition. Cancer Cell (2008) 4.46
Distinct epigenetic changes in the stromal cells of breast cancers. Nat Genet (2005) 4.33
Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell (2004) 4.17
Induction chemotherapy with cisplatin and fluorouracil alone or in combination with docetaxel in locally advanced squamous-cell cancer of the head and neck: long-term results of the TAX 324 randomised phase 3 trial. Lancet Oncol (2011) 3.95
A test of climate, sun, and culture relationships from an 1810-year Chinese cave record. Science (2008) 3.94
Ductal carcinoma in situ and the emergence of diversity during breast cancer evolution. Clin Cancer Res (2008) 3.83
Norovirus and histo-blood group antigens: demonstration of a wide spectrum of strain specificities and classification of two major binding groups among multiple binding patterns. J Virol (2005) 3.74
Racial survival disparity in head and neck cancer results from low prevalence of human papillomavirus infection in black oropharyngeal cancer patients. Cancer Prev Res (Phila) (2009) 3.70
Structural basis for the recognition of blood group trisaccharides by norovirus. J Virol (2007) 3.58
Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell (2013) 3.32
TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem (2009) 3.20
The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis. BMC Med Genomics (2008) 3.11
Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A (2008) 2.99
Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease. FASEB J (2005) 2.91
MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1) expression. J Biol Chem (2010) 2.85
Teamwork in the operating room: frontline perspectives among hospitals and operating room personnel. Anesthesiology (2006) 2.78
Retracted Novel HSP90 inhibitor NVP-HSP990 targets cell-cycle regulators to ablate Olig2-positive glioma tumor-initiating cells. Cancer Res (2013) 2.75
Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer. Clin Cancer Res (2006) 2.72
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. Nature (2013) 2.67
Quantitative PET imaging of tumor integrin alphavbeta3 expression with 18F-FRGD2. J Nucl Med (2006) 2.65
The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell (2011) 2.65
Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion. Cell (2009) 2.47
Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers. Clin Cancer Res (2004) 2.28
PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines. Cancer Res (2012) 2.23
Loss of HER2 amplification following trastuzumab-based neoadjuvant systemic therapy and survival outcomes. Clin Cancer Res (2009) 2.22
Growth of graphene from solid carbon sources. Nature (2010) 2.21
G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J Clin Invest (2012) 2.12
Nanochannel electroporation delivers precise amounts of biomolecules into living cells. Nat Nanotechnol (2011) 2.10
In vitro and in vivo characterization of 64Cu-labeled Abegrin, a humanized monoclonal antibody against integrin alpha v beta 3. Cancer Res (2006) 2.09
PD-L1 expression in triple-negative breast cancer. Cancer Immunol Res (2014) 2.06
The crosstalk of mTOR/S6K1 and Hedgehog pathways. Cancer Cell (2012) 2.02
Near-infrared fluorescent RGD peptides for optical imaging of integrin alphavbeta3 expression in living mice. Bioconjug Chem (2005) 2.01
Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptional upregulation of Twist1. Cancer Res (2012) 1.97
Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study. J Clin Oncol (2011) 1.92
ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction. FASEB J (2005) 1.89
A thiol-reactive 18F-labeling agent, N-[2-(4-18F-fluorobenzamido)ethyl]maleimide, and synthesis of RGD peptide-based tracer for PET imaging of alpha v beta 3 integrin expression. J Nucl Med (2006) 1.83
Structural basis for the receptor binding specificity of Norwalk virus. J Virol (2008) 1.82
Genome-wide functional synergy between amplified and mutated genes in human breast cancer. Cancer Res (2008) 1.82
NPHS2 mutations in late-onset focal segmental glomerulosclerosis: R229Q is a common disease-associated allele. J Clin Invest (2002) 1.81
Matrix-producing carcinoma of the breast: an aggressive subtype of metaplastic carcinoma. Am J Surg Pathol (2009) 1.79
Effect of combined laser acupuncture on knee osteoarthritis: a pilot study. Lasers Med Sci (2008) 1.77
14-3-3zeta overexpression defines high risk for breast cancer recurrence and promotes cancer cell survival. Cancer Res (2009) 1.74
Rad52-mediated DNA annealing after Rad51-mediated DNA strand exchange promotes second ssDNA capture. EMBO J (2006) 1.72
The stem cell-associated antigen CD133 (Prominin-1) is a molecular therapeutic target for metastatic melanoma. Stem Cells (2008) 1.70
Selective expression of KrasG12D in granulosa cells of the mouse ovary causes defects in follicle development and ovulation. Development (2008) 1.68
Differential expression of the CCN family members Cyr61, CTGF and Nov in human breast cancer. Endocr Relat Cancer (2004) 1.67
Profile of Ets gene expression in human breast carcinoma. Cancer Biol Ther (2007) 1.65
Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol. Mol Cancer (2010) 1.50
Systematic evaluation of three microRNA profiling platforms: microarray, beads array, and quantitative real-time PCR array. PLoS One (2011) 1.49
Blockade of endothelial-mesenchymal transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy. Diabetes (2010) 1.48
Genetic and phenotypic characterization of GII-4 noroviruses that circulated during 1987 to 2008. J Virol (2010) 1.46
Molecular classification of breast cancer: limitations and potential. Oncologist (2006) 1.46
Does timing of cytoreductive nephrectomy impact patient survival with metastatic renal cell carcinoma in the tyrosine kinase inhibitor era? A multi-institutional study. Urology (2013) 1.46
Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling. Pigment Cell Melanoma Res (2007) 1.45
Biomarkers of response to Akt inhibitor MK-2206 in breast cancer. Clin Cancer Res (2012) 1.44
Invasive neuroendocrine carcinoma of the breast: a distinctive subtype of aggressive mammary carcinoma. Cancer (2010) 1.44
Inhibition of lipocalin 2 impairs breast tumorigenesis and metastasis. Cancer Res (2009) 1.43
Position-dependent torque coupling and associated muscle activation in the hemiparetic upper extremity. Exp Brain Res (2006) 1.43
In situ imaging of the conducting filament in a silicon oxide resistive switch. Sci Rep (2012) 1.43
Neuraminidase inhibitor-rimantadine combinations exert additive and synergistic anti-influenza virus effects in MDCK cells. Antimicrob Agents Chemother (2004) 1.41
A cartilage ECM-derived 3-D porous acellular matrix scaffold for in vivo cartilage tissue engineering with PKH26-labeled chondrogenic bone marrow-derived mesenchymal stem cells. Biomaterials (2008) 1.39
Clear lens extraction with intraocular lens implantation for hyperopia. J Cataract Refract Surg (2003) 1.39
Rapid immune recovery and graft-versus-host disease-like engraftment syndrome following adoptive transfer of Costimulated autologous T cells. Clin Cancer Res (2009) 1.38
Spike protein VP8* of human rotavirus recognizes histo-blood group antigens in a type-specific manner. J Virol (2012) 1.38
Effects of tissue handling on RNA integrity and microarray measurements from resected breast cancers. J Natl Cancer Inst (2011) 1.38
Molecular profiling and characterization of luminal-like and basal-like in vivo breast cancer xenograft models. Mol Oncol (2009) 1.37
18F-labeled bombesin analogs for targeting GRP receptor-expressing prostate cancer. J Nucl Med (2006) 1.37
Activated leukocyte cell adhesion molecule in breast cancer: prognostic indicator. Breast Cancer Res (2004) 1.35
Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism. Cancer Res (2011) 1.35
B7-H4 expression associates with cancer progression and predicts patient's survival in human esophageal squamous cell carcinoma. Cancer Immunol Immunother (2011) 1.34
Prediction of antimicrobial peptides based on sequence alignment and feature selection methods. PLoS One (2011) 1.34
Functional analysis of the heat shock regulator HrcA of Chlamydia trachomatis. J Bacteriol (2002) 1.33
Growth of bilayer graphene on insulating substrates. ACS Nano (2011) 1.33
CPAF: a Chlamydial protease in search of an authentic substrate. PLoS Pathog (2012) 1.33
Growth of cancer cell lines under stem cell-like conditions has the potential to unveil therapeutic targets. Exp Cell Res (2008) 1.33
Identification of prognostic gene signatures of glioblastoma: a study based on TCGA data analysis. Neuro Oncol (2013) 1.32
Matrix metalloproteinases participate in osteosarcoma invasion. J Surg Res (2005) 1.32
Crystallography of a Lewis-binding norovirus, elucidation of strain-specificity to the polymorphic human histo-blood group antigens. PLoS Pathog (2011) 1.31
Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression. Clin Cancer Res (2008) 1.31
Sigma28 RNA polymerase regulates hctB, a late developmental gene in Chlamydia. Mol Microbiol (2003) 1.29
High-dose methotrexate pharmacokinetics and outcome of children and young adults with osteosarcoma. Cancer (2004) 1.29
The US postmarketing surveillance study of adult osteosarcoma and teriparatide: study design and findings from the first 7 years. J Bone Miner Res (2012) 1.28
Altered Abeta formation and long-term potentiation in a calsenilin knock-out. J Neurosci (2003) 1.27
Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion. J Biol Chem (2003) 1.27