Published in J Biochem Pharmacol Res on September 01, 2013
Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis. Autophagy (2015) 0.81
Interactions between Autophagy and Bacterial Toxins: Targets for Therapy? Toxins (Basel) (2015) 0.77
Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects. Int J Mol Sci (2015) 0.77
Nuclear cytoplasmic trafficking of proteins is a major response of human fibroblasts to oxidative stress. J Proteome Res (2014) 0.76
Immunity to uropathogens: the emerging roles of inflammasomes. Nat Rev Urol (2017) 0.75
Large-scale inference of gene function through phylogenetic annotation of Gene Ontology terms: case study of the apoptosis and autophagy cellular processes. Database (Oxford) (2016) 0.75
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J (2000) 41.48
Autophagy in the pathogenesis of disease. Cell (2008) 34.68
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature (1999) 23.62
The role of autophagy during the early neonatal starvation period. Nature (2004) 22.40
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell (2005) 21.01
TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 20.21
Methods in mammalian autophagy research. Cell (2010) 20.08
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol (2008) 17.81
The mammalian unfolded protein response. Annu Rev Biochem (2005) 16.31
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol (2011) 15.71
Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol (2007) 15.47
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol (2010) 12.26
Autophagy: renovation of cells and tissues. Cell (2011) 11.59
Autophagy and the integrated stress response. Mol Cell (2010) 11.21
Autophagy in immunity and inflammation. Nature (2011) 11.16
Mechanisms of mitophagy. Nat Rev Mol Cell Biol (2011) 10.66
Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol (2006) 9.36
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell (2009) 9.24
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci (2004) 9.20
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell (2009) 9.14
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol (2004) 8.85
Eaten alive: a history of macroautophagy. Nat Cell Biol (2010) 8.83
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol (2011) 8.75
Autophagy in human health and disease. N Engl J Med (2013) 8.71
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A (2009) 8.25
Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol (2009) 7.96
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev (2006) 7.76
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem (2008) 7.71
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell (2003) 7.71
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell (2008) 7.32
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J Cell Biol (2008) 7.16
Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. Mol Cell (2007) 7.09
Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes. J Cell Sci (2006) 6.98
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol (2010) 6.95
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell (2009) 6.88
Selective autophagy mediated by autophagic adapter proteins. Autophagy (2011) 6.88
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol (2011) 6.83
mTOR regulation of autophagy. FEBS Lett (2010) 6.59
Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev (2010) 6.35
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem (2009) 6.34
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med (2000) 6.32
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest (2004) 6.32
The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol (2010) 5.95
Autophagy, immunity, and microbial adaptations. Cell Host Microbe (2009) 5.84
Microsomal heme oxygenase. Characterization of the enzyme. J Biol Chem (1969) 5.35
Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov (2012) 5.26
The glucose-regulated proteins: stress induction and clinical applications. Trends Biochem Sci (2001) 5.18
Endoplasmic reticulum stress triggers autophagy. J Biol Chem (2006) 5.05
Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem (2009) 4.90
Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc Natl Acad Sci U S A (1989) 4.57
Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem (2005) 4.56
The Beclin 1 interactome. Curr Opin Cell Biol (2010) 4.13
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J (2010) 3.90
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem (2010) 3.84
Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J Biol Chem (2006) 3.74
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science (2013) 3.60
Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease. Physiol Rev (1992) 3.59
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature (2013) 3.57
Microautophagy of cytosolic proteins by late endosomes. Dev Cell (2011) 3.51
Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science (2012) 3.24
Cell death modalities: classification and pathophysiological implications. Cell Death Differ (2007) 3.19
Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell Death Differ (2009) 2.85
The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies. Oncogene (2012) 2.82
The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties. Free Radic Biol Med (2000) 2.61
Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature (2011) 2.58
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol (2012) 2.56
Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals. J Immunol (2004) 2.56
Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1. Autophagy (2008) 2.38
Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells. Cancer Res (1991) 2.30
The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO J (2009) 2.25
Ubiquitination and selective autophagy. Cell Death Differ (2012) 2.12
Atg9 vesicles are an important membrane source during early steps of autophagosome formation. J Cell Biol (2012) 2.12
To die or not to die: that is the autophagic question. Curr Mol Med (2008) 2.05
Mitochondria removal by autophagy. Autophagy (2011) 2.04
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy. Autophagy (2010) 1.93
Regulation of autophagy by ATF4 in response to severe hypoxia. Oncogene (2010) 1.93
Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. J Cell Sci (2009) 1.92
The heat shock response: systems biology of proteotoxic stress in aging and disease. Cold Spring Harb Symp Quant Biol (2012) 1.91
p53: The Janus of autophagy? Nat Cell Biol (2008) 1.86
Autophagic cell death: Loch Ness monster or endangered species? Autophagy (2011) 1.82
Selective degradation of p62 by autophagy. Semin Immunopathol (2010) 1.80
The ULK1 complex: sensing nutrient signals for autophagy activation. Autophagy (2013) 1.71
Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy. EMBO J (2011) 1.68
Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress. Cell Death Differ (2007) 1.64
Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling. Trends Cell Biol (2012) 1.63
Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice. Hepatology (2011) 1.61
Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors. Curr Opin Immunol (2011) 1.55
Keap1 degradation by autophagy for the maintenance of redox homeostasis. Proc Natl Acad Sci U S A (2012) 1.53
Aggrephagy: selective disposal of protein aggregates by macroautophagy. Int J Cell Biol (2012) 1.52
Autophagy and innate immunity: triggering, targeting and tuning. Semin Cell Dev Biol (2010) 1.49
Heme oxygenase-1 inhibits renal tubular macroautophagy in acute kidney injury. J Am Soc Nephrol (2010) 1.45
p62 at the interface of autophagy, oxidative stress signaling, and cancer. Antioxid Redox Signal (2012) 1.42
Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness. Cancer Res (2012) 1.41
Autophagy: an emerging immunological paradigm. J Immunol (2012) 1.40
Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning. Autophagy (2012) 1.34
Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. J Biol Chem (2012) 1.29
Chaperone-mediated autophagy at a glance. J Cell Sci (2011) 1.28
Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy. Proc Natl Acad Sci U S A (2013) 1.24
Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy. Am J Respir Cell Mol Biol (2009) 1.94