Published in Lab Invest on February 18, 2013
Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways. Proc Natl Acad Sci U S A (2013) 1.12
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Hypoxia-dependent regulation of inflammatory pathways in immune cells. J Clin Invest (2016) 0.86
The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogens. Mol Cell Pediatr (2016) 0.84
Hypoxia-inducible factor 1 in dendritic cells is crucial for the activation of protective regulatory T cells in murine colitis. Mucosal Immunol (2015) 0.81
Therapeutic treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates murine colitis. Clin Exp Gastroenterol (2014) 0.79
Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer. Oxid Med Cell Longev (2015) 0.78
Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn's disease/infectious colitis and healthy controls. J Inflamm (Lond) (2013) 0.77
Oxygen sensing in intestinal mucosal inflammation. Pflugers Arch (2015) 0.76
Protocol for a prospective, controlled, observational study to evaluate the influence of hypoxia on healthy volunteers and patients with inflammatory bowel disease: the Altitude IBD Study. BMJ Open (2017) 0.75
Hypoxia Inducible Factor (HIF) Hydroxylases as Regulators of Intestinal Epithelial Barrier Function. Cell Mol Gastroenterol Hepatol (2017) 0.75
Regulation of immunity and inflammation by hypoxia in immunological niches. Nat Rev Immunol (2017) 0.75
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. Proc Natl Acad Sci U S A (2006) 4.08
Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha. Science (2003) 3.91
Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation (2005) 2.99
The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. Gastroenterology (2007) 2.87
Hypoxia-responsive transcription factors. Pflugers Arch (2005) 2.64
Hypoxia: an alarm signal during intestinal inflammation. Nat Rev Gastroenterol Hepatol (2010) 2.18
MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia. Mol Cell Biol (2011) 1.81
A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2009) 1.78
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function. Gastroenterology (2010) 1.64
Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury. FASEB J (2006) 1.61
Regulation of oxygen distribution in tissues by endothelial nitric oxide. Circ Res (2009) 1.61
Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. Proc Natl Acad Sci U S A (2003) 1.52
Predictors of elevated nuclear factor-kappaB-dependent genes in obstructive sleep apnea syndrome. Am J Respir Crit Care Med (2006) 1.50
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. J Clin Invest (2011) 1.44
PGC-1alpha is coupled to HIF-1alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells. Proc Natl Acad Sci U S A (2009) 1.38
The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia. J Biol Chem (2003) 1.33
Stabilization of hypoxia-inducible factor-1alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production. J Biol Chem (2010) 1.33
Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog. Kidney Int (2003) 1.21
An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia. J Immunol (2010) 1.20
NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells. J Immunol (2010) 1.12
Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways. Proc Natl Acad Sci U S A (2013) 1.12
Gremlin plays a key role in the pathogenesis of pulmonary hypertension. Circulation (2012) 1.11
Carbon dioxide-sensing in organisms and its implications for human disease. Cell Mol Life Sci (2013) 1.10
15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure. J Am Soc Nephrol (2002) 1.08
Targeting the HIF pathway in inflammation and immunity. Curr Opin Pharmacol (2013) 1.07
c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1alpha-dependent P-glycoprotein expression in hypoxia. Cancer Res (2004) 1.05
A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network. J Cell Sci (2013) 1.03
Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung. Am J Respir Crit Care Med (2008) 0.97
A critical role for p38 map kinase in NF-kappaB signaling during intermittent hypoxia/reoxygenation. Biochem Biophys Res Commun (2007) 0.97
Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner. Am J Physiol Cell Physiol (2005) 0.96
Hypoxia increases antibiotic resistance in Pseudomonas aeruginosa through altering the composition of multidrug efflux pumps. Antimicrob Agents Chemother (2012) 0.96
Small ubiquitin-related modifier (SUMO)-1 promotes glycolysis in hypoxia. J Biol Chem (2010) 0.95
Hypoxia. Regulation of NFkappaB signalling during inflammation: the role of hydroxylases. Arthritis Res Ther (2009) 0.95
Potentiation of glucocorticoid activity in hypoxia through induction of the glucocorticoid receptor. J Immunol (2005) 0.94
NFκB and HIF display synergistic behaviour during hypoxic inflammation. Cell Mol Life Sci (2011) 0.94
Hypoxia activates NF-kappaB-dependent gene expression through the canonical signaling pathway. Antioxid Redox Signal (2009) 0.94
Hypoxia, innate immunity and infection in the lung. Respir Physiol Neurobiol (2010) 0.93
A comparative study of short- and medium-term outcomes comparing emergent surgery and stenting as a bridge to surgery in patients with acute malignant colonic obstruction. Dis Colon Rectum (2013) 0.93
The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells. Shock (2011) 0.93
Hypercapnia induces cleavage and nuclear localization of RelB protein, giving insight into CO2 sensing and signaling. J Biol Chem (2012) 0.92
SUMO, hypoxia and the regulation of metabolism. Biochem Soc Trans (2008) 0.89
Alterations in oxidative gene expression in equine skeletal muscle following exercise and training. Physiol Genomics (2009) 0.88
Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: altered apoptosis, Toll-like receptor-4 and CD11b expression compared with adults. Biol Neonate (2006) 0.87
Screening for tuberculosis and hepatitis B prior to the initiation of anti-tumor necrosis therapy. Inflamm Bowel Dis (2011) 0.87
Keeping the bowel regular: the emerging role of Treg as a therapeutic target in inflammatory bowel disease. Inflamm Bowel Dis (2013) 0.86
Hydroxylase-dependent regulation of the NF-κB pathway. Biol Chem (2013) 0.86
Hypoxia-dependent regulation of inflammatory pathways in immune cells. J Clin Invest (2016) 0.86
Hypoxic regulation of NF-kappaB signaling. Methods Enzymol (2007) 0.85
Regulation of protein phosphatase 1gamma activity in hypoxia through increased interaction with NIPP1: implications for cellular metabolism. J Cell Physiol (2006) 0.85
Hypoxia modulates infection of epithelial cells by Pseudomonas aeruginosa. PLoS One (2013) 0.83
The impact of hypoxia on cell death pathways. Biochem Soc Trans (2013) 0.83
Expression of COX-2 and prognostic outcome in uveal melanoma. Curr Eye Res (2008) 0.83
Lower expression of Nrf2 mRNA in older donor livers: a possible contributor to increased ischemia-reperfusion injury? Transplantation (2007) 0.82
Disruption of COX-2 modulates gene expression and the cardiac injury response to doxorubicin. Am J Physiol Heart Circ Physiol (2006) 0.81
Cholera toxin potentiates influences of IFN-gamma through activation of NF-kappaB and release of tumor necrosis factor-alpha. J Interferon Cytokine Res (2005) 0.80
Monitoring of cell oxygenation and responses to metabolic stimulation by intracellular oxygen sensing technique. Integr Biol (Camb) (2010) 0.80
Visceral Adiposity is a Risk Factor for Poor Prognosis in Colorectal Cancer Patients Receiving Adjuvant Chemotherapy. J Gastrointest Cancer (2015) 0.80
Body image dissatisfaction: clinical features, and psychosocial disability in inflammatory bowel disease. Inflamm Bowel Dis (2015) 0.79
The body image scale: a simple and valid tool for assessing body image dissatisfaction in inflammatory bowel disease. Inflamm Bowel Dis (2014) 0.79
Targeting EGFR in metastatic colorectal cancer beyond the limitations of KRAS status: alternative biomarkers and therapeutic strategies. Biomark Med (2015) 0.79
Mitochondria, oxygen sensing, and the regulation of HIF-2alpha. Focus on "Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line". Am J Physiol Cell Physiol (2008) 0.79
Hydroxylase inhibition attenuates colonic epithelial secretory function and ameliorates experimental diarrhea. FASEB J (2010) 0.79
Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na+/Ca2+ exchange. Biochim Biophys Acta (2010) 0.79
Impact of magnetic resonance enterography in the management of small bowel Crohn's disease. Eur J Gastroenterol Hepatol (2013) 0.78
Heightened Expression of CD39 by Regulatory T Lymphocytes Is Associated with Therapeutic Remission in Inflammatory Bowel Disease. Inflamm Bowel Dis (2015) 0.78
Glucose reintroduction triggers the activation of Nrf2 during experimental ischemia reperfusion. Mol Cell Biochem (2012) 0.78
Evaluation of the small bowel in inflammatory bowel disease. Expert Rev Gastroenterol Hepatol (2013) 0.77
A dynamic model of the hypoxia-inducible factor 1a (HIF-1a) network. J Cell Sci (2015) 0.77
Magnetic resonance enterography findings as predictors of clinical outcome following antitumor necrosis factor treatment in small bowel Crohn's disease. Eur J Gastroenterol Hepatol (2015) 0.77
The Short Health Scale: a valid and reliable measure of health related quality of life in English speaking inflammatory bowel disease patients. J Crohns Colitis (2012) 0.77
Endothelial COX-2 induction by hypoxia liberates 6-keto-PGF1 alpha, a potent epithelial secretagogue. Adv Exp Med Biol (2002) 0.77
The influence of CTGF single-nucleotide polymorphisms on outcomes in Crohn's disease. Ann Surg (2013) 0.77
Capsule endoscopy in suspected Crohn's disease: "yield" does not equal "diagnosis". Am J Gastroenterol (2010) 0.76
Restoring the regulatory regime in IBD: do anti-TNF agents rescue Treg? Inflamm Bowel Dis (2011) 0.75
CRP/Albumin Ratio: An Early Predictor of Steroid Responsiveness in Acute Severe Ulcerative Colitis. J Clin Gastroenterol (2017) 0.75
A survey of current practices used to maintain surgically induced remission following intestinal resection for Crohn's disease. Int J Colorectal Dis (2013) 0.75
Resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cells. Cancer (2005) 0.75
Enhanced sensitivity of protein kinase B/Akt to insulin in hypoxia is independent of HIF1alpha and promotes cell viability. Eur J Cell Biol (2007) 0.75
Identification of cyclic AMP response element-binding protein-dependent transcriptional responses in hypoxia by microarray analysis. Methods Enzymol (2004) 0.75
Development, validation and clinical assessment of a short questionnaire to assess disease-related knowledge in inflammatory bowel disease patients. Scand J Gastroenterol (2012) 0.75