Published in Recent Results Cancer Res on January 01, 2015
Molecular portraits of human breast tumours. Nature (2000) 94.14
Comprehensive molecular portraits of human breast tumours. Nature (2012) 47.39
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med (2012) 44.56
A genetic model for colorectal tumorigenesis. Cell (1990) 44.37
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science (2005) 39.06
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature (2007) 37.09
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med (2010) 36.78
Comprehensive molecular characterization of human colon and rectal cancer. Nature (2012) 34.13
Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A (1971) 31.05
A rapid banding technique for human chromosomes. Lancet (1971) 27.45
Genetic alterations during colorectal-tumor development. N Engl J Med (1988) 26.82
Genetic instabilities in human cancers. Nature (1998) 22.76
High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. Nat Genet (1998) 21.52
Comprehensive genomic characterization of squamous cell lung cancers. Nature (2012) 18.90
Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science (1992) 16.38
Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell (2006) 16.05
Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature (1973) 15.28
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol (2009) 15.23
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med (2013) 14.78
Integrated genomic characterization of endometrial carcinoma. Nature (2013) 14.29
Trastuzumab--mechanism of action and use in clinical practice. N Engl J Med (2007) 12.73
Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors. Proc Natl Acad Sci U S A (2002) 12.68
Genetic instability in colorectal cancers. Nature (1997) 12.51
Comprehensive molecular profiling of lung adenocarcinoma. Nature (2014) 11.02
Absolute quantification of somatic DNA alterations in human cancer. Nat Biotechnol (2012) 10.87
The impact of translocations and gene fusions on cancer causation. Nat Rev Cancer (2007) 9.81
ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol (2012) 9.76
Comprehensive molecular characterization of urothelial bladder carcinoma. Nature (2014) 8.48
Matrix-based comparative genomic hybridization: biochips to screen for genomic imbalances. Genes Chromosomes Cancer (1997) 8.27
Lessons from the cancer genome. Cell (2013) 8.12
Pan-cancer patterns of somatic copy number alteration. Nat Genet (2013) 7.73
Allele-specific copy number analysis of tumors. Proc Natl Acad Sci U S A (2010) 7.70
Multicolor spectral karyotyping of human chromosomes. Science (1996) 7.65
Reflecting on 25 years with MYC. Nat Rev Cancer (2008) 7.44
Chromosome aberrations in solid tumors. Nat Genet (2003) 7.01
Chemical differentiation along metaphase chromosomes. Exp Cell Res (1968) 6.82
Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. Nat Med (2012) 6.77
RET, ROS1 and ALK fusions in lung cancer. Nat Med (2012) 6.76
High-resolution genomic profiles of human lung cancer. Proc Natl Acad Sci U S A (2005) 6.52
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol (2009) 6.43
Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Sci Transl Med (2010) 6.39
CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature (2008) 6.24
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet (2010) 6.10
Recurrent gene fusions in prostate cancer. Nat Rev Cancer (2008) 6.08
Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol (2006) 6.06
New technique for distinguishing between human chromosomes. Nat New Biol (1971) 5.87
Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer. Nat Genet (2004) 5.75
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing. Nat Genet (2014) 5.74
Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc Natl Acad Sci U S A (1994) 5.74
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nat Genet (2011) 5.67
Methods and strategies for analyzing copy number variation using DNA microarrays. Nat Genet (2007) 5.64
The Behavior in Successive Nuclear Divisions of a Chromosome Broken at Meiosis. Proc Natl Acad Sci U S A (1939) 5.06
Liquid biopsies: genotyping circulating tumor DNA. J Clin Oncol (2014) 4.76
KIF5B-RET fusions in lung adenocarcinoma. Nat Med (2012) 4.38
A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing. Genome Res (2011) 4.15
Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst (1960) 4.15
Causes and consequences of aneuploidy in cancer. Nat Rev Genet (2012) 4.08
Karyotyping human chromosomes by combinatorial multi-fluor FISH. Nat Genet (1996) 4.02
The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome Res (2012) 3.80
Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol (2009) 3.79
Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients. J Clin Oncol (2009) 3.57
Intratumor heterogeneity: evolution through space and time. Cancer Res (2012) 3.45
Liquid biopsy: monitoring cancer-genetics in the blood. Nat Rev Clin Oncol (2013) 3.34
Breast tumor copy number aberration phenotypes and genomic instability. BMC Cancer (2006) 3.34
Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors. Genes Chromosomes Cancer (1996) 3.30
Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer. PLoS One (2011) 3.23
Replication stress links structural and numerical cancer chromosomal instability. Nature (2013) 3.11
Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J Exp Med (2002) 2.86
Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix. Proc Natl Acad Sci U S A (1996) 2.81
ALK in lung cancer: past, present, and future. J Clin Oncol (2013) 2.70
Genomics-driven oncology: framework for an emerging paradigm. J Clin Oncol (2013) 2.69
AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer Res (2012) 2.60
Genotyping and genomic profiling of non-small-cell lung cancer: implications for current and future therapies. J Clin Oncol (2013) 2.59
Silence of chromosomal amplifications in colon cancer. Cancer Res (2002) 2.58
Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: identification of a FIG-ROS1 fusion. Clin Cancer Res (2012) 2.53
Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing. Cancer Res (2013) 2.50
Acquired resistance to TKIs in solid tumours: learning from lung cancer. Nat Rev Clin Oncol (2014) 2.49
Clinical and molecular approaches to well differentiated and dedifferentiated liposarcoma. Curr Opin Oncol (2011) 2.39
Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis. Nature (2014) 2.38
Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles. Nature (2014) 2.33
The consequences of tetraploidy and aneuploidy. J Cell Sci (2008) 2.31
Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesis. Cancer Res (2012) 2.26
New targetable oncogenes in non-small-cell lung cancer. J Clin Oncol (2013) 2.25
Methodological and practical challenges for personalized cancer therapies. Nat Rev Clin Oncol (2011) 2.25
PVT1 dependence in cancer with MYC copy-number increase. Nature (2014) 2.13
Recurrent chromosome aberrations in cancer. Mutat Res (2000) 2.09
Advanced-stage cervical carcinomas are defined by a recurrent pattern of chromosomal aberrations revealing high genetic instability and a consistent gain of chromosome arm 3q. Genes Chromosomes Cancer (1997) 2.06
Comparative genomic hybridization of formalin-fixed, paraffin-embedded breast tumors reveals different patterns of chromosomal gains and losses in fibroadenomas and diploid and aneuploid carcinomas. Cancer Res (1995) 2.04
Treatment recommendations for anaplastic oligodendrogliomas that are codeleted. Oncology (Williston Park) (2013) 2.04
Uniparental disomy in cancer. Trends Mol Med (2009) 1.99
Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer. Genes Chromosomes Cancer (2009) 1.91
The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium. Annu Rev Cell Dev Biol (2004) 1.90
Chromosomal translocations: revisited yet again. Blood (2008) 1.86
Gene copy-number alterations: a cost-benefit analysis. Cell (2013) 1.79
Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression. Gut (2008) 1.77
Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells. Cancer Res (2004) 1.74
The identification of microRNAs in a genomically unstable region of human chromosome 8q24. Mol Cancer Res (2008) 1.71
Cancer genomics: technology, discovery, and translation. J Clin Oncol (2012) 1.70
Lessons learned from lung cancer genomics: the emerging concept of individualized diagnostics and treatment. J Clin Oncol (2013) 1.65