Published in J Biol Phys on December 03, 2011
Morphogen rules: design principles of gradient-mediated embryo patterning. Development (2015) 1.01
Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range. Proc Natl Acad Sci U S A (2014) 0.83
Spatiotemporal analysis of different mechanisms for interpreting morphogen gradients. Biophys J (2015) 0.80
The organelle of differentiation in embryos: the cell state splitter. Theor Biol Med Model (2016) 0.76
The Mitotic Spindle in the One-Cell C. elegans Embryo Is Positioned with High Precision and Stability. Biophys J (2016) 0.75
Physics of chemoreception. Biophys J (1977) 15.69
The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner. Cell (1988) 7.72
Probing the limits to positional information. Cell (2007) 6.23
Establishment of developmental precision and proportions in the early Drosophila embryo. Nature (2002) 5.55
Stability and nuclear dynamics of the bicoid morphogen gradient. Cell (2007) 5.31
The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo. Nature (1989) 4.81
The gradient morphogen bicoid is a concentration-dependent transcriptional activator. Cell (1989) 4.72
Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen. Nature (1989) 3.15
Pre-steady-state decoding of the Bicoid morphogen gradient. PLoS Biol (2007) 2.81
The products of the Drosophila gap genes hunchback and Krüppel bind to the hunchback promoters. Nature (1989) 1.98
Cooperative DNA-binding by Bicoid provides a mechanism for threshold-dependent gene activation in the Drosophila embryo. EMBO J (1998) 1.97
Synergy between the hunchback and bicoid morphogens is required for anterior patterning in Drosophila. Cell (1994) 1.97
Mutually repressive interactions between the gap genes giant and Krüppel define middle body regions of the Drosophila embryo. Development (1991) 1.88
A morphogenetic gradient of hunchback protein organizes the expression of the gap genes Krüppel and knirps in the early Drosophila embryo. Nature (1990) 1.84
Activation of transcription in Drosophila embryos is a gradual process mediated by the nucleocytoplasmic ratio. Genes Dev (1996) 1.78
Fundamental limits to position determination by concentration gradients. PLoS Comput Biol (2007) 1.76
The giant gene of Drosophila encodes a b-ZIP DNA-binding protein that regulates the expression of other segmentation gap genes. Development (1992) 1.75
Spatial and temporal patterns of Krüppel gene expression in early Drosophila embryos. Nature (1985) 1.73
cis-acting control elements for Krüppel expression in the Drosophila embryo. EMBO J (1990) 1.70
Interactions of the Drosophila gap gene giant with maternal and zygotic pattern-forming genes. Development (1991) 1.69
Competition for overlapping sites in the regulatory region of the Drosophila gene Krüppel. Science (1992) 1.66
The Drosophila morphogenetic protein Bicoid binds DNA cooperatively. Development (1996) 1.59
Known maternal gradients are not sufficient for the establishment of gap domains in Drosophila melanogaster. Mech Dev (2006) 1.57
Gene expression mediated by cis-acting sequences of the Krüppel gene in response to the Drosophila morphogens bicoid and hunchback. EMBO J (1991) 1.53
Bicoid cooperative DNA binding is critical for embryonic patterning in Drosophila. Proc Natl Acad Sci U S A (2005) 1.36
The time to measure positional information: maternal hunchback is required for the synchrony of the Bicoid transcriptional response at the onset of zygotic transcription. Development (2010) 1.30
When it pays to rush: interpreting morphogen gradients prior to steady-state. Phys Biol (2009) 1.12
Re-examining the stability of the Bicoid morphogen gradient. Cell (2008) 1.10
Analysis of maternal effect mutant combinations elucidates regulation and function of the overlap of hunchback and Krüppel gene expression in the Drosophila blastoderm embryo. Development (1989) 1.06
Precision and scaling in morphogen gradient read-out. Mol Syst Biol (2010) 1.05
Isolation of mutations that disrupt cooperative DNA binding by the Drosophila bicoid protein. J Mol Biol (2001) 1.03
Sequences outside the homeodomain of bicoid are required for protein-protein interaction. J Biol Chem (1996) 0.93
Physical aspects of precision in genetic regulation. J Biol Phys (2010) 0.77
Noise in protein expression scales with natural protein abundance. Nat Genet (2006) 8.03
Revealing modular organization in the yeast transcriptional network. Nat Genet (2002) 6.73
Similarities and differences in genome-wide expression data of six organisms. PLoS Biol (2003) 4.75
Robustness of the BMP morphogen gradient in Drosophila embryonic patterning. Nature (2002) 4.21
Two strategies for gene regulation by promoter nucleosomes. Genome Res (2008) 4.19
Principles of transcriptional control in the metabolic network of Saccharomyces cerevisiae. Nat Biotechnol (2003) 4.06
Mechanisms of noise-resistance in genetic oscillators. Proc Natl Acad Sci U S A (2002) 3.78
A genetic signature of interspecies variations in gene expression. Nat Genet (2006) 3.61
Defining transcription modules using large-scale gene expression data. Bioinformatics (2004) 3.33
A yeast hybrid provides insight into the evolution of gene expression regulation. Science (2009) 3.25
Rewiring of the yeast transcriptional network through the evolution of motif usage. Science (2005) 3.10
Pre-steady-state decoding of the Bicoid morphogen gradient. PLoS Biol (2007) 2.81
Iterative signature algorithm for the analysis of large-scale gene expression data. Phys Rev E Stat Nonlin Soft Matter Phys (2003) 2.51
Self-enhanced ligand degradation underlies robustness of morphogen gradients. Dev Cell (2003) 2.40
Comparative gene expression analysis by differential clustering approach: application to the Candida albicans transcription program. PLoS Genet (2005) 2.36
Scaling of the BMP activation gradient in Xenopus embryos. Nature (2008) 2.31
Noise propagation and signaling sensitivity in biological networks: a role for positive feedback. PLoS Comput Biol (2007) 1.94
Expansion-repression mechanism for scaling the Dpp activation gradient in Drosophila wing imaginal discs. Curr Biol (2011) 1.79
A biological solution to a fundamental distributed computing problem. Science (2011) 1.62
Threshold responses to morphogen gradients by zero-order ultrasensitivity. Mol Syst Biol (2005) 1.59
Promoter architecture and the evolvability of gene expression. J Biol (2009) 1.47
Divergence of nucleosome positioning between two closely related yeast species: genetic basis and functional consequences. Mol Syst Biol (2010) 1.44
On the relation between promoter divergence and gene expression evolution. Mol Syst Biol (2008) 1.43
The pattern and evolution of yeast promoter bendability. Trends Genet (2007) 1.37
Elucidating mechanisms underlying robustness of morphogen gradients. Curr Opin Genet Dev (2004) 1.36
Comparative analysis indicates regulatory neofunctionalization of yeast duplicates. Genome Biol (2007) 1.36
Strategy of transcription regulation in the budding yeast. PLoS One (2007) 1.30
The evolving doublecortin (DCX) superfamily. BMC Genomics (2006) 1.29
Epigenetically-inherited centromere and neocentromere DNA replicates earliest in S-phase. PLoS Genet (2010) 1.29
Evolution of gene sequence and gene expression are not correlated in yeast. Trends Genet (2008) 1.28
Modulation of the transcription regulatory program in yeast cells committed to sporulation. Genome Biol (2006) 1.26
Comparative biology: beyond sequence analysis. Curr Opin Biotechnol (2007) 1.24
Scaling of morphogen gradients by an expansion-repression integral feedback control. Proc Natl Acad Sci U S A (2010) 1.19
Noise-mean relationship in mutated promoters. Genome Res (2012) 1.18
The design of transcription-factor binding sites is affected by combinatorial regulation. Genome Biol (2005) 1.18
Widespread remodeling of mid-coding sequence nucleosomes by Isw1. Genome Biol (2010) 1.18
MRC1-dependent scaling of the budding yeast DNA replication timing program. Genome Res (2010) 1.18
Expression noise and acetylation profiles distinguish HDAC functions. Mol Cell (2012) 1.17
Chromatin regulators as capacitors of interspecies variations in gene expression. Mol Syst Biol (2010) 1.14
Linking the signaling cascades and dynamic regulatory networks controlling stress responses. Genome Res (2012) 1.14
Common and divergent roles for members of the mouse DCX superfamily. Cell Cycle (2006) 1.13
Evaluating putative mechanisms of the mitotic spindle checkpoint. Proc Natl Acad Sci U S A (2005) 1.12
Re-examining the stability of the Bicoid morphogen gradient. Cell (2008) 1.10
Spore germination in Saccharomyces cerevisiae: global gene expression patterns and cell cycle landmarks. Genome Biol (2007) 1.07
The competitive advantage of a dual-transporter system. Science (2011) 1.06
Morphogen gradient formation in a complex environment: an anomalous diffusion model. Phys Rev E Stat Nonlin Soft Matter Phys (2005) 1.02
Evolution of nucleosome occupancy: conservation of global properties and divergence of gene-specific patterns. Mol Cell Biol (2011) 1.01
Conservation of expression and sequence of metabolic genes is reflected by activity across metabolic states. PLoS Comput Biol (2006) 1.00
Error minimization in lateral inhibition circuits. Sci Signal (2010) 0.98
Coordination of gene expression with growth rate: a feedback or a feed-forward strategy? FEBS Lett (2009) 0.98
Scaling of morphogen gradients. Curr Opin Genet Dev (2011) 0.96
Noise resistance in the spindle assembly checkpoint. Mol Syst Biol (2006) 0.96
Self-organized shuttling: generating sharp dorsoventral polarity in the early Drosophila embryo. Cell (2012) 0.94
Computational verification of protein-protein interactions by orthologous co-expression. BMC Bioinformatics (2005) 0.94
Extensive divergence of yeast stress responses through transitions between induced and constitutive activation. Proc Natl Acad Sci U S A (2011) 0.93
Budding yeast escape commitment to the phosphate starvation program using gene expression noise. Curr Biol (2013) 0.90
Creating gradients by morphogen shuttling. Trends Genet (2013) 0.86
Autocorrelation analysis reveals widespread spatial biases in microarray experiments. BMC Genomics (2007) 0.86
Scaling morphogen gradients during tissue growth by a cell division rule. Development (2014) 0.85
Efficiency and specificity in microRNA biogenesis. Nat Struct Mol Biol (2012) 0.85
Inferring regulatory mechanisms from patterns of evolutionary divergence. Mol Syst Biol (2011) 0.85
Robust selection of sensory organ precursors by the Notch-Delta pathway. Curr Opin Cell Biol (2011) 0.84
Disentangling signaling gradients generated by equivalent sources. J Biol Phys (2011) 0.83
Nucleosome organization affects the sensitivity of gene expression to promoter mutations. Mol Cell (2012) 0.82
Interpreting clone-mediated perturbations of morphogen profiles. Dev Biol (2005) 0.82
Increasing population growth by asymmetric segregation of a limiting resource during cell division. Mol Syst Biol (2013) 0.81
Reverse engineering of the spindle assembly checkpoint. PLoS One (2009) 0.79
Checkpoint-independent scaling of the Saccharomyces cerevisiae DNA replication program. BMC Biol (2014) 0.78
Scaling of dorsal-ventral patterning in the Xenopus laevis embryo. Bioessays (2013) 0.78
Physical aspects of precision in genetic regulation. J Biol Phys (2010) 0.77
The ups and downs of biological timers. Theor Biol Med Model (2005) 0.77
Promoter nucleosome organization shapes the evolution of gene expression. PLoS Genet (2012) 0.77
The era of systems developmental biology. Curr Opin Genet Dev (2011) 0.77
EGF receptor signaling - a quantitative view. Curr Biol (2007) 0.76
Developmental biology: Segmentation within scale. Nature (2012) 0.75