Published in Cell Metab on March 05, 2013
Immune modulation of stem cells and regeneration. Cell Stem Cell (2014) 1.07
Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk. J Clin Invest (2014) 0.92
The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding. Prog Retin Eye Res (2014) 0.89
Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing. EMBO Mol Med (2016) 0.82
IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis. Mol Cell Biol (2015) 0.82
Truncated netrin-1 contributes to pathological vascular permeability in diabetic retinopathy. J Clin Invest (2016) 0.79
Assessment of vascular regeneration in the CNS using the mouse retina. J Vis Exp (2014) 0.79
PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response. Sci Rep (2015) 0.77
The endoplasmic reticulum stress and the HIF-1 signalling pathways are involved in the neuronal damage caused by chemical hypoxia. Br J Pharmacol (2015) 0.76
Netrin-1 Protects Hepatocytes Against Cell Death Through Sustained Translation During the Unfolded Protein Response. Cell Mol Gastroenterol Hepatol (2016) 0.75
Neurons and guidance cues in retinal vascular diseases. Oncotarget (2016) 0.75
Netrin-1 - DCC Signaling Systems and Age-Related Macular Degeneration. PLoS One (2015) 0.75
Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A. Proc Natl Acad Sci U S A (2015) 0.75
High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress. World J Diabetes (2017) 0.75
Disparity among neural injury models and the unfolded protein response. J Neurol Disord Stroke (2014) 0.75
Neurovascular cross talk in diabetic retinopathy: Pathophysiological roles and therapeutic implications. Am J Physiol Heart Circ Physiol (2016) 0.75
Molecular signal networks and regulating mechanisms of the unfolded protein response. J Zhejiang Univ Sci B (2017) 0.75
eIF2α signaling regulates ischemic osteonecrosis through endoplasmic reticulum stress. Sci Rep (2017) 0.75
The mammalian unfolded protein response. Annu Rev Biochem (2005) 16.31
Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol (2005) 9.25
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (2005) 7.98
A trip to the ER: coping with stress. Trends Cell Biol (2004) 7.67
From endoplasmic-reticulum stress to the inflammatory response. Nature (2008) 7.17
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol (2006) 6.45
ER stress and the unfolded protein response. Mutat Res (2005) 6.43
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev (2002) 6.37
The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol (2007) 5.59
Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc Natl Acad Sci U S A (2001) 5.59
Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal (2007) 5.17
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell (2006) 5.10
A time-dependent phase shift in the mammalian unfolded protein response. Dev Cell (2003) 4.99
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol (2003) 4.77
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. Dev Cell (2007) 4.39
The impact of the unfolded protein response on human disease. J Cell Biol (2012) 4.36
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest (2008) 4.30
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell (2008) 4.26
Endoplasmic reticulum stress in liver disease. J Hepatol (2010) 3.90
Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J Biol Chem (2003) 3.89
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol (2013) 3.84
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J (2005) 3.79
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. EMBO J (2004) 3.77
Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proc Natl Acad Sci U S A (2008) 3.58
The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev (2008) 3.56
The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology (2006) 3.46
Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A (2004) 3.40
Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nat Protoc (2009) 3.31
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol (2006) 3.31
Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab (2009) 3.28
Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations. J Clin Invest (2006) 3.27
That which does not kill me makes me stronger: adapting to chronic ER stress. Trends Biochem Sci (2007) 3.20
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature (2004) 3.18
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. J Clin Invest (2005) 3.16
A human CD34(+) subset resides in lymph nodes and differentiates into CD56bright natural killer cells. Immunity (2005) 3.14
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Mol Cell Biol (2003) 3.01
Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells. Nat Med (2005) 3.01
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol (2004) 3.00
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc Natl Acad Sci U S A (2006) 2.90
Signaling the unfolded protein response from the endoplasmic reticulum. J Biol Chem (2004) 2.87
Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure. J Biol Chem (2005) 2.85
Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation. Mol Biol Cell (2006) 2.84
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis. Nat Med (2005) 2.83
Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. J Cell Biol (2006) 2.76
Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. J Biochem (2004) 2.62
The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci (2010) 2.61
Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. Nat Cell Biol (2006) 2.58
The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader. Cell (2003) 2.50
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J (2006) 2.41
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab (2012) 2.39
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. PLoS Genet (2005) 2.33
Netrins: versatile extracellular cues with diverse functions. Development (2011) 2.29
Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response. J Biol Chem (2004) 2.29
Importance of eIF2alpha phosphorylation and stress granule assembly in alphavirus translation regulation. Mol Biol Cell (2005) 2.27
ER stress signaling by regulated splicing: IRE1/HAC1/XBP1. Methods (2005) 2.25
The role of p58IPK in protecting the stressed endoplasmic reticulum. Mol Biol Cell (2007) 2.20
PKR protects colonic epithelium against colitis through the unfolded protein response and prosurvival signaling. Inflamm Bowel Dis (2012) 2.20
Propranolol inhibition of β-adrenergic receptor does not suppress pathologic neovascularization in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci (2012) 2.19
ER stress controls iron metabolism through induction of hepcidin. Science (2009) 2.18
Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. J Clin Invest (2004) 2.12
Endoplasmic reticulum stress and type 2 diabetes. Annu Rev Biochem (2012) 2.10
The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis. Nat Med (2008) 2.08
Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family. J Lipid Res (2004) 2.08
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis. EMBO J (2011) 2.08
Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol (2002) 2.02
Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A. Blood (2011) 2.02
The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metab (2011) 2.02
The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. Mol Cell Biol (2010) 1.96
Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum. J Biol Chem (2008) 1.89
Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex. Nat Genet (2003) 1.82
Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Proc Natl Acad Sci U S A (2009) 1.78
Netrins and their receptors. Adv Exp Med Biol (2007) 1.78
Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa. J Biol Chem (2006) 1.78
Bioengineering of coagulation factor VIII for improved secretion. Blood (2004) 1.76
Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of APP, ETS2, and ERG genes. Proc Natl Acad Sci U S A (2004) 1.75
Inhibition of the ubiquitin-proteasome system induces stress granule formation. Mol Biol Cell (2007) 1.75
Reovirus induces and benefits from an integrated cellular stress response. J Virol (2006) 1.74
FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity. Mol Cell Biol (2006) 1.70
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development. Proc Natl Acad Sci U S A (2009) 1.68
The unfolded protein response--a stress signaling pathway of the endoplasmic reticulum. J Chem Neuroanat (2004) 1.63
The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain. J Biol Chem (2002) 1.63
5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids. Sci Transl Med (2011) 1.63
TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia. J Biol Chem (2003) 1.61
Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices. Am J Pathol (2010) 1.58
ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum. J Cell Sci (2009) 1.57
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis. Cell Metab (2012) 1.56
Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. Cell Host Microbe (2010) 1.56
FTY720 modulates human oligodendrocyte progenitor process extension and survival. Ann Neurol (2008) 1.55
The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1. Mol Cell Neurosci (2002) 1.55
Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. J Biol Chem (2006) 1.53
A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci Signal (2010) 1.52
Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress. J Biol Chem (2006) 1.52
Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. Mol Biol Cell (2006) 1.51
TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo. J Neurosci (2002) 1.51