Published in FEBS Lett on February 15, 1975
The soluble methane mono-oxygenase of Methylococcus capsulatus (Bath). Its ability to oxygenate n-alkanes, n-alkenes, ethers, and alicyclic, aromatic and heterocyclic compounds. Biochem J (1977) 7.57
Reductive beta-scission of the hydroperoxides of fatty acids and xenobiotics: role of alcohol-inducible cytochrome P-450. Proc Natl Acad Sci U S A (1990) 0.80
Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron (1995) 4.07
Phenobarbital-induced synthesis of the microsomal drug-metabolizing enzyme system and its relationship to the proliferation of endoplasmic membranes. A morphological and biochemical study. J Cell Biol (1965) 3.55
Calcium-activated DNA fragmentation kills immature thymocytes. FASEB J (1989) 3.26
Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration. Arch Biochem Biophys (1989) 3.07
Isolation and use of liver cells. Methods Enzymol (1978) 3.06
Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med (2000) 2.98
The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells. J Biol Chem (1982) 2.81
Cellular signalling in programmed cell death (apoptosis). Immunol Today (1990) 2.64
Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease. J Intern Med (2005) 2.62
CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis. J Biol Chem (1996) 2.40
Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells. EMBO J (1999) 2.36
Substrate-induced synthesis of the hydroxylating enzyme system of liver microsomes. Fed Proc (1966) 2.36
Role of Ca2+ in toxic cell killing. Trends Pharmacol Sci (1989) 2.17
Injected cytochrome c induces apoptosis. Nature (1998) 2.05
Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines. J Biol Chem (1994) 2.04
Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis. FEBS Lett (1997) 2.02
Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex. J Immunol (1989) 1.98
2,5-Di-(tert-butyl)-1,4-benzohydroquinone rapidly elevates cytosolic Ca2+ concentration by mobilizing the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool. J Biol Chem (1989) 1.96
Caspases: their intracellular localization and translocation during apoptosis. Cell Death Differ (1999) 1.92
2,5-Di(tert-butyl)-1,4-benzohydroquinone--a novel inhibitor of liver microsomal Ca2+ sequestration. FEBS Lett (1987) 1.90
Protease involvement in fodrin cleavage and phosphatidylserine exposure in apoptosis. J Biol Chem (1996) 1.88
Spermine prevents endonuclease activation and apoptosis in thymocytes. Exp Cell Res (1991) 1.87
Receptor-operated calcium influx in rat hepatocytes. Identification and characterization using manganese. J Biol Chem (1990) 1.84
The role of calcium in apoptosis. Cell Calcium (1998) 1.84
Calcium-mediated mechanisms in chemically induced cell death. Annu Rev Pharmacol Toxicol (1992) 1.82
2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation. Science (1988) 1.79
Inhibition of the TPNH-linked lipid peroxidation of liver microsomes by drugs undergoing oxidative demethylation. Biochem Biophys Res Commun (1964) 1.73
Involvement of caspases in neutrophil apoptosis: regulation by reactive oxygen species. Blood (1998) 1.70
Increased bronchial chloride concentration in cystic fibrosis. Scand J Clin Lab Invest (1989) 1.60
Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody. J Biol Chem (1996) 1.58
Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration. J Biol Chem (1998) 1.57
Heat shock proteins: regulators of stress response and apoptosis. Cell Stress Chaperones (1998) 1.57
ATP stimulates Ca2+ uptake and increases the free Ca2+ concentration in isolated rat liver nuclei. Proc Natl Acad Sci U S A (1989) 1.54
Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis. Arch Biochem Biophys (1984) 1.53
Review: nuclear events in apoptosis. J Struct Biol (2000) 1.52
Enzyme-membrane relationship in phenobarbital induction of synthesis of drug-metabolizing enzyme system and proliferation of endoplasmic membranes. J Cell Biol (1966) 1.48
Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli. Cell Stress Chaperones (2001) 1.47
Apoptosis induced by a human milk protein. Proc Natl Acad Sci U S A (1995) 1.47
The role of calcium in the regulation of apoptosis. Biochem Biophys Res Commun (1997) 1.45
Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis. FEBS Lett (1999) 1.42
Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. Oncogene (2006) 1.42
Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis. Science (1982) 1.41
Demonstration of nuclear compartmentalization of glutathione in hepatocytes. Proc Natl Acad Sci U S A (1992) 1.40
Regulation of intracellular calcium compartmentation: studies with isolated hepatocytes and t-butyl hydroperoxide. Proc Natl Acad Sci U S A (1982) 1.40
Comparison between the effects of the microsomal Ca(2+)-translocase inhibitors thapsigargin and 2,5-di-(t-butyl)-1,4-benzohydroquinone on cellular calcium fluxes. Biochem J (1991) 1.39
Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c. Gene Expr (2001) 1.38
DNA damage induces two distinct modes of cell death in ovarian carcinomas. Cell Death Differ (2007) 1.37
Involvement of multiple proteases during Fas-mediated apoptosis in T lymphocytes. FEBS Lett (1995) 1.37
Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca(2+)-ATPase inhibitor thapsigargin. Exp Cell Res (1994) 1.37
Cytochrome c release occurs via Ca2+-dependent and Ca2+-independent mechanisms that are regulated by Bax. J Biol Chem (2001) 1.36
Agents that elevate cAMP stimulate DNA fragmentation in thymocytes. J Immunol (1990) 1.36
Apoptosis: cell death defined by caspase activation. Cell Death Differ (1999) 1.32
Signal transduction pathways to apoptosis. Trends Cell Biol (1994) 1.32
An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death. Cell Death Differ (2008) 1.29
Molecular mechanisms of apoptosis induced by cytotoxic chemicals. Crit Rev Toxicol (2000) 1.29
Role of cardiolipin in cytochrome c release from mitochondria. Cell Death Differ (2007) 1.28
Apoptosis in human disease: a new skin for the old ceremony? Biochem Biophys Res Commun (1999) 1.28
Calcium-activated DNA fragmentation in rat liver nuclei. J Biol Chem (1989) 1.27
Cystamine induces toxicity in hepatocytes through the elevation of cytosolic Ca2+ and the stimulation of a nonlysosomal proteolytic system. J Biol Chem (1986) 1.25
Calcineurin and mitochondrial function in glutamate-induced neuronal cell death. FEBS Lett (1996) 1.25
All along the watchtower: on the regulation of apoptosis regulators. FASEB J (1999) 1.24
Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes. Arch Biochem Biophys (1984) 1.23
Dithiocarbamates induce apoptosis in thymocytes by raising the intracellular level of redox-active copper. J Biol Chem (1995) 1.23
Signalling mechanisms and oxidative stress in apoptosis. Toxicol Lett (1995) 1.23
Chelation of intracellular zinc triggers apoptosis in mature thymocytes. Lab Invest (1993) 1.23
Menadione-induced bleb formation in hepatocytes is associated with the oxidation of thiol groups in actin. Arch Biochem Biophys (1988) 1.21
Phenobarbital-induced synthesis of the oxidative demethylating enzymes of rat liver microsomes. Biochem Biophys Res Commun (1964) 1.21
Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes. Science (1993) 1.19
Cytochrome c release and caspase activation in hydrogen peroxide- and tributyltin-induced apoptosis. FEBS Lett (1998) 1.18
Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress. Toxicol Lett (1988) 1.18
Involvement of cellular proteolytic machinery in apoptosis. Biochem Biophys Res Commun (1997) 1.17
Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C. J Biol Chem (1989) 1.17
Cleavage of the calpain inhibitor, calpastatin, during apoptosis. Cell Death Differ (1998) 1.17
The role of calcium in the regulation of apoptosis. J Leukoc Biol (1996) 1.16
Tumor necrosis factor alpha induces apoptosis in mammary adenocarcinoma cells by an increase in intranuclear free Ca2+ concentration and DNA fragmentation. Cancer Res (1992) 1.16
Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts. Biochem J (1998) 1.15
Nuclear calcium transport and the role of calcium in apoptosis. Cell Calcium (1994) 1.15
Mitochondrial targeting of tBid/Bax: a role for the TOM complex? Cell Death Differ (2009) 1.14
Toxic injury to isolated hepatocytes is not dependent on extracellular calcium. Science (1981) 1.14
Ca2(+)-mobilizing hormones stimulate Ca2+ efflux from hepatocytes. J Biol Chem (1989) 1.13
Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression. Biochem Biophys Res Commun (1999) 1.13
An inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in liver nuclei. Proc Natl Acad Sci U S A (1990) 1.13
Evidence for two pathways of receptor-mediated Ca2+ entry in hepatocytes. Biochem J (1992) 1.13
Cytoskeletal breakdown and apoptosis elicited by NO donors in cerebellar granule cells require NMDA receptor activation. J Neurochem (1996) 1.13
Chromatin condensation during apoptosis requires ATP. Biochem J (1996) 1.12
Formation and reduction of glutathione-protein mixed disulfides during oxidative stress. A study with isolated hepatocytes and menadione (2-methyl-1,4-naphthoquinone). Biochem Pharmacol (1987) 1.12
Distinct pathways for stimulation of cytochrome c release by etoposide. J Biol Chem (2000) 1.12
Opening of plasma membrane voltage-dependent anion channels (VDAC) precedes caspase activation in neuronal apoptosis induced by toxic stimuli. Cell Death Differ (2005) 1.11
Apoptosis induced by microinjection of cytochrome c is caspase-dependent and is inhibited by Bcl-2. Cell Death Differ (1998) 1.11
Multiple proteases are involved in thymocyte apoptosis. Exp Cell Res (1995) 1.11
Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins. FEBS Lett (1999) 1.10
Detoxification reactions in isolated hepatocytes. Role of glutathione peroxidase, catalase, and formaldehyde dehydrogenase in reactions relating to N-demethylation by the cytochrome P-450 system. J Biol Chem (1978) 1.10
Metabolism of hydrogen peroxide in isolated hepatocytes: relative contributions of catalase and glutathione peroxidase in decomposition of endogenously generated H2O2. Arch Biochem Biophys (1981) 1.10
The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+. J Biol Chem (1985) 1.10
Cellular events in Fas/APO-1-mediated apoptosis in JURKAT T lymphocytes. Exp Cell Res (1995) 1.09
On the fatty acid and hydrocarbon hydroxylation in rat liver microsomes. Eur J Biochem (1968) 1.09
Redox regulation of the caspases during apoptosis. Ann N Y Acad Sci (1998) 1.08
The formation of plasma membrane blebs in hepatocytes exposed to agents that increase cytosolic Ca2+ is mediated by the activation of a non-lysosomal proteolytic system. FEBS Lett (1986) 1.08
Fatty acid interaction with the hydroxylating enzyme system of rat liver microsomes. Eur J Biochem (1969) 1.07
Role of apoptosis in pancreatic beta-cell death in diabetes. Diabetes (2001) 1.07