Published in Obesity (Silver Spring) on June 11, 2013
Look AHEAD: Action for Health in Diabetes (LookAHEAD) | NCT00017953
Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes. Control Clin Trials (2003) 9.97
Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest (2007) 8.71
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PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet (2007) 2.91
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Metabolic flexibility in response to glucose is not impaired in people with type 2 diabetes after controlling for glucose disposal rate. Diabetes (2008) 1.44
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WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake. Obesity (Silver Spring) (2008) 0.89
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med (2013) 15.58
Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care (2007) 14.35
Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med (2009) 12.38
Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes Care (2010) 8.52
The Look AHEAD study: a description of the lifestyle intervention and the evidence supporting it. Obesity (Silver Spring) (2006) 8.25
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med (2011) 8.00
Effect of weight loss with lifestyle intervention on risk of diabetes. Diabetes Care (2006) 7.09
Sugar-sweetened beverages, obesity, type 2 diabetes mellitus, and cardiovascular disease risk. Circulation (2010) 6.86
Achieving weight and activity goals among diabetes prevention program lifestyle participants. Obes Res (2004) 5.74
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Fast-food consumption among US adults and children: dietary and nutrient intake profile. J Am Diet Assoc (2003) 5.13
American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for developing a diabetes mellitus comprehensive care plan. Endocr Pract (2011) 4.69
Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. Am J Clin Nutr (2011) 4.60
Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nat Med (2006) 4.35
Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes (2005) 4.31
Effect of dietary protein content on weight gain, energy expenditure, and body composition during overeating: a randomized controlled trial. JAMA (2012) 4.30
Pioglitazone for diabetes prevention in impaired glucose tolerance. N Engl J Med (2011) 4.28
Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women. Diabetes Care (2003) 4.23
Zonisamide for weight reduction in obese adults: a 1-year randomized controlled trial. Arch Intern Med (2012) 3.95
Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med (2007) 3.92
A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes (2005) 3.84
A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82
Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes (2008) 3.80
Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet (2002) 3.68
Four-year weight losses in the Look AHEAD study: factors associated with long-term success. Obesity (Silver Spring) (2011) 3.62
Increased food energy supply is more than sufficient to explain the US epidemic of obesity. Am J Clin Nutr (2009) 3.59
Is it time to change the way we report and discuss weight loss? Obesity (Silver Spring) (2009) 3.57
Estimating the changes in energy flux that characterize the rise in obesity prevalence. Am J Clin Nutr (2009) 3.56
Racial differences in abdominal depot-specific adiposity in white and African American adults. Am J Clin Nutr (2009) 3.39
Lateral hypothalamic area deep brain stimulation for refractory obesity: a pilot study with preliminary data on safety, body weight, and energy metabolism. J Neurosurg (2013) 3.31
Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss. Arterioscler Thromb Vasc Biol (2006) 3.11
Calorie restriction and aging: review of the literature and implications for studies in humans. Am J Clin Nutr (2003) 3.11
Lifestyle change and mobility in obese adults with type 2 diabetes. N Engl J Med (2012) 2.90
Sex, race/ethnicity, socioeconomic status, and BMI in relation to self-perception of overweight. Obes Res (2002) 2.87
Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects. Diabetes Care (2006) 2.86
Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo. Diabetes (2005) 2.76
Clinical importance of obesity versus the metabolic syndrome in cardiovascular risk in women: a report from the Women's Ischemia Syndrome Evaluation (WISE) study. Circulation (2004) 2.67
Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss. PLoS One (2009) 2.56
The relationship of waist circumference and BMI to visceral, subcutaneous, and total body fat: sex and race differences. Obesity (Silver Spring) (2010) 2.47
Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus. Ann N Y Acad Sci (2002) 2.46
Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity. Diabetes (2003) 2.38
Validation study of energy expenditure and intake during calorie restriction using doubly labeled water and changes in body composition. Am J Clin Nutr (2007) 2.33
Effect of calorie restriction with or without exercise on body composition and fat distribution. J Clin Endocrinol Metab (2007) 2.33
The prevention of type 2 diabetes. Nat Clin Pract Endocrinol Metab (2008) 2.27
Obesity as a disease: a white paper on evidence and arguments commissioned by the Council of the Obesity Society. Obesity (Silver Spring) (2008) 2.23
The DASH diet for high blood pressure: from clinical trial to dinner table. Cleve Clin J Med (2004) 2.23
Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity. Obesity (Silver Spring) (2010) 2.23
Effects of exercise on mitochondrial content and function in aging human skeletal muscle. J Gerontol A Biol Sci Med Sci (2006) 2.23
Estimating the effects of energy imbalance on changes in body weight in children. Am J Clin Nutr (2006) 2.21
Defining insulin resistance from hyperinsulinemic-euglycemic clamps. Diabetes Care (2012) 2.21
Nonsurgical weight loss for extreme obesity in primary care settings: results of the Louisiana Obese Subjects Study. Arch Intern Med (2010) 2.17
A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans. Am J Clin Nutr (2006) 2.12
Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. Cell Metab (2012) 2.11
Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor. J Clin Invest (2005) 2.10
Role of adiponectin in human skeletal muscle bioenergetics. Cell Metab (2006) 2.09
Metabolic flexibility. Proc Nutr Soc (2004) 2.08
Effect of youth-onset type 2 diabetes mellitus on incidence of end-stage renal disease and mortality in young and middle-aged Pima Indians. JAMA (2006) 2.07
Childhood predictors of young-onset type 2 diabetes. Diabetes (2007) 2.06
Effect of calorie restriction on resting metabolic rate and spontaneous physical activity. Obesity (Silver Spring) (2007) 2.06
Profiles of sedentary behavior in children and adolescents: the US National Health and Nutrition Examination Survey, 2001-2006. Int J Pediatr Obes (2009) 2.05
Metabolic flexibility and insulin resistance. Am J Physiol Endocrinol Metab (2008) 2.02
Measurements of islet function and glucose metabolism with the dipeptidyl peptidase 4 inhibitor vildagliptin in patients with type 2 diabetes. J Clin Endocrinol Metab (2007) 2.02
Effects of weight loss and physical activity on muscle lipid content and droplet size. Obes Res (2004) 2.00
A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial. J Clin Endocrinol Metab (2011) 1.98
Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: a randomized, dose-ranging study. JAMA (2003) 1.97
Effects of traditional and western environments on prevalence of type 2 diabetes in Pima Indians in Mexico and the U.S. Diabetes Care (2006) 1.96
Effects of 4 weight-loss diets differing in fat, protein, and carbohydrate on fat mass, lean mass, visceral adipose tissue, and hepatic fat: results from the POUNDS LOST trial. Am J Clin Nutr (2012) 1.96
Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity. Expert Rev Cardiovasc Ther (2008) 1.95
The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake. Cell Metab (2008) 1.94
How bad is fructose? Am J Clin Nutr (2007) 1.93
Waist Circumference and Cardiometabolic Risk: a Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Obesity (Silver Spring) (2007) 1.87
Characteristics of skeletal muscle mitochondrial biogenesis induced by moderate-intensity exercise and weight loss in obesity. J Appl Physiol (1985) (2007) 1.86
Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes. Diabetes (2007) 1.84
Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content. Diabetes (2008) 1.82
Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy. J Gerontol A Biol Sci Med Sci (2010) 1.80
Self-report-based estimates of energy intake offer an inadequate basis for scientific conclusions. Am J Clin Nutr (2013) 1.79
Adipose tissue distribution is different in type 2 diabetes. Am J Clin Nutr (2009) 1.78
Adiponectin, change in adiponectin, and progression to diabetes in the Diabetes Prevention Program. Diabetes (2008) 1.78
The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss. Obes Surg (2004) 1.77