C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.

PubWeight™: 0.98‹?› | Rank: Top 15%

🔗 View Article (PMC 3634610)

Published in Int Rev Immunol on April 01, 2013

Authors

Anthony Plato1, Janet A Willment, Gordon D Brown

Author Affiliations

1: Aberdeen Fungal Group, Section of Immunology and Infection, University of Aberdeen, Aberdeen, UK.

Articles citing this

C-type lectins in immunity: recent developments. Curr Opin Immunol (2014) 1.31

IL-17-Mediated Immunity to the Opportunistic Fungal Pathogen Candida albicans. J Immunol (2015) 0.97

Helminth infections decrease host susceptibility to immune-mediated diseases. J Immunol (2014) 0.93

Recent insights into structures and functions of C-type lectins in the immune system. Curr Opin Struct Biol (2015) 0.93

Adaptive immune activation: glycosylation does matter. Nat Chem Biol (2013) 0.93

Pattern recognition receptors in antifungal immunity. Semin Immunopathol (2014) 0.90

Dectin-1 is expressed in human lung and mediates the proinflammatory immune response to nontypeable Haemophilus influenzae. MBio (2014) 0.88

E3 ubiquitin ligases Pellinos as regulators of pattern recognition receptor signaling and immune responses. Immunol Rev (2015) 0.87

Fungal β-glucan, a Dectin-1 ligand, promotes protection from type 1 diabetes by inducing regulatory innate immune response. J Immunol (2014) 0.86

Delinking CARD9 and IL-17: CARD9 Protects against Candida tropicalis Infection through a TNF-α-Dependent, IL-17-Independent Mechanism. J Immunol (2015) 0.84

Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology. Front Immunol (2013) 0.83

SHIP-1 Couples to the Dectin-1 hemITAM and Selectively Modulates Reactive Oxygen Species Production in Dendritic Cells in Response to Candida albicans. J Immunol (2015) 0.82

Glycans from Fasciola hepatica Modulate the Host Immune Response and TLR-Induced Maturation of Dendritic Cells. PLoS Negl Trop Dis (2015) 0.81

The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets. Blood (2014) 0.79

A Novel Mechanism for Binding of Galactose-terminated Glycans by the C-type Carbohydrate Recognition Domain in Blood Dendritic Cell Antigen 2. J Biol Chem (2015) 0.78

A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida albicans by Producing Peptidoglycan Recognition Proteins. PLoS One (2015) 0.77

Molecular Characterization and Biological Effects of a C-Type Lectin-Like Receptor in Large Yellow Croaker (Larimichthys crocea). Int J Mol Sci (2015) 0.76

Common Genetic Polymorphisms within NFκB-Related Genes and the Risk of Developing Invasive Aspergillosis. Front Microbiol (2016) 0.76

Molecular Functions of Glycoconjugates in Autophagy. J Mol Biol (2016) 0.75

Role of Pattern Recognition Receptors in the Modulation of Antimicrobial Peptide Expression in the Corneal Epithelial Innate Response to F. solani. Invest Ophthalmol Vis Sci (2017) 0.75

C-type lectins: their network and roles in pathogen recognition and immunity. Histochem Cell Biol (2016) 0.75

N-Dihydrogalactochitosan as a potent immune activator for dendritic cells. J Biomed Mater Res A (2016) 0.75

Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis. J Immunol (2016) 0.75

STIM1 and STIM2 cooperatively regulate mouse neutrophil store operated calcium entry and cytokine production. Blood (2017) 0.75

C-type lectin receptors in tuberculosis: what we know. Med Microbiol Immunol (2016) 0.75

Articles cited by this

Pathogen recognition and innate immunity. Cell (2006) 44.14

Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol (2005) 18.32

Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol (1989) 12.08

Immune recognition. A new receptor for beta-glucans. Nature (2001) 6.54

Pathogen recognition by the innate immune system. Int Rev Immunol (2011) 5.76

Peroxisomes are signaling platforms for antiviral innate immunity. Cell (2010) 5.24

Signalling through C-type lectin receptors: shaping immune responses. Nat Rev Immunol (2009) 4.98

Pattern recognition receptors: doubling up for the innate immune response. Cell (2002) 4.84

Dectin-1: a signalling non-TLR pattern-recognition receptor. Nat Rev Immunol (2006) 4.84

Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev Immunol (2006) 4.55

The C-type lectin-like domain superfamily. FEBS J (2005) 4.22

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature (2009) 3.93

Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells. J Exp Med (2010) 3.84

Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood (2005) 3.57

C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB. Immunity (2007) 3.32

Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J Clin Invest (2008) 3.14

On regulation of phagosome maturation and antigen presentation. Nat Immunol (2006) 3.11

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood (2005) 2.90

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc Natl Acad Sci U S A (2010) 2.90

Toll-like receptors: linking innate and adaptive immunity. Adv Exp Med Biol (2005) 2.85

The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement. Blood (2008) 2.83

Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. J Biol Chem (2000) 2.83

F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells. Immunity (2012) 2.72

Self- and nonself-recognition by C-type lectins on dendritic cells. Annu Rev Immunol (2004) 2.62

Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. Eur J Immunol (2008) 2.62

A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation? Nat Immunol (2012) 2.59

Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk. Nat Immunol (2009) 2.48

Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells. J Biol Chem (2007) 2.44

CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes. J Biol Chem (2008) 2.34

Toll-like receptors--taking an evolutionary approach. Nat Rev Genet (2008) 2.31

Approaching the asymptote: 20 years later. Immunity (2009) 2.29

The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes. Nat Rev Immunol (2006) 2.25

The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade. J Biol Chem (2007) 2.24

Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 levels are elevated in acute coronary syndrome: a novel marker for early diagnosis. Circulation (2005) 2.06

Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori. Nat Immunol (2009) 2.00

Signaling by myeloid C-type lectin receptors in immunity and homeostasis. Annu Rev Immunol (2012) 1.95

C-type lectin receptors orchestrate antifungal immunity. Nat Immunol (2012) 1.89

The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. Immunity (2012) 1.89

The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages. J Immunol (2004) 1.82

The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells. Blood (2007) 1.81

CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. J Immunol (2009) 1.80

Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells. Circulation (2000) 1.71

The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice. J Clin Invest (2012) 1.69

Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells. Eur J Immunol (2000) 1.67

The role of Syk/CARD9 coupled C-type lectins in antifungal immunity. Eur J Immunol (2011) 1.65

Molecular analysis of the pathophysiological binding of the platelet aggregation-inducing factor podoplanin to the C-type lectin-like receptor CLEC-2. Cancer Sci (2007) 1.64

A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex. Eur J Immunol (2001) 1.62

Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2. PLoS Pathog (2011) 1.62

Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes. J Biol Chem (2004) 1.57

Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA. J Immunol (2006) 1.57

CLEC-2 activates Syk through dimerization. Blood (2010) 1.49

Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs. Immunol Rev (2010) 1.46

The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat Immunol (2012) 1.45

Syk-coupled C-type lectins in immunity. Trends Immunol (2011) 1.44

The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors. FEMS Microbiol Lett (2008) 1.41

Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk. Cold Spring Harb Perspect Biol (2011) 1.38

Renal cells activate the platelet receptor CLEC-2 through podoplanin. Biochem J (2008) 1.35

Fungal Recognition by TLR2 and Dectin-1. Handb Exp Pharmacol (2008) 1.35

CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function. J Biol Chem (2005) 1.35

C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity. Cell Signal (2010) 1.33

Oxidized LDL, LOX-1 and atherosclerosis. Cardiovasc Drugs Ther (2011) 1.33

NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease. Mucosal Immunol (2011) 1.30

CD63 tetraspanin slows down cell migration and translocates to the endosomal-lysosomal-MIICs route after extracellular stimuli in human immature dendritic cells. Blood (2004) 1.30

Current views of toll-like receptor signaling pathways. Gastroenterol Res Pract (2010) 1.27

The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease. Biochem J (2008) 1.26

Molecular mechanism of the Syk activation switch. J Biol Chem (2008) 1.22

Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production. Blood (2005) 1.22

NFAT control of innate immunity. Blood (2012) 1.18

CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses. Eur J Immunol (2011) 1.16

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac. Blood (2010) 1.11

LOX-1 supports adhesion of Gram-positive and Gram-negative bacteria. J Immunol (2001) 1.10

Rac1 is essential for phospholipase C-gamma2 activation in platelets. Pflugers Arch (2008) 1.08

The β-glucan receptor Dectin-1 activates the integrin Mac-1 in neutrophils via Vav protein signaling to promote Candida albicans clearance. Cell Host Microbe (2011) 1.04

Targeting C-type lectin-like molecule-1 for antibody-mediated immunotherapy in acute myeloid leukemia. Haematologica (2009) 1.03

SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL. J Biol Chem (2000) 1.03

Nod-like receptors in the control of intestinal inflammation. Curr Opin Immunol (2012) 1.00

ROS and innate immunity. Anticancer Res (2009) 1.00

The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2. J Biol Chem (2006) 0.98

Molecular mechanisms of viral inhibitors of RIG-I-like receptors. Trends Microbiol (2012) 0.96

KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity. Blood (2004) 0.95

Inhibitory C-type lectin receptors in myeloid cells. Immunol Lett (2010) 0.94

Dectin-1 is not required for controlling Candida albicans colonization of the gastrointestinal tract. Infect Immun (2012) 0.93

The C-type lectin-like receptor CLEC-1, expressed by myeloid cells and endothelial cells, is up-regulated by immunoregulatory mediators and moderates T cell activation. J Immunol (2009) 0.93

Identification of CLEC12B, an inhibitory receptor on myeloid cells. J Biol Chem (2007) 0.93

Intracellular signaling of LOX-1 in endothelial cell apoptosis. Circ Res (2009) 0.92

Cardiac troponin T is a sensitive, specific biomarker of cardiac injury in laboratory animals. Lab Anim Sci (1997) 0.91

Regulation of immune pathways by the NOD-like receptor NLRC5. Immunobiology (2011) 0.87

C-type lectin SIGNR1 enhances cellular oxidative burst response against C. albicans in cooperation with Dectin-1. Eur J Immunol (2011) 0.86

SYK kinase signaling and the NLRP3 inflammasome in antifungal immunity. J Mol Med (Berl) (2010) 0.84

The new role of LOX-1 in hypertension induced neuronal apoptosis. Biochem Biophys Res Commun (2012) 0.83

Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2). J Biol Chem (2012) 0.81

The human C-type lectin-like receptor CLEC-1 is upregulated by TGF-β and primarily localized in the endoplasmic membrane compartment. Scand J Immunol (2012) 0.79

NLRC5: a NOD-like receptor protein with many faces in immune regulation. Cell Res (2012) 0.78

Surface-associated GroEL facilitates the adhesion of Escherichia coli to macrophages through lectin-like oxidized low-density lipoprotein receptor-1. Microbes Infect (2012) 0.78

Actin' as a death signal. Immunity (2012) 0.78

Evolutionary development and expression pattern of the myeloid lectin-like receptor gene family encoded within the NK gene complex. Scand J Immunol (2010) 0.77

Mucins and toll-like receptors: kith and kin in infection and cancer. Cancer Lett (2012) 0.76

Articles by these authors

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol (2007) 8.92

Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding. Science (2010) 7.41

Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol (2006) 6.36

Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity (2005) 6.21

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer. Nature (2012) 5.84

Dectin-1 mediates the biological effects of beta-glucans. J Exp Med (2003) 5.82

Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. Science (2012) 5.34

Human dectin-1 deficiency and mucocutaneous fungal infections. N Engl J Med (2009) 5.27

An integrated model of the recognition of Candida albicans by the innate immune system. Nat Rev Microbiol (2008) 5.13

Dectin-1 is a major beta-glucan receptor on macrophages. J Exp Med (2002) 4.87

ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions. Methods (2009) 4.69

A CTCF-independent role for cohesin in tissue-specific transcription. Genome Res (2010) 3.89

An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans. Cell Host Microbe (2009) 3.52

Waves of retrotransposon expansion remodel genome organization and CTCF binding in multiple mammalian lineages. Cell (2012) 3.48

The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus. PLoS Pathog (2005) 3.13

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. J Exp Med (2009) 3.12

The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. J Immunol (2002) 3.09

Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages. Blood (2004) 2.84

A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J Exp Med (2005) 2.80

Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus. J Immunol (2009) 2.74

Development and application of a salmonid EST database and cDNA microarray: data mining and interspecific hybridization characteristics. Genome Res (2004) 2.72

Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. Eur J Immunol (2008) 2.62

Alveolar macrophage-mediated killing of Pneumocystis carinii f. sp. muris involves molecular recognition by the Dectin-1 beta-glucan receptor. J Exp Med (2003) 2.52

Early stop polymorphism in human DECTIN-1 is associated with increased candida colonization in hematopoietic stem cell transplant recipients. Clin Infect Dis (2009) 2.49

Tackling human fungal infections. Science (2012) 2.49

Dectin-1 expression and function are enhanced on alternatively activated and GM-CSF-treated macrophages and are negatively regulated by IL-10, dexamethasone, and lipopolysaccharide. J Immunol (2003) 2.38

Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J Immunol (2010) 2.38

Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor. Cell Rep (2013) 2.37

CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes. J Biol Chem (2008) 2.34

Ligands for the beta-glucan receptor, Dectin-1, assigned using "designer" microarrays of oligosaccharide probes (neoglycolipids) generated from glucan polysaccharides. J Biol Chem (2005) 2.32

Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo. Eur J Immunol (2003) 2.30

Immune recognition of Candida albicans beta-glucan by dectin-1. J Infect Dis (2007) 2.24

Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation. J Exp Med (2009) 2.03

Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1. Nat Med (2012) 1.93

Pattern recognition: recent insights from Dectin-1. Curr Opin Immunol (2009) 1.93

The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose. Glycobiology (2006) 1.89

C-type lectin receptors in antifungal immunity. Trends Microbiol (2007) 1.89

C-type lectin receptors orchestrate antifungal immunity. Nat Immunol (2012) 1.89

The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages. J Immunol (2004) 1.82

CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. J Immunol (2009) 1.80

The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells. Eur J Immunol (2005) 1.80

Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses. Blood (2008) 1.78

The role of Dectin-1 in the host defence against fungal infections. Curr Opin Microbiol (2011) 1.77

Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells. J Immunol (2007) 1.77

Fish and chips: various methodologies demonstrate utility of a 16,006-gene salmonid microarray. BMC Genomics (2005) 1.75

Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan. Eur J Immunol (2007) 1.69

The role of Syk/CARD9 coupled C-type lectins in antifungal immunity. Eur J Immunol (2011) 1.65

The role of the beta-glucan receptor Dectin-1 in control of fungal infection. J Leukoc Biol (2007) 1.65

Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity. Immunity (2012) 1.61

Neutrophils produce interleukin 17A (IL-17A) in a dectin-1- and IL-23-dependent manner during invasive fungal infection. Infect Immun (2011) 1.58

Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo. Eur J Immunol (2005) 1.57

Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes. J Biol Chem (2004) 1.57

The induction of inflammation by dectin-1 in vivo is dependent on myeloid cell programming and the progression of phagocytosis. J Immunol (2008) 1.56

Recognition and blocking of innate immunity cells by Candida albicans chitin. Infect Immun (2011) 1.54

Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1. Infect Immun (2005) 1.53

Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching. J Pharmacol Exp Ther (2008) 1.52

Loss of cell wall mannosylphosphate in Candida albicans does not influence macrophage recognition. J Biol Chem (2004) 1.51

Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs. Immunol Rev (2010) 1.46

Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways. Eur J Immunol (2009) 1.44

Syk-coupled C-type lectins in immunity. Trends Immunol (2011) 1.44

Soluble Dectin-1 as a tool to detect beta-glucans. J Immunol Methods (2006) 1.43

Dectin-1 and its role in the recognition of beta-glucans by macrophages. Mol Immunol (2004) 1.41

The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors. FEMS Microbiol Lett (2008) 1.41

beta-Glucans and dectin-1. Ann N Y Acad Sci (2008) 1.41

Dectin-1 promotes fungicidal activity of human neutrophils. Eur J Immunol (2007) 1.41

C-type lectins and phagocytosis. Immunobiology (2009) 1.41

Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin. Cell Host Microbe (2011) 1.36

Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis. PLoS Pathog (2008) 1.34

Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge. J Pharmacol Exp Ther (2005) 1.34

The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells. Blood (2012) 1.34

The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through Syk kinase. J Biol Chem (2012) 1.27

Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1. PLoS Pathog (2013) 1.27

Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions. J Leukoc Biol (2004) 1.26

Regulation of cytosolic phospholipase A2 activation and cyclooxygenase 2 expression in macrophages by the beta-glucan receptor. J Biol Chem (2006) 1.23

Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies. J Leukoc Biol (2003) 1.23

The potential for Toll-like receptors to collaborate with other innate immune receptors. Immunology (2004) 1.22

Expression of functionally different dectin-1 isoforms by murine macrophages. J Immunol (2006) 1.21

Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand. Eur J Immunol (2008) 1.21

The Dectin-2 family of C-type lectins in immunity and homeostasis. Cytokine (2009) 1.20

The Dectin-2 family of C-type lectin-like receptors: an update. Int Immunol (2013) 1.16

Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation. Eur J Immunol (2006) 1.14

Development of an Illumina-based ChIP-exonuclease method provides insight into FoxA1-DNA binding properties. Genome Biol (2013) 1.14

A comprehensive survey of the genes involved in maturation and development of the rainbow trout ovary. Biol Reprod (2004) 1.14

Microarray analyses identify molecular biomarkers of Atlantic salmon macrophage and hematopoietic kidney response to Piscirickettsia salmonis infection. Physiol Genomics (2004) 1.14

The β-glucan receptor dectin-1 promotes lung immunopathology during fungal allergy via IL-22. J Immunol (2012) 1.13