Published in J Biol Chem on February 10, 2005
A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation? Nat Immunol (2012) 2.59
The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals. J Biol Chem (2005) 2.21
NLR proteins: integral members of innate immunity and mediators of inflammatory diseases. J Leukoc Biol (2007) 1.73
Neonicotinoid clothianidin adversely affects insect immunity and promotes replication of a viral pathogen in honey bees. Proc Natl Acad Sci U S A (2013) 1.71
NLR functions beyond pathogen recognition. Nat Immunol (2011) 1.57
A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses. J Biol Chem (2010) 1.55
A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish. BMC Evol Biol (2008) 1.54
NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature (2016) 1.51
NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondii-infected monocytic cells. Infect Immun (2010) 1.46
Phase II study of dasatinib in relapsed or refractory chronic lymphocytic leukemia. Clin Cancer Res (2011) 1.46
The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat Immunol (2012) 1.45
Activation and regulation of cellular inflammasomes: gaps in our knowledge for central nervous system injury. J Cereb Blood Flow Metab (2014) 1.20
An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology. Front Immunol (2013) 1.17
Nlrp2, a maternal effect gene required for early embryonic development in the mouse. PLoS One (2012) 1.04
Characterization of NLRP12 during the in vivo host immune response to Klebsiella pneumoniae and Mycobacterium tuberculosis. PLoS One (2013) 1.02
Monarch-1/PYPAF7 and other CATERPILLER (CLR, NOD, NLR) proteins with negative regulatory functions. Microbes Infect (2007) 1.01
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways. Int Rev Immunol (2013) 0.98
Prediction of molecular mimicry candidates in human pathogenic bacteria. Virulence (2013) 0.96
Non-Inflammasome Forming NLRs in Inflammation and Tumorigenesis. Front Immunol (2014) 0.96
NOD2 deficiency results in increased susceptibility to peptidoglycan-induced uveitis in mice. Invest Ophthalmol Vis Sci (2011) 0.89
Emerging significance of NLRs in inflammatory bowel disease. Inflamm Bowel Dis (2014) 0.86
Post-transcriptional inhibition of luciferase reporter assays by the Nod-like receptor proteins NLRX1 and NLRC3. J Biol Chem (2012) 0.84
NOD-Like Receptors in Infection, Immunity, and Diseases. Yonsei Med J (2016) 0.83
Characterization of NLRP12 during the development of allergic airway disease in mice. PLoS One (2012) 0.82
Host-Viral Interactions: Role of Pattern Recognition Receptors (PRRs) in Human Pneumovirus Infections. Pathogens (2013) 0.82
Modeling-Enabled Characterization of Novel NLRX1 Ligands. PLoS One (2015) 0.79
Transcriptome profiling of immune tissues reveals habitat-specific gene expression between lake and river sticklebacks. Mol Ecol (2016) 0.79
Holding the inflammatory system in check: NLRs keep it cool. F1000Prime Rep (2015) 0.77
Beyond the inflammasome: regulatory NOD-like receptor modulation of the host immune response following virus exposure. J Gen Virol (2016) 0.76
NLR members in inflammation-associated carcinogenesis. Cell Mol Immunol (2017) 0.75
Interaction of Tetracapsuloides bryosalmonae, the causative agent of proliferative kidney disease, with host proteins in the kidney of Salmo trutta. Parasitol Res (2015) 0.75
NLRC3 protein inhibits inflammation by disrupting NALP3 inflammasome assembly via competition with the adaptor protein ASC for pro-caspase-1 binding. J Biol Chem (2017) 0.75
NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancer. Cell Cycle (2017) 0.75
Alternative Pre-mRNA Splicing in Mammals and Teleost Fish: A Effective Strategy for the Regulation of Immune Responses Against Pathogen Infection. Int J Mol Sci (2017) 0.75
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol (2011) 6.53
The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity (2009) 6.37
The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol (2011) 5.73
The NLR gene family: a standard nomenclature. Immunity (2008) 4.77
Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J Immunol (2008) 4.60
NLRX1 is a regulator of mitochondrial antiviral immunity. Nature (2008) 4.55
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med (2010) 4.37
Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC. Cell Host Microbe (2007) 3.52
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci U S A (2006) 3.41
Novel role of PKR in inflammasome activation and HMGB1 release. Nature (2012) 3.13
CATERPILLER: a novel gene family important in immunity, cell death, and diseases. Annu Rev Immunol (2005) 3.04
Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev (2008) 2.89
A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation? Nat Immunol (2012) 2.59
Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties. J Immunol (2003) 2.48
NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways. J Immunol (2009) 2.39
Discovery of a viral NLR homolog that inhibits the inflammasome. Science (2011) 2.36
NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways. Immunity (2011) 2.29
The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals. J Biol Chem (2005) 2.21
Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains. J Immunol (2002) 2.18
CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions. Nat Immunol (2003) 2.13
Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome. J Immunol (2009) 2.09
NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling. Immunity (2012) 2.07
Mechanisms of NOD-like receptor-associated inflammasome activation. Immunity (2013) 2.02
Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes. J Immunol (2007) 1.97
Cutting edge: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways. J Immunol (2006) 1.84
Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome. Sci Signal (2012) 1.82
NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses. J Immunol (2010) 1.73
Epigenetic regulation of MHC-II and CIITA genes. Trends Immunol (2006) 1.73
MAVS-mediated apoptosis and its inhibition by viral proteins. PLoS One (2009) 1.67
Cutting edge: NLRC5-dependent activation of the inflammasome. J Immunol (2010) 1.66
Immunomodulatory roles of surfactant proteins A and D: implications in lung disease. Proc Am Thorac Soc (2007) 1.65
Criteria for effective design, construction, and gene knockdown by shRNA vectors. BMC Biotechnol (2006) 1.60
Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity. J Immunol (2010) 1.59
De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis. J Immunol (2002) 1.58
Differential induction of type I interferon responses in myeloid dendritic cells by mosquito and mammalian-cell-derived alphaviruses. J Virol (2006) 1.57
Chromosomal clustering of genes controlled by the aire transcription factor. Proc Natl Acad Sci U S A (2005) 1.49
TLR2/MyD88/NF-κB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection. PLoS One (2012) 1.48
Monocytic microparticles activate endothelial cells in an IL-1β-dependent manner. Blood (2011) 1.48
Inflammasome inhibition as a pathogenic stealth mechanism. Cell Host Microbe (2010) 1.47
The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat Immunol (2012) 1.45
Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1. PLoS One (2010) 1.44
Regulation of mitochondrial antiviral signaling pathways. Immunity (2008) 1.44
The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity (2012) 1.44
The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18. J Neurosci (2010) 1.37
NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice. J Immunol (2012) 1.34
Proteomic profiling drug-induced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIalpha. Cancer Res (2003) 1.34
Cutting edge: Monarch-1: a pyrin/nucleotide-binding domain/leucine-rich repeat protein that controls classical and nonclassical MHC class I genes. J Immunol (2003) 1.33
The SecA2 secretion factor of Mycobacterium tuberculosis promotes growth in macrophages and inhibits the host immune response. Infect Immun (2006) 1.30
NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A (2012) 1.29
Deletion of ripA alleviates suppression of the inflammasome and MAPK by Francisella tularensis. J Immunol (2010) 1.27
13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice. Proc Natl Acad Sci U S A (2004) 1.26
Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP. J Biol Chem (2012) 1.26
ATP binding by monarch-1/NLRP12 is critical for its inhibitory function. Mol Cell Biol (2007) 1.25
C-C chemokine receptor 5 on pulmonary fibrocytes facilitates migration and promotes metastasis via matrix metalloproteinase 9. Am J Pathol (2008) 1.22
The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence. Cell Host Microbe (2011) 1.21
Analysis of NLRP3 in the development of allergic airway disease in mice. J Immunol (2012) 1.18
Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells. PLoS Pathog (2013) 1.18
Enhancement of CIITA transcriptional function by ubiquitin. Nat Immunol (2003) 1.18
Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocyte regeneration. J Neurosci (2003) 1.18
The inflammasome component NLRP3 impairs antitumor vaccine by enhancing the accumulation of tumor-associated myeloid-derived suppressor cells. Cancer Res (2010) 1.18
Cross-regulation between the IL-1β/IL-18 processing inflammasome and other inflammatory cytokines. Curr Opin Immunol (2011) 1.17
Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol (2004) 1.17
Histone deacetylase 1/mSin3A disrupts gamma interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation. Mol Cell Biol (2003) 1.16
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes. Curr Opin Immunol (2005) 1.16
Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome. J Immunol (2013) 1.15
Microtubule stabilizing agents: their molecular signaling consequences and the potential for enhancement by drug combination. Cancer Treat Rev (2006) 1.14
Plexin-A4-semaphorin 3A signaling is required for Toll-like receptor- and sepsis-induced cytokine storm. J Exp Med (2010) 1.12
Retinoic acid signaling and function in the adult hippocampus. J Neurobiol (2006) 1.12
Interplay among coactivator-associated arginine methyltransferase 1, CBP, and CIITA in IFN-gamma-inducible MHC-II gene expression. Proc Natl Acad Sci U S A (2005) 1.08
Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling. J Exp Med (2012) 1.07
Positive regulatory domain I (PRDM1) and IRF8/PU.1 counter-regulate MHC class II transactivator (CIITA) expression during dendritic cell maturation. J Biol Chem (2011) 1.04
The 19S proteasome ATPase Sug1 plays a critical role in regulating MHC class II transcription. Mol Immunol (2008) 1.02
Regulation of class I major histocompatibility complex (MHC) by nucleotide-binding domain, leucine-rich repeat-containing (NLR) proteins. J Biol Chem (2012) 1.01
Direct manipulation of activator protein-1 controls thymocyte proliferation in vitro. Eur J Immunol (2006) 1.00
Cryopyrin: in from the cold. Immunity (2006) 0.98
Transfection of macrophage inflammatory protein 1 alpha into B16 F10 melanoma cells inhibits growth of pulmonary metastases but not subcutaneous tumors. J Immunol (2002) 0.97
Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase. J Immunol (2007) 0.97
Somatic embryogenesis receptor kinases control root development mainly via brassinosteroid-independent actions in Arabidopsis thaliana. J Integr Plant Biol (2012) 0.97
Astroglial-derived lymphotoxin-alpha exacerbates inflammation and demyelination, but not remyelination. Glia (2005) 0.97
Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome. EMBO Rep (2013) 0.96
The CATERPILLER family: an ancient family of immune/apoptotic proteins. Clin Immunol (2005) 0.95
Serine residues 286, 288, and 293 within the CIITA: a mechanism for down-regulating CIITA activity through phosphorylation. J Immunol (2004) 0.95
The role of surfactant protein A in bleomycin-induced acute lung injury. Am J Respir Crit Care Med (2010) 0.94
Plexin-D1 is a novel regulator of germinal centers and humoral immune responses. J Immunol (2011) 0.94
Cuprizone induces similar demyelination in male and female C57BL/6 mice and results in disruption of the estrous cycle. J Neurosci Res (2010) 0.94
Inflammasome-associated nucleotide-binding domain, leucine-rich repeat proteins and inflammatory diseases. J Immunol (2009) 0.93
Blimp-1/PRDM1 mediates transcriptional suppression of the NLR gene NLRP12/Monarch-1. J Immunol (2009) 0.93
CATERPILLER (NLR) family members as positive and negative regulators of inflammatory responses. Proc Am Thorac Soc (2007) 0.93