Published in PLoS One on April 09, 2013
p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway. Oncotarget (2014) 1.15
Machine-learning techniques applied to antibacterial drug discovery. Chem Biol Drug Des (2015) 0.81
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem (2010) 25.20
AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. J Comput Chem (2009) 23.19
LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. J Chem Inf Model (2011) 6.49
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J Clin Invest (2001) 5.87
New regulators of NF-kappaB in inflammation. Nat Rev Immunol (2008) 5.79
IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain. J Biol Chem (1999) 5.16
Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. J Clin Invest (2001) 4.92
Avogadro: an advanced semantic chemical editor, visualization, and analysis platform. J Cheminform (2012) 4.10
To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene (2003) 3.37
NF-kB in development and progression of human cancer. Virchows Arch (2005) 2.94
IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex. Mol Cell (2000) 2.52
Nuclear factor-kappaB activation: from bench to bedside. Exp Biol Med (Maywood) (2008) 2.19
Posttranslational modifications of NF-kappaB: another layer of regulation for NF-kappaB signaling pathway. Cell Signal (2010) 1.99
Crystal structure of inhibitor of κB kinase β. Nature (2011) 1.92
Mechanisms of constitutive NF-kappaB activation in human prostate cancer cells. Prostate (2002) 1.86
Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway. Proc Natl Acad Sci U S A (1995) 1.81
The NF-kappa B activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536. J Biol Chem (2002) 1.77
NF-kappaB activation in development and progression of cancer. Cancer Sci (2007) 1.67
The transcription factor nuclear factor-kappa B and cancer. Clin Oncol (R Coll Radiol) (2007) 1.64
Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene (1999) 1.62
Concern Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells. Blood (2008) 1.42
BINANA: a novel algorithm for ligand-binding characterization. J Mol Graph Model (2011) 1.12
NNScore 2.0: a neural-network receptor-ligand scoring function. J Chem Inf Model (2011) 1.12
Ghrelin prevents doxorubicin-induced cardiotoxicity through TNF-alpha/NF-kappaB pathways and mitochondrial protective mechanisms. Toxicology (2008) 1.02
Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells. Oncogene (2004) 0.99
Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic adenocarcinoma PC-3 cells. PLoS One (2011) 0.96
Pro-apototic and anti-apoptotic effects of tumor necrosis factor in tumor cells. Role of nuclear transcription factor NF-kappaB. Cancer Treat Res (2005) 0.93
Cryptopleurine targets NF-κB pathway, leading to inhibition of gene products associated with cell survival, proliferation, invasion, and angiogenesis. PLoS One (2012) 0.91
Structure-activity relationships in platelet-activating factor. Part 13: synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral activity. Bioorg Med Chem (2006) 0.91
Negative feedback regulation of NF-κB action by CITED2 in the nucleus. J Immunol (2010) 0.91
STAT3 mutations correlated with hyper-IgE syndrome lead to blockage of IL-6/STAT3 signalling pathway. J Biosci (2012) 0.87
PMS-601, a new platelet-activating factor receptor antagonist that inhibits human immunodeficiency virus replication and potentiates zidovudine activity in macrophages. Antimicrob Agents Chemother (2000) 0.81
Structure-activity relationships in platelet-activating factor (PAF). 10. From PAF antagonism to inhibition of HIV-1 replication. J Med Chem (2000) 0.80
Apoptosis of human Burkitt's lymphoma cells induced by 2-N,N-diethylaminocarbonyloxymethyl-1-diphenylmethyl-4-(3,4,5-trimethoxybenzoyl) piperazine hydrochloride (PMS-1077). Arch Pharm Res (2010) 0.78
Structure-activity relationships in platelet-activating factor. 12. Synthesis and biological evaluation of platelet-activating factor antagonists with anti-HIV-1 activity. J Med Chem (2004) 0.78
Role of IKK/NF-κB signaling in extinction of conditioned place aversion memory in rats. PLoS One (2012) 0.77
Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med (2011) 13.18
Major causes of death among men and women in China. N Engl J Med (2005) 11.80
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
FGF23 induces left ventricular hypertrophy. J Clin Invest (2011) 7.22
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet (2011) 5.73
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci Signal (2009) 5.57
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol Cell (2006) 5.51
Impact of creatinine calibration on performance of GFR estimating equations in a pooled individual patient database. Am J Kidney Dis (2007) 5.06
Prevalence of the metabolic syndrome and overweight among adults in China. Lancet (2005) 5.05
Mortality attributable to smoking in China. N Engl J Med (2009) 4.75
Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. Kidney Int (2011) 4.74
Community cyberinfrastructure for Advanced Microbial Ecology Research and Analysis: the CAMERA resource. Nucleic Acids Res (2010) 4.39
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
Utilization and outcomes of minimally invasive radical prostatectomy. J Clin Oncol (2008) 4.23
A versatile assay for high-throughput gene expression profiling on universal array matrices. Genome Res (2004) 4.19
Prevalence, awareness, treatment, and control of hypertension in china. Hypertension (2002) 4.18
The genomic sequence of the accidental pathogen Legionella pneumophila. Science (2004) 4.08
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. Nat Genet (2013) 3.87
The contribution of health literacy to disparities in self-rated health status and preventive health behaviors in older adults. Ann Fam Med (2009) 3.84
Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81
High-throughput SNP genotyping on universal bead arrays. Mutat Res (2005) 3.78
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet (2011) 3.66
Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL. Lancet Neurol (2008) 3.41
Body weight and mortality among men and women in China. JAMA (2006) 3.41
Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nat Protoc (2009) 3.31
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet (2005) 3.28
Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med (2010) 3.26
Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet (2012) 3.20
Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors. Nat Neurosci (2005) 3.17
Quantitative gene expression profiling in formalin-fixed, paraffin-embedded tissues using universal bead arrays. Am J Pathol (2004) 3.04
The prevalence of nontraditional risk factors for coronary heart disease in patients with chronic kidney disease. Ann Intern Med (2004) 2.94
Illumina universal bead arrays. Methods Enzymol (2006) 2.88
Gonadotropin-releasing hormone agonists and fracture risk: a claims-based cohort study of men with nonmetastatic prostate cancer. J Clin Oncol (2005) 2.87
Effect of soybean protein on blood pressure: a randomized, controlled trial. Ann Intern Med (2005) 2.79
Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3. J Biol Chem (2008) 2.75
Premature deaths attributable to blood pressure in China: a prospective cohort study. Lancet (2009) 2.62
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Mol Cell (2011) 2.61
Resiniferatoxin for treatment of lifelong premature ejaculation: a preliminary study. Int J Urol (2014) 2.61
The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci (2010) 2.61
Genome-wide genetic changes during modern breeding of maize. Nat Genet (2012) 2.60
MicroRNA function is globally suppressed in mouse oocytes and early embryos. Curr Biol (2010) 2.57
FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway. Cancer Cell (2007) 2.56
Comprehensive microRNA profiling reveals a unique human embryonic stem cell signature dominated by a single seed sequence. Stem Cells (2008) 2.52
Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport. Nat Cell Biol (2005) 2.50
Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis. Cardiovasc Res (2007) 2.49
H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet (2012) 2.47
Pax6 is a human neuroectoderm cell fate determinant. Cell Stem Cell (2010) 2.46
Sequencing and automated whole-genome optical mapping of the genome of a domestic goat (Capra hircus). Nat Biotechnol (2012) 2.45
Estimating GFR among participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis (2012) 2.42
An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition. EMBO J (2010) 2.42
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell (2012) 2.39
A heme export protein is required for red blood cell differentiation and iron homeostasis. Science (2008) 2.36
Body mass index and risk of stroke among Chinese men and women. Ann Neurol (2010) 2.33
PII signal transduction proteins: sensors of alpha-ketoglutarate that regulate nitrogen metabolism. Curr Opin Microbiol (2005) 2.25
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet (2013) 2.24
Marine cloud brightening. Philos Trans A Math Phys Eng Sci (2012) 2.23
Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers. J Neurosci (2006) 2.22
miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer. Cancer Res (2011) 2.22
Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system. Neuropsychopharmacology (2007) 2.20
Effectiveness and tolerability of high-dose (23 mg/d) versus standard-dose (10 mg/d) donepezil in moderate to severe Alzheimer's disease: A 24-week, randomized, double-blind study. Clin Ther (2010) 2.19
Early diagnosis of novel SFTS bunyavirus infection by quantitative real-time RT-PCR assay. J Clin Virol (2011) 2.19
Risk factors and prevention of inguinal hernia after radical prostatectomy: a systematic review and meta-analysis. J Urol (2012) 2.17
Hypothesis testing and power calculations for taxonomic-based human microbiome data. PLoS One (2012) 2.15
The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo. Blood (2005) 2.14
MicroRNA expression signatures of bladder cancer revealed by deep sequencing. PLoS One (2011) 2.10
Associations between kidney function and subclinical cardiac abnormalities in CKD. J Am Soc Nephrol (2012) 2.10
Association of serum bicarbonate with risk of renal and cardiovascular outcomes in CKD: a report from the Chronic Renal Insufficiency Cohort (CRIC) study. Am J Kidney Dis (2013) 2.09
A comparison of RNA-Seq and high-density exon array for detecting differential gene expression between closely related species. Nucleic Acids Res (2010) 2.07
Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes. Proc Natl Acad Sci U S A (2010) 2.06
Gender difference in blood pressure responses to dietary sodium intervention in the GenSalt study. J Hypertens (2009) 2.06
Investigation of resistive switching in Cu-doped HfO2 thin film for multilevel non-volatile memory applications. Nanotechnology (2009) 2.06
Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. Nature (2009) 2.05
Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Cancer Cell (2011) 2.04
MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury. Circulation (2010) 2.03
Factors associated with hypertension control in the general population of the United States. Arch Intern Med (2002) 2.01
A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nat Cell Biol (2007) 2.00
Long term measurements of indoor radon equilibrium factor. Health Phys (2012) 1.99
FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase. J Immunol (2008) 1.97
Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure. Blood (2003) 1.96
Membrane trafficking of G protein-coupled receptors. Annu Rev Pharmacol Toxicol (2004) 1.94
Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis. Mol Cell Biol (2003) 1.92
Dynamin 2 binds gamma-tubulin and participates in centrosome cohesion. Nat Cell Biol (2004) 1.91
Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet (2013) 1.88
IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. Proc Natl Acad Sci U S A (2007) 1.88
Myxobacteria gliding motility requires cytoskeleton rotation powered by proton motive force. Proc Natl Acad Sci U S A (2011) 1.86
A regulatory toolbox of MiniPromoters to drive selective expression in the brain. Proc Natl Acad Sci U S A (2010) 1.85
Integrated profiling of microRNAs and mRNAs: microRNAs located on Xq27.3 associate with clear cell renal cell carcinoma. PLoS One (2010) 1.82
Prehypertension and risk of cardiovascular disease in Chinese adults. J Hypertens (2009) 1.81
19p13.1 is a triple-negative-specific breast cancer susceptibility locus. Cancer Res (2012) 1.81
Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating the glomerular filtration rate in multiple ethnicities. Kidney Int (2010) 1.81
The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3. Proc Natl Acad Sci U S A (2003) 1.80
CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. Mol Cancer Ther (2007) 1.80
Alcohol consumption and risk for stroke among Chinese men. Ann Neurol (2007) 1.79
Serum total and lipoprotein cholesterol levels and awareness, treatment, and control of hypercholesterolemia in China. Circulation (2004) 1.78
CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP. Blood (2010) 1.77
Increased urinary excretion of angiotensinogen is associated with risk of chronic kidney disease. Nephrol Dial Transplant (2012) 1.75
Blood pressure and risk of cardiovascular disease in Chinese men and women. Am J Hypertens (2008) 1.74
Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis. Biochem Biophys Res Commun (2009) 1.74
Structural basis of the recognition of a methylated histone tail by JMJD2A. Proc Natl Acad Sci U S A (2007) 1.74