Published in Semin Immunopathol on April 18, 2013
PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock. Blood (2015) 1.21
Cellular dissection of psoriasis for transcriptome analyses and the post-GWAS era. BMC Med Genomics (2014) 0.93
Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity. FASEB J (2014) 0.92
New aspects on the structure of neutrophil extracellular traps from chronic obstructive pulmonary disease and in vitro generation. PLoS One (2014) 0.86
Neutrophil extracellular trap (NET) formation characterises stable and exacerbated COPD and correlates with airflow limitation. Respir Res (2015) 0.84
Escherichia coli and Candida albicans induced macrophage extracellular trap-like structures with limited microbicidal activity. PLoS One (2014) 0.83
Clearance of Apoptotic Bodies, NETs, and Biofilm DNA: Implications for Autoimmunity. Front Immunol (2014) 0.83
Parietal and intravascular innate mechanisms of vascular inflammation. Arthritis Res Ther (2015) 0.82
Chance, genetics, and the heterogeneity of disease and pathogenesis in systemic lupus erythematosus. Semin Immunopathol (2014) 0.80
Innate immunity in disease. Clin Gastroenterol Hepatol (2014) 0.79
Epigenetics of autoantigens: new opportunities for therapy of autoimmune diseases. Genet Epigenet (2013) 0.79
Disruption of a Regulatory Network Consisting of Neutrophils and Platelets Fosters Persisting Inflammation in Rheumatic Diseases. Front Immunol (2016) 0.77
NETosis provides the link between activation of neutrophils on hemodialysis membrane and comorbidities in dialyzed patients. Inflamm Res (2016) 0.77
Tear fluid extracellular DNA: diagnostic and therapeutic implications in dry eye disease. Invest Ophthalmol Vis Sci (2013) 0.76
Pathogenic immunity in systemic lupus erythematosus and atherosclerosis: common mechanisms and possible targets for intervention. J Intern Med (2015) 0.76
Extracellular Acidification Inhibits the ROS-Dependent Formation of Neutrophil Extracellular Traps. Front Immunol (2017) 0.75
Peptidylarginine deiminase 4 promotes age-related organ fibrosis. J Exp Med (2016) 0.75
Role of Neutrophil Extracellular Traps in Asthma and Chronic Obstructive Pulmonary Disease. Chin Med J (Engl) (2017) 0.75
Capability of Neutrophils to Form NETs Is Not Directly Influenced by a CMA-Targeting Peptide. Front Immunol (2017) 0.75
Bet on NETs! Or on How to Translate Basic Science into Clinical Practice. Front Immunol (2016) 0.75
Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils. Front Immunol (2017) 0.75
Re-Examining Neutrophil Participation in GN. J Am Soc Nephrol (2017) 0.75
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer (1972) 35.74
Neutrophil extracellular traps kill bacteria. Science (2004) 23.64
Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol (2006) 12.29
Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med (1978) 11.99
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature (2002) 11.05
Novel cell death program leads to neutrophil extracellular traps. J Cell Biol (2007) 10.92
Immunological studies concerning the nephritis of systemic lupus erythematosus. J Exp Med (1967) 10.22
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature (2007) 8.88
Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med (1994) 8.21
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet (2003) 7.04
Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest (1998) 6.92
Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med (2009) 6.72
Bactericidal action of histone. J Exp Med (1958) 6.58
Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Sci Transl Med (2011) 5.60
Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans. PLoS Pathog (2009) 5.40
Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science (2006) 5.30
Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J Cell Biol (2009) 5.27
Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proc Natl Acad Sci U S A (2010) 5.05
PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J Exp Med (2010) 4.74
The role of clonal selection and somatic mutation in autoimmunity. Nature (1987) 4.66
Beneficial suicide: why neutrophils die to make NETs. Nat Rev Microbiol (2007) 4.65
Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Sci Transl Med (2011) 4.51
Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms. Cell Microbiol (2006) 4.47
Restoration of NET formation by gene therapy in CGD controls aspergillosis. Blood (2009) 4.06
Delineating the genetic basis of systemic lupus erythematosus. Immunity (2001) 4.02
Autoimmunity and the clearance of dead cells. Cell (2010) 3.90
Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc Natl Acad Sci U S A (1987) 3.90
Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus. J Immunol (2011) 3.83
A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci U S A (2006) 3.70
An electron microscope study of the glomerulus in nephrosis, glomerulonephritis, and lupus erythematosus. J Exp Med (1957) 3.65
Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med (2012) 3.63
A DNA-reacting factor in serum of a patient with lupus erythematosus diffusus. Proc Soc Exp Biol Med (1957) 3.59
The epidemiology of rheumatoid arthritis. Rheum Dis Clin North Am (2001) 3.58
Histone deimination as a response to inflammatory stimuli in neutrophils. J Immunol (2008) 3.48
Affinity between the lupus erythematosus serum factor and cell nuclei and nucleoprotein. Science (1957) 3.43
Neutrophil extracellular traps promote deep vein thrombosis in mice. J Thromb Haemost (2012) 3.39
Neutrophil extracellular traps: is immunity the second function of chromatin? J Cell Biol (2012) 3.39
Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees. Proc Natl Acad Sci U S A (1998) 3.35
Kinetic maturation of an immune response. Nature (1991) 3.26
Antibodies to DNA. N Engl J Med (1998) 3.04
Systemic exposure to irradiated apoptotic cells induces autoantibody production. J Exp Med (1998) 3.01
Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. Science (1998) 2.95
The neutrophil in vascular inflammation. Nat Med (2011) 2.84
Nuclear localization of peptidylarginine deiminase V and histone deimination in granulocytes. J Biol Chem (2002) 2.78
C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited. J Immunol (1997) 2.69
Complement-dependent clearance of apoptotic cells by human macrophages. J Exp Med (1998) 2.69
Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps. Proc Natl Acad Sci U S A (2009) 2.68
The role of complement in the development of systemic lupus erythematosus. Annu Rev Immunol (2004) 2.67
Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol (2009) 2.47
Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu Rev Immunol (1994) 2.45
Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation. Nat Chem Biol (2010) 2.39
Residues that mediate DNA binding of autoimmune antibodies. J Immunol (1993) 2.37
Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity. Blood (2010) 2.32
Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: role of proteases. J Immunol (2001) 2.22
N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis. J Immunol (2011) 2.18
Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis. Cell Host Microbe (2012) 2.17
Neutrophil extracellular traps that are not degraded in systemic lupus erythematosus activate complement exacerbating the disease. J Immunol (2012) 2.12
C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease. J Clin Invest (2002) 2.11
The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat Immunol (2012) 2.11
Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits. J Immunol (1987) 2.09
TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus. J Immunol (2010) 2.09
Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis. Kidney Int (2007) 2.08
Signaling and cytoskeletal requirements in erythroblast enucleation. Blood (2012) 2.05
Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death. FEBS Lett (2010) 2.03
Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites. Kidney Int (1992) 2.01
Cross-reactivity of human and murine anti-DNA antibodies with heparan sulfate. The major glycosaminoglycan in glomerular basement membranes. J Clin Invest (1986) 2.00
Fifty years of anti-ds DNA antibodies: are we approaching journey's end? Rheumatology (Oxford) (2007) 1.95
C1q, autoimmunity and apoptosis. Immunobiology (2002) 1.94
Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3). J Biol Chem (1999) 1.93
Responsiveness of autoimmune and normal mice to nucleic acid antigens. J Immunol (1984) 1.85
IgG anti-DNA autoantibodies within an individual autoimmune mouse are the products of clonal selection. J Immunol (1989) 1.81
Impaired thymic development in mouse embryos deficient in apoptotic DNA degradation. Nat Immunol (2003) 1.77
Increased apoptotic peripheral blood neutrophils in systemic lupus erythematosus: relations with disease activity, antibodies to double stranded DNA, and neutropenia. Ann Rheum Dis (1999) 1.75
Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice. Kidney Int (2012) 1.74
Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice. J Exp Med (1992) 1.67
Nucleosomes are exposed at the cell surface in apoptosis. J Immunol (2004) 1.66
Regulation of extracellular chromatin release from neutrophils. J Innate Immun (2009) 1.64
Diagnostic accuracy for lupus and other systemic autoimmune diseases in the community setting. Arch Intern Med (2004) 1.63
Taming lupus-a new understanding of pathogenesis is leading to clinical advances. Nat Med (2012) 1.63
DNA degradation in development and programmed cell death. Annu Rev Immunol (2005) 1.61
Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking. Immunity (2011) 1.59
C5a initiates the inflammatory cascade in immune complex peritonitis. J Immunol (2004) 1.57
Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes. PLoS Genet (2011) 1.57
Immune complex systems in the nephritis of systemic lupus erythematosus. Kidney Int (1973) 1.55
Effect of cationized antibodies in performed immune complexes on deposition and persistence in renal glomeruli. J Exp Med (1982) 1.54
Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo. J Clin Invest (1994) 1.54
The evolution of human anti-double-stranded DNA autoantibodies. Proc Natl Acad Sci U S A (2005) 1.53
Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus. J Exp Med (2007) 1.53
Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity. Blood (2012) 1.52
Direct binding of C1q to apoptotic cells and cell blebs induces complement activation. Eur J Immunol (2002) 1.52
Neutrophil elastase enhances sputum solubilization in cystic fibrosis patients receiving DNase therapy. PLoS One (2011) 1.51
Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis. J Immunol (2007) 1.49
Alpha-actinin is a cross-reactive renal target for pathogenic anti-DNA antibodies. J Immunol (2002) 1.49
Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation. J Immunol (2005) 1.45
Unconventional roles of the NADPH oxidase: signaling, ion homeostasis, and cell death. Sci STKE (2007) 1.44
Relationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study. Arthritis Res Ther (2009) 1.44
FcR-bearing myeloid cells are responsible for triggering murine lupus nephritis. J Immunol (2006) 1.42
PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection. PLoS One (2011) 1.39
Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps. Arthritis Rheum (2011) 1.38
PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures. Front Immunol (2012) 1.37
Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene. Arthritis Rheum (2003) 2.53
Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice. Kidney Int (2012) 1.74
Induction of autoantibody production is limited in nonautoimmune mice. J Immunol (2002) 1.13
Vitamin D-binding protein gene polymorphisms may contribute to the racial disparity in genotype 1 chronic hepatitis C treatment outcome. Hepatology (2013) 1.08
Immunization with heat-killed Francisella tularensis LVS elicits protective antibody-mediated immunity. Eur J Immunol (2007) 1.00
Tolerance to DNA in (NZB x NZW)F1 mice that inherit an anti-DNA V(H) as a conventional micro H chain transgene but not as a V(H) knock-in transgene. J Immunol (2004) 0.90
Vitamin D and the racial difference in the genotype 1 chronic hepatitis C treatment response. Am J Clin Nutr (2012) 0.90
The Chlamydia trachomatis CT149 protein exhibits esterase activity in vitro and catalyzes cholesteryl ester hydrolysis when expressed in HeLa cells. Microbes Infect (2012) 0.77
Atrophic cardiomyocyte signaling in hypertensive heart disease. J Cardiovasc Pharmacol (2013) 0.76
Small dedifferentiated cardiomyocytes bordering on microdomains of fibrosis: evidence for reverse remodeling with assisted recovery. J Cardiovasc Pharmacol (2014) 0.76