Published in J Exp Med on December 01, 1958
The isolation and properties of the specific cytoplasmic granules of rabbit polymorphonuclear leucocytes. J Exp Med (1960) 21.07
Interactions between rabbit polymorphonuclear leucocytes and staphylococci. J Exp Med (1959) 17.17
Cationic proteins of polymorphonuclear leukocyte lysosomes. II. Composition, properties, and mechanism of antibacterial action. J Bacteriol (1966) 4.81
PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J Exp Med (2010) 4.74
Further studies on preparation and properties of phagocytin. J Exp Med (1960) 4.74
Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J Cell Biol (2010) 4.50
Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. Blood (2009) 3.90
Antimicrobial factors in tissues and phagocytic cells. Bacteriol Rev (1960) 3.85
Cationic proteins of polymorphonuclear leukocyte lysosomes. I. Resolution of antibacterial and enzymatic activities. J Bacteriol (1966) 3.61
Neutrophil extracellular traps: is immunity the second function of chromatin? J Cell Biol (2012) 3.39
Antibacterial activity of cationic proteins from human granulocytes. J Clin Invest (1975) 2.97
Further observations on the behavior of staphylococci within human leukocytes. J Exp Med (1960) 2.89
Histones induce rapid and profound thrombocytopenia in mice. Blood (2011) 2.66
Partial characterization and purification of a rabbit granulocyte factor that increases permeability of Escherichia coli. J Clin Invest (1975) 2.16
Mechanisms for the microbicidal activity of cationic proteins of human granulocytes. Infect Immun (1976) 2.05
Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature. Nat Commun (2015) 1.73
The interferon-alpha signature of systemic lupus erythematosus. Lupus (2010) 1.69
The effects of mammalian and other cationic polypeptides on the cytochemical character of bacterial cells. J Exp Med (1961) 1.69
Bactericidal activity of human lysozyme, muramidase-inactive lysozyme, and cationic polypeptides against Streptococcus sanguis and Streptococcus faecalis: inhibition by chitin oligosaccharides. Infect Immun (1985) 1.64
Physiochemical and biological properties of the major basic protein from guinea pig eosinophil granules. J Exp Med (1974) 1.61
Microbicidal cationic proteins of rabbit alveolar macrophages: amino acid composition and functional attributes. Infect Immun (1981) 1.61
Growth-inhibitory and bactericidal effects of human parotid salivary histidine-rich polypeptides on Streptococcus mutans. Infect Immun (1984) 1.60
Neutrophil extracellular trap (NET)-mediated killing of Pseudomonas aeruginosa: evidence of acquired resistance within the CF airway, independent of CFTR. PLoS One (2011) 1.58
Antimicrobial proteins of murine macrophages. Infect Immun (1993) 1.50
Phagocytosis, with particular reference to encapsulated bacteria. Bacteriol Rev (1960) 1.37
Automatic quantification of in vitro NET formation. Front Immunol (2013) 1.35
Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury. FASEB J (2013) 1.26
Innate immunity and coagulation. J Thromb Haemost (2011) 1.24
Potential role of epithelial cell-derived histone H1 proteins in innate antimicrobial defense in the human gastrointestinal tract. Infect Immun (1998) 1.22
Neutrophil extracellular traps - the dark side of neutrophils. J Clin Invest (2016) 1.19
Proteins derived from neutrophil extracellular traps may serve as self-antigens and mediate organ damage in autoimmune diseases. Front Immunol (2012) 1.11
Retracted Neutrophil extracellular traps: Their role in periodontal disease. J Indian Soc Periodontol (2015) 1.10
Release and activity of histone in diseases. Cell Death Dis (2014) 1.10
Protamine-induced permeabilization of cell envelopes of gram-positive and gram-negative bacteria. Appl Environ Microbiol (1997) 1.09
Antibacterial effects associated with changes in bacterial cytology produced by cationic polypeptides. J Exp Med (1961) 1.09
Expanding roles for lipid droplets. Curr Biol (2015) 1.06
A novel role for lipid droplets in the organismal antibacterial response. Elife (2012) 1.06
Role of Nox2 in elimination of microorganisms. Semin Immunopathol (2008) 1.01
Plasmodium falciparum histones induce endothelial proinflammatory response and barrier dysfunction. Am J Pathol (2012) 1.01
Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity. Semin Immunopathol (2013) 0.99
Anti-microbial properties of histone H2A from skin secretions of rainbow trout, Oncorhynchus mykiss. Biochem J (2002) 0.99
Chemical biology of protein arginine modifications in epigenetic regulation. Chem Rev (2015) 0.99
Sepsis: the dark side of histones. Nat Med (2009) 0.97
Conventional and unconventional antimicrobials from fish, marine invertebrates and micro-algae. Mar Drugs (2010) 0.96
The proteomic profile of circulating pentraxin 3 (PTX3) complex in sepsis demonstrates the interaction with azurocidin 1 and other components of neutrophil extracellular traps. Mol Cell Proteomics (2012) 0.96
Synergy of histone-derived peptides of coho salmon with lysozyme and flounder pleurocidin. Antimicrob Agents Chemother (2001) 0.95
The stimulation by endotoxin of the nonspecific resistance of mice to bacterial infections. Br J Exp Pathol (1974) 0.90
Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae. Nucleic Acids Res (2010) 0.89
Heparin inhibits phagocytosis by polymorphonuclear leukocytes. Infect Immun (1981) 0.89
Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon. Nat Commun (2014) 0.89
Midkine in host defence. Br J Pharmacol (2014) 0.88
Fatal attraction evaded. How pathogenic bacteria resist cationic polypeptides. J Exp Med (2001) 0.87
Enhanced malignant behaviour of cells treated with crude rat liver histone. Br J Cancer (1973) 0.86
Changes in cell morphology of Listeria monocytogenes and Shewanella putrefaciens resulting from the action of protamine. Appl Environ Microbiol (1996) 0.86
Neutrophil Extracellular Trap-Related Extracellular Histones Cause Vascular Necrosis in Severe GN. J Am Soc Nephrol (2015) 0.84
Pathophysiology, staging and therapy of severe sepsis in baboon models. J Cell Mol Med (2012) 0.84
Clearance of Apoptotic Bodies, NETs, and Biofilm DNA: Implications for Autoimmunity. Front Immunol (2014) 0.83
Protein-based therapies for acute lung injury: targeting neutrophil extracellular traps. Expert Opin Ther Targets (2014) 0.81
Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity. Infect Immun (2015) 0.80
Extracellular histone H1 is neurotoxic and drives a pro-inflammatory response in microglia. F1000Res (2013) 0.80
Proteomic analysis of pure human airway gland mucus reveals a large component of protective proteins. PLoS One (2015) 0.79
Actin and DNA Protect Histones from Degradation by Bacterial Proteases but Inhibit Their Antimicrobial Activity. Front Microbiol (2016) 0.79
As the fat flies: The dynamic lipid droplets of Drosophila embryos. Biochim Biophys Acta (2015) 0.79
N-acetyl-heparin attenuates acute lung injury caused by acid aspiration mainly by antagonizing histones in mice. PLoS One (2014) 0.79
Anatomical site-specific contributions of pneumococcal virulence determinants. Pneumonia (Nathan) (2016) 0.79
A Critical Reappraisal of Neutrophil Extracellular Traps and NETosis Mimics Based on Differential Requirements for Protein Citrullination. Front Immunol (2016) 0.78
O-antigen protects gram-negative bacteria from histone killing. PLoS One (2013) 0.78
Escaping Underground Nets: Extracellular DNases Degrade Plant Extracellular Traps and Contribute to Virulence of the Plant Pathogenic Bacterium Ralstonia solanacearum. PLoS Pathog (2016) 0.78
The interaction of leukocytes and their hydrolases with bacteria in vitro and in vivo: the modification of the bactericidal and bacteriolytic reactions by cationic and anionic macromolecular substances and by anti-inflammatory agents. Agents Actions (1976) 0.78
Molecular Characterization and Phylogenetic Analysis of a Histone-Derived Antimicrobial Peptide Teleostin from the Marine Teleost Fishes, Tachysurus jella and Cynoglossus semifasciatus. ISRN Mol Biol (2013) 0.77
Rifaximin-mediated changes to the epithelial cell proteome: 2-D gel analysis. PLoS One (2013) 0.77
NETosis. Autoimmune Dis (2013) 0.76
Inhibitory effects of protamines on proteolytic and adhesive activities of Porphyromonas gingivalis. Infect Immun (1999) 0.76
From amino acids polymers, antimicrobial peptides, and histones, to their possible role in the pathogenesis of septic shock: a historical perspective. J Inflamm Res (2017) 0.75
The Role of Cationic Polypeptides in Modulating HIV-1 Infection of the Cervicovaginal Mucosa. Antibiotics (Basel) (2014) 0.75
Histones from Avian Erythrocytes Exhibit Antibiofilm activity against methicillin-sensitive and methicillin-resistant Staphylococcus aureus. Sci Rep (2017) 0.75
Group A Streptococcal M1 Protein Provides Resistance against the Antimicrobial Activity of Histones. Sci Rep (2017) 0.75
The Protective Effect against Extracellular Histones Afforded by Long-Pentraxin PTX3 as a Regulator of NETs. Front Immunol (2016) 0.75
Selective Biological Responses of Phagocytes and Lungs to Purified Histones. J Innate Immun (2017) 0.75
Komodo dragon-inspired synthetic peptide DRGN-1 promotes wound-healing of a mixed-biofilm infected wound. NPJ Biofilms Microbiomes (2017) 0.75
Lipid droplet functions beyond energy storage. Biochim Biophys Acta (2017) 0.75
Phagocytin: a bactericidal substance from polymorphonuclear leucocytes. J Exp Med (1956) 14.38
Antimicrobial factors of normal tissues and fluids. Bacteriol Rev (1957) 7.64
Chromatographic fractionation of calf thymus histone. J Biol Chem (1955) 4.75
ANTIBACTERIAL PROPERTIES OF PROTAMINE AND HISTONE. Science (1942) 3.32
The fractionation and composition of histones from thymus nucleoprotein. Biochim Biophys Acta (1954) 3.24
The histones of calf thymus deoxyribonucleoprotein. II. Electrophoretic and sedimentation behaviour and a partial fractionation. Biochim Biophys Acta (1954) 2.97
Comparative studies on chromatographically purified histones. J Biol Chem (1957) 2.97
The histones of calf thymus deoxyribonucleoprotein. I. Preparation and homogeneity. Biochim Biophys Acta (1954) 2.34
Surface behaviour of Bacterium coli. I. The nature of the surface. Proc R Soc Lond B Biol Sci (1956) 1.66
The antibacterial activity of hemoglobin. J Exp Med (1958) 1.51
Displacement fractionation of deoxyribonucleoproteins by heparin and dextran sulphate. Biochem J (1958) 1.39
The isolation and properties of the specific cytoplasmic granules of rabbit polymorphonuclear leucocytes. J Exp Med (1960) 21.07
Phagocytin: a bactericidal substance from polymorphonuclear leucocytes. J Exp Med (1956) 14.38
Studies of phagocytosis of group A streptococci by polymorphonuclear leucocytes in vitro. J Exp Med (1960) 12.03
Degranulation of polymorphonuclear leucocytes following phagocytosis of microorganisms. J Exp Med (1960) 10.03
STUDIES ON HEAT-LABILE OPSONIN IN RABBIT SERUM. J Immunol (1964) 6.88
ELECTRON MICROSCOPE STUDIES ON THE DEGRANULATION OF RABBIT PERITONEAL LEUKOCYTES DURING PHAGOCYTOSIS. J Exp Med (1964) 6.12
Studies of the bactericidal action of phagocytin. J Exp Med (1956) 5.88
Cinemicrophotographic observations on granule lysis in polymorphonuclear leucocytes during phagocytosis. J Exp Med (1962) 5.42
The influence of phagocytosis on the intracellular distribution of granule-associated components of polymorphonuclear leucocytes. J Exp Med (1960) 5.27
Further studies on preparation and properties of phagocytin. J Exp Med (1960) 4.74
The effect of spermine on tubercle bacilli. J Exp Med (1952) 4.09
Antimicrobial factors in tissues and phagocytic cells. Bacteriol Rev (1960) 3.85
MOTION PICTURE STUDY OF THE TOXIC ACTION OF STREPTOLYSINS ON LEUCOCYTES. J Exp Med (1963) 3.68
ISOLATION OF GRANULES FROM EOSINOPHIL LEUCOCYTES AND STUDY OF THEIR ENZYME CONTENT. J Exp Med (1963) 3.21
Comparative bactericidal activities of blood serum and plasma serum. J Exp Med (1960) 3.12
MOTION PICTURE STUDIES ON DEGRANULATION OF HORSE EOSINOPHILS DURING PHAGOCYTOSIS. J Exp Med (1963) 2.71
Spermine oxidase: an amine oxidase with specificity for spermine and spermidine. J Exp Med (1953) 2.28
Immunity to infectious diseases: review of some concepts of Metchnikoff. Bacteriol Rev (1959) 2.12
Adrenal steroids and infection: the effect of cortisone administration on polymorphonuclear leukocytic functions and on serum opsonins and bactericidins. J Clin Invest (1961) 1.93
Charcoal media for the cultivation of tubercle bacilli. Am Rev Tuberc (1954) 1.83
Studies on egg-yolk growth factors for tubercle bacilli. Am Rev Tuberc (1954) 1.68
The antimycobacterial activity of a peptide preparation derived from calf thymus. J Exp Med (1954) 1.60
Chemical studies on a basic peptide preparation derived from calf thymus. J Exp Med (1954) 1.53
The antibacterial activity of hemoglobin. J Exp Med (1958) 1.51
DIGESTIVE AND AUTOLYTIC FUNCTIONS OF LYSOSOMES IN PHAGOCYTIC CELLS. Fed Proc (1965) 1.49
A study comparing the effects of bed rest and physical activity on recovery from pulmonary tuberculosis. Am Rev Tuberc (1957) 1.28
Mechanisms involved in the antimycobacterial activity of certain basic peptides. J Exp Med (1954) 1.20
Evaluation of the Kveim reaction as a diagnostic test for sarcoidosis. N Engl J Med (1961) 1.18
The resistance of tubercle bacilli to the bactericidal action of benzalkonium chloride (zephiran). Am Rev Tuberc (1954) 1.15
The essential participation of an enzyme in the inhibition of growth of tubercle bacilli by spermine. J Exp Med (1953) 1.03
Studies on the stability of isoniazid. Am Rev Tuberc (1955) 1.01
Ciliocytophthoria: relationship to viral respiratory infections of humans. Proc Soc Exp Biol Med (1958) 0.97
DEMONSTRATION BY FLUORESCENCE MICROSCOPY OF ADSORPTION ONTO BACTERIA OF A HEAT-LABILE FACTOR FROM GUINEA PIG SERUM. J Immunol (1964) 0.97
The treatment of sarcoidosis with chloroquine. Am J Med (1961) 0.96
ANTISERUM TO LEUCOCYTE LYSOSOMES. ITS CYTOTOXIC, GRANULOLYTIC, AND HEMOLYTIC ACTIVITIES. J Exp Med (1964) 0.90
The antimycobacterial activity of various amines related to spermine in chemical structure. J Exp Med (1953) 0.85
ADSORPTION AND AGGREGATION OF GAMMA GLOBULIN ONTO CHYLOMICRONS IN SERUM OF LOWERED IONIC STRENGTH. Yale J Biol Med (1963) 0.84
Rapid detection of drug-resistant tubercle bacilli in sputum by slide cultures. Am Rev Tuberc (1957) 0.81
Experimental treatment with chloroquine. Am Rev Respir Dis (1961) 0.75
Acute rheumatic fever in the young adult white male. Am J Med Sci (1951) 0.75
Sinus bradycardia in acute rheumatic fever. Ann Intern Med (1952) 0.75
The use of charcoal in diluents for tubercle bacilli. Am Rev Tuberc (1954) 0.75
Drug susceptibilities of M. tuberculosis on charcoal agar medium. Am Rev Tuberc (1955) 0.75
The use of triton WR 1339 and of malachite green in charcoal media for tubercle bacilli. Am Rev Tuberc (1955) 0.75