Published in J Cell Biol on April 22, 2013
PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication. Mol Cell (2013) 1.50
Human Pol ζ purified with accessory subunits is active in translesion DNA synthesis and complements Pol η in cisplatin bypass. Proc Natl Acad Sci U S A (2014) 1.18
DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation. EMBO J (2013) 1.05
Repeat instability during DNA repair: Insights from model systems. Crit Rev Biochem Mol Biol (2015) 0.97
Spartan deficiency causes genomic instability and progeroid phenotypes. Nat Commun (2014) 0.95
Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress? Cell Mol Life Sci (2014) 0.90
Updating the mechanisms of common fragile site instability: how to reconcile the different views? Cell Mol Life Sci (2014) 0.90
TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells. J Cell Biol (2015) 0.88
Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks. Cell Rep (2014) 0.87
Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA. PLoS Genet (2015) 0.86
A concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression. Nucleic Acids Res (2014) 0.85
Replication stress in Mammalian cells and its consequences for mitosis. Genes (Basel) (2015) 0.85
Replication of Structured DNA and its implication in epigenetic stability. Front Genet (2015) 0.83
Cooperative motion of a key positively charged residue and metal ions for DNA replication catalyzed by human DNA Polymerase-η. Nucleic Acids Res (2016) 0.83
Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis. Proc Natl Acad Sci U S A (2016) 0.82
Microsatellite interruptions stabilize primate genomes and exist as population-specific single nucleotide polymorphisms within individual human genomes. PLoS Genet (2014) 0.82
A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress. Nucleic Acids Res (2015) 0.81
Control of structure-specific endonucleases to maintain genome stability. Nat Rev Mol Cell Biol (2017) 0.81
Pol κ in replication checkpoint. Cell Cycle (2013) 0.81
Unlocking the steric gate of DNA polymerase η leads to increased genomic instability in Saccharomyces cerevisiae. DNA Repair (Amst) (2015) 0.80
Polymerase η suppresses telomere defects induced by DNA damaging agents. Nucleic Acids Res (2014) 0.80
Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork. Mol Cell (2017) 0.80
Detection of G-quadruplex DNA using primer extension as a tool. PLoS One (2015) 0.79
Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres. Cell Rep (2016) 0.77
Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA. Nat Commun (2016) 0.77
DNA polymerase η is regulated by poly(rC)-binding protein 1 via mRNA stability. Biochem J (2014) 0.77
Characterization of human translesion DNA synthesis across a UV-induced DNA lesion. Elife (2016) 0.77
Mechanisms of chromosomal instability in melanoma. Environ Mol Mutagen (2014) 0.77
Both high-fidelity replicative and low-fidelity Y-family polymerases are involved in DNA rereplication. Mol Cell Biol (2014) 0.76
Cyclin Kinase-independent role of p21(CDKN1A) in the promotion of nascent DNA elongation in unstressed cells. Elife (2016) 0.76
PrimPol-A new polymerase on the block. Mol Cell Oncol (2014) 0.76
Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells. Biol Open (2016) 0.75
Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells. Nucleic Acids Res (2017) 0.75
ATR and a Chk1-Aurora B pathway coordinate postmitotic genome surveillance with cytokinetic abscission. Mol Biol Cell (2015) 0.75
First molecular-cytogenetic characterization of Fanconi anemia fragile sites in primary lymphocytes of FA-D2 patients in different stages of the disease. Mol Cytogenet (2016) 0.75
Rescue from replication stress during mitosis. Cell Cycle (2017) 0.75
Role of DNA polymerase κ in the maintenance of genomic stability. Mol Cell Oncol (2014) 0.75
TopBP1-mediated DNA processing during mitosis. Cell Cycle (2016) 0.75
Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases. Genes (Basel) (2017) 0.75
Fragile sites in cancer: more than meets the eye. Nat Rev Cancer (2017) 0.75
DNA repair factor RAD18 and DNA polymerase Polκ confer tolerance of oncogenic DNA replication stress. J Cell Biol (2017) 0.75
Dormant origins as a built-in safeguard in eukaryotic DNA replication against genome instability and disease development. DNA Repair (Amst) (2017) 0.75
Regulation and Modulation of Human DNA Polymerase δ Activity and Function. Genes (Basel) (2017) 0.75
The impact of replication stress on replication dynamics and DNA damage in vertebrate cells. Nat Rev Genet (2017) 0.75
The "enemies within": regions of the genome that are inherently difficult to replicate. F1000Res (2017) 0.75
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Signatures of mutation and selection in the cancer genome. Nature (2010) 9.75
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Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage. Mol Cell (2004) 6.12
Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol (2010) 5.88
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science (2005) 5.75
Expandable DNA repeats and human disease. Nature (2007) 5.50
Repeat instability: mechanisms of dynamic mutations. Nat Rev Genet (2005) 5.37
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Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev (2002) 4.58
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat Cell Biol (2011) 4.57
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Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs. Mol Cell Biol (2001) 4.19
Replication stress induces sister-chromatid bridging at fragile site loci in mitosis. Nat Cell Biol (2009) 4.15
Structure and mechanism of human DNA polymerase eta. Nature (2010) 2.69
Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site. Nature (2011) 2.69
Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes. Mol Cell (2011) 2.66
The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities. Nat Cell Biol (2009) 2.62
Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity. Nature (2004) 2.40
Replication stress induces 53BP1-containing OPT domains in G1 cells. J Cell Biol (2011) 2.18
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An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cerevisiae. Mol Cell (2007) 1.51
Differential regulation of homologous recombination at DNA breaks and replication forks by the Mrc1 branch of the S-phase checkpoint. EMBO J (2009) 1.50
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Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication. Mol Cell Biol (2009) 1.45
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Effect of proliferating cell nuclear antigen ubiquitination and chromatin structure on the dynamic properties of the Y-family DNA polymerases. Mol Biol Cell (2008) 1.29
Formation of (dA-dT)n cruciforms in Escherichia coli cells under different environmental conditions. J Bacteriol (1991) 1.23
Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme. Biochemistry (2002) 1.19
DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D. Nucleic Acids Res (2009) 1.02
Role of the ubiquitin-binding domain of Polη in Rad18-independent translesion DNA synthesis in human cell extracts. Nucleic Acids Res (2010) 0.93
T(3;7)(q27;q32) fuses BCL6 to a non-coding region at FRA7H near miR-29. Leukemia (2007) 0.91
Construct validity of the five facet mindfulness questionnaire in meditating and nonmeditating samples. Assessment (2008) 3.93
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nat Struct Mol Biol (2010) 3.27
High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome. EMBO J (2010) 2.89
The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities. Nat Cell Biol (2009) 2.62
The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways. EMBO J (2004) 2.20
Nonapoptotic role for Apaf-1 in the DNA damage checkpoint. Mol Cell (2007) 2.20
Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. J Biol Chem (2003) 1.98
Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression. EMBO J (2006) 1.59
Hyperhomocysteinemia, a cardiac metabolic disease: role of nitric oxide and the p22phox subunit of NADPH oxidase. Circulation (2005) 1.55
The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells. Nucleic Acids Res (2006) 1.51
ERCC1 and MUS81-EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis. Nat Cell Biol (2013) 1.49
BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks. EMBO J (2004) 1.48
RIalpha influences cellular proliferation in cancer cells by transporting RFC40 into the nucleus. Cancer Biol Ther (2005) 1.48
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability. Proc Natl Acad Sci U S A (2010) 1.48
DNA polymerases and human diseases. Radiat Res (2006) 1.47
An outcome evaluation of the Sources of Strength suicide prevention program delivered by adolescent peer leaders in high schools. Am J Public Health (2010) 1.47
Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication. Mol Cell Biol (2009) 1.45
Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator. Biochemistry (2005) 1.41
Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. PLoS Genet (2008) 1.41
What is a microsatellite: a computational and experimental definition based upon repeat mutational behavior at A/T and GT/AC repeats. Genome Biol Evol (2010) 1.40
A genome-wide analysis of common fragile sites: what features determine chromosomal instability in the human genome? Genome Res (2012) 1.37
Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle. Oncogene (2003) 1.34
Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen. J Biol Chem (2003) 1.32
Involvement of DNA polymerase mu in the repair of a specific subset of DNA double-strand breaks in mammalian cells. Nucleic Acids Res (2007) 1.27
Functional roles of p12, the fourth subunit of human DNA polymerase delta. J Biol Chem (2006) 1.27
Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis. Cancer Res (2002) 1.27
A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta. J Biol Chem (2007) 1.25
Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells. Mol Carcinog (2009) 1.24
Catechol-O-methyltransferase genotype modulates cancer treatment-related cognitive deficits in breast cancer survivors. Cancer (2010) 1.23
Quantitation of DNA double-strand break resection intermediates in human cells. Nucleic Acids Res (2013) 1.20
Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme. Biochemistry (2002) 1.19
Defective mismatch repair, microsatellite mutation bias, and variability in clinical cancer phenotypes. Cancer Res (2010) 1.19
Loss of CHK1 function impedes DNA damage-induced FANCD2 monoubiquitination but normalizes the abnormal G2 arrest in Fanconi anemia. Hum Mol Genet (2007) 1.17
Cohesin protects genes against γH2AX Induced by DNA double-strand breaks. PLoS Genet (2012) 1.17
DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein. Hum Mol Genet (2002) 1.16
Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells. Biochem Biophys Res Commun (2004) 1.13
PCNA is ubiquitinated by RNF8. Cell Cycle (2008) 1.13
DNA damage alters DNA polymerase delta to a form that exhibits increased discrimination against modified template bases and mismatched primers. Nucleic Acids Res (2008) 1.13
Positive correlation between DNA polymerase alpha-primase pausing and mutagenesis within polypyrimidine/polypurine microsatellite sequences. J Mol Biol (2004) 1.11
Mammalian Ino80 mediates double-strand break repair through its role in DNA end strand resection. Mol Cell Biol (2011) 1.10
Aberrant activation of stress-response pathways leads to TNF-alpha oversecretion in Fanconi anemia. Blood (2007) 1.09
Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis. Cancer Res (2005) 1.09
Beyond translesion synthesis: polymerase κ fidelity as a potential determinant of microsatellite stability. Nucleic Acids Res (2011) 1.07
Further characterization of human DNA polymerase delta interacting protein 38. J Biol Chem (2005) 1.07
DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation. EMBO J (2013) 1.05
Drosophila Dgt6 interacts with Ndc80, Msps/XMAP215, and gamma-tubulin to promote kinetochore-driven MT formation. Curr Biol (2009) 1.05
The E1A-associated p400 protein modulates cell fate decisions by the regulation of ROS homeostasis. PLoS Genet (2010) 1.05
A role for DNA polymerase beta in mutagenic UV lesion bypass. J Biol Chem (2002) 1.04
Tip60 acetyltransferase activity is controlled by phosphorylation. J Biol Chem (2002) 1.04
3R coordination by Fanconi anemia proteins. Biochimie (2005) 1.04
Deciphering the chromatin landscape induced around DNA double strand breaks. Cell Cycle (2010) 1.03
The proofreading 3'-->5' exonuclease activity of DNA polymerases: a kinetic barrier to translesion DNA synthesis. Mutat Res (2002) 1.03
The FANC pathway and mitosis: a replication legacy. Cell Cycle (2009) 1.03
Structure of monoubiquitinated PCNA: implications for DNA polymerase switching and Okazaki fragment maturation. Cell Cycle (2012) 1.03
A matter of life or death: how microsatellites emerge in and vanish from the human genome. Genome Res (2011) 1.02
Distinct mutational behaviors differentiate short tandem repeats from microsatellites in the human genome. Genome Biol Evol (2013) 1.02
Psoralen-induced DNA adducts are substrates for the base excision repair pathway in human cells. Nucleic Acids Res (2007) 1.02
DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D. Nucleic Acids Res (2009) 1.02
The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation. DNA Repair (Amst) (2012) 1.02
Fanconi anemia proteins and the s phase checkpoint. Cell Cycle (2004) 1.02
The human oxidative DNA glycosylase NEIL1 excises psoralen-induced interstrand DNA cross-links in a three-stranded DNA structure. J Biol Chem (2009) 1.01
DNA polymerase kappa produces interrupted mutations and displays polar pausing within mononucleotide microsatellite sequences. Nucleic Acids Res (2007) 1.01
The p12 subunit of human polymerase delta modulates the rate and fidelity of DNA synthesis. Biochemistry (2010) 1.01
Deregulated DNA polymerase beta strengthens ionizing radiation-induced nucleotidic and chromosomal instabilities. Oncogene (2002) 0.99
Active site mutations in mammalian DNA polymerase delta alter accuracy and replication fork progression. J Biol Chem (2010) 0.99
Upregulation of error-prone DNA polymerases beta and kappa slows down fork progression without activating the replication checkpoint. Cell Cycle (2007) 0.99
Distinctive activities of DNA polymerases during human DNA replication. FEBS J (2006) 0.99
X-chromosome targeting and dosage compensation are mediated by distinct domains in MSL-3. EMBO Rep (2006) 0.98
Localisation of human DNA polymerase kappa to replication foci. J Cell Sci (2002) 0.98
Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site. J Biol Chem (2002) 0.97
Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans. DNA Repair (Amst) (2013) 0.97
Characterization of human DNA polymerase delta and its subassemblies reconstituted by expression in the MultiBac system. PLoS One (2012) 0.97
The human specialized DNA polymerases and non-B DNA: vital relationships to preserve genome integrity. J Mol Biol (2013) 0.96
p210 BCR/ABL kinase regulates nucleotide excision repair (NER) and resistance to UV radiation. Blood (2003) 0.96
DNA polymerase beta can incorporate ribonucleotides during DNA synthesis of undamaged and CPD-damaged DNA. J Mol Biol (2003) 0.96
Interplay between DNA repair and inflammation, and the link to cancer. Crit Rev Biochem Mol Biol (2014) 0.96
Involvement of DNA polymerase beta in DNA replication and mutagenic consequences. J Mol Biol (2002) 0.95
Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia. PLoS One (2008) 0.95
Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage. Cell Cycle (2012) 0.95
A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase. J Biol Chem (2013) 0.93
Tumor-specific microsatellite instability: do distinct mechanisms underlie the MSI-L and EMAST phenotypes? Mutat Res (2012) 0.93