Published in Genes Cancer on November 01, 2012
The capable ABL: what is its biological function? Mol Cell Biol (2014) 1.00
RB1: a prototype tumor suppressor and an enigma. Genes Dev (2016) 0.93
The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death. Autophagy (2013) 0.89
Activation of p107 by fibroblast growth factor, which is essential for chondrocyte cell cycle exit, is mediated by the protein phosphatase 2A/B55α holoenzyme. Mol Cell Biol (2013) 0.82
The retinoblastoma tumor suppressor promotes efficient human cytomegalovirus lytic replication. J Virol (2015) 0.80
Retinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategies. World J Stem Cells (2016) 0.79
Early and Late G1/S Cyclins and Cdks Act Complementarily to Enhance Authentic Human β-Cell Proliferation and Expansion. Diabetes (2015) 0.79
The role of high cell density in the promotion of neuroendocrine transdifferentiation of prostate cancer cells. Mol Cancer (2014) 0.79
Transcriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53. Mol Biol Cell (2016) 0.78
SUMOylation of Rb enhances its binding with CDK2 and phosphorylation at early G1 phase. Cell Cycle (2016) 0.77
Kaempferol Induces Cell Cycle Arrest in HT-29 Human Colon Cancer Cells. J Cancer Prev (2013) 0.77
Differentiation resistance through altered retinoblastoma protein function in acute lymphoblastic leukemia: in silico modeling of the deregulations in the G1/S restriction point pathway. BMC Syst Biol (2016) 0.77
PRMT4-mediated arginine methylation negatively regulates retinoblastoma tumor suppressor protein and promotes E2F-1 dissociation. Mol Cell Biol (2014) 0.76
SENP1-modulated sumoylation regulates retinoblastoma protein (RB) and Lamin A/C interaction and stabilization. Oncogene (2016) 0.76
Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression. Nucleic Acids Res (2015) 0.76
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence. Cancer Lett (2017) 0.75
Translating the histone code. Science (2001) 56.77
Chromatin modifications and their function. Cell (2007) 55.98
Cancer cell cycles. Science (1996) 21.29
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science (2009) 20.49
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell (2007) 17.98
Cell cycle checkpoints: preventing an identity crisis. Science (1996) 13.74
The regulation of E2F by pRB-family proteins. Genes Dev (1998) 12.77
A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A (2008) 10.07
Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature (1998) 8.75
A tissue-specific atlas of mouse protein phosphorylation and expression. Cell (2010) 8.65
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal (2010) 8.61
Rb targets histone H3 methylation and HP1 to promoters. Nature (2001) 8.26
The RB and p53 pathways in cancer. Cancer Cell (2002) 8.02
PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse. Nucleic Acids Res (2011) 7.84
Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell (2011) 7.30
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science (2011) 6.75
The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell (1989) 6.68
Differential regulation and properties of MAPKs. Oncogene (2007) 6.36
Mechanisms of specificity in protein phosphorylation. Nat Rev Mol Cell Biol (2007) 6.11
Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature (2003) 6.01
Distinct roles for E2F proteins in cell growth control and apoptosis. Proc Natl Acad Sci U S A (1997) 5.83
p300/CBP proteins: HATs for transcriptional bridges and scaffolds. J Cell Sci (2001) 5.74
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science (2011) 5.73
A decade of CDK5. Nat Rev Mol Cell Biol (2001) 5.24
Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer (2008) 5.19
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet (2000) 5.09
Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell (1999) 4.94
Identification of multiple cyclin subunits of human P-TEFb. Genes Dev (1998) 4.73
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nat Cell Biol (2004) 4.72
The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J (1996) 4.55
The retinoblastoma tumour suppressor in development and cancer. Nat Rev Cancer (2002) 4.48
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Mol Cell Proteomics (2011) 4.40
E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway. Cancer Res (1996) 4.14
Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis. Curr Mol Med (2006) 3.86
A curated compendium of phosphorylation motifs. Nat Biotechnol (2007) 3.79
RB and cell cycle progression. Oncogene (2006) 3.77
Modulation of p53 function by SET8-mediated methylation at lysine 382. Mol Cell (2007) 3.68
Tyrosine phosphorylation: thirty years and counting. Curr Opin Cell Biol (2009) 3.31
Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Proc Natl Acad Sci U S A (2006) 3.26
Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature (2001) 3.25
Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. J Biol Chem (1997) 3.18
The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J (1991) 3.15
MAP kinase pathways. J Cell Sci (2005) 3.04
Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature (1997) 2.98
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal (2009) 2.92
The Aurora kinase family in cell division and cancer. Biochim Biophys Acta (2008) 2.84
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Cell (1993) 2.80
Interaction between ATM protein and c-Abl in response to DNA damage. Nature (1997) 2.70
Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol Biol Cell (1997) 2.67
Is there a code embedded in proteins that is based on post-translational modifications? Nat Rev Mol Cell Biol (2008) 2.64
Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein. Nature (1997) 2.60
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal (2011) 2.54
Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase. Nat Med (2001) 2.51
Loss of pRB causes centromere dysfunction and chromosomal instability. Genes Dev (2010) 2.50
Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma. Mol Cell (2009) 2.50
p38(MAPK): stress responses from molecular mechanisms to therapeutics. Trends Mol Med (2009) 2.44
Mdm2-mediated ubiquitylation: p53 and beyond. Cell Death Differ (2010) 2.43
Phosphoserine/threonine-binding domains. Curr Opin Cell Biol (2001) 2.40
Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell (2009) 2.39
Inside the human cancer tyrosine phosphatome. Nat Rev Cancer (2011) 2.38
PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. Proc Natl Acad Sci U S A (1994) 2.29
MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. Mol Cell (2005) 2.29
The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor. Genes Dev (2010) 2.27
Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation. Mol Cell Biol (1997) 2.25
Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites. J Biol Chem (1996) 2.23
Heterochromatin protein 1: don't judge the book by its cover! Curr Opin Genet Dev (2006) 2.20
Non-classical p38 map kinase functions: cell cycle checkpoints and survival. Int J Biol Sci (2008) 2.18
Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive. Genes Dev (2010) 2.12
Phosphotyrosine-binding domains in signal transduction. Nat Rev Mol Cell Biol (2002) 2.09
Acetylation control of the retinoblastoma tumour-suppressor protein. Nat Cell Biol (2001) 2.05
Transcriptional repression by the retinoblastoma protein through the recruitment of a histone methyltransferase. Mol Cell Biol (2001) 2.00
Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. Mol Cell (2008) 1.99
Enhanced SMYD3 expression is essential for the growth of breast cancer cells. Cancer Sci (2006) 1.90
The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis. Mol Cell (2006) 1.90
Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell (2005) 1.90
Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response. DNA Repair (Amst) (2009) 1.89
Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein. Proc Natl Acad Sci U S A (2003) 1.88
Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response. Mol Cell Proteomics (2010) 1.81
Cyclin C/cdk3 promotes Rb-dependent G0 exit. Cell (2004) 1.81
Regulation of cell death by the Abl tyrosine kinase. Oncogene (2000) 1.81
Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication. Nucleic Acids Res (2011) 1.78
Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo. Mol Cell Biol (2001) 1.78
Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint. Mol Cell Biol (1996) 1.75
Methylation of the retinoblastoma tumor suppressor by SMYD2. J Biol Chem (2010) 1.73
Proapoptotic function of the retinoblastoma tumor suppressor protein. Cancer Cell (2009) 1.73
Raf family kinases: old dogs have learned new tricks. Genes Cancer (2011) 1.72
Retinoblastoma family proteins as key targets of the small DNA virus oncoproteins. Oncogene (2006) 1.71
Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb. Proc Natl Acad Sci U S A (1997) 1.67
14-3-3 proteins as signaling integration points for cell cycle control and apoptosis. Semin Cell Dev Biol (2011) 1.65
Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation. Mol Cell Biol (1998) 1.63
Chromosomal instability and cancer: a complex relationship with therapeutic potential. J Clin Invest (2012) 1.62
Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons. Cell Cycle (2012) 1.62
The nuclear tyrosine kinase c-Abl negatively regulates cell growth. Cell (1994) 1.62
Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes. Curr Opin Genet Dev (2002) 1.58
Substrate discrimination among mitogen-activated protein kinases through distinct docking sequence motifs. J Biol Chem (2008) 1.57
CDC25B mediates rapamycin-induced oncogenic responses in cancer cells. Cancer Res (2009) 1.57
Structural basis of substrate methylation and inhibition of SMYD2. Structure (2011) 1.54
Phosphorylation-induced conformational changes in the retinoblastoma protein inhibit E2F transactivation domain binding. J Biol Chem (2010) 1.54
Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily. Genes Dev (2001) 1.54
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J (2007) 1.52
Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. Nat Cell Biol (2006) 2.60
Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive. Genes Dev (2010) 2.12
The retinoblastoma protein regulates pericentric heterochromatin. Mol Cell Biol (2006) 1.68
The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle. Cell Div (2012) 1.46
A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescence. Mol Cell Biol (2009) 1.23
An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein. Nat Struct Mol Biol (2010) 1.20
DNA damage signals through differentially modified E2F1 molecules to induce apoptosis. Mol Cell Biol (2011) 1.03
The biochemical basis of CDK phosphorylation-independent regulation of E2F1 by the retinoblastoma protein. Biochem J (2011) 1.03
Regulation of transcription and chromatin structure by pRB: here, there and everywhere. Cell Cycle (2012) 0.99
Chromosome instability and deregulated proliferation: an unavoidable duo. Cell Mol Life Sci (2012) 0.99
A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development. Mol Cell Biol (2009) 0.97
A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice. Mol Cell Biol (2014) 0.95
Analysis of cell cycle position in mammalian cells. J Vis Exp (2012) 0.91
A cancer derived mutation in the retinoblastoma gene with a distinct defect for LXCXE dependent interactions. Cancer Cell Int (2010) 0.88
Conserved region 3 of human papillomavirus 16 E7 contributes to deregulation of the retinoblastoma tumor suppressor. J Virol (2012) 0.87
Mutation of the LXCXE binding cleft of pRb facilitates transformation by ras in vitro but does not promote tumorigenesis in vivo. PLoS One (2013) 0.87
Analyzing RB and E2F during the G1-S transition. Methods Mol Biol (2014) 0.81
A context-specific role for retinoblastoma protein-dependent negative growth control in suppressing mammary tumorigenesis. PLoS One (2011) 0.81
Cell Synchronization of Mouse Embryonic Fibroblasts. Methods Mol Biol (2016) 0.77