Epigenetic Modulations of Induced Pluripotent Stem Cells: Novel Therapies and Disease Models.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 23646061)

Published in Drug Discov Today Dis Models on January 01, 2012

Authors

Chengyang Huang1, Joseph C Wu

Author Affiliations

1: Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA ; Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA ; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Articles cited by this

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51

Induced pluripotent stem cell lines derived from human somatic cells. Science (2007) 71.50

Generation of germline-competent induced pluripotent stem cells. Nature (2007) 32.77

Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24

The mammalian epigenome. Cell (2007) 18.13

Human induced pluripotent stem cells free of vector and transgene sequences. Science (2009) 17.16

Disease-specific induced pluripotent stem cells. Cell (2008) 16.95

Dissecting direct reprogramming through integrative genomic analysis. Nature (2008) 16.47

Stability and flexibility of epigenetic gene regulation in mammalian development. Nature (2007) 14.57

Epigenetic memory in induced pluripotent stem cells. Nature (2010) 14.31

Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science (2008) 14.26

Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell (2010) 14.18

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature (2011) 13.94

Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell (2009) 13.02

Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (2007) 12.41

Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature (2008) 12.21

Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet (2009) 12.08

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature (2009) 11.27

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol (2008) 10.97

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet (2009) 10.54

Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell (2009) 10.52

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol (2008) 10.29

Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature (2009) 9.29

Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol (2010) 9.24

Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N Engl J Med (2010) 9.19

Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell (2009) 8.62

Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell (2008) 7.79

Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol (2009) 7.59

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A (2008) 7.52

The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature (2009) 7.39

Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature (2010) 7.05

Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell (2011) 6.11

Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells. Nat Cell Biol (2011) 4.77

A nonviral minicircle vector for deriving human iPS cells. Nat Methods (2010) 4.42

Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature (2010) 4.38

Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. Cell Stem Cell (2011) 3.73

Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells (2010) 3.53

Reprogramming factor expression initiates widespread targeted chromatin remodeling. Cell Stem Cell (2011) 3.16

Transcriptional signature and memory retention of human-induced pluripotent stem cells. PLoS One (2009) 3.07

Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus. Stem Cells (2006) 3.07

Lab-specific gene expression signatures in pluripotent stem cells. Cell Stem Cell (2010) 2.95

Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells. Circulation (2009) 2.93

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc Natl Acad Sci U S A (1994) 2.92

Histone H3 Lys 4 methylation: caught in a bind? Genes Dev (2006) 2.86

Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes. PLoS One (2008) 2.85

Harnessing the potential of induced pluripotent stem cells for regenerative medicine. Nat Cell Biol (2011) 2.74

Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells. J Clin Invest (2011) 2.69

Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors. Proc Natl Acad Sci U S A (2011) 2.51

Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer. Biochem Biophys Res Commun (2005) 2.43

Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts. Proc Natl Acad Sci U S A (2008) 2.25

DNA methylation dynamics in human induced pluripotent stem cells over time. PLoS Genet (2011) 2.00

ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency. Cell Stem Cell (2010) 1.98

Clone- and gene-specific aberrations of parental imprinting in human induced pluripotent stem cells. Stem Cells (2009) 1.98

Heterogeneity of pluripotent marker gene expression in colonies generated in human iPS cell induction culture. Stem Cell Res (2008) 1.97

Molecular analyses of human induced pluripotent stem cells and embryonic stem cells. Cell Stem Cell (2010) 1.81

Histone deacetylase inhibitors: from bench to clinic. J Med Chem (2008) 1.79

Memory in induced pluripotent stem cells: reprogrammed human retinal-pigmented epithelial cells show tendency for spontaneous redifferentiation. Stem Cells (2010) 1.71

G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells. Stem Cells (2008) 1.68

Butyrate promotes induced pluripotent stem cell generation. J Biol Chem (2010) 1.48

PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming. Stem Cells (2011) 1.37

Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4. Cell Res (2010) 1.33

Human iPS cell-based therapy: considerations before clinical applications. Cell Cycle (2010) 1.29

Epigenetic reprogramming--taking a lesson from the embryo. Curr Opin Cell Biol (2010) 1.09

Recreating pluripotency? Cell Stem Cell (2010) 1.02

Advances in the computational development of DNA methyltransferase inhibitors. Drug Discov Today (2011) 0.90

Articles by these authors

(truncated to the top 100)

In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Circulation (2006) 4.48

A nonviral minicircle vector for deriving human iPS cells. Nat Methods (2010) 4.42

Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. Cell Stem Cell (2012) 3.66

Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Proc Natl Acad Sci U S A (2009) 3.57

Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. Sci Transl Med (2012) 3.53

An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells. Nat Biotechnol (2011) 3.05

Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells. PLoS One (2010) 2.86

Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes. PLoS One (2008) 2.85

Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells. J Clin Invest (2011) 2.69

Imaging survival and function of transplanted cardiac resident stem cells. J Am Coll Cardiol (2009) 2.58

Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation (2013) 2.57

MicroRNA profiling of human-induced pluripotent stem cells. Stem Cells Dev (2009) 2.44

Short-term immunosuppression promotes engraftment of embryonic and induced pluripotent stem cells. Cell Stem Cell (2011) 2.35

Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell (2013) 2.33

MicroRNA-210 as a novel therapy for treatment of ischemic heart disease. Circulation (2010) 2.32

Effects of cell number on teratoma formation by human embryonic stem cells. Cell Cycle (2009) 2.30

Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts. Proc Natl Acad Sci U S A (2008) 2.25

Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells: role for miR-499. Circ Cardiovasc Genet (2010) 2.24

Comparison of different adult stem cell types for treatment of myocardial ischemia. Circulation (2008) 2.22

Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease. Circulation (2007) 2.21

Human cardiac progenitor cells engineered with Pim-I kinase enhance myocardial repair. J Am Coll Cardiol (2012) 2.18

Patient-specific stem cells and cardiovascular drug discovery. JAMA (2013) 2.06

Dissecting the molecular relationship among various cardiogenic progenitor cells. Circ Res (2013) 2.06

Effects of intracoronary CD34+ stem cell transplantation in nonischemic dilated cardiomyopathy patients: 5-year follow-up. Circ Res (2012) 2.02

Molecular imaging of bone marrow mononuclear cell homing and engraftment in ischemic myocardium. Stem Cells (2007) 1.93

Comparison of reporter gene and iron particle labeling for tracking fate of human embryonic stem cells and differentiated endothelial cells in living subjects. Stem Cells (2008) 1.90

Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nucleases for cellular imaging. Circ Res (2012) 1.84

Multimodality cardiovascular molecular imaging, Part II. Circ Cardiovasc Imaging (2009) 1.82

In vivo functional and transcriptional profiling of bone marrow stem cells after transplantation into ischemic myocardium. Arterioscler Thromb Vasc Biol (2011) 1.80

Human germ cell differentiation from fetal- and adult-derived induced pluripotent stem cells. Hum Mol Genet (2010) 1.79

Quantum dot imaging for embryonic stem cells. BMC Biotechnol (2007) 1.78

Microfluidic single-cell analysis shows that porcine induced pluripotent stem cell-derived endothelial cells improve myocardial function by paracrine activation. Circ Res (2012) 1.74

Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart. Transplantation (2009) 1.73

Spatial and temporal kinetics of teratoma formation from murine embryonic stem cell transplantation. Stem Cells Dev (2007) 1.65

Functional and transcriptional characterization of human embryonic stem cell-derived endothelial cells for treatment of myocardial infarction. PLoS One (2009) 1.64

Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation. Cloning Stem Cells (2007) 1.62

Trafficking mesenchymal stem cell engraftment and differentiation in tumor-bearing mice by bioluminescence imaging. Stem Cells (2009) 1.58

Positron emission tomography imaging of conditional gene activation in the heart. J Mol Cell Cardiol (2007) 1.56

Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation (2013) 1.54

Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction. Circulation (2009) 1.54

Microfluidic single-cell real-time PCR for comparative analysis of gene expression patterns. Nat Protoc (2012) 1.53

Effects of epigenetic modulation on reporter gene expression: implications for stem cell imaging. FASEB J (2005) 1.52

Molecular imaging of bone marrow mononuclear cell survival and homing in murine peripheral artery disease. JACC Cardiovasc Imaging (2012) 1.49

Novel microRNA prosurvival cocktail for improving engraftment and function of cardiac progenitor cell transplantation. Circulation (2011) 1.48

In vivo imaging of embryonic stem cells reveals patterns of survival and immune rejection following transplantation. Stem Cells Dev (2008) 1.46

Novel minicircle vector for gene therapy in murine myocardial infarction. Circulation (2009) 1.45

Human neural stem cell grafts modify microglial response and enhance axonal sprouting in neonatal hypoxic-ischemic brain injury. Stroke (2010) 1.44

Chronotherapeutics (light and wake therapy) in affective disorders. Psychol Med (2005) 1.42

Embryonic stem cell-derived endothelial cells engraft into the ischemic hindlimb and restore perfusion. Arterioscler Thromb Vasc Biol (2010) 1.42

MicroRNA-302 increases reprogramming efficiency via repression of NR2F2. Stem Cells (2013) 1.41

Imaging gene expression in human mesenchymal stem cells: from small to large animals. Radiology (2009) 1.37

18F-labeled bombesin analogs for targeting GRP receptor-expressing prostate cancer. J Nucl Med (2006) 1.37

Short hairpin RNA interference therapy for ischemic heart disease. Circulation (2008) 1.34

Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes. PLoS One (2011) 1.34

Molecular and magnetic resonance imaging of human embryonic stem cell-derived neural stem cell grafts in ischemic rat brain. Mol Ther (2009) 1.34

Comparison of imaging techniques for tracking cardiac stem cell therapy. J Nucl Med (2007) 1.33

A PET study of the pathophysiology of negative symptoms in schizophrenia. Positron emission tomography. Am J Psychiatry (2002) 1.32

Imaging: guiding the clinical translation of cardiac stem cell therapy. Circ Res (2011) 1.30

Generation of adult human induced pluripotent stem cells using nonviral minicircle DNA vectors. Nat Protoc (2010) 1.30

Human iPS cell-based therapy: considerations before clinical applications. Cell Cycle (2010) 1.29

Noninvasive de novo imaging of human embryonic stem cell-derived teratoma formation. Cancer Res (2009) 1.28

Comparison of optical bioluminescence reporter gene and superparamagnetic iron oxide MR contrast agent as cell markers for noninvasive imaging of cardiac cell transplantation. Mol Imaging Biol (2008) 1.27

Long term non-invasive imaging of embryonic stem cells using reporter genes. Nat Protoc (2009) 1.27

Multimodality cardiovascular molecular imaging, part I. Circ Cardiovasc Imaging (2008) 1.25

Cardiovascular molecular imaging: focus on clinical translation. Circulation (2011) 1.24

Report of the National Heart, Lung, and Blood Institute working group on the translation of cardiovascular molecular imaging. Circulation (2011) 1.23

CRY2 is associated with depression. PLoS One (2010) 1.23

Effects of ionizing radiation on self-renewal and pluripotency of human embryonic stem cells. Cancer Res (2010) 1.23

The use of human mesenchymal stem cells encapsulated in RGD modified alginate microspheres in the repair of myocardial infarction in the rat. Biomaterials (2010) 1.20

In vivo bioluminescence for tracking cell fate and function. Am J Physiol Heart Circ Physiol (2011) 1.20

Molecular imaging of human embryonic stem cells: keeping an eye on differentiation, tumorigenicity and immunogenicity. Cell Cycle (2006) 1.19

Clonal precursor of bone, cartilage, and hematopoietic niche stromal cells. Proc Natl Acad Sci U S A (2013) 1.19

Immunogenicity of pluripotent stem cells and their derivatives. Circ Res (2013) 1.19

Derivation of human induced pluripotent stem cells for cardiovascular disease modeling. Circ Res (2011) 1.17

Genetic modification of embryonic stem cells with VEGF enhances cell survival and improves cardiac function. Cloning Stem Cells (2007) 1.17

Functional characterization and expression profiling of human induced pluripotent stem cell- and embryonic stem cell-derived endothelial cells. Stem Cells Dev (2011) 1.17

Tumorigenicity of pluripotent stem cells: biological insights from molecular imaging. J R Soc Interface (2010) 1.16

Comparison of transendocardial and intracoronary CD34+ cell transplantation in patients with nonischemic dilated cardiomyopathy. Circulation (2013) 1.16

In vivo directed differentiation of pluripotent stem cells for skeletal regeneration. Proc Natl Acad Sci U S A (2012) 1.14

Double knockdown of prolyl hydroxylase and factor-inhibiting hypoxia-inducible factor with nonviral minicircle gene therapy enhances stem cell mobilization and angiogenesis after myocardial infarction. Circulation (2011) 1.14

Early stem cell engraftment predicts late cardiac functional recovery: preclinical insights from molecular imaging. Circ Cardiovasc Imaging (2012) 1.13

Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation. Arterioscler Thromb Vasc Biol (2012) 1.12

Tracking cardiac engraftment and distribution of implanted bone marrow cells: Comparing intra-aortic, intravenous, and intramyocardial delivery. J Thorac Cardiovasc Surg (2009) 1.12

Nonintegrating knockdown and customized scaffold design enhances human adipose-derived stem cells in skeletal repair. Stem Cells (2011) 1.11

Atomic force mechanobiology of pluripotent stem cell-derived cardiomyocytes. PLoS One (2012) 1.11

Image-guided cardiac cell delivery using high-resolution small-animal ultrasound. Mol Ther (2005) 1.11

Micro-positron emission tomography imaging of cardiac gene expression in rats using bicistronic adenoviral vector-mediated gene delivery. Circulation (2004) 1.10

Differences in osteogenic differentiation of adipose-derived stromal cells from murine, canine, and human sources in vitro and in vivo. Plast Reconstr Surg (2011) 1.10

Construction and validation of nano gold tripods for molecular imaging of living subjects. J Am Chem Soc (2014) 1.10

The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells. J Biol Chem (2013) 1.09

Induced pluripotent stem cells as a disease modeling and drug screening platform. J Cardiovasc Pharmacol (2012) 1.09

Imaging of VEGF receptor in a rat myocardial infarction model using PET. J Nucl Med (2008) 1.09

Overview of stem cells and imaging modalities for cardiovascular diseases. J Nucl Cardiol (2006) 1.08

Timing of bone marrow cell delivery has minimal effects on cell viability and cardiac recovery after myocardial infarction. Circ Cardiovasc Imaging (2009) 1.08

Molecular imaging of stem cells: tracking survival, biodistribution, tumorigenicity, and immunogenicity. Theranostics (2012) 1.08

In vivo imaging and evaluation of different biomatrices for improvement of stem cell survival. J Tissue Eng Regen Med (2008) 1.07

mTORC1 and mTORC2 play different roles in the functional survival of transplanted adipose-derived stromal cells in hind limb ischemic mice via regulating inflammation in vivo. Stem Cells (2013) 1.07

In vitro and in vivo bioluminescence reporter gene imaging of human embryonic stem cells. J Vis Exp (2008) 1.06

Comparison of human induced pluripotent and embryonic stem cells: fraternal or identical twins? Mol Ther (2011) 1.05

Dynamic microRNA expression during the transition from right ventricular hypertrophy to failure. Physiol Genomics (2012) 1.05