Published in Endocr Dev on April 25, 2013
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron (2003) 6.05
Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab (2006) 3.14
Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci U S A (2004) 2.99
Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol (2003) 2.73
Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism. Neuron (2012) 2.30
Mutations in NR4A2 associated with familial Parkinson disease. Nat Genet (2002) 2.27
Ghrelin promotes thymopoiesis during aging. J Clin Invest (2007) 1.83
Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology (2006) 1.67
Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance. Endocrinology (2007) 1.64
Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers. Mol Endocrinol (2006) 1.53
An age-dependent interaction with leptin unmasks ghrelin's bone-protective effects. Endocrinology (2012) 1.50
Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexia. J Clin Endocrinol Metab (2005) 1.42
Aging leads to a programmed loss of brown adipocytes in murine subcutaneous white adipose tissue. Aging Cell (2012) 1.26
Cyclin D3 maintains growth-inhibitory activity of C/EBPalpha by stabilizing C/EBPalpha-cdk2 and C/EBPalpha-Brm complexes. Mol Cell Biol (2006) 1.22
Ghrelin and growth hormone secretagogue receptor expression in mice during aging. Endocrinology (2006) 1.18
Desensitization and endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor 1a. Endocrinology (2003) 1.17
An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain. J Neurosci (2002) 1.15
Ghrelin prevents cisplatin-induced mechanical hyperalgesia and cachexia. Endocrinology (2007) 1.06
Deficient ghrelin receptor-mediated signaling compromises thymic stromal cell microenvironment by accelerating thymic adiposity. J Biol Chem (2008) 1.06
Central and peripheral roles of ghrelin on glucose homeostasis. Neuroendocrinology (2007) 1.05
Growth hormone corrects proliferation and transcription of phosphoenolpyruvate carboxykinase in livers of old mice via elimination of CCAAT/enhancer-binding protein alpha-Brm complex. J Biol Chem (2006) 1.03
Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release. Proc Natl Acad Sci U S A (2012) 1.02
The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice. Proc Natl Acad Sci U S A (2009) 1.02
Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (citric acid) tastants. PLoS One (2010) 1.01
Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice. J Clin Invest (2013) 0.99
Restricted feeding-induced sleep, activity, and body temperature changes in normal and preproghrelin-deficient mice. Am J Physiol Regul Integr Comp Physiol (2009) 0.99
The growth hormone secretagogue receptor. Vitam Horm (2008) 0.97
Unacylated ghrelin rapidly modulates lipogenic and insulin signaling pathway gene expression in metabolically active tissues of GHSR deleted mice. PLoS One (2010) 0.97
Spontaneous sleep and homeostatic sleep regulation in ghrelin knockout mice. Am J Physiol Regul Integr Comp Physiol (2007) 0.93
Inhibition of cisplatin-induced lipid catabolism and weight loss by ghrelin in male mice. Endocrinology (2013) 0.91
Ghrelin is dispensable for embryonic pancreatic islet development and differentiation. Regul Pept (2009) 0.88
Increased expression of CYP24A1 correlates with advanced stages of prostate cancer and can cause resistance to vitamin D3-based therapies. FASEB J (2013) 0.88
Physiological roles revealed by ghrelin and ghrelin receptor deficient mice. Peptides (2011) 0.87
Brown-to-white transition in subcutaneous fat: linking aging and disease. Aging (Albany NY) (2012) 0.86
Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1. Arthritis Rheumatol (2014) 0.86
Growth hormone secretagogue receptor (GHS-R1a) knockout mice exhibit improved spatial memory and deficits in contextual memory. Behav Brain Res (2012) 0.85
Growth hormone secretagogues modulate the electrical and contractile properties of rat skeletal muscle through a ghrelin-specific receptor. Br J Pharmacol (2003) 0.83
The steroidogenic acute regulatory protein is expressed in steroidogenic cells of the day-old brain. Endocrinology (2004) 0.83
Impact of food restriction and cocaine on locomotion in ghrelin- and ghrelin-receptor knockout mice. Addict Biol (2010) 0.82
Antidiabetic activity of a highly potent and selective nonpeptide somatostatin receptor subtype-2 agonist. Endocrinology (2006) 0.81
Reduction in hypophyseal growth hormone and prolactin expression due to deficiency in ghrelin receptor signaling is associated with Pit-1 suppression: relevance to the immune system. Brain Behav Immun (2008) 0.81
Assessing interactions between Ghsr and Mc3r reveals a role for AgRP in the expression of food anticipatory activity in male mice. Endocrinology (2014) 0.80
Genetic manipulation of the ghrelin signaling system in male mice reveals bone compartment specificity of acylated and unacylated ghrelin in the regulation of bone remodeling. Endocrinology (2014) 0.79
Agonist-specific coupling of growth hormone secretagogue receptor type 1a to different intracellular signaling systems. Role of adenosine. Neuroendocrinology (2004) 0.78
Nonhereditary enhancement of progeny growth. Endocrinology (2002) 0.75