Published in Proc Natl Acad Sci U S A on July 01, 1990
Cerebellar Purkinje cells incorporate immunoglobulins and immunotoxins in vitro: implications for human neurological disease and immunotherapeutics. J Neuroinflammation (2009) 0.97
Recombinant Immunotoxin Therapy of Solid Tumors: Challenges and Strategies. J Basic Clin Med (2013) 0.78
Effects of hyperbilirubinaemia on glutathione S-transferase isoenzymes in cerebellar cortex of the Gunn rat. Biochem J (1993) 0.78
Diphtheria toxin. Annu Rev Biochem (1977) 8.44
Diphtheria toxin and related proteins. I. Isolation and properties of mutant proteins serologically related to diphtheria toxin. J Biol Chem (1973) 3.78
Phase and electron microscopic studies of experimental demyelination. II. Schwann cell changes in guinea pig sciatic nerves during experimental diphtheritic neuritis. J Neuropathol Exp Neurol (1961) 3.02
Mechanism of membrane damage mediated by human eosinophil cationic protein. Nature (1986) 2.41
Binding of triton X-100 to diphtheria toxin, crossreacting material 45, and their fragments. Proc Natl Acad Sci U S A (1976) 2.27
NEUROLOGICAL SEQUELAE FOLLOWING DILANTIN OVERDOSE IN A PATIENT AND IN EXPERIMENTAL ANIMALS. Neurology (1965) 1.93
Neurotoxicity of human eosinophils. Proc Natl Acad Sci U S A (1979) 1.89
Monoclonal antibodies against human T lymphocytes label Purkinje neurones of many species. Nature (1982) 1.85
Immunotoxins. Cell (1986) 1.82
Redesigning nature's poisons to create anti-tumor reagents. Science (1987) 1.81
Diphtheria toxin and related proteins: effect of route of injection on toxicity and the determination of cytotoxicity for various cultured cells. J Infect Dis (1982) 1.67
Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease. Proc Natl Acad Sci U S A (1986) 1.67
Ribonuclease activity associated with human eosinophil-derived neurotoxin and eosinophil cationic protein. J Immunol (1986) 1.65
Experimental study of diphtheritic polyneuritis in the rabbit and guinea pig. III. The bloodnerve barrier in the rabbit. J Neuropathol Exp Neurol (1961) 1.48
Intraneural injection of diphtheria toxin. Br J Exp Pathol (1966) 1.44
Kinetics of protein synthesis inactivation by ricin-anti-Thy 1.1 monoclonal antibody hybrids. Role of the ricin B subunit demonstrated by reconstitution. J Biol Chem (1982) 1.31
Diphtheritic polyneuritis; a pathological study. J Neuropathol Exp Neurol (1956) 1.26
Base cleavage specificity of angiogenin with Saccharomyces cerevisiae and Escherichia coli 5S RNAs. Biochemistry (1988) 1.26
Mutations in diphtheria toxin separate binding from entry and amplify immunotoxin selectivity. Science (1987) 1.25
Expression of soluble and fully functional ricin A chain in Escherichia coli is temperature-sensitive. J Biol Chem (1988) 1.16
Angiogenin abolishes cell-free protein synthesis by specific ribonucleolytic inactivation of ribosomes. Proc Natl Acad Sci U S A (1987) 1.08
Cerebellar degeneration following long-term phenytoin therapy. Neurology (1976) 1.05
Suicide transport: destruction of neurons by retrograde transport of ricin, abrin, and modeccin. Science (1982) 1.04
The role of the diphtheria toxin receptor in cytosol translocation. J Biol Chem (1988) 1.03
Autoimmune pathogenesis of paraneoplastic neurological syndromes. Crit Rev Neurobiol (1987) 0.99
Selective extraction of small and large molecules from the cerebrospinal fluid by Purkinje neurons. Science (1985) 0.96
Anti-Thy-1 immunotoxin, OX7-saporin, destroys cerebellar Purkinje cells after intraventricular injection in rats. Brain Res (1989) 0.89
Intraneuronal accumulation of myeloma proteins. Arch Neurol (1985) 0.85
In vitro studies on the comparative sensitivities of cells of the central nervous system to diphtheria toxin. J Neurol Sci (1985) 0.80
Quantitative analysis of ethanol effects on Purkinje cell dendritic tree. Brain Res (1982) 0.80
Selective uptake by Purkinje neurons of antibodies to S-100 protein. Exp Neurol (1987) 0.79
Cell lineage relationships in the development of the mammalian CNS: role of cell lineage in control of cerebellar Purkinje cell number. Dev Biol (1986) 0.78
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell (2001) 10.33
Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol (1997) 9.18
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc Natl Acad Sci U S A (1997) 7.25
Structure of Bax: coregulation of dimer formation and intracellular localization. Cell (2000) 7.00
Nonionic detergents induce dimerization among members of the Bcl-2 family. J Biol Chem (1997) 5.95
Conformation of the Bax C-terminus regulates subcellular location and cell death. EMBO J (1999) 5.10
Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations. J Biol Chem (1998) 4.71
Dynamics of mitochondrial morphology in healthy cells and during apoptosis. Cell Death Differ (2003) 3.75
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis. J Cell Biol (2001) 3.09
Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors. Nat Med (1997) 2.76
Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations. Proc Natl Acad Sci U S A (1999) 2.32
Engineering receptor-mediated cytotoxicity into human ribonucleases by steric blockade of inhibitor interaction. Nat Biotechnol (1999) 2.22
A study of the interferon antiviral mechanism: apoptosis activation by the 2-5A system. J Exp Med (1997) 2.15
The role of thrombin in gliomas. J Thromb Haemost (2005) 2.13
The role of free radicals and p53 in neuron apoptosis in vivo. J Neurosci (1995) 1.79
p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. J Cell Biol (2000) 1.74
Which came first, the cytochrome c release or the mitochondrial fission? Cell Death Differ (2006) 1.71
Organelle-specific Isozymes of Aspartate-alpha-Ketoglutarate Transaminase in Spinach Leaves. Plant Physiol (1976) 1.64
A cytotoxic ribonuclease. Study of the mechanism of onconase cytotoxicity. J Biol Chem (1993) 1.60
In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum. Neuron (1993) 1.58
Role of the N terminus in RNase A homologues: differences in catalytic activity, ribonuclease inhibitor interaction and cytotoxicity. J Mol Biol (1996) 1.57
Lymphocytic hypophysitis presenting with diabetes insipidus in a 14-year-old girl: case report and review of the literature. Eur J Pediatr (1997) 1.46
In vivo MR determination of water diffusion coefficients and diffusion anisotropy: correlation with structural alteration in gliomas of the cerebral hemispheres. AJNR Am J Neuroradiol (1995) 1.44
The mannose 6-phosphate receptor of Chinese Hamster ovary cells. Isolation of mutants with altered receptors. J Biol Chem (1981) 1.42
The role of 2'-5' oligoadenylate-activated ribonuclease L in apoptosis. Cell Death Differ (1998) 1.41
Anti-Thy 1.2 monoclonal antibody linked to ricin is a potent cell-type-specific toxin. Proc Natl Acad Sci U S A (1980) 1.36
Kinetics of protein synthesis inactivation by ricin-anti-Thy 1.1 monoclonal antibody hybrids. Role of the ricin B subunit demonstrated by reconstitution. J Biol Chem (1982) 1.31
Bcl-2 family interaction with the mitochondrial morphogenesis machinery. Cell Death Differ (2010) 1.31
The 2-5A system in viral infection and apoptosis. Biomed Pharmacother (1998) 1.30
Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak. Oncogene (2011) 1.28
Mutations in diphtheria toxin separate binding from entry and amplify immunotoxin selectivity. Science (1987) 1.25
Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. Mol Cell Biol (2001) 1.23
Bax translocation to mitochondria subsequent to a rapid loss of mitochondrial membrane potential. Cell Death Differ (2001) 1.22
Angiogenin is a cytotoxic, tRNA-specific ribonuclease in the RNase A superfamily. J Biol Chem (1992) 1.18
The C-terminal helix of Bcl-x(L) mediates Bax retrotranslocation from the mitochondria. Cell Death Differ (2012) 1.15
Monoclonal antibody-ricin or ricin A chain hybrids: kinetic analysis of cell killing for tumor therapy. Immunol Rev (1982) 1.13
Identification and characterization of a monoclonal antibody recognizing a galactose-binding domain of the toxin ricin. J Immunol (1987) 1.09
Cell surface and intracellular functions for ricin galactose binding. J Biol Chem (1992) 1.08
A study of the intracellular routing of cytotoxic ribonucleases. J Biol Chem (1995) 1.08
Ex-vivo treatment of donor bone marrow with anti-T-cell immunotoxins for prevention of graft-versus-host disease. Lancet (1984) 1.07
Hybridoma cells containing intracellular anti-ricin antibodies show ricin meets secretory antibody before entering the cytosol. J Biol Chem (1987) 1.06
The role of the diphtheria toxin receptor in cytosol translocation. J Biol Chem (1988) 1.03
Development and properties of fructose 1,6-bisphosphatase in the endosperm of castor-bean seedlings. Biochem J (1976) 1.03
Mitochondria in Ca2+ signaling and apoptosis. J Bioenerg Biomembr (2000) 1.03
Mitochondria, calcium and pro-apoptotic proteins as mediators in cell death signaling. Braz J Med Biol Res (2003) 1.02
Cloned fragment of diphtheria toxin linked to T cell-specific antibody identifies regions of B chain active in cell entry. J Biol Chem (1986) 1.01
Pharmacokinetic analysis of immunotoxin uptake in solid tumors: role of plasma kinetics, capillary permeability, and binding. Cancer Res (1990) 1.01
Magnetic resonance imaging of ethyl-nitrosourea-induced rat gliomas: a model for experimental therapeutics of low-grade gliomas. J Neurooncol (2001) 0.99
Comparison of RNases and toxins upon injection into Xenopus oocytes. J Biol Chem (1991) 0.99
Exogenous Bcl-xL fusion protein spares neurons after spinal cord injury. J Neurosci Res (2005) 0.99
Anti-T-cell reagents for human bone marrow transplantation: ricin linked to three monoclonal antibodies. Science (1983) 0.99
Ricin subunit association. Thermodynamics and the role of the disulfide bond in toxicity. J Biol Chem (1986) 0.97
Toxicity of an antitumor ribonuclease to Purkinje neurons. J Neurosci (1994) 0.97
Molecular determinants in the plasma clearance and tissue distribution of ribonucleases of the ribonuclease A superfamily. Cancer Res (1996) 0.97
X-ray crystallographic structure of recombinant eosinophil-derived neurotoxin at 1.83 A resolution. J Mol Biol (1996) 0.97
Studies on the galactose-binding site of ricin and the hybrid toxin Man6P-ricin. Cell (1981) 0.96
Use of multiple T cell-directed intact ricin immunotoxins for autologous bone marrow transplantation. Blood (1985) 0.96
Potent and specific killing of human malignant brain tumor cells by an anti-transferrin receptor antibody-ricin immunotoxin. J Neurosurg (1987) 0.96
Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons. Biochem Biophys Res Commun (1991) 0.96
Intraventricular immunotoxin therapy for leptomeningeal neoplasia. Neurosurgery (1997) 0.95
Cytotoxic potential of ribonuclease and ribonuclease hybrid proteins. J Biol Chem (1991) 0.94
Suppression of the immune response to immunotoxins with anti-CD4 monoclonal antibodies. J Immunol (1991) 0.92
Bax affects intracellular Ca2+ stores and induces Ca2+ wave propagation. Cell Death Differ (2004) 0.92
Shunt failure without ventriculomegaly proclaimed by ophthalmic findings. J Neurosurg (1994) 0.91
Characterization of the mechanism of cellular and cell free protein synthesis inhibition by an anti-tumor ribonuclease. Biochem Biophys Res Commun (1994) 0.91
Inhibition of HIV-1 production and selective degradation of viral RNA by an amphibian ribonuclease. J Biol Chem (1996) 0.91
Efficacy of direct intratumoral therapy with targeted protein toxins for solid human gliomas in nude mice. J Neurosurg (1994) 0.90
The spatial distribution of immunotoxins in solid tumors: assessment by quantitative autoradiography. Cancer Res (1993) 0.90
Caspase inhibition prevents the mitochondrial release of apoptosis-inducing factor. Cell Death Differ (2003) 0.90
Ricin linked to monophosphopentamannose binds to fibroblast lysosomal hydrolase receptors, resulting in a cell-type-specific toxin. Proc Natl Acad Sci U S A (1979) 0.90
Programmed cell death in heterokaryons. A study of the transfer of apoptosis between nuclei. Am J Pathol (1992) 0.90
Characterization of single-chain antibody (sFv)-toxin fusion proteins produced in vitro in rabbit reticulocyte lysate. J Biol Chem (1993) 0.90
Metopic synostosis: evaluation of aesthetic results. Plast Reconstr Surg (1994) 0.89
Pediatric midbrain tumors: a benign subgroup of brainstem gliomas. Pediatr Neurosurg (1995) 0.89
Efficacy of transferrin receptor-targeted immunotoxins in brain tumor cell lines and pediatric brain tumors. Cancer Res (1993) 0.88
Acute effects of the skeletal muscle-specific immunotoxin ricin-mAb 35 on extraocular muscles of rabbits. Invest Ophthalmol Vis Sci (2000) 0.88
Retinoic acid disrupts the Golgi apparatus and increases the cytosolic routing of specific protein toxins. J Cell Biol (1994) 0.88
Receptor-mediated transport of the hybrid protein ricin-diphtheria toxin fragment A with subsequent ADP-ribosylation of intracellular elongation factor II. J Biol Chem (1979) 0.88
Expression and characterization of recombinant human eosinophil-derived neurotoxin and eosinophil-derived neurotoxin-anti-transferrin receptor sFv. J Biol Chem (1994) 0.88
The role of proline 345 in diphtheria toxin translocation. J Biol Chem (1993) 0.88
Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein. J Biol Chem (2001) 0.87
Vascular protection by chloroquine during brain tumor therapy with Tf-CRM107. Cancer Res (2000) 0.87
Apoptosis and free radicals. Ann N Y Acad Sci (1994) 0.85
A point mutation of proline 308 in diphtheria toxin B chain inhibits membrane translocation of toxin conjugates. J Biol Chem (1989) 0.85
Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors. J Biol Chem (2001) 0.83
Cytotoxic ribonuclease chimeras. Targeted tumoricidal activity in vitro and in vivo. J Biol Chem (1992) 0.83
Genetic engineering of immunotoxins. Cancer Treat Res (1988) 0.83
Skeletal muscle-specific immunotoxin for the treatment of focal muscle spasm. Neurology (1998) 0.83
Humanization of immunotoxins. Proc Natl Acad Sci U S A (1992) 0.82
Pharmacokinetics and toxicology of immunotoxins administered into the subarachnoid space in nonhuman primates and rodents. Cancer Res (1993) 0.82
Graft-versus-host disease prevention in allogeneic bone marrow transplantation from histocompatible siblings. A pilot study using immunotoxins for T cell depletion of donor bone marrow. Transplantation (1987) 0.82
Hepatoblastoma metastatic to brain: prolonged survival after multiple surgical resections of a solitary brain lesion. J Pediatr Hematol Oncol (1997) 0.82
Immunotoxins for brain tumor therapy. Curr Top Microbiol Immunol (1998) 0.81
Albumin storage protein and allergens in cottonseeds. J Agric Food Chem (1979) 0.81
Use of lumbar periosteal turnover flaps in myelomeningocele closure. Neurosurgery (1996) 0.80
The structure of diphtheria toxin as a guide to rational design. Targeted Diagn Ther (1992) 0.80
Myxopapillary ependymoma. Results of nucleolar organizing region staining. Cancer (1993) 0.80