Nrf2 and cardiovascular defense.

NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage. J Clin Invest (2015) 1.05

Oxidative stress response and Nrf2 signaling in aging. Free Radic Biol Med (2015) 0.99

The role of Nrf2-mediated pathway in cardiac remodeling and heart failure. Oxid Med Cell Longev (2014) 0.90

Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives. Antioxidants (Basel) (2015) 0.85

AMPK is critical for mitochondrial function during reperfusion after myocardial ischemia. J Mol Cell Cardiol (2015) 0.83

Reactive Oxygen Species and Nuclear Factor Erythroid 2-Related Factor 2 Activation in Diabetic Nephropathy: A Hidden Target. J Diabetes Metab (2015) 0.79

The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation. Redox Biol (2015) 0.79

Nuclear Factor (Erythroid-Derived)-Related Factor 2-Associated Retinal Pigment Epithelial Cell Protection under Blue Light-Induced Oxidative Stress. Oxid Med Cell Longev (2016) 0.79

Spatial and temporal dynamics of the cardiac mitochondrial proteome. Expert Rev Proteomics (2015) 0.77

Oxidative stress serves as a key checkpoint for IL-33 release by airway epithelium. Allergy (2017) 0.77

Ω3 Supplementation and intermittent hypobaric hypoxia induce cardioprotection enhancing antioxidant mechanisms in adult rats. Mar Drugs (2015) 0.76

Genetic Polymorphisms of Transcription Factor NRF2 and of its Host Gene Sulfiredoxin (SRXN1) are Associated with Cerebrovascular Disease in a Finnish Cohort, the TAMRISK Study. Int J Med Sci (2016) 0.75

Combination of Hypertension Along with a High Fat and Cholesterol Diet Induces Severe Hepatic Inflammation in Rats via a Signaling Network Comprising NF-κB, MAPK, and Nrf2 Pathways. Nutrients (2017) 0.75

The Role of the Nrf2/ARE Antioxidant System in Preventing Cardiovascular Diseases. Diseases (2016) 0.75

Strange Bedfellows: Nuclear Factor, Erythroid 2-Like 2 (Nrf2) and Hypoxia-Inducible Factor 1 (HIF-1) in Tumor Hypoxia. Antioxidants (Basel) (2017) 0.75

Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease. Heart Fail Rev (2016) 0.75

Atherosclerosis--an inflammatory disease. N Engl J Med (1999) 59.28

Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science (1992) 11.83

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell (1992) 10.97

Executive summary: heart disease and stroke statistics--2010 update: a report from the American Heart Association. Circulation (2010) 9.18

Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol (2006) 7.84

Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress. Arteriosclerosis (1985) 7.44

Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med (2004) 5.88

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res (2002) 5.43

Oxidative stress and vascular disease. Arterioscler Thromb Vasc Biol (2004) 5.34

Vascular endothelial growth factor enhances atherosclerotic plaque progression. Nat Med (2001) 4.07

ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence. FEBS J (2009) 4.05

MAPK signal specificity: the right place at the right time. Trends Biochem Sci (2006) 3.96

Role of oxidative stress in atherosclerosis. Am J Cardiol (2003) 3.66

Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury. J Biol Chem (1996) 3.65

Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. Cell (2007) 3.54

Heme oxygenase-1 protects against vascular constriction and proliferation. Nat Med (2001) 3.11

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci U S A (2004) 3.07

The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinase. Circ Res (2000) 2.99

Inflammation in atherosclerosis: transition from theory to practice. Circ J (2010) 2.98

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proc Natl Acad Sci U S A (2010) 2.95

Hydrogen sulfide mediates cardioprotection through Nrf2 signaling. Circ Res (2009) 2.83

Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury. J Biol Chem (1988) 2.80

Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice. Circulation (2005) 2.79

Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc Natl Acad Sci U S A (2008) 2.53

The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J (1998) 2.50

Cell and tissue responses to oxidative damage. Lab Invest (1993) 2.45

Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J Clin Invest (1997) 2.44

Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice. J Clin Invest (2005) 2.44

Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues. Proc Natl Acad Sci U S A (1988) 2.34

Adenovirus-mediated heme oxygenase-1 gene transfer inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. Circulation (2001) 2.32

Morphologic changes in pulmonary oxygen toxicity. Annu Rev Physiol (1986) 2.25

Extracellular superoxide dismutase deficiency exacerbates pressure overload-induced left ventricular hypertrophy and dysfunction. Hypertension (2007) 2.20

Flow patterns and spatial distribution of atherosclerotic lesions in human coronary arteries. Circ Res (1990) 2.18

Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance. Mol Cell Biochem (2002) 2.16

Heme oxygenase-1 inhibits atherosclerotic lesion formation in ldl-receptor knockout mice. Circ Res (2001) 2.14

Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med (2011) 2.03

The challenge of multiple comorbidity for the US health care system. JAMA (2010) 2.01

Can oxidative damage be treated nutritionally? Clin Nutr (2005) 1.96

Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal. Circ Res (2004) 1.95

Heme oxygenase-1 inhibits angiotensin II-induced cardiac hypertrophy in vitro and in vivo. Circulation (2004) 1.94

Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction. Basic Res Cardiol (2011) 1.87

Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2. Am J Respir Cell Mol Biol (2006) 1.86

Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo. Diabetes (2011) 1.84

gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension. Circulation (2004) 1.77

Laminar flow induction of antioxidant response element-mediated genes in endothelial cells. A novel anti-inflammatory mechanism. J Biol Chem (2002) 1.75

Oxidative stress and cardiovascular disease: novel tools give (free) radical insight. J Mol Cell Cardiol (2009) 1.74

Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol (2010) 1.73

NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells. J Biol Chem (2004) 1.73

Linkage analysis of susceptibility to hyperoxia. Nrf2 is a candidate gene. Am J Respir Cell Mol Biol (2002) 1.73

Nrf2 protects against maladaptive cardiac responses to hemodynamic stress. Arterioscler Thromb Vasc Biol (2009) 1.67

Treatment with tin prevents the development of hypertension in spontaneously hypertensive rats. Science (1989) 1.67

Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide. J Clin Invest (1995) 1.65

Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2. Circ Res (2007) 1.63

Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling. FASEB J (2003) 1.58

Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice. Cancer Lett (2006) 1.57

Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. J Biol Chem (2005) 1.54

Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway. Clin Immunol (2008) 1.54

Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease. Am J Respir Crit Care Med (2008) 1.53

Endothelial mechanotransduction, nitric oxide and vascular inflammation. J Intern Med (2006) 1.53

NADPH oxidases in cardiovascular disease. Free Radic Biol Med (2010) 1.53

Nitric oxide and atherosclerosis: an update. Nitric Oxide (2006) 1.52

Socioeconomic status and progression of carotid atherosclerosis. Prospective evidence from the Kuopio Ischemic Heart Disease Risk Factor Study. Arterioscler Thromb Vasc Biol (1997) 1.48

Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state. Arterioscler Thromb Vasc Biol (2009) 1.43

Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia. Am J Physiol Heart Circ Physiol (2011) 1.42

Heme oxygenase-1 attenuates vascular remodeling following balloon injury in rat carotid arteries. Atherosclerosis (2001) 1.41

Flow shear stress and atherosclerosis: a matter of site specificity. Antioxid Redox Signal (2011) 1.39

Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium. Free Radic Biol Med (2011) 1.39

Relation of vessel wall shear stress to atherosclerosis progression in human coronary arteries. Arterioscler Thromb (1993) 1.38

Ischemia-reperfusion injury: processes in pathogenetic networks: a review. Transplant Proc (2007) 1.37

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis. Eur J Immunol (2011) 1.37

Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium. Am J Respir Cell Mol Biol (2003) 1.36

Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. Cell Metab (2012) 1.35

Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis. Circ Res (2007) 1.34

Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice. PLoS One (2008) 1.32

NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection. Arterioscler Thromb Vasc Biol (2010) 1.32

Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo. Circ Res (2008) 1.32

Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta. J Gerontol A Biol Sci Med Sci (2011) 1.31

Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: novel point of convergence between electrophilic and unfolded protein stress pathways. Arterioscler Thromb Vasc Biol (2010) 1.29

Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging. Int J Biochem Cell Biol (2012) 1.25

Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes. PLoS One (2009) 1.24

Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging. J Gerontol A Biol Sci Med Sci (2011) 1.24

Oxidative stress in hypertension. Clin Exp Hypertens (2005) 1.23

Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response. Am J Physiol Heart Circ Physiol (2011) 1.22

Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo. Free Radic Biol Med (2011) 1.22

Loss in oxidative stress tolerance with aging linked to reduced extracellular signal-regulated kinase and Akt kinase activities. FASEB J (2001) 1.20

Does increased oxidative stress cause hypertension? Diabetes Care (2008) 1.18

Coronary thrombolysis for the elderly? JAMA (1991) 1.18

The role of peroxidases in the pathogenesis of atherosclerosis. BMB Rep (2011) 1.18

Attenuation of dysfunction in the postischemic 'stunned' myocardium by dimethylthiourea. Circulation (1987) 1.17

A central role of heme oxygenase-1 in cardiovascular protection. Antioxid Redox Signal (2011) 1.16

Exposure to hyperoxia induces p53 expression in mouse lung epithelium. Am J Respir Cell Mol Biol (1998) 1.12

Altered pulmonary response to hyperoxia in Clara cell secretory protein deficient mice. Am J Respir Cell Mol Biol (1997) 1.11

Effect of heme arginate administration on blood pressure in spontaneously hypertensive rats. J Clin Invest (1990) 1.11

Heme oxygenase-1 inhibits atherogenesis in Watanabe heritable hyperlipidemic rabbits. Circulation (2001) 1.11

Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training. PLoS One (2012) 1.10

Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells. Am J Physiol (1999) 1.09

Oxidative stress and hypertension. J Am Soc Hypertens (2010) 1.09

Oxidative stress: a theoretical model or a biological reality? C R Biol (2004) 1.09

4-hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathway. J Mol Cell Cardiol (2010) 1.07

Exacerbation of chronic renovascular hypertension and acute renal failure in heme oxygenase-1-deficient mice. Circ Res (2001) 1.07