Published in J Biol Chem on May 29, 2013
Targeting hexokinase II to mitochondria to modulate energy metabolism and reduce ischaemia-reperfusion injury in heart. Br J Pharmacol (2014) 0.93
Metformin impairs mitochondrial function in skeletal muscle of both lean and diabetic rats in a dose-dependent manner. PLoS One (2014) 0.85
Effects of metformin, buformin, and phenformin on the post-initiation stage of chemically induced mammary carcinogenesis in the rat. Cancer Prev Res (Phila) (2015) 0.84
Metformin Promotes Apoptosis but Suppresses Autophagy in Glucose-Deprived H4IIE Hepatocellular Carcinoma Cells. Diabetes Metab J (2015) 0.79
Metformin as a cellular protector; a synoptic view of modern evidences. J Nephropharmacol (2015) 0.75
Measurement of protein using bicinchoninic acid. Anal Biochem (1985) 74.03
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest (2001) 23.21
On respiratory impairment in cancer cells. Science (1956) 14.07
AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol (2012) 10.42
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J (2000) 7.77
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem (2000) 6.86
The AMP-activated protein kinase pathway--new players upstream and downstream. J Cell Sci (2004) 5.65
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest (2010) 5.39
Cytosolic phosphorylation potential. J Biol Chem (1979) 4.90
Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnol Annu Rev (2005) 4.72
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes (2002) 4.14
Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation. Cell Metab (2010) 4.14
Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells. Endocrinology (1992) 2.94
AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J Biol Chem (2004) 2.83
Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein. Cell (2009) 2.69
Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. Cancer Res (2010) 2.60
Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions? Diabetes (2004) 2.39
Biguanides and NIDDM. Diabetes Care (1992) 2.34
Metformin and the fate of fat. Gastroenterology (2006) 2.18
Separate measures of ATP utilization and recovery in human skeletal muscle. J Physiol (1993) 2.13
Metformin activates AMP kinase through inhibition of AMP deaminase. J Biol Chem (2010) 1.76
Comparison of MTT and ATP-based assays for the measurement of viable cell number. J Biolumin Chemilumin (1995) 1.67
Neither LKB1 nor AMPK are the direct targets of metformin. Gastroenterology (2006) 1.63
Skeletal muscle phosphocreatine recovery in exercise-trained humans is dependent on O2 availability. J Appl Physiol (1985) (1999) 1.60
Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle. Proc Natl Acad Sci U S A (2010) 1.48
Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status. Diabetologia (2011) 1.48
Metformin increases the PGC-1alpha protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo. J Appl Physiol (1985) (2006) 1.45
Criteria of viability of isolated liver cells. Hoppe Seylers Z Physiol Chem (1975) 1.40
Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study. Biochem J (2004) 1.37
5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK. Biochem J (2005) 1.35
Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5. J Endocrinol (2010) 1.28
AMP activated protein kinase: a next generation target for total metabolic control. Expert Opin Ther Targets (2008) 1.20
Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt. Eur J Pharmacol (2010) 1.14
Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay. Diabetologia (1992) 1.12
Synergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivity. Diabetes Metab Syndr Obes (2013) 1.12
Counteracting roles of AMP deaminase and AMP kinase in the development of fatty liver. PLoS One (2012) 1.12
Luminometric assays of ATP, phosphocreatine, and creatine for estimation of free ADP and free AMP. Anal Biochem (1999) 1.11
Metformin promotes isolated rat liver mitochondria impairment. Mol Cell Biochem (2007) 1.10
Stimulation of hexose transport by metformin in L6 muscle cells in culture. Endocrinology (1992) 1.05
AMP-activated protein kinase and type 2 diabetes. Curr Med Chem (2006) 0.95
The role of AMP kinase in diabetes. Indian J Med Res (2007) 0.95
Creatine kinase equilibration follows solution thermodynamics in skeletal muscle. 31P NMR studies using creatine analogs. J Biol Chem (1995) 0.93
Interaction of biguanides with mitochondrial and synthetic membranes. Eur J Biochem (1972) 0.91
Studies on the relationship between glycolysis, lipogenesis, gluconeogenesis, and pyruvate kinase activity of rat and chicken hepatocytes. Arch Biochem Biophys (1978) 0.89
Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism. PLoS One (2012) 0.88
Metformin inhibits glycogen synthesis and gluconeogenesis in cultured rat hepatocytes. Diabetes Obes Metab (2003) 0.86
Metformin. Endocr Res (2007) 0.83
Inhibition of phosphoenolpyruvate carboxykinase gene expression by metformin in cultured hepatocytes. Chin Med J (Engl) (2002) 0.82
Evaluation of in vitro cytotoxicity and paracellular permeability of intact monolayers with mouse embryonic stem cells. Toxicol In Vitro (2008) 0.81
Effects of metformin on glucose metabolism of perfused rat livers. Mol Cell Biochem (2010) 0.80
Metformin-induced suppression of glucose-6-phosphatase expression is independent of insulin signaling in rat hepatoma cells. Int J Mol Med (2005) 0.78
Metformin activates AMP kinase through inhibition of AMP deaminase. J Biol Chem (2010) 1.76
Mechanism for the paradoxical inhibition and stimulation of calcineurin by the immunosuppresive drug tacrolimus (FK506). Arch Biochem Biophys (2003) 0.83
A direct mass-action mechanism explains capacitative calcium entry in Jurkat and skeletal L6 muscle cells. J Biol Chem (2003) 0.80
A new hypothesis for Ca2+ flows in skeletal muscle and its implications for other cell types. Cell Biochem Biophys (2006) 0.77
A mechanism for both capacitative Ca(2+) entry and excitation-contraction coupled Ca(2+) release by the sarcoplasmic reticulum of skeletal muscle cells. Exp Biol Med (Maywood) (2002) 0.76
Delivery of TEM beta-lactamase by gene-transformed Lactococcus lactis subsp. lactis through cervical cell monolayer. Int J Pharm (2006) 0.76