Published in Biochemistry on May 15, 1990
Anesthetic inhibition of firefly luciferase, a protein model for general anesthesia, does not exhibit pressure reversal. Biophys J (1991) 1.17
Actions of general anaesthetics on 5-HT3 receptors in N1E-115 neuroblastoma cells. Br J Pharmacol (1996) 1.12
Modulation of the general anesthetic sensitivity of a protein: a transition between two forms of firefly luciferase. Proc Natl Acad Sci U S A (1991) 1.04
Actions of general anaesthetics on a neuronal nicotinic acetylcholine receptor in isolated identified neurones of Lymnaea stagnalis. Br J Pharmacol (1995) 0.98
Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting. Eur J Pharmacol (2013) 0.95
Probing the molecular dimensions of general anaesthetic target sites in tadpoles (Xenopus laevis) and model systems using cycloalcohols. Br J Pharmacol (1991) 0.87
Prediction of volatile anesthetic binding sites in proteins. Biophys J (2006) 0.79
Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational Anesthetics. Biophys J (2015) 0.78
The effect of methanol on the structural parameters of neuronal membrane lipid bilayers. Korean J Physiol Pharmacol (2012) 0.77
The worm sheds light on anesthetic mechanisms. Worm (2012) 0.75
Effect of anesthetics on the self-sustained oscillation in an artificial membrane induced by repetitive conformational change of DOPH molecules between hydrophilic and hydrophobic phases. J Anesth (1998) 0.75
Molecular and cellular mechanisms of general anaesthesia. Nature (1994) 6.94
The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway. Nat Neurosci (2002) 3.52
Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes. Structure (1996) 3.51
Structural analysis of hydrated egg lecithin and cholesterol bilayers. II. Neutrol diffraction. J Mol Biol (1976) 3.30
Do general anaesthetics act by competitive binding to specific receptors? Nature (1984) 3.09
Molecular mechanisms of general anaesthesia. Nature (1982) 2.76
The structure of lipid bilayers and the effects of general anaesthetics. An x-ray and neutron diffraction study. J Mol Biol (1979) 2.67
Stereoselective effects of etomidate optical isomers on gamma-aminobutyric acid type A receptors and animals. Anesthesiology (1998) 2.50
Structural analysis of hydrated egg lecithin and cholesterol bilayers. I. X-ray diffraction. J Mol Biol (1976) 2.44
Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures. J Biol Chem (2000) 2.37
Mapping of general anaesthetic target sites provides a molecular basis for cutoff effects. Nature (1985) 2.27
Contrasting synaptic actions of the inhalational general anesthetics isoflurane and xenon. Anesthesiology (2000) 1.93
Relevant concentrations of inhaled anesthetics for in vitro studies of anesthetic mechanisms. Anesthesiology (2001) 1.87
Xenon: no stranger to anaesthesia. Br J Anaesth (2003) 1.86
Differential sensitivities of mammalian neuronal and muscle nicotinic acetylcholine receptors to general anesthetics. Anesthesiology (1997) 1.84
Structural basis for the inhibition of firefly luciferase by a general anesthetic. Biophys J (1998) 1.83
Where do general anaesthetics act? Nature (1978) 1.81
Biological membranes behave as non-porous polymeric sheets with respect to the diffusion of non-electrolytes. Nature (1969) 1.69
Stereospecific effects of inhalational general anesthetic optical isomers on nerve ion channels. Science (1991) 1.63
Partitioning of long-chain alcohols into lipid bilayers: implications for mechanisms of general anesthesia. Proc Natl Acad Sci U S A (1986) 1.61
Cation movements in the high sodium erythrocyte of the cat. J Gen Physiol (1967) 1.52
How does xenon produce anaesthesia? Nature (1998) 1.49
Volatile general anaesthetics activate a novel neuronal K+ current. Nature (1988) 1.49
Testing and characterizing the simple carrier. Biochim Biophys Acta (1974) 1.44
Fatty acid binding to human serum albumin: new insights from crystallographic studies. Biochim Biophys Acta (1999) 1.42
Temperature dependence of the potency of volatile general anesthetics: implications for in vitro experiments. Anesthesiology (1996) 1.38
Carrier and non-carrier models for sugar transport in the human red blood cell. Biochim Biophys Acta (1972) 1.35
Selective actions of volatile general anaesthetics at molecular and cellular levels. Br J Anaesth (1993) 1.34
Effects of inhalational general anaesthetics on native glycine receptors in rat medullary neurones and recombinant glycine receptors in Xenopus oocytes. Br J Pharmacol (1996) 1.32
Diffusion within egg lecithin bilayers resembles that within soft polymers. J Gen Physiol (1978) 1.32
Kinetic parameters of glucose efflux from human red blood cells under zero-trans conditions. Biochim Biophys Acta (1972) 1.25
Mechanisms of general anesthesia. Environ Health Perspect (1990) 1.23
Insensitivity of P-type calcium channels to inhalational and intravenous general anesthetics. Anesthesiology (1994) 1.20
Anesthetic inhibition of firefly luciferase, a protein model for general anesthesia, does not exhibit pressure reversal. Biophys J (1991) 1.17
Actions of general anaesthetics on 5-HT3 receptors in N1E-115 neuroblastoma cells. Br J Pharmacol (1996) 1.12
The effects of general anaesthetics on carbachol-evoked gamma oscillations in the rat hippocampus in vitro. Neuropharmacology (2003) 1.12
Is membrane expansion relevant to anaesthesia? Nature (1981) 1.11
A direct method for determination of membrane electron density profiles on an absolute scale. Nature (1978) 1.11
Which molecular targets are most relevant to general anaesthesia? Toxicol Lett (1998) 1.09
Quantitative predictions of a noncarrier model for glucose transport across the human red cell membrane. Biophys J (1970) 1.09
A modle for active transport of sodium and potassium ions as mediated by a tetrameric enzyme. Proc Natl Acad Sci U S A (1973) 1.08
Thermodynamics of anesthetic/protein interactions. Temperature studies on firefly luciferase. Biophys J (1993) 1.07
Do clinical levels of general anaesthetics affect lipid bilayers? Evidence from Raman scattering. Biochim Biophys Acta (1982) 1.05
Modulation of the general anesthetic sensitivity of a protein: a transition between two forms of firefly luciferase. Proc Natl Acad Sci U S A (1991) 1.04
An X-ray diffraction analysis of oriented lipid multilayers containing basic proteins. Biochim Biophys Acta (1985) 1.03
Low-angle x-ray diffraction. Mol Biol Biochem Biophys (1981) 1.02
New theory for glucose transport across membranes. Nat New Biol (1971) 1.01
Combined effects of ATP and phosphate on rubidium exchange mediated by Na-K-ATPase reconstituted into phospholipid vesicles. J Physiol (1982) 1.01
Effects of temperature and volatile anesthetics on GABA(A) receptors. Anesthesiology (1999) 1.01
Stereoselective and non-stereoselective actions of isoflurane on the GABAA receptor. Br J Pharmacol (1994) 1.01
Structure of myelin lipid bilayers. Changes during maturation. J Mol Biol (1982) 1.00
Actions of general anaesthetics on a neuronal nicotinic acetylcholine receptor in isolated identified neurones of Lymnaea stagnalis. Br J Pharmacol (1995) 0.98
Testing and characterizing the simple pore. Biochim Biophys Acta (1974) 0.97
Role of hydrogen bonding in general anesthesia. J Pharm Sci (1991) 0.96
Rejection criteria for the asymmetric carrier and their application to glucose transport in the human red blood cell. Biochim Biophys Acta (1972) 0.95
Can the stereoselective effects of the anesthetic isoflurane be accounted for by lipid solubility? Biophys J (1994) 0.94
Stereoselective loss of righting reflex in rats by isoflurane. Anesthesiology (2000) 0.93
Non-Stokesian nature of transverse diffusion within human red cell membranes. J Membr Biol (1986) 0.93
Neuroprotective and neurotoxic properties of the 'inert' gas, xenon. Br J Anaesth (2002) 0.92
Molecular organization of liquid n-octanol: an X-ray diffraction analysis. J Pharm Sci (1993) 0.91
Background K+ channels: an important target for volatile anesthetics? Nat Neurosci (1999) 0.90
Preparation of barbiturate optical isomers and their effects on GABA(A) receptors. Anesthesiology (1999) 0.90
Crystallization and preliminary diffraction studies of firefly luciferase from Photinus pyralis. Acta Crystallogr D Biol Crystallogr (1996) 0.89
Mapping the polarity profiles of general anesthetic target sites using n-alkane-(alpha, omega)-diols. Biochemistry (1991) 0.87
Asynchronous administration of xenon and hypothermia significantly reduces brain infarction in the neonatal rat. Br J Anaesth (2007) 0.87
Probing the molecular dimensions of general anaesthetic target sites in tadpoles (Xenopus laevis) and model systems using cycloalcohols. Br J Pharmacol (1991) 0.87
Neuron membranes: anaesthetics on the mind. Nature (1987) 0.86
Inhibitory synapses. Anaesthetics set their sites on ion channels. Nature (1997) 0.86
Actions of general anaesthetics and arachidonic pathway inhibitors on K+ currents activated by volatile anaesthetics and FMRFamide in molluscan neurones. Br J Pharmacol (1998) 0.86