Roles of small molecules in somatic cell reprogramming.

Progress and prospects in stem cell therapy and drug discovery. Acta Pharmacol Sin (2013) 0.76

Cellular reprogramming for clinical cartilage repair. Cell Biol Toxicol (2017) 0.75

The ground state of embryonic stem cell self-renewal. Nature (2008) 19.44

Dissecting direct reprogramming through integrative genomic analysis. Nature (2008) 16.47

Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet (2012) 15.21

Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell (2009) 11.65

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol (2008) 10.97

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol (2008) 10.29

Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol (2008) 8.55

Regulation of chromatin by histone modifications. Cell Res (2011) 8.44

A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell (2010) 7.94

Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell (2008) 7.79

Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell (2010) 7.51

Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell (2010) 7.20

Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature (2010) 7.05

Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell (2011) 6.11

A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell (2008) 5.90

The transcriptional and epigenomic foundations of ground state pluripotency. Cell (2012) 5.87

Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell (2009) 5.49

Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet (2012) 5.42

A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell (2009) 4.64

A chemical platform for improved induction of human iPSCs. Nat Methods (2009) 4.54

Expanding chemical biology of 2-oxoglutarate oxygenases. Nat Chem Biol (2008) 4.52

A molecular roadmap of reprogramming somatic cells into iPS cells. Cell (2012) 4.41

Hypoxia enhances the generation of induced pluripotent stem cells. Cell Stem Cell (2009) 4.38

Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol (2009) 4.32

Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet (2011) 4.25

Chromatin-modifying enzymes as modulators of reprogramming. Nature (2012) 4.22

Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming. Cell Metab (2011) 4.15

Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell (2010) 3.82

Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells (2010) 3.53

Induced pluripotent stem cells: past, present, and future. Cell Stem Cell (2012) 3.43

The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells. Stem Cells (2010) 3.17

Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei. Nature (1958) 3.16

Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal. Cell Stem Cell (2012) 3.03

Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells. Cell Stem Cell (2012) 2.93

Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc. Curr Biol (2009) 2.89

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases. Nat Struct Mol Biol (2009) 2.87

A high glycolytic flux supports the proliferative potential of murine embryonic stem cells. Antioxid Redox Signal (2007) 2.77

The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell (2011) 2.65

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature (2013) 2.63

Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. J Biol Chem (2010) 2.59

H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet (2012) 2.47

Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes. Cell Stem Cell (2012) 2.38

Metabolic plasticity in stem cell homeostasis and differentiation. Cell Stem Cell (2012) 2.36

Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet (2012) 2.35

Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells (2009) 2.29

The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. Mol Cell (2012) 2.20

Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell (2013) 2.17

Different roles for Tet1 and Tet2 proteins in reprogramming-mediated erasure of imprints induced by EGC fusion. Mol Cell (2013) 2.10

E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation. Stem Cells (2010) 1.97

Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal. Cell Stem Cell (2012) 1.89

Histone code modifications on pluripotential nuclei of reprogrammed somatic cells. Mol Cell Biol (2004) 1.67

Generation of integration-free neural progenitor cells from cells in human urine. Nat Methods (2012) 1.58

Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways. Nat Med (2012) 1.58

Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell (2012) 1.54

BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone. Cell Res (2010) 1.51

Butyrate promotes induced pluripotent stem cell generation. J Biol Chem (2010) 1.48

Induced pluripotent stem cells and senescence: learning the biology to improve the technology. EMBO Rep (2010) 1.38

Epigenetic factors influencing resistance to nuclear reprogramming. Trends Genet (2011) 1.14

A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation. Nat Commun (2012) 1.14

The mesenchymal-to-epithelial transition in somatic cell reprogramming. Curr Opin Genet Dev (2012) 1.13

Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells. Cell Res (2011) 1.13

Vitamin C improves the quality of somatic cell reprogramming. Nat Genet (2012) 1.07

Induced pluripotent stem cells at nanoscale. Stem Cells Dev (2010) 1.05

Concise review: A chemical approach to control cell fate and function. Stem Cells (2012) 1.03

Cellular reprogramming: a small molecule perspective. Curr Opin Cell Biol (2012) 0.97

A synthetic small molecule for rapid induction of multiple pluripotency genes in mouse embryonic fibroblasts. Sci Rep (2012) 0.92

Stress-mediated p38 activation promotes somatic cell reprogramming. Cell Res (2012) 0.90

Epigenetic landscape of pluripotent stem cells. Antioxid Redox Signal (2012) 0.86

Nuclear cloning and direct reprogramming: the long and the short path to Stockholm. Cell Stem Cell (2012) 0.84