Published in Nat Rev Genet on December 01, 2010
Prioritizing candidate disease genes by network-based boosting of genome-wide association data. Genome Res (2011) 4.39
Interpreting noncoding genetic variation in complex traits and human disease. Nat Biotechnol (2012) 3.01
Beyond GWASs: illuminating the dark road from association to function. Am J Hum Genet (2013) 2.67
Pathview: an R/Bioconductor package for pathway-based data integration and visualization. Bioinformatics (2013) 2.23
Genetics and epigenetics of rheumatoid arthritis. Nat Rev Rheumatol (2013) 2.20
Large-scale replication and heterogeneity in Parkinson disease genetic loci. Neurology (2012) 2.18
Biological interpretation of genome-wide association studies using predicted gene functions. Nat Commun (2015) 2.16
Leveraging models of cell regulation and GWAS data in integrative network-based association studies. Nat Genet (2012) 2.02
Pathway analysis of genomic data: concepts, methods, and prospects for future development. Trends Genet (2012) 1.86
Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia. Mol Psychiatry (2011) 1.86
Gene set analysis of genome-wide association studies: methodological issues and perspectives. Genomics (2011) 1.76
Gene set analysis of SNP data: benefits, challenges, and future directions. Eur J Hum Genet (2011) 1.73
Boosting signal-to-noise in complex biology: prior knowledge is power. Cell (2011) 1.71
Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity. Neuron (2014) 1.70
The role of replicates for error mitigation in next-generation sequencing. Nat Rev Genet (2013) 1.66
Hierarchical generalized linear models for multiple groups of rare and common variants: jointly estimating group and individual-variant effects. PLoS Genet (2011) 1.61
Integrated genomic analyses in bronchopulmonary dysplasia. J Pediatr (2014) 1.58
Literature based drug interaction prediction with clinical assessment using electronic medical records: novel myopathy associated drug interactions. PLoS Comput Biol (2012) 1.58
Natural selection and infectious disease in human populations. Nat Rev Genet (2014) 1.48
Transcriptome analysis reveals differential splicing events in IPF lung tissue. PLoS One (2014) 1.45
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. PLoS Genet (2011) 1.45
Cancer pharmacogenomics: strategies and challenges. Nat Rev Genet (2012) 1.41
Genotype distribution-based inference of collective effects in genome-wide association studies: insights to age-related macular degeneration disease mechanism. BMC Genomics (2016) 1.41
Pathway, in silico and tissue-specific expression quantitative analyses of oesophageal squamous cell carcinoma genome-wide association studies data. Int J Epidemiol (2015) 1.41
A powerful and adaptive association test for rare variants. Genetics (2014) 1.40
Inflated type I error rates when using aggregation methods to analyze rare variants in the 1000 Genomes Project exon sequencing data in unrelated individuals: summary results from Group 7 at Genetic Analysis Workshop 17. Genet Epidemiol (2011) 1.40
Genomic structure and marker-derived gene networks for growth and meat quality traits of Brazilian Nelore beef cattle. BMC Genomics (2016) 1.38
Intersection of population variation and autoimmunity genetics in human T cell activation. Science (2014) 1.27
Gene-environment interactions in cancer epidemiology: a National Cancer Institute Think Tank report. Genet Epidemiol (2013) 1.27
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways. Age (Dordr) (2011) 1.26
Gene coexpression network alignment and conservation of gene modules between two grass species: maize and rice. Plant Physiol (2011) 1.25
Comparisons of seven algorithms for pathway analysis using the WTCCC Crohn's Disease dataset. BMC Res Notes (2011) 1.24
Pathways of distinction analysis: a new technique for multi-SNP analysis of GWAS data. PLoS Genet (2011) 1.24
Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers. Brain Imaging Behav (2014) 1.23
From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseases. Semin Immunopathol (2012) 1.21
Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer. Carcinogenesis (2012) 1.20
Insights into pancreatic cancer etiology from pathway analysis of genome-wide association study data. PLoS One (2012) 1.19
Functional and genomic context in pathway analysis of GWAS data. Trends Genet (2014) 1.18
From SNPs to genes: disease association at the gene level. PLoS One (2011) 1.18
Integrated enrichment analysis of variants and pathways in genome-wide association studies indicates central role for IL-2 signaling genes in type 1 diabetes, and cytokine signaling genes in Crohn's disease. PLoS Genet (2013) 1.14
Multi-ethnic studies in complex traits. Hum Mol Genet (2011) 1.14
A comprehensive network and pathway analysis of candidate genes in major depressive disorder. BMC Syst Biol (2011) 1.13
Master regulators of FGFR2 signalling and breast cancer risk. Nat Commun (2013) 1.12
Host genetic susceptibility, dysbiosis, and viral triggers in inflammatory bowel disease. Curr Opin Gastroenterol (2011) 1.12
Gowinda: unbiased analysis of gene set enrichment for genome-wide association studies. Bioinformatics (2012) 1.11
Identification of gene pathways implicated in Alzheimer's disease using longitudinal imaging phenotypes with sparse regression. Neuroimage (2012) 1.10
A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm. Hum Mol Genet (2013) 1.10
Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence. Am J Hum Genet (2013) 1.10
Laying a solid foundation for Manhattan--'setting the functional basis for the post-GWAS era'. Trends Genet (2014) 1.10
Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders. Am J Neurodegener Dis (2013) 1.08
Analysis of natural variation reveals neurogenetic networks for Drosophila olfactory behavior. Proc Natl Acad Sci U S A (2012) 1.08
Implications for health and disease in the genetic signature of the Ashkenazi Jewish population. Genome Biol (2012) 1.08
Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population. Carcinogenesis (2013) 1.08
Linkage-disequilibrium-based binning affects the interpretation of GWASs. Am J Hum Genet (2012) 1.07
ICSNPathway: identify candidate causal SNPs and pathways from genome-wide association study by one analytical framework. Nucleic Acids Res (2011) 1.07
Functional interpretation of non-coding sequence variation: concepts and challenges. Bioessays (2013) 1.06
Genetic association test for multiple traits at gene level. Genet Epidemiol (2012) 1.06
Comparison of human cell signaling pathway databases--evolution, drawbacks and challenges. Database (Oxford) (2015) 1.06
dbPTB: a database for preterm birth. Database (Oxford) (2012) 1.05
The statistical properties of gene-set analysis. Nat Rev Genet (2016) 1.04
Comparison of methods for competitive tests of pathway analysis. PLoS One (2012) 1.03
Network analysis of GWAS data. Curr Opin Genet Dev (2013) 1.02
Genetic determinants of depression: recent findings and future directions. Harv Rev Psychiatry (2015) 1.02
Use of the gamma method for self-contained gene-set analysis of SNP data. Eur J Hum Genet (2011) 1.01
Genome-wide association and systems genetic analyses of residual feed intake, daily feed consumption, backfat and weight gain in pigs. BMC Genet (2014) 1.01
Genome-wide pathway analysis of memory impairment in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort implicates gene candidates, canonical pathways, and networks. Brain Imaging Behav (2012) 1.00
Large-scale pathway-based analysis of bladder cancer genome-wide association data from five studies of European background. PLoS One (2012) 1.00
Pathway-based genetic analysis of preterm birth. Genomics (2013) 1.00
High-order SNP combinations associated with complex diseases: efficient discovery, statistical power and functional interactions. PLoS One (2012) 1.00
Gene, pathway and network frameworks to identify epistatic interactions of single nucleotide polymorphisms derived from GWAS data. BMC Syst Biol (2012) 1.00
Comparison of pathway analysis approaches using lung cancer GWAS data sets. PLoS One (2012) 1.00
PUMA: a unified framework for penalized multiple regression analysis of GWAS data. PLoS Comput Biol (2013) 1.00
Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders. Eur J Hum Genet (2011) 0.99
Genome-wide gene-environment interaction analysis for asbestos exposure in lung cancer susceptibility. Carcinogenesis (2012) 0.99
BiForce Toolbox: powerful high-throughput computational analysis of gene-gene interactions in genome-wide association studies. Nucleic Acids Res (2012) 0.98
Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia. Mol Psychiatry (2014) 0.98
Annotating individual human genomes. Genomics (2011) 0.97
Genome-wide association studies in Sjögren's syndrome: What do the genes tell us about disease pathogenesis? Autoimmun Rev (2014) 0.96
Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data. Carcinogenesis (2014) 0.96
A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation. J Med Genet (2011) 0.96
Human genetics and genomics a decade after the release of the draft sequence of the human genome. Hum Genomics (2011) 0.95
Genetic variability in the NMDA-dependent AMPA trafficking cascade is associated with alcohol dependence. Addict Biol (2011) 0.95
Use of pleiotropy to model genetic interactions in a population. PLoS Genet (2012) 0.95
Integrative pathway analysis of genome-wide association studies and gene expression data in prostate cancer. BMC Syst Biol (2012) 0.95
Network.assisted analysis to prioritize GWAS results: principles, methods and perspectives. Hum Genet (2014) 0.94
Farnesoid X receptor (FXR) activation and FXR genetic variation in inflammatory bowel disease. PLoS One (2011) 0.94
The implications of relationships between human diseases and metabolic subpathways. PLoS One (2011) 0.94
The cancer cell map initiative: defining the hallmark networks of cancer. Mol Cell (2015) 0.94
Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls. Hum Genet (2013) 0.93
Inferring gene ontologies from pairwise similarity data. Bioinformatics (2014) 0.93
Uncovering networks from genome-wide association studies via circular genomic permutation. G3 (Bethesda) (2012) 0.93
Genome-wide association and pathway analysis of feed efficiency in pigs reveal candidate genes and pathways for residual feed intake. Front Genet (2014) 0.93
Revealing the genetic basis of multiple sclerosis: are we there yet? Curr Opin Genet Dev (2011) 0.93
SNP-based analysis of neuroactive ligand-receptor interaction pathways implicates PGE2 as a novel mediator of antipsychotic treatment response: data from the CATIE study. Schizophr Res (2011) 0.93
Pathway analysis of genome-wide association study and transcriptome data highlights new biological pathways in colorectal cancer. Mol Genet Genomics (2014) 0.92
Integration of biological networks and pathways with genetic association studies. Hum Genet (2012) 0.92
Integrative pathway analysis of a genome-wide association study of (V)O(2max) response to exercise training. J Appl Physiol (1985) (2013) 0.91
Pharmacogenomics of 17-alpha hydroxyprogesterone caproate for recurrent preterm birth prevention. Am J Obstet Gynecol (2014) 0.91
Complex biomarker discovery in neuroimaging data: Finding a needle in a haystack. Neuroimage Clin (2013) 0.91
Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types. Cancer Discov (2016) 0.90
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res (2000) 117.00
Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res (2003) 103.76
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
Complement factor H polymorphism in age-related macular degeneration. Science (2005) 31.10
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data. Am J Hum Genet (2008) 26.79
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
A groupwise association test for rare mutations using a weighted sum statistic. PLoS Genet (2009) 19.64
Genotype imputation. Annu Rev Genomics Hum Genet (2009) 18.64
A HapMap harvest of insights into the genetics of common disease. J Clin Invest (2008) 18.31
Complement factor H variant increases the risk of age-related macular degeneration. Science (2005) 17.95
Complement factor H polymorphism and age-related macular degeneration. Science (2005) 17.79
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Genotype imputation for genome-wide association studies. Nat Rev Genet (2010) 14.59
Pooled association tests for rare variants in exon-resequencing studies. Am J Hum Genet (2010) 13.18
Genome-wide association analysis by lasso penalized logistic regression. Bioinformatics (2009) 12.21
Analyzing gene expression data in terms of gene sets: methodological issues. Bioinformatics (2007) 9.87
TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat Rev Immunol (2008) 8.95
A versatile gene-based test for genome-wide association studies. Am J Hum Genet (2010) 8.44
Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature (2009) 7.39
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med (1995) 6.89
GSEA-P: a desktop application for Gene Set Enrichment Analysis. Bioinformatics (2007) 6.63
Powerful SNP-set analysis for case-control genome-wide association studies. Am J Hum Genet (2010) 6.60
Molecular networks as sensors and drivers of common human diseases. Nature (2009) 6.14
Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder. Am J Hum Genet (2009) 5.98
A data-adaptive sum test for disease association with multiple common or rare variants. Hum Hered (2010) 5.95
Using linkage genome scans to improve power of association in genome scans. Am J Hum Genet (2006) 5.67
Prioritizing GWAS results: A review of statistical methods and recommendations for their application. Am J Hum Genet (2010) 5.39
A powerful and flexible multilocus association test for quantitative traits. Am J Hum Genet (2008) 4.96
Testing association between disease and multiple SNPs in a candidate gene. Genet Epidemiol (2007) 4.50
Pathway analysis by adaptive combination of P-values. Genet Epidemiol (2009) 4.48
Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron (2000) 4.29
Extensions to gene set enrichment. Bioinformatics (2006) 4.26
Pathway analysis of seven common diseases assessed by genome-wide association. Genomics (2008) 4.11
Diabetes and cancer: a consensus report. CA Cancer J Clin (2010) 3.95
Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum Mol Genet (2009) 3.92
A general modular framework for gene set enrichment analysis. BMC Bioinformatics (2009) 3.92
Improving gene set analysis of microarray data by SAM-GS. BMC Bioinformatics (2007) 3.68
Improved power by use of a weighted score test for linkage disequilibrium mapping. Am J Hum Genet (2006) 3.36
A genomic pathway approach to a complex disease: axon guidance and Parkinson disease. PLoS Genet (2007) 3.28
Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. Am J Hum Genet (2009) 3.19
Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Am J Hum Genet (2008) 3.11
Gene and pathway-based second-wave analysis of genome-wide association studies. Eur J Hum Genet (2010) 3.03
From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetes. PLoS Genet (2009) 2.99
A principal components regression approach to multilocus genetic association studies. Genet Epidemiol (2008) 2.89
Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach. Diabetes (2009) 2.85
Methods for interpreting lists of affected genes obtained in a DNA microarray experiment. BMC Proc (2009) 2.80
Using genome-wide pathway analysis to unravel the etiology of complex diseases. Genet Epidemiol (2009) 2.72
Association screening of common and rare genetic variants by penalized regression. Bioinformatics (2010) 2.67
Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. Mol Psychiatry (2010) 2.59
GSEA-SNP: applying gene set enrichment analysis to SNP data from genome-wide association studies. Bioinformatics (2008) 2.52
Insights into colon cancer etiology via a regularized approach to gene set analysis of GWAS data. Am J Hum Genet (2010) 2.50
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS Genet (2010) 2.43
Strategies and issues in the detection of pathway enrichment in genome-wide association studies. Hum Genet (2009) 2.31
Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmission. Hum Genet (2008) 2.18
Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation. Genet Epidemiol (2007) 2.14
On the utility of gene set methods in genomewide association studies of quantitative traits. Genet Epidemiol (2008) 2.12
GSA-SNP: a general approach for gene set analysis of polymorphisms. Nucleic Acids Res (2010) 2.09
A genetic link between type 2 diabetes and prostate cancer. Diabetologia (2008) 2.07
Microarray-based gene set analysis: a comparison of current methods. BMC Bioinformatics (2008) 2.06
Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases. PLoS One (2009) 2.03
The SNP ratio test: pathway analysis of genome-wide association datasets. Bioinformatics (2009) 2.03
Interleukin-23/Th17 pathways and inflammatory bowel disease. Inflamm Bowel Dis (2009) 1.99
IL-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease. Annu Rev Med (2009) 1.85
i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study. Nucleic Acids Res (2010) 1.83
Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Hum Mol Genet (2010) 1.81
Gene set enrichment analysis made simple. Stat Methods Med Res (2009) 1.79
Genome-wide gene and pathway analysis. Eur J Hum Genet (2010) 1.79
Gene set-based analysis of polymorphisms: finding pathways or biological processes associated to traits in genome-wide association studies. Nucleic Acids Res (2009) 1.69
Self-contained gene-set analysis of expression data: an evaluation of existing and novel methods. PLoS One (2010) 1.67
Implication of the immune system in Alzheimer's disease: evidence from genome-wide pathway analysis. J Alzheimers Dis (2010) 1.65
BiNoM: a Cytoscape plugin for manipulating and analyzing biological networks. Bioinformatics (2007) 1.65
IL-23: a master regulator in Crohn disease. Nat Med (2007) 1.59
Interleukin 27: a double-edged sword for offense and defense. J Leukoc Biol (2009) 1.56
Unite and conquer: univariate and multivariate approaches for finding differentially expressed gene sets. Bioinformatics (2009) 1.48
Prioritizing risk pathways: a novel association approach to searching for disease pathways fusing SNPs and pathways. Bioinformatics (2008) 1.46
ATOM: a powerful gene-based association test by combining optimally weighted markers. Bioinformatics (2008) 1.44
GLOSSI: a method to assess the association of genetic loci-sets with complex diseases. BMC Bioinformatics (2009) 1.38
Gene, region and pathway level analyses in whole-genome studies. Genet Epidemiol (2010) 1.36
Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases. Arthritis Rheum (2008) 1.26
Comparing gene set analysis methods on single-nucleotide polymorphism data from Genetic Analysis Workshop 16. BMC Proc (2009) 1.26
Use of pathway information in molecular epidemiology. Hum Genomics (2009) 1.22
Multiple gene polymorphisms in the complement factor h gene are associated with exudative age-related macular degeneration in chinese. Invest Ophthalmol Vis Sci (2008) 1.21
A flexible two-stage procedure for identifying gene sets that are differentially expressed. Bioinformatics (2009) 1.20
A new permutation strategy of pathway-based approach for genome-wide association study. BMC Bioinformatics (2009) 1.19
Human variation in alcohol response is influenced by variation in neuronal signaling genes. Alcohol Clin Exp Res (2010) 1.19
Evidence for association between multiple complement pathway genes and AMD. Genet Epidemiol (2007) 1.15
Pathway-based genome-wide association analysis identified the importance of regulation-of-autophagy pathway for ultradistal radius BMD. J Bone Miner Res (2010) 1.15
Pathway analysis comparison using Crohn's disease genome wide association studies. BMC Med Genomics (2010) 1.13
Beyond Parkinson disease: amyotrophic lateral sclerosis and the axon guidance pathway. PLoS One (2008) 1.13
Complex diseases, complex genes: keeping pathways on the right track. Epidemiology (2009) 1.10
Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset. PLoS One (2010) 1.06
Inclusion of a priori information in genome-wide association analysis. Genet Epidemiol (2009) 1.06
Network-based model weighting to detect multiple loci influencing complex diseases. Hum Genet (2008) 1.02
Genoscape: a Cytoscape plug-in to automate the retrieval and integration of gene expression data and molecular networks. Bioinformatics (2009) 1.02
Discovery of complex pathways from observational data. Stat Med (2010) 1.02
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res (2010) 43.51
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data. Genome Res (2007) 19.07
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Rare variants create synthetic genome-wide associations. PLoS Biol (2010) 14.43
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Pathway-based approaches for analysis of genomewide association studies. Am J Hum Genet (2007) 12.27
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature (2009) 9.47
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature (2009) 7.39
Identification of ALK as a major familial neuroblastoma predisposition gene. Nature (2008) 7.38
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet (2010) 5.52
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet (2004) 5.31
De novo mutations in histone-modifying genes in congenital heart disease. Nature (2013) 5.15
A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nat Genet (2010) 4.96
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87
Impact of in-scanner head motion on multiple measures of functional connectivity: relevance for studies of neurodevelopment in youth. Neuroimage (2012) 4.84
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62
A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Nat Genet (2005) 4.45
The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genet Med (2013) 4.37
High-resolution mapping and analysis of copy number variations in the human genome: a data resource for clinical and research applications. Genome Res (2009) 4.32
An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity data. Neuroimage (2012) 4.30
Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications. Am J Psychiatry (2011) 4.29
Adjustment of genomic waves in signal intensities from whole-genome SNP genotyping platforms. Nucleic Acids Res (2008) 4.22
Variants of DENND1B associated with asthma in children. N Engl J Med (2009) 4.18
Copy number variation at 1q21.1 associated with neuroblastoma. Nature (2009) 4.10
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet (2009) 3.82
Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. N Engl J Med (2008) 3.80
Mechanisms of mosaicism, chimerism and uniparental disomy identified by single nucleotide polymorphism array analysis. Hum Mol Genet (2010) 3.64
Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency. Am J Hum Genet (2011) 3.43
A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet (2010) 3.42
Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. PLoS Genet (2009) 3.42
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41
Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nat Genet (2008) 3.36
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration. Am J Hum Genet (2005) 3.19
Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. Am J Hum Genet (2009) 3.19
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circ Cardiovasc Genet (2010) 3.15
Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry (2010) 3.13
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet (2011) 3.07
The landscape of recombination in African Americans. Nature (2011) 3.06
Sex differences in the structural connectome of the human brain. Proc Natl Acad Sci U S A (2013) 3.06
Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review. Am J Epidemiol (2005) 3.00
From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetes. PLoS Genet (2009) 2.99
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nat Genet (2011) 2.97
Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis. Nat Med (2013) 2.94
Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol (2010) 2.91
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. Nat Genet (2009) 2.85
Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP. PLoS One (2008) 2.67
To identify associations with rare variants, just WHaIT: Weighted haplotype and imputation-based tests. Am J Hum Genet (2010) 2.63
Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene. Brain Pathol (2008) 2.61
A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet (2012) 2.60
Age group and sex differences in performance on a computerized neurocognitive battery in children age 8-21. Neuropsychology (2012) 2.54
A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol (2009) 2.53
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53
Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. Am J Psychiatry (2012) 2.48
Phasing of many thousands of genotyped samples. Am J Hum Genet (2012) 2.47
Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. Nat Genet (2009) 2.47
Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet (2010) 2.47
Individual common variants exert weak effects on the risk for autism spectrum disorderspi. Hum Mol Genet (2012) 2.46
A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24. J Pediatr (2009) 2.44
The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI. Obesity (Silver Spring) (2009) 2.34
Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. Hum Mol Genet (2005) 2.32
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet (2010) 2.30
Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism. Biol Psychiatry (2011) 2.28
Familial aggregation of atrial fibrillation in Iceland. Eur Heart J (2006) 2.27
SNVer: a statistical tool for variant calling in analysis of pooled or individual next-generation sequencing data. Nucleic Acids Res (2011) 2.27
Simvastatin vs therapeutic lifestyle changes and supplements: randomized primary prevention trial. Mayo Clin Proc (2008) 2.26
Integrative genomics identifies LMO1 as a neuroblastoma oncogene. Nature (2010) 2.21
Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study. J Am Coll Cardiol (2013) 2.18
Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol (2010) 2.17
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet (2010) 2.15
Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology (2012) 2.08
Interpretation of association signals and identification of causal variants from genome-wide association studies. Am J Hum Genet (2010) 2.06
Genomic copy number determination in cancer cells from single nucleotide polymorphism microarrays based on quantitative genotyping corrected for aneuploidy. Genome Res (2009) 2.02