Implications of Dll4-Notch signaling activation in primary glioblastoma multiforme.

PubWeight™: 0.86‹?›

🔗 View Article (PMC 3779034)

Published in Neuro Oncol on June 20, 2013

Authors

Nicolai El Hindy1, Kathy Keyvani, Axel Pagenstecher, Philip Dammann, I Erol Sandalcioglu, Ulrich Sure, Yuan Zhu

Author Affiliations

1: Corresponding Author: Dr. Yuan Zhu, PhD, Department of Neurosurgery, University of Duisburg-Essen, Hufelandstraße 55, 45122 Essen, Germany. yuan.zhu@uk-essen.de.

Articles cited by this

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med (2005) 74.55

Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc (2008) 62.52

MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med (2005) 29.65

Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83

Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Engl J Med (1991) 19.46

Genetic pathways to glioblastoma: a population-based study. Cancer Res (2004) 8.87

The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol (2002) 8.62

HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol (2003) 7.32

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature (2006) 7.01

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature (2006) 6.56

Epidemiology and etiology of gliomas. Acta Neuropathol (2005) 6.14

Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev (2000) 4.24

Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat (1995) 3.88

Dll4, a novel Notch ligand expressed in arterial endothelium. Genes Dev (2000) 3.86

Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res (2005) 3.63

Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. Cancer Res (2007) 3.45

Notch signaling in development and cancer. Endocr Rev (2007) 3.22

Molecular mechanisms of glioma cell migration and invasion. J Neurooncol (2004) 3.04

The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth. Nat Rev Cancer (2007) 2.96

Notch and cancer: a double-edged sword. Cell Mol Life Sci (2007) 2.59

Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis. Differentiation (2001) 2.46

Contribution of Notch signaling activation to human glioblastoma multiforme. J Neurosurg (2007) 2.43

Notch signaling in vascular development. Arterioscler Thromb Vasc Biol (2003) 2.31

Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo. Cancer Res (2007) 2.31

Antiangiogenic therapies for high-grade glioma. Nat Rev Neurol (2009) 2.29

Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res (2005) 2.16

Prognostic significance of preoperative MRI scans in glioblastoma multiforme. J Neurooncol (1996) 2.04

Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways. J Cell Biochem (2010) 1.93

The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia. Cell Cycle (2008) 1.83

Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme. BMC Cancer (2009) 1.80

DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo. Cancer Res (2011) 1.78

Glioblastoma multiforme: radiologic-pathologic correlation. Radiographics (1996) 1.76

HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes. Blood (2012) 1.76

Distribution and characterization of microglia/macrophages in human brain tumors. Acta Neuropathol (1996) 1.73

Ras pathway signals are required for notch-mediated oncogenesis. Oncogene (2000) 1.65

Microglia/macrophages promote glioma progression. Glia (2010) 1.51

Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors. Int J Cancer (2005) 1.48

Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer. Clin Cancer Res (2006) 1.40

The functional role of Notch signaling in human gliomas. Neuro Oncol (2009) 1.39

Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. Genes Cancer (2010) 1.33

Human ligands of the Notch receptor. Am J Pathol (1999) 1.32

Glioma cells on the run - the migratory transcriptome of 10 human glioma cell lines. BMC Genomics (2008) 1.28

Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-cell acute lymphoblastic leukemias and lymphomas. Clin Cancer Res (2008) 1.27

NOTCH and PI3K-AKT pathways intertwined. Cancer Cell (2007) 1.26

Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer. Br J Cancer (2009) 1.22

Dll4-Notch signaling as a therapeutic target in tumor angiogenesis. Vasc Cell (2011) 1.20

Determination of p53 mutations, EGFR overexpression, and loss of p16 expression in pediatric glioblastomas. J Neuropathol Exp Neurol (1997) 1.19

Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer. Am J Pathol (2010) 1.17

Notch1 promotes glioma cell migration and invasion by stimulating β-catenin and NF-κB signaling via AKT activation. Cancer Sci (2011) 1.13

Vascular patterns in glioblastoma influence clinical outcome and associate with variable expression of angiogenic proteins: evidence for distinct angiogenic subtypes. Brain Pathol (2003) 1.11

Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms. Curr Opin Genet Dev (2008) 1.11

A MDR1 (ABCB1) gene single nucleotide polymorphism predicts outcome of temozolomide treatment in glioblastoma patients. Ann Oncol (2008) 1.04

APRIL, a new member of the tumor necrosis factor family, modulates death ligand-induced apoptosis. Cell Death Differ (2001) 1.03

Cross-talk between endothelial cells and tumor via delta-like ligand 4/Notch/PTEN signaling inhibits lung cancer growth. Oncogene (2011) 1.02

Histopathologic assessment of hot-spot microvessel density and vascular patterns in glioblastoma: Poor observer agreement limits clinical utility as prognostic factors: a translational research project of the European Organization for Research and Treatment of Cancer Brain Tumor Group. Cancer (2006) 1.01

MGMT modulates glioblastoma angiogenesis and response to the tyrosine kinase inhibitor sunitinib. Neuro Oncol (2010) 0.99

Glioblastoma: clinical characteristics, prognostic factors and survival in 492 patients. Clin Neurol Neurosurg (2012) 0.99

Silencing of HTR1B and reduced expression of EDN1 in human lung cancers, revealed by methylation-sensitive representational difference analysis. Oncogene (2001) 0.98

Identification and functional validation of CDH11, PCSK6 and SH3GL3 as novel glioma invasion-associated candidate genes. Neuropathol Appl Neurobiol (2012) 0.96

Antiangiogenic therapy in malignant gliomas. Curr Opin Oncol (2008) 0.94

Colony stimulating factor-1 expression in human glioma. Mol Chem Neuropathol (1994) 0.93

Notch signaling as a target in multimodality cancer therapy. Curr Opin Mol Ther (2000) 0.89

Building a vessel wall with notch signaling. Circ Res (2009) 0.85

The contribution of Notch signaling to glioblastoma via activation of cancer stem cell self-renewal: the role of the endothelial network. Neurosurgery (2012) 0.84

Survival rates for primary malignant brain tumours in Europe. EUROCARE Working Group. Eur J Cancer (1998) 0.83

Expression of vascular Notch ligands Delta-like 4 and Jagged-1 in glioblastoma. Histopathology (2012) 0.83

[Prognostic and predictive factors for gliomas in adults]. Bull Cancer (2009) 0.82

Expression of the transcription factor HEY1 in glioblastoma: a preliminary clinical study. Tumori (2010) 0.81

Cyclooxygenase-2 (Cox-2) expression and angiogenesis in glioblastoma. Neuropathology (2008) 0.80

[Prognostic factors in malignant gliomas]. Gan To Kagaku Ryoho (1996) 0.76

Algorithm for the standardized assessment of vascular patterns in glioblastoma specimens. Clin Neuropathol (2004) 0.76

Articles by these authors

Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow. Cell (2008) 2.84

Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Mol Cell Biol (2002) 2.65

Neurofibromin regulation of ERK signaling modulates GABA release and learning. Cell (2008) 2.65

Evaluation of an estrogen receptor-beta agonist in animal models of human disease. Endocrinology (2003) 2.63

Nf1 has an essential role in endothelial cells. Nat Genet (2002) 2.63

Dysfunction of axonemal dynein heavy chain Mdnah5 inhibits ependymal flow and reveals a novel mechanism for hydrocephalus formation. Hum Mol Genet (2004) 2.63

Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder. Blood (2004) 2.42

Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity. Cancer Res (2003) 2.30

Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell (2009) 2.14

A two-hit mechanism causes cerebral cavernous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cells. Hum Mol Genet (2008) 2.02

Cavernoma-related epilepsy: review and recommendations for management--report of the Surgical Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia (2013) 2.00

Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling. Proc Natl Acad Sci U S A (2010) 1.61

Nuclear factor I X deficiency causes brain malformation and severe skeletal defects. Mol Cell Biol (2007) 1.59

Deletion of Nf1 in neurons induces increased axon collateral branching after dorsal root injury. J Neurosci (2007) 1.54

The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell (2008) 1.54

Cerebral cavernomas in the adult. Review of the literature and analysis of 72 surgically treated patients. Neurosurg Rev (2002) 1.53

Retinal amino acid neurochemistry in health and disease. Clin Exp Optom (2013) 1.51

Molecular classification of low-grade diffuse gliomas. Am J Pathol (2010) 1.51

Induction of abnormal proliferation by nonmyelinating schwann cells triggers neurofibroma formation. Cancer Cell (2008) 1.46

Effective surgical treatment of cerebral cavernous malformations: a multicenter study of 79 pediatric patients. J Neurosurg Pediatr (2011) 1.45

Correlation of screening and confirmatory results in tiered immunogenicity testing by solution-phase bridging assays. J Pharm Biomed Anal (2012) 1.43

Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity. Cancer Res (2002) 1.43

IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis. J Clin Invest (2012) 1.40

Metalloproteinase disintegrins ADAM8 and ADAM19 are highly regulated in human primary brain tumors and their expression levels and activities are associated with invasiveness. J Neuropathol Exp Neurol (2006) 1.32

Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in-frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex. Hum Mutat (2008) 1.31

Comparative pathology of nerve sheath tumors in mouse models and humans. Cancer Res (2004) 1.31

p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo. Cell Rep (2013) 1.30

Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease. J Neurosci (2011) 1.26

Role of intestinal microbiota in transformation of bismuth and other metals and metalloids into volatile methyl and hydride derivatives in humans and mice. Appl Environ Microbiol (2008) 1.26

The TIMPs tango with MMPs and more in the central nervous system. J Neurosci Res (2004) 1.26

FIP200 is required for maintenance and differentiation of postnatal neural stem cells. Nat Neurosci (2013) 1.25

Gene and noncoding RNA regulation underlying photoreceptor protection: microarray study of dietary antioxidant saffron and photobiomodulation in rat retina. Mol Vis (2010) 1.20

ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities. Cell (2012) 1.18

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma. Oncotarget (2013) 1.17

RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27. Proc Natl Acad Sci U S A (2009) 1.16

Tie2-Cre-induced inactivation of a conditional mutant Nf1 allele in mouse results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia. Pediatr Res (2004) 1.14

SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation. Dev Cell (2011) 1.13

Increased expression of EphA2 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients. Oncol Rep (2008) 1.11

Identification of novel diagnostic markers for choroid plexus tumors: a microarray-based approach. Am J Surg Pathol (2006) 1.07

Antagonism of TIM-1 blocks the development of disease in a humanized mouse model of allergic asthma. J Clin Invest (2010) 1.06

The brain tumor board: lessons to be learned from an interdisciplinary conference. Onkologie (2005) 1.05

Regulation of signal transducer and activator of transcription and suppressor of cytokine-signaling gene expression in the brain of mice with astrocyte-targeted production of interleukin-12 or experimental autoimmune encephalomyelitis. Am J Pathol (2002) 1.03

Prion protein (PrPc) promotes beta-amyloid plaque formation. Neurobiol Aging (2004) 1.03

Gelatinase B deficiency protects against endotoxin shock. Eur J Immunol (2002) 1.03

Sexual activity and reproduction delay ageing in a mammal. Curr Biol (2006) 1.02

5-(3-Cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile: A novel, highly potent, selective, and orally active non-steroidal progesterone receptor agonist. Bioorg Med Chem (2007) 1.02

Environmental enrichment enhances cellular plasticity in transgenic mice with Alzheimer-like pathology. Exp Neurol (2008) 1.01

Influence of hormones and hormone metabolites on the growth of Schwann cells derived from embryonic stem cells and on tumor cell lines expressing variable levels of neurofibromin. Dev Dyn (2008) 1.01

Effects of environmental enrichment on exploration, anxiety, and memory in female TgCRND8 Alzheimer mice. Behav Brain Res (2008) 1.00

Alterations in the RB1 pathway in low-grade diffuse gliomas lacking common genetic alterations. Brain Pathol (2011) 1.00

A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Elife (2013) 0.99

Implication of PTEN in production of reactive oxygen species and neuronal death in in vitro models of stroke and Parkinson's disease. Neurochem Int (2006) 0.98

Immunohistochemical study in dural arteriovenous fistulas and possible role of local hypoxia for the de novo formation of dural arteriovenous fistulas. Clin Neurol Neurosurg (2004) 0.97

Environmental enrichment counteracts Alzheimer's neurovascular dysfunction in TgCRND8 mice. Brain Pathol (2007) 0.97

Enhancement of oral bioavailability of the poorly water-soluble drug silybin by sodium cholate/phospholipid-mixed micelles. Acta Pharmacol Sin (2010) 0.97

Differential angiogenesis function of CCM2 and CCM3 in cerebral cavernous malformations. Neurosurg Focus (2010) 0.97

ZmCPK11 is involved in abscisic acid-induced antioxidant defence and functions upstream of ZmMPK5 in abscisic acid signalling in maize. J Exp Bot (2012) 0.96

Is the image guidance of ultrasonography beneficial for neurosurgical routine? Surg Neurol (2007) 0.96

Spontaneous cerebellar hemorrhage--experience with 57 surgically treated patients and review of the literature. Neurosurg Rev (2010) 0.95

Surgical closure and reconstruction of a large occipital encephalocele without parenchymal excision. Childs Nerv Syst (2004) 0.95

Image-guided transsylvian, transinsular approach for insular cavernous angiomas. Neurosurgery (2003) 0.95

Clinicopathologic features of aggressive meningioma emphasizing the role of radiotherapy in treatment. Strahlenther Onkol (2006) 0.95

The venous angioarchitecture of sporadic cerebral cavernous malformations: a susceptibility weighted imaging study at 7 T MRI. J Neurol Neurosurg Psychiatry (2012) 0.95

Intraoperative ultrasound assistance in treatment of intradural spinal tumours. Clin Neurol Neurosurg (2011) 0.94

Magnetic and highly recyclable macroporous carbon nanotubes for spilled oil sorption and separation. ACS Appl Mater Interfaces (2013) 0.94

Reduction of amyloid angiopathy and Abeta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways. Am J Pathol (2006) 0.94

CD8 T cells require gamma interferon to clear borna disease virus from the brain and prevent immune system-mediated neuronal damage. J Virol (2005) 0.94

Matrix metalloproteinases, tissue inhibitors of MMPs and TACE in experimental cerebral malaria. Lab Invest (2006) 0.94

Neuroform stent-assisted treatment of intracranial aneurysms: long-term follow-up study of aneurysm recurrence and in-stent stenosis rates. Neuroradiology (2013) 0.94

Age- and sex-dependent development of adrenocortical hyperactivity in a transgenic mouse model of Alzheimer's disease. Neurobiol Aging (2004) 0.93

CCM1 gene deletion identified by MLPA in cerebral cavernous malformation. Neurosurg Rev (2006) 0.93

Wheel-running in a transgenic mouse model of Alzheimer's disease: protection or symptom? Behav Brain Res (2008) 0.93

Exercise during pregnancy mitigates Alzheimer-like pathology in mouse offspring. FASEB J (2011) 0.93

Chemoselective imaging of mouse brain tissue via multiplex CARS microscopy. Biomed Opt Express (2011) 0.93

Preventive and therapeutic types of environmental enrichment counteract beta amyloid pathology by different molecular mechanisms. Neurobiol Dis (2011) 0.92

Frequent BRAF gain in low-grade diffuse gliomas with 1p/19q loss. Brain Pathol (2012) 0.92

Transplantation of vascular endothelial growth factor-transfected neural stem cells into the rat brain provides neuroprotection after transient focal cerebral ischemia. Neurosurgery (2005) 0.92

WGS catalysis and in situ studies of CoO(1-x), PtCo(n)/Co3O4, and Pt(m)Co(m')/CoO(1-x) nanorod catalysts. J Am Chem Soc (2013) 0.92

Characterization of hemangioblastomas of spinal nerves. Neurosurgery (2005) 0.92

Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations. J Cell Mol Med (2013) 0.92

Activity changes and marked stereotypic behavior precede Abeta pathology in TgCRND8 Alzheimer mice. Neurobiol Aging (2005) 0.91

Synthesis and structure-activity relationship of novel 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones as progesterone receptor modulators leading to the potent and selective nonsteroidal progesterone receptor agonist tanaproget. J Med Chem (2005) 0.91

Transsulcal approach supported by navigation-guided neurophysiological monitoring for resection of paracentral cavernomas. Clin Neurol Neurosurg (2008) 0.91

Malignant pineal parenchymal tumors in adult patients: patterns of care and prognostic factors. Neurosurgery (2002) 0.90

SAR studies of 6-(arylamino)-4,4-disubstituted-1-methyl-1,4-dihydro-benzo[d][1,3]oxazin-2-ones as progesterone receptor antagonists. Bioorg Med Chem Lett (2006) 0.90

GSK3β is a checkpoint for TNF-α-mediated impaired osteogenic differentiation of mesenchymal stem cells in inflammatory microenvironments. Biochim Biophys Acta (2013) 0.90

Splenic marginal zone lymphoma: transformation to diffuse large B-cell lymphoma with isolated cerebral manifestation. J Clin Oncol (2008) 0.90

Caudal image contrast inversion in MPRAGE at 7 Tesla: problem and solution. Acad Radiol (2011) 0.90

Ascending colon adenocarcinoma with tonsillar metastasis: a case report and review of the literature. World J Gastroenterol (2008) 0.90