Published in Cell Mol Life Sci on November 01, 2007
Therapeutic antibody targeting of individual Notch receptors. Nature (2010) 4.56
The many facets of Notch ligands. Oncogene (2008) 2.57
Targeting Notch to target cancer stem cells. Clin Cancer Res (2010) 2.46
The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. EMBO J (2011) 2.29
Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell (2009) 2.19
Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2009) 2.17
DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism. Cancer Res (2011) 1.73
Notch post-translationally regulates β-catenin protein in stem and progenitor cells. Nat Cell Biol (2011) 1.66
Canonical and non-canonical Notch ligands. Curr Top Dev Biol (2010) 1.62
Targeting Notch signaling pathway to overcome drug resistance for cancer therapy. Biochim Biophys Acta (2010) 1.59
The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance. Clin Cancer Res (2010) 1.58
Notch signaling contributes to the pathogenesis of human osteosarcomas. Hum Mol Genet (2009) 1.56
Notch activation inhibits AML growth and survival: a potential therapeutic approach. J Exp Med (2013) 1.54
Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Invest (2011) 1.51
The Notch signaling pathway as a mediator of tumor survival. Carcinogenesis (2013) 1.50
Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells. PLoS One (2011) 1.48
Notch and disease: a growing field. Semin Cell Dev Biol (2012) 1.48
Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. Genes Dev (2010) 1.44
Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way. Nat Rev Clin Oncol (2009) 1.43
Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells. Oncogene (2011) 1.41
The functional role of Notch signaling in human gliomas. Neuro Oncol (2009) 1.39
Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism. J Nanobiotechnology (2011) 1.39
Non-canonical Notch signaling: emerging role and mechanism. Trends Cell Biol (2012) 1.37
Cancer stem cells: cell culture, markers, and targets for new therapies. J Cell Biochem (2009) 1.35
Physiological roles of class I HDAC complex and histone demethylase. J Biomed Biotechnol (2010) 1.33
KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol (2008) 1.33
Development and cancer: at the crossroads of Nodal and Notch signaling. Cancer Res (2009) 1.30
The Regulatory Role of MicroRNAs in EMT and Cancer. J Oncol (2015) 1.22
ATF2 - at the crossroad of nuclear and cytosolic functions. J Cell Sci (2012) 1.20
Notch ligand endocytosis: mechanistic basis of signaling activity. Semin Cell Dev Biol (2012) 1.14
PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Cell (2012) 1.11
Transcriptional dynamics elicited by a short pulse of notch activation involves feed-forward regulation by E(spl)/Hes genes. PLoS Genet (2013) 1.03
Matrix metalloproteinase-9 functions as a tumor suppressor in colitis-associated cancer. Cancer Res (2010) 1.03
Notch3 activation promotes invasive glioma formation in a tissue site-specific manner. Cancer Res (2011) 1.01
Notch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression. Blood (2011) 1.00
Notch activation as a driver of osteogenic sarcoma. Cancer Cell (2014) 0.99
Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling. Cancer Biol Ther (2009) 0.98
ETOILE regulates developmental patterning in the filamentous brown alga Ectocarpus siliculosus. Plant Cell (2011) 0.98
Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy. Oncotarget (2015) 0.97
Genomic loss of the putative tumor suppressor gene E2A in human lymphoma. J Exp Med (2011) 0.97
Notch signaling in pancreatic cancer: oncogene or tumor suppressor? Trends Mol Med (2013) 0.95
Specific changes in the expression of imprinted genes in prostate cancer--implications for cancer progression and epigenetic regulation. Asian J Androl (2012) 0.95
RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. EMBO J (2010) 0.94
The roles of Notch1 expression in the migration of intrahepatic cholangiocarcinoma. BMC Cancer (2013) 0.94
Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulation. Blood (2009) 0.94
Distinct contextual roles for Notch signalling in skeletal muscle stem cells. BMC Dev Biol (2014) 0.94
Late SV40 factor: a key mediator of Notch signaling in human hepatocarcinogenesis. World J Gastroenterol (2011) 0.93
Notch1-mediated tumor suppression in cervical cancer with the involvement of SST signaling and its application in enhanced SSTR-targeted therapeutics. Oncologist (2012) 0.92
Differential expression of Notch1 intracellular domain and p21 proteins, and their clinical significance in gastric cancer. Oncol Lett (2013) 0.92
METT-10, a putative methyltransferase, inhibits germ cell proliferative fate in Caenorhabditis elegans. Genetics (2009) 0.92
A role for Numb in p53 stabilization. Genome Biol (2008) 0.91
Epigenetic silencing of Notch signaling in gastrointestinal cancers. Cell Cycle (2012) 0.91
Role of Notch signaling pathway in gastric cancer pathogenesis. Contemp Oncol (Pozn) (2013) 0.91
Notch is a direct negative regulator of the DNA-damage response. Nat Struct Mol Biol (2015) 0.90
Notch1 signaling is activated in cells expressing embryonic stem cell proteins in human primary nasopharyngeal carcinoma. J Otolaryngol Head Neck Surg (2010) 0.90
Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor. Mol Cancer (2011) 0.89
Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation. Mol Cell Biol (2013) 0.88
Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye. Proc Natl Acad Sci U S A (2013) 0.87
Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC). Br J Cancer (2014) 0.87
Loss of the Notch effector RBPJ promotes tumorigenesis. J Exp Med (2014) 0.87
Brain angiogenesis in developmental and pathological processes: mechanism and therapeutic intervention in brain tumors. FEBS J (2009) 0.86
MiR-191 Regulates Primary Human Fibroblast Proliferation and Directly Targets Multiple Oncogenes. PLoS One (2015) 0.86
NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma. Acta Neuropathol Commun (2014) 0.86
Implications of Dll4-Notch signaling activation in primary glioblastoma multiforme. Neuro Oncol (2013) 0.86
Notch2 regulates matrix metallopeptidase 9 via PI3K/AKT signaling in human gastric carcinoma cell MKN-45. World J Gastroenterol (2012) 0.86
p16 Stimulates CDC42-dependent migration of hepatocellular carcinoma cells. PLoS One (2013) 0.85
Notch1 is a 5-fluorouracil resistant and poor survival marker in human esophagus squamous cell carcinomas. PLoS One (2013) 0.85
Transcriptome profiling of whole blood cells identifies PLEK2 and C1QB in human melanoma. PLoS One (2011) 0.84
Molecular and cellular processes underlying the hallmarks of head and neck cancer. Eur Arch Otorhinolaryngol (2012) 0.84
Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleen. J Hematol Oncol (2014) 0.83
Pro-oncogenic and anti-oncogenic pathways: opportunities and challenges of cancer therapy. Future Oncol (2010) 0.82
No evidence for induction of key components of the Notch signaling pathway (Notch-1, Jagged-1) by treatment with UV-B, 1,25(OH)(2)D(3), and/or epigenetic drugs (TSA, 5-Aza) in human keratinocytes in vitro. Dermatoendocrinol (2012) 0.81
Quinomycin A targets Notch signaling pathway in pancreatic cancer stem cells. Oncotarget (2016) 0.81
Role of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases in skin cancer. J Genet Genomics (2013) 0.81
Distinctive effects of the cellular inhibitor of apoptosis protein c-IAP2 through stabilization by XIAP in glioblastoma multiforme cells. Cell Cycle (2014) 0.80
Role of liver stem cells in hepatocarcinogenesis. World J Stem Cells (2014) 0.79
Citrobacter Infection and Wnt signaling. Curr Colorectal Cancer Rep (2012) 0.79
Cooperation of deregulated Notch signaling and Ras pathway in human hepatocarcinogenesis. J Mol Histol (2011) 0.79
Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells. Oncotarget (2016) 0.79
A combined gene signature of hypoxia and notch pathway in human glioblastoma and its prognostic relevance. PLoS One (2015) 0.79
sel-11 and cdc-42, two negative modulators of LIN-12/Notch activity in C. elegans. PLoS One (2010) 0.79
A novel high throughput 1536-well Notch1 γ -secretase AlphaLISA assay. Comb Chem High Throughput Screen (2013) 0.78
Oncogenesis and cancer stem cells: current opinions and future directions. J Cell Mol Med (2009) 0.78
Cutaneous Notch signaling in health and disease. Cold Spring Harb Perspect Med (2013) 0.78
Notch signaling activation suppresses v-Src-induced transformation of neural cells by restoring TGF-β-mediated differentiation. PLoS One (2010) 0.78
Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor. Mol Med Rep (2015) 0.78
Dissecting and circumventing the requirement for RAM in CSL-dependent Notch signaling. PLoS One (2012) 0.77
Activated Notch1 expression is associated with angiogenesis in cutaneous melanoma. Clin Exp Med (2014) 0.77
Notch signaling in hematopoietic cell transplantation and T cell alloimmunity. Blood Rev (2013) 0.76
Therapeutic targeting of cancer stem cells. Front Oncol (2011) 0.76
Clinical significance of bax/bcl-2 ratio in chronic lymphocytic leukemia. Haematologica (2015) 0.76
Inflammation and Notch signaling: a crosstalk with opposite effects on tumorigenesis. Cell Death Dis (2016) 0.76
The role of Notch and gamma-secretase inhibition in an ovarian cancer model. Anticancer Res (2013) 0.76
Silencing of MAP4K4 by short hairpin RNA suppresses proliferation, induces G1 cell cycle arrest and induces apoptosis in gastric cancer cells. Mol Med Rep (2015) 0.76
Glycosylated Notch and Cancer. Front Oncol (2016) 0.75
MicroRNA-133a-3p exerts inhibitory effects on gallbladder carcinoma via targeting RBPJ. Am J Cancer Res (2016) 0.75
Anti-Cancer Phytometabolites Targeting Cancer Stem Cells. Curr Genomics (2017) 0.75
The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res (2016) 0.75
Generation of a murine hepatic angiosarcoma cell line and reproducible mouse tumor model. Lab Invest (2014) 0.75
Proteomic technologies for the study of osteosarcoma. Sarcoma (2012) 0.75
VEGF is required for growth and survival in neonatal mice. Development (1999) 6.16
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J (2001) 5.29
Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development. Nat Immunol (2001) 3.89
The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression. EMBO J (1994) 2.19
Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J Exp Med (2001) 2.02
Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors. Dev Biol (2000) 1.53
Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1. Nucleic Acids Res (1994) 1.42
Notch1 and T-cell development: insights from conditional knockout mice. Trends Immunol (2001) 1.08
Delayed treatment of delirium increases mortality rate in intensive care unit patients. J Int Med Res (2011) 0.99
Cutting edge: an essential role for Notch-1 in the development of both thymus-independent and -dependent T cells in the gut. J Immunol (2000) 0.90
RBP-Jκ-dependent Notch signaling enhances retinal pigment epithelial cell proliferation in transgenic mice. Oncogene (2010) 0.87
T cell fate specification and alphabeta/gammadelta lineage commitment. Curr Opin Immunol (2001) 0.84
Toxicological evaluation of an electrically heated cigarette. Part 4: Subchronic inhalation toxicology. J Appl Toxicol (2003) 0.81
Cytotoxicity, mutagenicity, and tumorigenicity of mainstream smoke from three reference cigarettes machine-smoked to the same yields of total particulate matter per cigarette. Food Chem Toxicol (2009) 0.80
To be or not to be a pro-T? Curr Opin Immunol (2000) 0.80
Improving the detection of illicit substance use in preoperative anesthesiological assessment. Minerva Anestesiol (2009) 0.78
[Postoperative cognition disorders in elderly patients. The results of the "International Study of Postoperative Cognitive Dysfunction" ISPOCD 1)]. Anaesthesist (1999) 0.78
Regulation of metallothionein gene expression in Cd- or Zn-adapted RK-13 cells. Experientia (1995) 0.76
Formation of Hydrogen Cyanide over Cu/ZSM-5 Catalyst Used for the Removal of Nitrogen Oxides from Exhausts of Lean-Burn Engines. Environ Sci Technol (1995) 0.75