Integrins in mechanotransduction.

Regulation of integrin-mediated adhesions. Curr Opin Cell Biol (2015) 1.11

Role of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections. Circ Res (2015) 1.04

Rewiring mesenchymal stem cell lineage specification by switching the biophysical microenvironment. Sci Rep (2014) 1.01

The role of BMPs in endothelial cell function and dysfunction. Trends Endocrinol Metab (2014) 1.00

The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts. J Biol Chem (2014) 0.99

Mechanism of regulation of stem cell differentiation by matrix stiffness. Stem Cell Res Ther (2015) 0.93

Gene expression response of mice after a single dose of 137CS as an internal emitter. Radiat Res (2014) 0.92

Endothelial fluid shear stress sensing in vascular health and disease. J Clin Invest (2016) 0.92

TGFβ signaling promotes matrix assembly during mechanosensitive embryonic salivary gland restoration. Matrix Biol (2015) 0.84

FAK, talin and PIPKIγ regulate endocytosed integrin activation to polarize focal adhesion assembly. Nat Cell Biol (2016) 0.83

Filamin A Mediates Wound Closure by Promoting Elastic Deformation and Maintenance of Tension in the Collagen Matrix. J Invest Dermatol (2015) 0.82

Effects of substrate stiffness and cell-cell contact on mesenchymal stem cell differentiation. Biomaterials (2016) 0.82

Extracellular matrix as a contextual determinant of transforming growth factor-β signaling in epithelial-mesenchymal transition and in cancer. Cell Adh Migr (2014) 0.81

The importance of foetal movement for co-ordinated cartilage and bone development in utero : clinical consequences and potential for therapy. Bone Joint Res (2015) 0.81

The Lymphatic System in Disease Processes and Cancer Progression. Annu Rev Biomed Eng (2016) 0.80

Biomaterial-mediated strategies targeting vascularization for bone repair. Drug Deliv Transl Res (2016) 0.79

An approach to quantifying 3D responses of cells to extreme strain. Sci Rep (2016) 0.78

Nano- and microstructured materials for in vitro studies of the physiology of vascular cells. Beilstein J Nanotechnol (2016) 0.77

Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line. Sci Rep (2015) 0.77

Proliferation of preosteoblasts on TiO2 nanotubes is FAK/RhoA related. RSC Adv (2015) 0.77

Interplay of the physical microenvironment, contact guidance, and intracellular signaling in cell decision making. FASEB J (2016) 0.77

Spatiotemporal organization and mechanosensory function of podosomes. Cell Adh Migr (2014) 0.77

A novel multilayer immunoisolating encapsulation system overcoming protrusion of cells. Sci Rep (2014) 0.77

Cell-cell junctional mechanotransduction in endothelial remodeling. Cell Mol Life Sci (2016) 0.76

The role of integrins in glaucoma. Exp Eye Res (2016) 0.76

Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. Mol Biol Cell (2017) 0.76

Blood Brothers: Hemodynamics and Cell-Matrix Interactions in Endothelial Function. Antioxid Redox Signal (2016) 0.75

Integrative systems and synthetic biology of cell-matrix adhesion sites. Cell Adh Migr (2016) 0.75

Forces and mechanotransduction in 3D vascular biology. Curr Opin Cell Biol (2016) 0.75

Diverse integrin adhesion stoichiometries caused by varied actomyosin activity. Open Biol (2017) 0.75

Membrane-bound ICAM-1 contributes to the onset of proinvasive tumor stroma by controlling acto-myosin contractility in carcinoma-associated fibroblasts. Oncotarget (2016) 0.75

Mechanical stretch regulates microRNA expression profile via NF-κB activation in C2C12 myoblasts. Mol Med Rep (2016) 0.75

Impact of mechanical stretch on the cell behaviors of bone and surrounding tissues. J Tissue Eng (2016) 0.75

Impact of mechanical stretch on the cell behaviors of bone and surrounding tissues. J Tissue Eng (2015) 0.75

Biomechanical relationships between the corneal endothelium and Descemet's membrane. Exp Eye Res (2016) 0.75

The likely role of proteolytic enzymes in unwanted differentiation of stem cells in culture. Future Sci OA (2015) 0.75

Integrin signaling in atherosclerosis. Cell Mol Life Sci (2017) 0.75

Shear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis. J Biomech (2016) 0.75

Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2. Cell Mol Life Sci (2017) 0.75

Cytoskeleton modifications and autophagy induction in TCam-2 seminoma cells exposed to simulated microgravity. Biomed Res Int (2014) 0.75

Evaluation of the Genetic Response of U937 and Jurkat Cells to 10-Nanosecond Electrical Pulses (nsEP). PLoS One (2016) 0.75

Inhibition on Apoptosis Induced by Elevated Hydrostatic Pressure in Retinal Ganglion Cell-5 via Laminin Upregulating β1-integrin/Focal Adhesion Kinase/Protein Kinase B Signaling Pathway. Chin Med J (Engl) (2016) 0.75

β1-Integrin-Mediated Adhesion Is Lipid-Bilayer Dependent. Biophys J (2017) 0.75

Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second. Nat Mater (2017) 0.75

Exercise and bone health across the lifespan. Biogerontology (2017) 0.75

DDR2 controls the epithelial-mesenchymal-transition-related gene expression via c-Myb acetylation upon matrix stiffening. Sci Rep (2017) 0.75

A Nociceptive Role for Integrin Signaling in Pain After Mechanical Injury to the Spinal Facet Capsular Ligament. Ann Biomed Eng (2017) 0.75

Adult human dermal fibroblasts exposed to nanosecond electrical pulses exhibit genetic biomarkers of mechanical stress. Biochem Biophys Rep (2017) 0.75

Matrix elasticity directs stem cell lineage specification. Cell (2006) 43.00

Role of YAP/TAZ in mechanotransduction. Nature (2011) 11.56

Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol (2009) 9.56

Stretching single talin rod molecules activates vinculin binding. Science (2009) 8.11

A tense situation: forcing tumour progression. Nat Rev Cancer (2009) 7.80

Periodic lamellipodial contractions correlate with rearward actin waves. Cell (2004) 6.46

Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science (2010) 6.29

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature (2010) 6.25

Traction dynamics of filopodia on compliant substrates. Science (2008) 4.57

Mechanical integration of actin and adhesion dynamics in cell migration. Annu Rev Cell Dev Biol (2010) 4.06

Mechanotransduction gone awry. Nat Rev Mol Cell Biol (2009) 4.00

Balancing forces: architectural control of mechanotransduction. Nat Rev Mol Cell Biol (2011) 3.87

Integrins in mechanotransduction. J Biol Chem (2004) 3.57

Dynamic molecular processes mediate cellular mechanotransduction. Nature (2011) 3.38

Vascular remodeling of the mouse yolk sac requires hemodynamic force. Development (2007) 3.26

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. J Cell Biol (2010) 2.96

Hippo pathway regulation by cell morphology and stress fibers. Development (2011) 2.94

Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration. Cell (2012) 2.87

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch. Proc Natl Acad Sci U S A (2012) 2.82

Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing. Dev Cell (2010) 2.65

Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing. Nat Cell Biol (2011) 2.54

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins. Nat Cell Biol (2011) 2.45

Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation. Dev Cell (2012) 2.45

Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch. Nature (2007) 2.36

Effects of cell tension on the small GTPase Rac. J Cell Biol (2002) 2.24

Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A. Nature (2011) 2.22

An introductory review of cell mechanobiology. Biomech Model Mechanobiol (2006) 2.04

Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1. Curr Biol (2013) 2.02

TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res (2009) 1.84

Integrin activation and matrix binding mediate cellular responses to mechanical stretch. J Biol Chem (2005) 1.80

Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis. J Vasc Res (2009) 1.78

Synthetic materials in the study of cell response to substrate rigidity. Ann Biomed Eng (2009) 1.69

Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site. J Biol Chem (2003) 1.60

Mechanotransduction in vivo by repeated talin stretch-relaxation events depends upon vinculin. PLoS Biol (2011) 1.52

A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ. FEBS J (2008) 1.49

Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum. J Cell Sci (2010) 1.45

The tension mounts: stress fibers as force-generating mechanotransducers. J Cell Biol (2013) 1.41

Detecting force-induced molecular transitions with fluorescence resonant energy transfer. Angew Chem Int Ed Engl (2007) 1.39

Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels. Proc Natl Acad Sci U S A (2012) 1.38

Cardiovascular protection by ApoE and ApoE-HDL linked to suppression of ECM gene expression and arterial stiffening. Cell Rep (2012) 1.34

Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells. J Cell Biol (2012) 1.33

Visualizing dynamic cytoplasmic forces with a compliance-matched FRET sensor. J Cell Sci (2010) 1.30

Atheroprone hemodynamics regulate fibronectin deposition to create positive feedback that sustains endothelial inflammation. Circ Res (2010) 1.29

The role of FilGAP-filamin A interactions in mechanoprotection. Mol Biol Cell (2009) 1.28

Mechanoinduction of lymph vessel expansion. EMBO J (2011) 1.19

Dynamic force sensing of filamin revealed in single-molecule experiments. Proc Natl Acad Sci U S A (2012) 1.17

Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts. Sci Signal (2010) 1.11

Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators. Mol Biol Cell (2012) 1.10

The effect of pressure-induced mechanical stretch on vascular wall differential gene expression. J Vasc Res (2012) 1.10

Recent advances and new opportunities in lung mechanobiology. J Biomech (2009) 1.06

Cyclic mechanical reinforcement of integrin-ligand interactions. Mol Cell (2013) 1.05

Lateral communication between stress fiber sarcomeres facilitates a local remodeling response. Biophys J (2012) 0.89

Cell migration: integrating signals from front to back. Science (2003) 29.13

Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol (2010) 7.27

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature (2010) 6.25

Integrins regulate Rac targeting by internalization of membrane domains. Science (2004) 5.07

Mechanotransduction in vascular physiology and atherogenesis. Nat Rev Mol Cell Biol (2009) 4.58

Mechanisms of mechanotransduction. Dev Cell (2006) 3.95

Dynamic molecular processes mediate cellular mechanotransduction. Nature (2011) 3.38

Integrin-dependent actomyosin contraction regulates epithelial cell scattering. J Cell Biol (2005) 3.20

Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization. Nat Cell Biol (2005) 3.13

Rapid signal transduction in living cells is a unique feature of mechanotransduction. Proc Natl Acad Sci U S A (2008) 3.04

Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep (2008) 2.90

Cadherin adhesion, tissue tension, and noncanonical Wnt signaling regulate fibronectin matrix organization. Dev Cell (2009) 2.32

Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1. Curr Biol (2013) 2.02

In vivo dynamics of Rac-membrane interactions. Mol Biol Cell (2006) 1.95

Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis. J Cell Biol (2003) 1.93

Integrin-mediated adhesion regulates membrane order. J Cell Biol (2006) 1.92

Rho mediates the shear-enhancement of endothelial cell migration and traction force generation. Biophys J (2004) 1.77

Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins. Nat Cell Biol (2002) 1.76

Endothelial cell PECAM-1 promotes atherosclerotic lesions in areas of disturbed flow in ApoE-deficient mice. Arterioscler Thromb Vasc Biol (2008) 1.76

Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway. EMBO J (2007) 1.69

Matrix-specific suppression of integrin activation in shear stress signaling. Mol Biol Cell (2006) 1.67

Siah1/SIP regulates p27(kip1) stability and cell migration under metabolic stress. Cell Cycle (2011) 1.59

Adaptor functions of Cdc42, Ste50, and Sho1 in the yeast osmoregulatory HOG MAPK pathway. EMBO J (2006) 1.55

12/15-lipoxygenase regulates intercellular adhesion molecule-1 expression and monocyte adhesion to endothelium through activation of RhoA and nuclear factor-kappaB. Arterioscler Thromb Vasc Biol (2005) 1.41

VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function. J Biol Chem (2004) 1.38

Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels. Proc Natl Acad Sci U S A (2012) 1.38

Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway. J Cell Biol (2009) 1.36

Atheroprone hemodynamics regulate fibronectin deposition to create positive feedback that sustains endothelial inflammation. Circ Res (2010) 1.29

The role of cellular adaptation to mechanical forces in atherosclerosis. Arterioscler Thromb Vasc Biol (2008) 1.28

The spatiotemporal pattern of Src activation at lipid rafts revealed by diffusion-corrected FRET imaging. PLoS Comput Biol (2008) 1.27

Long-range mechanical force enables self-assembly of epithelial tubular patterns. Proc Natl Acad Sci U S A (2012) 1.24

The yeast endocytic protein Epsin 2 functions in a cell-division signaling pathway. J Cell Sci (2009) 1.21

Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases. Cancer Res (2009) 1.21

Substrate rigidity regulates Ca2+ oscillation via RhoA pathway in stem cells. J Cell Physiol (2009) 1.21

Rapid activation of Rac GTPase in living cells by force is independent of Src. PLoS One (2009) 1.20

Regulation of LKB1/STRAD localization and function by E-cadherin. Curr Biol (2008) 1.18

Visualization of Src activity at different compartments of the plasma membrane by FRET imaging. Chem Biol (2009) 1.18

Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function. Proc Natl Acad Sci U S A (2009) 1.17

Src and caveolin-1 reciprocally regulate metastasis via a common downstream signaling pathway in bladder cancer. Cancer Res (2010) 1.14

Rac, membrane heterogeneity, caveolin and regulation of growth by integrins. Trends Cell Biol (2007) 1.13

Matrix metalloproteinase inhibitors as prospective agents for the prevention and treatment of cardiovascular and neoplastic diseases. Curr Top Med Chem (2006) 1.12

Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins. Circ Res (2003) 1.11

Lessons from the endothelial junctional mechanosensory complex. F1000 Biol Rep (2012) 1.08

Endothelial-to-mesenchymal transition drives atherosclerosis progression. J Clin Invest (2015) 1.06

Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching. Circulation (2012) 1.06

Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer. Nat Commun (2011) 1.06

Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes. FEBS Lett (2005) 1.05

A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration. J Biol Chem (2002) 1.03

Enzymatic properties of rat myelencephalon-specific protease. Biochemistry (2002) 1.03

Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltration. Am J Respir Crit Care Med (2007) 1.01

Dynamic control of yeast MAP kinase network by induced association and dissociation between the Ste50 scaffold and the Opy2 membrane anchor. Mol Cell (2010) 1.00

Flow-dependent cellular mechanotransduction in atherosclerosis. J Cell Sci (2013) 1.00

The intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling. J Biol Chem (2003) 0.98

N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways. Nat Commun (2013) 0.98

Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities. Biochem J (2004) 0.98

Guanine exchange-dependent and -independent effects of Vav1 on integrin-induced T cell spreading. J Immunol (2003) 0.96

Enhancing QM/MM molecular dynamics sampling in explicit environments via an orthogonal-space-random-walk-based strategy. J Phys Chem B (2011) 0.95

Cell biology. Dysfunctional mechanosensing in aneurysms. Science (2014) 0.95

Change of direction in the biomechanics of atherosclerosis. Ann Biomed Eng (2014) 0.95

Phospholipase C-gamma1 is a guanine nucleotide exchange factor for dynamin-1 and enhances dynamin-1-dependent epidermal growth factor receptor endocytosis. J Cell Sci (2004) 0.94

A fluorescence resonance energy transfer activation sensor for Arf6. Anal Biochem (2007) 0.93

Spatiotemporal organization, regulation, and functions of tractions during neutrophil chemotaxis. Blood (2010) 0.93

Rho proteins in cell migration and metastasis. Crit Rev Eukaryot Gene Expr (2005) 0.92

Computational analysis of the spatiotemporal coordination of polarized PI3K and Rac1 activities in micro-patterned live cells. PLoS One (2011) 0.92

Endothelial fluid shear stress sensing in vascular health and disease. J Clin Invest (2016) 0.92

Light-triggered myosin activation for probing dynamic cellular processes. Angew Chem Int Ed Engl (2011) 0.91

JNK2 promotes endothelial cell alignment under flow. PLoS One (2011) 0.89

Plectin contributes to mechanical properties of living cells. Am J Physiol Cell Physiol (2009) 0.89

Function of the N-terminus of zizimin1: autoinhibition and membrane targeting. Biochem J (2008) 0.89

Effects of integrin-mediated cell adhesion on plasma membrane lipid raft components and signaling. Mol Biol Cell (2011) 0.87

DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling. Nat Commun (2012) 0.85

Inhibition of enzyme activity of and cell-mediated substrate cleavage by membrane type 1 matrix metalloproteinase by newly developed mercaptosulphide inhibitors. Biochem J (2005) 0.83

Lethal gastric rupture caused by acute gastric ulcer in a 6-year-old girl. Pediatr Surg Int (2005) 0.83

Life-threatening airway obstruction caused by mediastinal germinoma in a 9-year-old girl. J Pediatr Surg (2005) 0.82

Electroporation-delivered fluorescent protein biosensors for probing molecular activities in cells without genetic encoding. Chem Commun (Camb) (2014) 0.81

Crystal structure of filamentous aggregates of human DJ-1 formed in an inorganic phosphate-dependent manner. J Biol Chem (2008) 0.81

Rho kinase regulation of vasopressin-induced calcium entry in vascular smooth muscle cell: comparison between rat isolated aorta and cultured aortic cells. Cell Calcium (2012) 0.80

Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2. Nat Commun (2013) 0.80

A femtomol range FRET biosensor reports exceedingly low levels of cell surface furin: implications for the processing of anthrax protective antigen. PLoS One (2010) 0.78

Grb2 negatively regulates epidermal growth factor-induced phospholipase C-gamma1 activity through the direct interaction with tyrosine-phosphorylated phospholipase C-gamma1. Cell Signal (2005) 0.78

Wide-field optical sectioning for live-tissue imaging by plane-projection multiphoton microscopy. J Biomed Opt (2011) 0.78

Cell migration: Towards the void. Nat Mater (2013) 0.78

Putting the squeeze on mechanotransduction. Dev Cell (2004) 0.77

Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interaction. J Cell Biol (2015) 0.76

Profilin phosphorylation as a VEGFR effector in angiogenesis. Nat Cell Biol (2012) 0.76

Matrix metalloproteinase inhibitors based on the 3-mercaptopyrrolidine core. J Med Chem (2013) 0.76

[Diagnosis of mild hemophilia A made by massive intraabdominal bleeding in a 13-year-old boy]. Rinsho Ketsueki (2012) 0.75

Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. Am J Hum Genet (2016) 0.75

Integrin adjunct therapy for melanoma. Pigment Cell Melanoma Res (2014) 0.75

Correction: Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity. J Cell Biol (2016) 0.75

VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN. Curr Biol (2017) 0.75

[Evaluation of beta-lactamase detection reagent with used HMRZ-86 for the detection of extended-spectrum beta-lactamase and metallo-beta-lactamase]. Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi (2004) 0.75