Published in Clin Cancer Res on June 24, 2013
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov (2013) 3.03
Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A (2013) 2.76
Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers. Nat Med (2014) 2.03
Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma. Sci Signal (2014) 1.61
Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis. Clin Cancer Res (2013) 1.18
Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP. Genes Dev (2015) 1.12
Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells. Nat Commun (2015) 1.09
A novel role for microRNA-129-5p in inhibiting ovarian cancer cell proliferation and survival via direct suppression of transcriptional co-activators YAP and TAZ. Oncotarget (2015) 1.00
A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells. Genes Dev (2015) 0.90
Transcriptional co-activator TAZ sustains proliferation and tumorigenicity of neuroblastoma by targeting CTGF and PDGF-β. Oncotarget (2015) 0.90
FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature. J Clin Invest (2015) 0.89
Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development (2016) 0.88
The Hippo pathway in disease and therapy: cancer and beyond. Clin Transl Med (2014) 0.87
A novel HMGA1-CCNE2-YAP axis regulates breast cancer aggressiveness. Oncotarget (2015) 0.86
Dual function of Yap in the regulation of lens progenitor cells and cellular polarity. Dev Biol (2013) 0.85
Functional genomics screen identifies YAP1 as a key determinant to enhance treatment sensitivity in lung cancer cells. Oncotarget (2016) 0.84
A role for the transducer of the Hippo pathway, TAZ, in the development of aggressive types of endometrial cancer. Mod Pathol (2015) 0.83
Nanotopographical Surfaces for Stem Cell Fate Control: Engineering Mechanobiology from the Bottom. Nano Today (2014) 0.81
YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells. Stem Cells (2015) 0.81
RNAi screens for Rho GTPase regulators of cell shape and YAP/TAZ localisation in triple negative breast cancer. Sci Data (2017) 0.80
Antitumor activity of curcumin is involved in down-regulation of YAP/TAZ expression in pancreatic cancer cells. Oncotarget (2016) 0.79
Emerging role of Hippo pathway in gastric and other gastrointestinal cancers. World J Gastroenterol (2016) 0.79
Glial progenitors as targets for transformation in glioma. Adv Cancer Res (2014) 0.78
Global deletion of Ankrd1 results in a wound-healing phenotype associated with dermal fibroblast dysfunction. Am J Pathol (2014) 0.77
The RAS and YAP1 dance, who is leading? EMBO J (2014) 0.77
The transcriptional coactivator Taz regulates proximodistal patterning of the pronephric tubule in zebrafish. Mech Dev (2015) 0.76
Angiomotin regulates prostate cancer cell proliferation by signaling through the Hippo-YAP pathway. Oncotarget (2016) 0.76
SerpinB3 and Yap Interplay Increases Myc Oncogenic Activity. Sci Rep (2015) 0.76
Fluid shear stress activates YAP1 to promote cancer cell motility. Nat Commun (2017) 0.75
Mechanoregulation of Wound Healing and Skin Homeostasis. Biomed Res Int (2016) 0.75
A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination. Nat Commun (2017) 0.75
Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma. Int J Mol Sci (2017) 0.75
Genome-wide analysis of the WW domain-containing protein genes in silkworm and their expansion in eukaryotes. Mol Genet Genomics (2014) 0.75
A potential role for genome structure in the translation of mechanical force during immune cell development. Nucleus (2016) 0.75
Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ. Oncogene (2017) 0.75
Bone regeneration in the stem cell era: safe play for the patient? Clin Rheumatol (2017) 0.75
Role of YAP/TAZ in mechanotransduction. Nature (2011) 11.56
Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci U S A (2003) 7.60
A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell (2009) 6.03
The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell (2011) 5.06
A MicroRNA targeting dicer for metastasis control. Cell (2010) 4.81
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell (2009) 4.11
Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads. Cell (2003) 3.45
A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. Cell (2013) 3.17
Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat Rev Mol Cell Biol (2012) 3.07
Role of TAZ as mediator of Wnt signaling. Cell (2012) 3.05
Emilin1 links TGF-beta maturation to blood pressure homeostasis. Cell (2006) 2.84
Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell (2005) 2.66
SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors. Nature (2012) 2.46
MicroRNA control of Nodal signalling. Nature (2007) 2.09
BMP signaling controls muscle mass. Nat Genet (2013) 1.68
Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation. Science (2007) 1.65
USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol (2011) 1.61
Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities. Mol Cell (2011) 1.43
Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo. Development (2010) 1.35
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. Genes Dev (2004) 1.32
Convergence of p53 and TGF-beta signaling networks. Cancer Lett (2004) 1.05
Fat facets deubiquitylation of Medea/Smad4 modulates interpretation of a Dpp morphogen gradient. Development (2012) 0.87
Inflammation and pancreatic cancer: molecular and functional interactions between S100A8, S100A9, NT-S100A8 and TGFβ1. Cell Commun Signal (2014) 0.83
Self-regulation of the head-inducing properties of the Spemann organizer. Proc Natl Acad Sci U S A (2012) 0.82
The sweet side of YAP/TAZ. Cell Cycle (2015) 0.76