Published in Cell on April 03, 2009
Role of YAP/TAZ in mechanotransduction. Nature (2011) 11.56
Modulation of microRNA processing by p53. Nature (2009) 7.88
Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer (2013) 6.13
MicroRNA control of signal transduction. Nat Rev Mol Cell Biol (2010) 5.74
TGFbeta signalling: a complex web in cancer progression. Nat Rev Cancer (2010) 5.27
p53 mutations in cancer. Nat Cell Biol (2013) 5.18
Mutant p53: one name, many proteins. Genes Dev (2012) 4.33
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 4.09
Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer (2009) 4.06
p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol (2011) 3.70
Mutant p53 in cancer: new functions and therapeutic opportunities. Cancer Cell (2014) 3.68
Mutant p53 gain-of-function in cancer. Cold Spring Harb Perspect Biol (2010) 3.65
The expanding universe of p53 targets. Nat Rev Cancer (2009) 3.49
Inflammation and EMT: an alliance towards organ fibrosis and cancer progression. EMBO Mol Med (2009) 3.05
TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression. Trends Immunol (2010) 2.61
Allele-specific p53 mutant reactivation. Cancer Cell (2012) 2.51
p53 and its mutants in tumor cell migration and invasion. J Cell Biol (2011) 2.49
SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors. Nature (2012) 2.46
Posttranslational modification of p53: cooperative integrators of function. Cold Spring Harb Perspect Biol (2009) 2.34
A microRNA circuit mediates transforming growth factor-β1 autoregulation in renal glomerular mesangial cells. Kidney Int (2011) 2.30
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. J Cell Biol (2011) 2.19
Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis. Genes Cancer (2011) 2.18
p63 and p73, the ancestors of p53. Cold Spring Harb Perspect Biol (2010) 2.16
Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling. Cell (2014) 2.12
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97
p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ (2011) 1.94
Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model. Proc Natl Acad Sci U S A (2009) 1.81
Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells. Mol Cancer Res (2011) 1.77
SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis. Cell Death Differ (2011) 1.76
TGF-β signaling in myeloid cells is required for tumor metastasis. Cancer Discov (2013) 1.76
ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis. Cell Stem Cell (2011) 1.75
Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity. Mol Cell (2013) 1.72
Inhibiting microRNA-192 ameliorates renal fibrosis in diabetic nephropathy. J Am Soc Nephrol (2012) 1.70
The rebel angel: mutant p53 as the driving oncogene in breast cancer. Carcinogenesis (2012) 1.67
Transforming growth factor-β and the hallmarks of cancer. Cell Signal (2010) 1.66
USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor. Nat Cell Biol (2012) 1.65
Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. Oncogene (2012) 1.62
USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol (2011) 1.61
New insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy. J Biomed Biotechnol (2012) 1.57
Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature (2010) 1.57
Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors. Cancer Res (2010) 1.52
Mutant p53 cooperates with ETS2 to promote etoposide resistance. Genes Dev (2012) 1.47
Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53. Cancer Res (2011) 1.44
ERK1/2 and p38α/β signaling in tumor cell quiescence: opportunities to control dormant residual disease. Clin Cancer Res (2011) 1.44
Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer. PLoS One (2012) 1.41
Computational identification of a p38SAPK-regulated transcription factor network required for tumor cell quiescence. Cancer Res (2009) 1.41
Links between mutant p53 and genomic instability. J Cell Biochem (2012) 1.41
A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells. Proc Natl Acad Sci U S A (2009) 1.41
p63-microRNA feedback in keratinocyte senescence. Proc Natl Acad Sci U S A (2012) 1.41
The metastasis-promoting roles of tumor-associated immune cells. J Mol Med (Berl) (2013) 1.40
Apoptosis, autophagy, necroptosis, and cancer metastasis. Mol Cancer (2015) 1.39
Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth. Nat Cell Biol (2015) 1.39
p53 ancestry: gazing through an evolutionary lens. Nat Rev Cancer (2009) 1.37
p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity. J Biol Chem (2009) 1.37
Wild-type p53 controls cell motility and invasion by dual regulation of MET expression. Proc Natl Acad Sci U S A (2011) 1.36
p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis. Nat Rev Cancer (2013) 1.34
p53 Family and Cellular Stress Responses in Cancer. Front Oncol (2014) 1.33
Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis. J Clin Invest (2014) 1.33
Contribution of p53 to metastasis. Cancer Discov (2014) 1.28
Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome. Oncotarget (2011) 1.27
p53 Family: Role of Protein Isoforms in Human Cancer. J Nucleic Acids (2011) 1.26
TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis. J Oncol (2015) 1.23
Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res (2012) 1.22
Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration. J Cell Biol (2012) 1.21
New plays in the p53 theater. Curr Opin Genet Dev (2010) 1.19
Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis. Nat Commun (2013) 1.19
MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function. Cell Death Differ (2011) 1.18
Notch and TGFβ form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity. Cell Stem Cell (2012) 1.16
Targeting TGF-β signaling in cancer. Expert Opin Ther Targets (2013) 1.16
Epithelial-mesenchymal transition in breast cancer progression and metastasis. Chin J Cancer (2011) 1.14
p63 regulates glutaminase 2 expression. Cell Cycle (2013) 1.12
p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner. Cancer Res (2010) 1.12
Aerobic glycolysis tunes YAP/TAZ transcriptional activity. EMBO J (2015) 1.11
Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity. Cell Signal (2014) 1.11
EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours. Sci Rep (2012) 1.10
WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cells. Oncogene (2013) 1.09
Pla2g16 phospholipase mediates gain-of-function activities of mutant p53. Proc Natl Acad Sci U S A (2014) 1.09
Novel p63 target genes involved in paracrine signaling and keratinocyte differentiation. Cell Death Dis (2010) 1.08
The consequence of oncomorphic TP53 mutations in ovarian cancer. Int J Mol Sci (2013) 1.07
Mutant p53 regulates Dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype. J Biol Chem (2013) 1.07
Role of DeltaNp63gamma in epithelial to mesenchymal transition. J Biol Chem (2010) 1.04
Acetylation of the cell-fate factor dachshund determines p53 binding and signaling modules in breast cancer. Oncotarget (2013) 1.03
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. EMBO Rep (2012) 1.03
MicroRNAs and p63 in epithelial stemness. Cell Death Differ (2014) 1.03
Mutant p53: One, No One, and One Hundred Thousand. Front Oncol (2015) 1.02
Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy. Cell Death Dis (2013) 1.02
Microenvironments dictating tumor cell dormancy. Recent Results Cancer Res (2012) 1.01
Fascin protein is critical for transforming growth factor β protein-induced invasion and filopodia formation in spindle-shaped tumor cells. J Biol Chem (2011) 1.00
Ribophorin II regulates breast tumor initiation and metastasis through the functional suppression of GSK3β. Sci Rep (2013) 1.00
Regulation of tumor cell dormancy by tissue microenvironments and autophagy. Adv Exp Med Biol (2013) 1.00
Clinical relevance of gain-of-function mutations of p53 in high-grade serous ovarian carcinoma. PLoS One (2013) 0.99
Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy. EMBO Mol Med (2015) 0.99
p63 regulates human keratinocyte proliferation via MYC-regulated gene network and differentiation commitment through cell adhesion-related gene network. J Biol Chem (2011) 0.98
Pancreatic cancer biology and genetics from an evolutionary perspective. Nat Rev Cancer (2016) 0.98
Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin. J Biol Chem (2012) 0.97
TGF-beta induces serous borderline ovarian tumor cell invasion by activating EMT but triggers apoptosis in low-grade serous ovarian carcinoma cells. PLoS One (2012) 0.97
Critical role of the WASF3 gene in JAK2/STAT3 regulation of cancer cell motility. Carcinogenesis (2013) 0.97
TGF-β induces acetylation of chromatin and of Ets-1 to alleviate repression of miR-192 in diabetic nephropathy. Sci Signal (2013) 0.97
{alpha}7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation. Am J Pathol (2009) 0.97
MicroRNAs and the glomerulus. Exp Cell Res (2012) 0.97
Role of YAP/TAZ in mechanotransduction. Nature (2011) 11.56
Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci U S A (2003) 7.60
Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest (2006) 6.61
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature (2007) 6.56
MicroRNA control of signal transduction. Nat Rev Mol Cell Biol (2010) 5.74
The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell (2011) 5.06
A MicroRNA targeting dicer for metastasis control. Cell (2010) 4.81
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature (2004) 4.35
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell (2009) 4.11
Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. Immunity (2010) 3.88
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science (2008) 3.78
Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat Genet (2003) 3.70
Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol (2002) 3.52
Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads. Cell (2003) 3.45
A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. Cell (2013) 3.17
Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. J Neurosci (2004) 3.12
Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat Rev Mol Cell Biol (2012) 3.07
Role of TAZ as mediator of Wnt signaling. Cell (2012) 3.05
IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors. Blood (2012) 3.02
Emilin1 links TGF-beta maturation to blood pressure homeostasis. Cell (2006) 2.84
Methods for interpreting lists of affected genes obtained in a DNA microarray experiment. BMC Proc (2009) 2.80
Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells. Nat Immunol (2011) 2.76
Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol (2005) 2.73
Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell (2005) 2.66
Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse. J Cell Biol (2004) 2.57
The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction. Nat Chem Biol (2006) 2.56
CASD-NMR: critical assessment of automated structure determination by NMR. Nat Methods (2009) 2.50
SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors. Nature (2012) 2.46
Resiliency and vulnerability in the HER2-HER3 tumorigenic driver. Sci Transl Med (2010) 2.42
Counting the zinc-proteins encoded in the human genome. J Proteome Res (2006) 2.38
Stem-cell hierarchy in skin cancer. Nat Rev Cancer (2003) 2.36
Novel definition files for human GeneChips based on GeneAnnot. BMC Bioinformatics (2007) 2.32
Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma. Nat Genet (2011) 2.29
Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol (2007) 2.26
Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancer. Am J Pathol (2007) 2.23
Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell (2009) 2.17
Zinc through the three domains of life. J Proteome Res (2006) 2.11
Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation. Nat Med (2010) 2.10
MicroRNA control of Nodal signalling. Nature (2007) 2.09
Identification of microRNA expression patterns and definition of a microRNA/mRNA regulatory network in distinct molecular groups of multiple myeloma. Blood (2009) 2.08
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer. Nat Genet (2008) 2.05
Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays. Nat Biotechnol (2002) 2.04
A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells. Blood (2011) 2.03
Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development (2008) 1.96
A Pin1/mutant p53 axis promotes aggressiveness in breast cancer. Cancer Cell (2011) 1.95
Genomic segmental polymorphisms in inbred mouse strains. Nat Genet (2004) 1.93
Genetic architecture of mouse skin inflammation and tumour susceptibility. Nature (2009) 1.89
Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma. J Mol Med (Berl) (2011) 1.87
A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma. Cancer Discov (2012) 1.87
Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife (2013) 1.85
Toll-like receptor 2 regulates intestinal inflammation by controlling integrity of the enteric nervous system. Gastroenterology (2013) 1.83
A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice. Nat Genet (2006) 1.79
Changing epidemiology of hand, foot, and mouth disease in Hong Kong, 2001-2009. Jpn J Infect Dis (2010) 1.74
Mapping segmental and sequence variations among laboratory mice using BAC array CGH. Genome Res (2005) 1.71
BMP signaling controls muscle mass. Nat Genet (2013) 1.68
Unexpected structural and functional consequences of the R33Q homozygous mutation in cardiac calsequestrin: a complex arrhythmogenic cascade in a knock in mouse model. Circ Res (2008) 1.67
Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation. Science (2007) 1.65
Application of the ABCD2 score to identify cerebrovascular causes of dizziness in the emergency department. Stroke (2012) 1.65
USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol (2011) 1.61
The reconstruction of transcriptional networks reveals critical genes with implications for clinical outcome of multiple myeloma. Clin Cancer Res (2011) 1.61
Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types. Carcinogenesis (2005) 1.61
Quantitative imaging of the T cell antitumor response by positron-emission tomography. Proc Natl Acad Sci U S A (2003) 1.60
Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell (2007) 1.59
HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis. Proc Natl Acad Sci U S A (2007) 1.58