Published in Cell on August 15, 2013
Cytokinesis failure triggers hippo tumor suppressor pathway activation. Cell (2014) 3.15
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov (2013) 3.03
The emerging roles of YAP and TAZ in cancer. Nat Rev Cancer (2015) 2.74
Cell adhesion. Mechanical strain induces E-cadherin-dependent Yap1 and β-catenin activation to drive cell cycle entry. Science (2015) 2.45
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. Cell (2015) 2.31
Cytoskeletal tension inhibits Hippo signaling through an Ajuba-Warts complex. Cell (2014) 1.98
Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell (2014) 1.96
The Hippo signaling pathway in stem cell biology and cancer. EMBO Rep (2014) 1.73
Designer matrices for intestinal stem cell and organoid culture. Nature (2016) 1.51
Mechanical stretch triggers rapid epithelial cell division through Piezo1. Nature (2017) 1.48
Mechanisms of Hippo pathway regulation. Genes Dev (2016) 1.45
Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth. Nat Cell Biol (2015) 1.39
Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling. Genes Dev (2014) 1.33
Angiomotins link F-actin architecture to Hippo pathway signaling. Mol Biol Cell (2014) 1.32
The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy. Circ Res (2013) 1.30
Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis. Am J Physiol Lung Cell Mol Physiol (2014) 1.29
The Hippo-YAP signaling pathway and contact inhibition of growth. J Cell Sci (2014) 1.29
A FAK-Cas-Rac-lamellipodin signaling module transduces extracellular matrix stiffness into mechanosensitive cell cycling. Sci Signal (2014) 1.15
Epithelial homeostasis. Curr Biol (2014) 1.12
Cell shape and the microenvironment regulate nuclear translocation of NF-κB in breast epithelial and tumor cells. Mol Syst Biol (2015) 1.11
Aerobic glycolysis tunes YAP/TAZ transcriptional activity. EMBO J (2015) 1.11
MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun (2015) 1.11
Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway. Cell Res (2015) 1.09
Spatial constraints control cell proliferation in tissues. Proc Natl Acad Sci U S A (2014) 1.08
Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway. J Cell Biol (2015) 1.05
Topological defects in epithelia govern cell death and extrusion. Nature (2017) 1.02
YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells. Nat Neurosci (2016) 1.01
Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer. Trends Biotechnol (2015) 0.99
Biomechanics of TGFβ-induced epithelial-mesenchymal transition: implications for fibrosis and cancer. Clin Transl Med (2014) 0.99
Genome-Wide Analysis of Wilms' Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms. J Am Soc Nephrol (2015) 0.99
Neuregulin 1-activated ERBB4 interacts with YAP to induce Hippo pathway target genes and promote cell migration. Sci Signal (2014) 0.98
Rho, nuclear actin, and actin-binding proteins in the regulation of transcription and gene expression. Small GTPases (2014) 0.98
The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila. Dev Cell (2014) 0.98
Regulation of YAP by mechanical strain through Jnk and Hippo signaling. Curr Biol (2014) 0.98
Α-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion. Mol Biol Cell (2014) 0.96
Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells. Stem Cell Reports (2015) 0.96
Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice. Sci Signal (2015) 0.95
Organ Size Control: Lessons from Drosophila. Dev Cell (2015) 0.95
Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer. J Hepatol (2015) 0.95
A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures. EMBO J (2014) 0.93
Control of organ growth by patterning and hippo signaling in Drosophila. Cold Spring Harb Perspect Biol (2015) 0.92
Intranuclear Actin Regulates Osteogenesis. Stem Cells (2015) 0.91
The hippo pathway in heart development, regeneration, and diseases. Circ Res (2015) 0.91
Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction. Nat Cell Biol (2015) 0.90
Asymmetric division of contractile domains couples cell positioning and fate specification. Nature (2016) 0.90
The Hippo pathway is controlled by Angiotensin II signaling and its reactivation induces apoptosis in podocytes. Cell Death Dis (2014) 0.90
Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation. EMBO J (2015) 0.89
G Protein-Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation. Mol Pharmacol (2015) 0.89
Impact of the physical microenvironment on tumor progression and metastasis. Curr Opin Biotechnol (2016) 0.89
Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade. Dev Cell (2015) 0.89
FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature. J Clin Invest (2015) 0.89
Mechanical force sensing in tissues. Prog Mol Biol Transl Sci (2014) 0.89
Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development (2016) 0.88
Cyclic stretching of soft substrates induces spreading and growth. Nat Commun (2015) 0.88
Integrin-mediated mechanotransduction. J Cell Biol (2016) 0.88
Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network. Trends Cell Biol (2016) 0.88
The Spectrin cytoskeleton regulates the Hippo signalling pathway. EMBO J (2015) 0.87
Control of Proliferation and Cancer Growth by the Hippo Signaling Pathway. Mol Cancer Res (2015) 0.87
Mutual regulation between Hippo signaling and actin cytoskeleton. Protein Cell (2013) 0.87
Mechanical stimulation induces formin-dependent assembly of a perinuclear actin rim. Proc Natl Acad Sci U S A (2015) 0.87
The Hippo pathway in disease and therapy: cancer and beyond. Clin Transl Med (2014) 0.87
ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival. Cell Rep (2015) 0.87
Structural basis for the phosphorylation-regulated interaction between the cytoplasmic tail of cell polarity protein crumbs and the actin-binding protein moesin. J Biol Chem (2015) 0.86
Amotl2a interacts with the Hippo effector Yap1 and the Wnt/β-catenin effector Lef1 to control tissue size in zebrafish. Elife (2015) 0.86
Yes-Associated Protein is up-regulated by mechanical overload and is sufficient to induce skeletal muscle hypertrophy. FEBS Lett (2015) 0.86
Confrontation of fibroblasts with cancer cells in vitro: gene network analysis of transcriptome changes and differential capacity to inhibit tumor growth. J Exp Clin Cancer Res (2015) 0.86
Role of Merlin/NF2 inactivation in tumor biology. Oncogene (2015) 0.85
On human pluripotent stem cell control: The rise of 3D bioengineering and mechanobiology. Biomaterials (2015) 0.84
Spectrin regulates Hippo signaling by modulating cortical actomyosin activity. Elife (2015) 0.84
MST kinases in development and disease. J Cell Biol (2015) 0.84
YAP Nuclear Localization in the Absence of Cell-Cell Contact Is Mediated by a Filamentous Actin-dependent, Myosin II- and Phospho-YAP-independent Pathway during Extracellular Matrix Mechanosensing. J Biol Chem (2016) 0.83
Cadherin signaling: keeping cells in touch. F1000Res (2015) 0.83
FGF8 promotes colorectal cancer growth and metastasis by activating YAP1. Oncotarget (2015) 0.83
SMIFH2 has effects on Formins and p53 that perturb the cell cytoskeleton. Sci Rep (2015) 0.82
Myocardin-Related Transcription Factor A and Yes-Associated Protein Exert Dual Control in G Protein-Coupled Receptor- and RhoA-Mediated Transcriptional Regulation and Cell Proliferation. Mol Cell Biol (2015) 0.82
Evidence That an Unconventional Actin Can Provide Essential F-Actin Function and That a Surveillance System Monitors F-Actin Integrity in Chlamydomonas. Genetics (2015) 0.82
Integrated micro/nanoengineered functional biomaterials for cell mechanics and mechanobiology: a materials perspective. Adv Mater (2013) 0.82
Cardiac Regeneration: Lessons From Development. Circ Res (2017) 0.82
Stem cell mechanobiology: diverse lessons from bone marrow. Trends Cell Biol (2015) 0.82
mTORC2 regulates cardiac response to stress by inhibiting MST1. Cell Rep (2015) 0.82
Confocal reference free traction force microscopy. Nat Commun (2016) 0.82
Nanotopographical Surfaces for Stem Cell Fate Control: Engineering Mechanobiology from the Bottom. Nano Today (2014) 0.81
β-Spectrin regulates the hippo signaling pathway and modulates the basal actin network. J Biol Chem (2015) 0.81
Regulation of epithelial cell organization by tuning cell-substrate adhesion. Integr Biol (Camb) (2015) 0.81
Scalloped and Yorkie are required for cell cycle re-entry of quiescent cells after tissue damage. Development (2015) 0.81
Extracellular Matrix Stiffness Regulates Osteogenic Differentiation through MAPK Activation. PLoS One (2015) 0.80
The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP. J Mol Cell Cardiol (2015) 0.80
The role of phosphoinositide-regulated actin reorganization in chemotaxis and cell migration. Br J Pharmacol (2014) 0.80
Inhibitory mechanism of FAT4 gene expression in response to actin dynamics during Src-induced carcinogenesis. PLoS One (2015) 0.80
Extracellular matrix elasticity and topography: material-based cues that affect cell function via conserved mechanisms. J Biomed Mater Res A (2014) 0.80
The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling. J Cell Biol (2015) 0.80
Integrin α2β1 inhibits MST1 kinase phosphorylation and activates Yes-associated protein oncogenic signaling in hepatocellular carcinoma. Oncotarget (2016) 0.79
Osteoblast-specific deletion of Pkd2 leads to low-turnover osteopenia and reduced bone marrow adiposity. PLoS One (2014) 0.79
A journey to uncharted territory: new technical frontiers in studying tumor-stromal cell interactions. Integr Biol (Camb) (2015) 0.79
Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling. Mol Biol Cell (2015) 0.79
Zebrafish yap1 plays a role in differentiation of hair cells in posterior lateral line. Sci Rep (2014) 0.79
Cell shape and the microenvironment regulate nuclear translocation of NF-κB in breast epithelial and tumor cells. Mol Syst Biol (2015) 0.79
The Hippo signaling pathway provides novel anti-cancer drug targets. Oncotarget (2016) 0.79
Retinal pigment epithelial cell multinucleation in the aging eye - a mechanism to repair damage and maintain homoeostasis. Aging Cell (2016) 0.78
Occludin S471 Phosphorylation Contributes to Epithelial Monolayer Maturation. Mol Cell Biol (2016) 0.78
Role of YAP/TAZ in mechanotransduction. Nature (2011) 11.56
Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci U S A (2003) 7.60
A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell (2009) 6.03
MicroRNA control of signal transduction. Nat Rev Mol Cell Biol (2010) 5.74
The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell (2011) 5.06
A MicroRNA targeting dicer for metastasis control. Cell (2010) 4.81
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell (2009) 4.11
Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads. Cell (2003) 3.45
Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. J Neurosci (2004) 3.12
Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat Rev Mol Cell Biol (2012) 3.07
Role of TAZ as mediator of Wnt signaling. Cell (2012) 3.05
Emilin1 links TGF-beta maturation to blood pressure homeostasis. Cell (2006) 2.84
Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol (2005) 2.73
Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell (2005) 2.66
Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse. J Cell Biol (2004) 2.57
SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors. Nature (2012) 2.46
Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol (2007) 2.26
Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell (2009) 2.17
MicroRNA control of Nodal signalling. Nature (2007) 2.09
Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development (2008) 1.96
PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases. J Cell Biol (2006) 1.81
BMP signaling controls muscle mass. Nat Genet (2013) 1.68
Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation. Science (2007) 1.65
USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol (2011) 1.61
The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis. Development (2006) 1.55
Micro-bioreactor array for controlling cellular microenvironments. Lab Chip (2007) 1.52
Electrical stimulation of human embryonic stem cells: cardiac differentiation and the generation of reactive oxygen species. Exp Cell Res (2009) 1.49
Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities. Mol Cell (2011) 1.43
Beta-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression. Development (2009) 1.39
Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo. Development (2010) 1.35
Molecular pathways: YAP and TAZ take center stage in organ growth and tumorigenesis. Clin Cancer Res (2013) 1.34
Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival. Blood (2005) 1.25
Targeting triple negative breast cancer: is p53 the answer? Cancer Treat Rev (2013) 1.23
In vivo tissue engineering of functional skeletal muscle by freshly isolated satellite cells embedded in a photopolymerizable hydrogel. FASEB J (2011) 1.20
Microfluidic device generating stable concentration gradients for long term cell culture: application to Wnt3a regulation of β-catenin signaling. Lab Chip (2010) 1.20
Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2. Genesis (2007) 1.15
Practical aspects of cardiac tissue engineering with electrical stimulation. Methods Mol Med (2007) 1.11
Micro-bioreactor arrays for controlling cellular environments: design principles for human embryonic stem cell applications. Methods (2008) 1.07
Epithelial-mesenchymal transition in malignant mesothelioma. Mod Pathol (2011) 1.05
Convergence of p53 and TGF-beta signaling networks. Cancer Lett (2004) 1.05
Soft substrates drive optimal differentiation of human healthy and dystrophic myotubes. Integr Biol (Camb) (2010) 1.04
Identification of new p63 targets in human keratinocytes. Cell Cycle (2006) 0.97
Micro-arrayed human embryonic stem cells-derived cardiomyocytes for in vitro functional assay. PLoS One (2012) 0.96
Muscle differentiation and myotubes alignment is influenced by micropatterned surfaces and exogenous electrical stimulation. Tissue Eng Part A (2009) 0.94
Neovascularization induced by porous collagen scaffold implanted on intact and cryoinjured rat hearts. Biomaterials (2007) 0.93
Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections. J Neurosci (2007) 0.92
Optimal periodic perfusion strategy for robust long-term microfluidic cell culture. Lab Chip (2013) 0.91
Electrophysiologic stimulation improves myogenic potential of muscle precursor cells grown in a 3D collagen scaffold. Neurol Res (2008) 0.90
Confined 3D microenvironment regulates early differentiation in human pluripotent stem cells. Biotechnol Bioeng (2012) 0.90
Fat facets deubiquitylation of Medea/Smad4 modulates interpretation of a Dpp morphogen gradient. Development (2012) 0.87
Production of arrays of cardiac and skeletal muscle myofibers by micropatterning techniques on a soft substrate. Biomed Microdevices (2009) 0.87
Micropatterning topology on soft substrates affects myoblast proliferation and differentiation. Langmuir (2012) 0.87
miRNAs and morphogen gradients. Curr Opin Cell Biol (2011) 0.86
Effective protein release from PEG/PLA nano-particles produced by compressed gas anti-solvent precipitation techniques. J Control Release (2004) 0.86
Microfluidic-driven viral infection on cell cultures: Theoretical and experimental study. Biomicrofluidics (2012) 0.85
Tissue engineering: an option for esophageal replacement? Semin Pediatr Surg (2009) 0.84
Efficient delivery of human single fiber-derived muscle precursor cells via biocompatible scaffold. Cell Transplant (2008) 0.84
Satellite cells delivered by micro-patterned scaffolds: a new strategy for cell transplantation in muscle diseases. Tissue Eng (2007) 0.84
Inflammation and pancreatic cancer: molecular and functional interactions between S100A8, S100A9, NT-S100A8 and TGFβ1. Cell Commun Signal (2014) 0.83
Stochastic model-assisted development of efficient low-dose viral transduction in microfluidics. Biophys J (2013) 0.82
Self-regulation of the head-inducing properties of the Spemann organizer. Proc Natl Acad Sci U S A (2012) 0.82
Single-cell PCR analysis of murine embryonic stem cells cultured on different substrates highlights heterogeneous expression of stem cell markers. Biol Cell (2013) 0.80
Biopharmaceutical characterisation of insulin and recombinant human growth hormone loaded lipid submicron particles produced by supercritical gas micro-atomisation. Int J Pharm (2009) 0.79
Dynamic culture of droplet-confined cell arrays. Biotechnol Prog (2010) 0.79
Flow biosensing and sampling in indirect electrochemical detection. Biomicrofluidics (2012) 0.79
Micropatterned biopolymer 3D scaffold for static and dynamic culture of human fibroblasts. Biotechnol Prog (2007) 0.79
Microliter-bioreactor array with buoyancy-driven stirring for human hematopoietic stem cell culture. Biomicrofluidics (2010) 0.78
Production of solid lipid submicron particles for protein delivery using a novel supercritical gas-assisted melting atomization process. J Pharm Sci (2009) 0.78
LIF-ting Hippo averts metastasis. Nat Med (2012) 0.78
Nisin-loaded poly-L-lactide nano-particles produced by CO2 anti-solvent precipitation for sustained antimicrobial activity. Int J Pharm (2004) 0.78
A combining method to enhance the in vitro differentiation of hepatic precursor cells. Tissue Eng Part C Methods (2010) 0.78
Design of a stirred multiwell bioreactor for expansion of CD34+ umbilical cord blood cells in hypoxic conditions. Biotechnol Prog (2011) 0.78
Determination of glucose flux in live myoblasts by microfluidic nanosensing and mathematical modeling. Integr Biol (Camb) (2014) 0.77
The sweet side of YAP/TAZ. Cell Cycle (2015) 0.76
Unilateral rosacea in patients with facial nerve palsy: a mere example of immunocompromised district. J Dermatol (2013) 0.75
Three-dimensional porous scaffold allows long-term wild-type cell delivery in dystrophic muscle. J Tissue Eng Regen Med (2011) 0.75
Flow cytometric cell cycle analysis of muscle precursor cells cultured within 3D scaffolds in a perfusion bioreactor. Biotechnol Prog (2009) 0.75
Theoretical analysis of insulin-dependent glucose uptake heterogeneity in 3D bioreactor cell culture. Biotechnol Prog (2012) 0.75
Gas anti-solvent precipitation assisted salt leaching for generation of micro- and nano-porous wall in bio-polymeric 3D scaffolds. Mater Sci Eng C Mater Biol Appl (2012) 0.75