Published in Clin Transl Med on July 10, 2014
A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis. Nat Cell Biol (2017) 0.85
Interaction of the EGF Receptor and the Hippo Pathway in the Diabetic Kidney. J Am Soc Nephrol (2015) 0.80
Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor. J Biol Chem (2015) 0.78
HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension. Am J Respir Crit Care Med (2016) 0.77
Evaluation of LATS1 and LATS2 Promoter Methylation with the Risk of Pterygium Formation. J Ophthalmol (2016) 0.76
Early protective role of MST1 knockdown in response to experimental diabetic nephropathy. Am J Transl Res (2016) 0.75
ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. Cancer Cell (2016) 0.75
miR-285-Yki/Mask double-negative feedback loop mediates blood-brain barrier integrity in Drosophila. Proc Natl Acad Sci U S A (2017) 0.75
Differential localization of A-Raf regulates MST2-mediated apoptosis during epithelial differentiation. Cell Death Differ (2016) 0.75
Cartography of Pathway Signal Perturbations Identifies Distinct Molecular Pathomechanisms in Malignant and Chronic Lung Diseases. Front Genet (2016) 0.75
Mapping the STK4/Hippo signaling network in prostate cancer cell. PLoS One (2017) 0.75
Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer (2009) 18.53
Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell (2007) 13.04
Discovery and saturation analysis of cancer genes across 21 tumour types. Nature (2014) 11.68
Role of YAP/TAZ in mechanotransduction. Nature (2011) 11.56
TEAD mediates YAP-dependent gene induction and growth control. Genes Dev (2008) 9.88
YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol (2007) 8.11
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A (2006) 8.01
Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell (2009) 7.39
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell (2012) 6.80
Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nat Biotechnol (2014) 5.71
Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J Biol Chem (2007) 5.49
A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev (2010) 5.38
The Hippo pathway and human cancer. Nat Rev Cancer (2013) 5.17
The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell (2011) 5.06
TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol (2008) 5.02
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A (2010) 4.95
Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell (2011) 4.85
Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science (2011) 4.76
The Hippo pathway: regulators and regulations. Genes Dev (2013) 4.55
The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol (2001) 4.33
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev (2012) 4.19
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A (2010) 4.17
Comprehensive identification of mutational cancer driver genes across 12 tumor types. Sci Rep (2013) 3.92
Restriction of intestinal stem cell expansion and the regenerative response by YAP. Nature (2012) 3.54
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol (2008) 3.44
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev (2010) 3.37
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell (2012) 3.33
Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell (2013) 3.26
TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem (2009) 3.20
A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. Cell (2013) 3.17
Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat Rev Mol Cell Biol (2012) 3.07
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov (2013) 3.03
The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev (2010) 3.02
Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Development (2008) 2.98
NDR kinases regulate essential cell processes from yeast to humans. Nat Rev Mol Cell Biol (2006) 2.88
Metabolic control of YAP and TAZ by the mevalonate pathway. Nat Cell Biol (2014) 2.84
Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A (2013) 2.76
Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway. Cancer Res (2008) 2.63
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol (2008) 2.62
The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain. Proc Natl Acad Sci U S A (2012) 2.51
Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Sci Signal (2011) 2.38
The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. J Biol Chem (2010) 2.27
LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nat Med (2012) 2.24
The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathway. Semin Cell Dev Biol (2012) 2.21
Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF. Cancer Res (2011) 2.21
Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J Clin Invest (2003) 2.20
YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A (2012) 2.13
The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat Rev Cancer (2013) 2.05
Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein. Cancer Res (2009) 2.05
Hippo signaling in Drosophila: recent advances and insights. Dev Dyn (2011) 2.01
A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription. J Biochem (2011) 2.00
TEADs mediate nuclear retention of TAZ to promote oncogenic transformation. J Biol Chem (2009) 1.96
Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat Med (2013) 1.93
Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP. Chem Biol (2012) 1.91
Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs). Genes Dev (2012) 1.86
Hippo signaling regulates differentiation and maintenance in the exocrine pancreas. Gastroenterology (2013) 1.85
The phenotype of human STK4 deficiency. Blood (2012) 1.84
Hippo signaling impedes adult heart regeneration. Development (2013) 1.81
MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival. Blood (2011) 1.76
MicroRNA-141 confers resistance to cisplatin-induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma. J Hum Genet (2011) 1.71
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal (2013) 1.69
A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell (2014) 1.68
YAP: at the crossroad between transformation and tumor suppression. Cell Cycle (2009) 1.67
Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction. Circ Res (2007) 1.66
The Hippo superhighway: signaling crossroads converging on the Hippo/Yap pathway in stem cells and development. Curr Opin Cell Biol (2013) 1.64
The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci U S A (2008) 1.61
Protein kinases of the Hippo pathway: regulation and substrates. Semin Cell Dev Biol (2012) 1.61
Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes. EMBO J (2009) 1.58
Lats2 is a negative regulator of myocyte size in the heart. Circ Res (2008) 1.53
The Hippo signaling pathway interactome. Science (2013) 1.42
Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment. Proc Natl Acad Sci U S A (2013) 1.38
YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14. Oncogene (2012) 1.36
Molecular pathways: YAP and TAZ take center stage in organ growth and tumorigenesis. Clin Cancer Res (2013) 1.34
Angiomotins link F-actin architecture to Hippo pathway signaling. Mol Biol Cell (2014) 1.32
The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy. Circ Res (2013) 1.30
Targeting protein-protein interactions as an anticancer strategy. Trends Pharmacol Sci (2013) 1.29
The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes. J Exp Med (2012) 1.25
Coordinating developmental signaling: novel roles for the Hippo pathway. Trends Cell Biol (2011) 1.23
Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling. Biofactors (2009) 1.23
Hippo signaling regulates pancreas development through inactivation of Yap. Mol Cell Biol (2012) 1.21
MOB control: reviewing a conserved family of kinase regulators. Cell Signal (2011) 1.21
VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex. Cell Res (2014) 1.20
Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. J Biol Chem (2012) 1.18
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J Clin Invest (2012) 1.16
Novel insights into G protein and G protein-coupled receptor signaling in cancer. Curr Opin Cell Biol (2014) 1.14
Defining the protein-protein interaction network of the human hippo pathway. Mol Cell Proteomics (2013) 1.14
Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase. Nat Commun (2013) 1.12
A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response. Nat Commun (2014) 1.12
Control of the hippo pathway by Set7-dependent methylation of Yap. Dev Cell (2013) 1.11
Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus. Nat Commun (2012) 1.11
Yap is a novel regulator of C2C12 myogenesis. Biochem Biophys Res Commun (2010) 1.10
A conserved DNA damage response pathway responsible for coupling the cell division cycle to the circadian and metabolic cycles. Cell Cycle (2007) 1.10
Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. Mol Syst Biol (2013) 1.10
Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling. Cell Biosci (2013) 1.09
MicroRNA-138 plays a role in hypoxic pulmonary vascular remodelling by targeting Mst1. Biochem J (2013) 1.08
Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila. Nat Cell Biol (2013) 1.08
Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming. Hum Mol Genet (2012) 1.07
Regulation of the Hippo pathway and implications for anticancer drug development. Trends Pharmacol Sci (2013) 1.07
The Hippo pathway member Yap plays a key role in influencing fate decisions in muscle satellite cells. J Cell Sci (2012) 1.04