|
1
|
Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans.
|
Mech Ageing Dev
|
2006
|
5.61
|
|
2
|
Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control.
|
J Clin Endocrinol Metab
|
2003
|
2.40
|
|
3
|
Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons.
|
Am J Physiol Endocrinol Metab
|
2002
|
1.76
|
|
4
|
Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes.
|
Proc Natl Acad Sci U S A
|
2003
|
1.56
|
|
5
|
Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians.
|
Mech Ageing Dev
|
2005
|
1.49
|
|
6
|
An APOE haplotype associated with decreased ε4 expression increases the risk of late onset Alzheimer's disease.
|
J Alzheimers Dis
|
2011
|
1.45
|
|
7
|
Impact of telemonitoring at home on the management of elderly patients with congestive heart failure.
|
J Telemed Telecare
|
2008
|
1.17
|
|
8
|
Genetic polymorphism in long-lived people: cues for the presence of an insulin/IGF-pathway-dependent network affecting human longevity.
|
Mol Cell Endocrinol
|
2008
|
1.09
|
|
9
|
Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease.
|
PLoS One
|
2010
|
1.06
|
|
10
|
-174 G>C polymorphism of interleukin 6 gene promoter affects interleukin 6 serum level in patients with colorectal cancer.
|
Clin Cancer Res
|
2003
|
1.05
|
|
11
|
Retention of the p53 codon 72 arginine allele is associated with a reduction of disease-free and overall survival in arginine/proline heterozygous breast cancer patients.
|
Clin Cancer Res
|
2003
|
1.04
|
|
12
|
The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians.
|
Aging Cell
|
2004
|
1.04
|
|
13
|
Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity.
|
Exp Gerontol
|
2004
|
1.03
|
|
14
|
Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis.
|
Exp Gerontol
|
2004
|
1.01
|
|
15
|
Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain.
|
Neurobiol Aging
|
2003
|
1.01
|
|
16
|
What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians.
|
Exp Gerontol
|
2002
|
0.97
|
|
17
|
Effects of donepezil, galantamine and rivastigmine in 938 Italian patients with Alzheimer's disease: a prospective, observational study.
|
CNS Drugs
|
2010
|
0.97
|
|
18
|
Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians.
|
Mech Ageing Dev
|
2005
|
0.96
|
|
19
|
p53 codon 72 genotype affects apoptosis by cytosine arabinoside in blood leukocytes.
|
Biochem Biophys Res Commun
|
2002
|
0.95
|
|
20
|
Is chronic inflammation a determinant of blood pressure in the elderly?
|
Am J Hypertens
|
2003
|
0.94
|
|
21
|
Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: a proof of principle on type 2 diabetes.
|
Aging (Albany NY)
|
2013
|
0.94
|
|
22
|
The -174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing.
|
Exp Gerontol
|
2004
|
0.92
|
|
23
|
The role of IL-1 gene cluster in longevity: a study in Italian population.
|
Mech Ageing Dev
|
2003
|
0.92
|
|
24
|
Allele frequencies of +874T-->A single nucleotide polymorphism at the first intron of interferon-gamma gene in a group of Italian centenarians.
|
Exp Gerontol
|
2002
|
0.92
|
|
25
|
Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians.
|
Eur J Hum Genet
|
2002
|
0.91
|
|
26
|
Human longevity within an evolutionary perspective: the peculiar paradigm of a post-reproductive genetics.
|
Exp Gerontol
|
2007
|
0.91
|
|
27
|
Conventional and novel diagnostic biomarkers of acute myocardial infarction: a promising role for circulating microRNAs.
|
Biomarkers
|
2013
|
0.90
|
|
28
|
Paraoxonase 1: genetics and activities during aging.
|
Rejuvenation Res
|
2008
|
0.89
|
|
29
|
A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity.
|
J Gerontol A Biol Sci Med Sci
|
2006
|
0.89
|
|
30
|
Tumor necrosis factor-alpha gene -308G>A polymorphism is associated with ST-elevation myocardial infarction and with high plasma levels of biochemical ischemia markers.
|
Coron Artery Dis
|
2005
|
0.88
|
|
31
|
Circulating microRNAs (miRs) for diagnosing acute myocardial infarction: an exciting challenge.
|
Int J Cardiol
|
2012
|
0.88
|
|
32
|
An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity.
|
Gene
|
2002
|
0.85
|
|
33
|
Predicting microRNA modulation in human prostate cancer using a simple String IDentifier (SID1.0).
|
J Biomed Inform
|
2011
|
0.85
|
|
34
|
The interleukin-6 -174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients.
|
Int J Cardiol
|
2005
|
0.85
|
|
35
|
Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes.
|
Age (Dordr)
|
2011
|
0.85
|
|
36
|
Paraoxonase activity and genotype predispose to successful aging.
|
J Gerontol A Biol Sci Med Sci
|
2006
|
0.84
|
|
37
|
Lipoxygenase inhibitors for cancer prevention: promises and risks.
|
Curr Pharm Des
|
2010
|
0.83
|
|
38
|
Mismatch repair system and aging: microsatellite instability in peripheral blood cells from differently aged participants.
|
J Gerontol A Biol Sci Med Sci
|
2005
|
0.83
|
|
39
|
A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene.
|
Gene
|
2004
|
0.82
|
|
40
|
mRNAs and miRNAs profiling of mesenchymal stem cells derived from amniotic fluid and skin: the double face of the coin.
|
Cell Tissue Res
|
2013
|
0.81
|
|
41
|
Chlamydia pneumoniae seropositivity and cardiovascular risk factors: The InCHIANTI Study.
|
J Am Geriatr Soc
|
2004
|
0.80
|
|
42
|
The p53 codon 72 (Arg72Pro) polymorphism is associated with the degree of insulin resistance in type 2 diabetic subjects: a cross-sectional study.
|
Acta Diabetol
|
2012
|
0.80
|
|
43
|
Prevention of cardiovascular events in early menopause: a possible role for hormone replacement therapy.
|
Int J Cardiol
|
2008
|
0.80
|
|
44
|
The MALVA (MAntova LongeVA) study: an investigation on people 98 years of age and over in a province of Northern Italy.
|
Exp Gerontol
|
2003
|
0.78
|
|
45
|
Genome-wide association studies: is there a genotype for cognitive decline in older persons with type 2 diabetes?
|
Curr Pharm Des
|
2011
|
0.78
|
|
46
|
Platelet nitric oxide production and IR: relation with obesity and hypertriglyceridemia.
|
Nutr Metab Cardiovasc Dis
|
2007
|
0.77
|
|
47
|
[The role of molecular biology in the diagnosis and treatment of cardiovascular diseases].
|
G Ital Cardiol (Rome)
|
2010
|
0.77
|
|
48
|
Paraoxonase2 C311S polymorphism and low levels of HDL contribute to a higher mortality risk after acute myocardial infarction in elderly patients.
|
Mol Genet Metab
|
2009
|
0.76
|
|
49
|
Frailty and safety: the example of diabetes.
|
Drug Saf
|
2012
|
0.76
|
|
50
|
Failure to replicate an association of rs5984894 SNP in the PCDH11X gene in a collection of 1,222 Alzheimer's disease affected patients.
|
J Alzheimers Dis
|
2010
|
0.76
|
|
51
|
Myocardial bridging: A 'forgotten' cause of acute coronary syndrome - a case report.
|
Int J Angiol
|
2007
|
0.75
|
|
52
|
Genes of human longevity: an endless quest?
|
Curr Vasc Pharmacol
|
2014
|
0.75
|
|
53
|
The Pro/Pro genotype of the p53 codon 72 polymorphism modulates PAI-1 plasma levels in ageing.
|
Mech Ageing Dev
|
2009
|
0.75
|
|
54
|
The PON1192RR genotype is associated with a higher prevalence of arterial hypertension.
|
J Hypertens
|
2006
|
0.75
|
|
55
|
Progress of research on microRNAs with diagnostic value in asbestos exposure: A call for method standardization.
|
Biosci Trends
|
2017
|
0.75
|
|
56
|
Tako-tsubo-like syndrome with atypical clinical presentation: case report and literature review.
|
Angiology
|
2008
|
0.75
|