Published in Chromosoma on June 28, 2013
Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization. Glia (2014) 0.84
Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains. J Virol (2015) 0.80
Dynamic Sumoylation of a Conserved Transcription Corepressor Prevents Persistent Inclusion Formation during Hyperosmotic Stress. PLoS Genet (2016) 0.78
Aberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription. FEBS J (2014) 0.77
SUMOylation of EHD3 Modulates Tubulation of the Endocytic Recycling Compartment. PLoS One (2015) 0.76
SUMOylation of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 Increases Surface Expression and the Maximal Conductance of the Hyperpolarization-Activated Current. Front Mol Neurosci (2017) 0.75
Modification by SUMOylation Controls Both the Transcriptional Activity and the Stability of Delta-Lactoferrin. PLoS One (2015) 0.75
Is Transthyretin a Regulator of Ubc9 SUMOylation? PLoS One (2016) 0.75
SUMO and the robustness of cancer. Nat Rev Cancer (2017) 0.75
Genetic Polymorphism of SUMO-Specific Cysteine Proteases - SENP1 and SENP2 in Breast Cancer. Pathol Oncol Res (2016) 0.75
Identification of Unintuitive Features of Sumoylation through Mathematical Modeling. J Biol Chem (2016) 0.75
The ubiquitin system. Annu Rev Biochem (1998) 43.36
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature (2002) 14.63
SUMO: a history of modification. Mol Cell (2005) 10.40
SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. Mol Cell (1998) 6.62
Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature (2003) 6.31
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat Cell Biol (2008) 5.90
Oxidant signals and oxidative stress. Curr Opin Cell Biol (2003) 5.67
Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3. J Biol Chem (2000) 5.30
An E3-like factor that promotes SUMO conjugation to the yeast septins. Cell (2001) 4.81
Genomic analysis of mouse retinal development. PLoS Biol (2004) 4.66
Identification of a SUMO-binding motif that recognizes SUMO-modified proteins. Proc Natl Acad Sci U S A (2004) 4.19
Modification in reverse: the SUMO proteases. Trends Biochem Sci (2007) 3.84
Specification of SUMO1- and SUMO2-interacting motifs. J Biol Chem (2006) 3.59
Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae. J Biol Chem (2004) 3.53
System-wide changes to SUMO modifications in response to heat shock. Sci Signal (2009) 3.50
A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science (2011) 3.49
Regulation of DNA damage responses by ubiquitin and SUMO. Mol Cell (2013) 3.43
SUMOylation and De-SUMOylation: wrestling with life's processes. J Biol Chem (2008) 3.22
PDSM, a motif for phosphorylation-dependent SUMO modification. Proc Natl Acad Sci U S A (2005) 3.01
Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes. Mol Cell (2006) 2.90
The small ubiquitin-like modifier (SUMO) protein modification system in Arabidopsis. Accumulation of SUMO1 and -2 conjugates is increased by stress. J Biol Chem (2002) 2.88
Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption. J Virol (1999) 2.87
Global analysis of protein sumoylation in Saccharomyces cerevisiae. J Biol Chem (2004) 2.60
Function and regulation of SUMO proteases. Nat Rev Mol Cell Biol (2012) 2.55
Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1. EMBO J (2005) 2.54
An essential yeast gene encoding a homolog of ubiquitin-activating enzyme. J Biol Chem (1995) 2.50
Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif: a reversal of the bound orientation. J Biol Chem (2005) 2.44
RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. Cell (2007) 2.34
Differential regulation of sentrinized proteins by a novel sentrin-specific protease. J Biol Chem (2000) 2.34
Global analyses of sumoylated proteins in Saccharomyces cerevisiae. Induction of protein sumoylation by cellular stresses. J Biol Chem (2004) 2.27
Alphaherpesvirus proteins related to herpes simplex virus type 1 ICP0 affect cellular structures and proteins. J Virol (2000) 2.25
SUMO modifications control assembly of synaptonemal complex and polycomplex in meiosis of Saccharomyces cerevisiae. Genes Dev (2006) 2.16
Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif. Mol Cell (2010) 2.10
The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity. J Cell Biol (2003) 1.97
A mechanism for inhibiting the SUMO pathway. Mol Cell (2004) 1.93
Role of desumoylation in the development of prostate cancer. Neoplasia (2006) 1.90
Yeast Ull1/Siz1 is a novel SUMO1/Smt3 ligase for septin components and functions as an adaptor between conjugating enzyme and substrates. J Biol Chem (2001) 1.89
Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity. Cell (2007) 1.89
Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1. J Biol Chem (2003) 1.88
Ubc9p and the conjugation of SUMO-1 to RanGAP1 and RanBP2. Curr Biol (1998) 1.86
Ubc9 sumoylation regulates SUMO target discrimination. Mol Cell (2008) 1.86
An extended consensus motif enhances the specificity of substrate modification by SUMO. EMBO J (2006) 1.86
A role for Ubc9 in tumorigenesis. Oncogene (2005) 1.76
Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes. Proc Natl Acad Sci U S A (1996) 1.74
Purification and identification of endogenous polySUMO conjugates. EMBO Rep (2011) 1.72
Genome-scale profiling of gene expression in hepatocellular carcinoma: classification, survival prediction, and identification of therapeutic targets. Gastroenterology (2004) 1.71
SUMO conjugation and deconjugation. Mol Gen Genet (2000) 1.64
Unconventional tethering of Ulp1 to the transport channel of the nuclear pore complex by karyopherins. Nat Cell Biol (2003) 1.63
Broad spectrum identification of cellular small ubiquitin-related modifier (SUMO) substrate proteins. J Biol Chem (2004) 1.59
Global shifts in protein sumoylation in response to electrophile and oxidative stress. Chem Res Toxicol (2004) 1.57
Comparative proteomic analysis identifies a role for SUMO in protein quality control. Sci Signal (2011) 1.54
Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. Proc Natl Acad Sci U S A (2003) 1.52
Detecting endogenous SUMO targets in mammalian cells and tissues. Nat Struct Mol Biol (2013) 1.44
Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas. Clin Cancer Res (2002) 1.39
Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2. Mol Cell (2006) 1.37
Translocation of SenP5 from the nucleoli to the mitochondria modulates DRP1-dependent fission during mitosis. J Biol Chem (2009) 1.37
Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors. J Clin Endocrinol Metab (2004) 1.35
Molecular basis of the redox regulation of SUMO proteases: a protective mechanism of intermolecular disulfide linkage against irreversible sulfhydryl oxidation. FASEB J (2007) 1.35
Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo. FEBS Lett (2004) 1.34
Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease. J Gen Virol (2002) 1.30
Differential PIAS3 expression in human malignancy. Oncol Rep (2004) 1.30
SUMOylation in carcinogenesis. Cancer Lett (2011) 1.29
Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2. Mol Cell Biol (2006) 1.29
SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms. J Biol Chem (2010) 1.29
Sumoylation dynamics during keratinocyte differentiation. J Cell Sci (2006) 1.26
Quality control of a transcriptional regulator by SUMO-targeted degradation. Mol Cell Biol (2009) 1.25
The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB. J Biol Chem (2006) 1.25
Expression and regulation of the mammalian SUMO-1 E1 enzyme. FASEB J (2001) 1.25
The role of karyopherins in the regulated sumoylation of septins. J Cell Biol (2007) 1.22
Viral oncoproteins E1A and E7 and cellular LxCxE proteins repress SUMO modification of the retinoblastoma tumor suppressor. Oncogene (2005) 1.21
Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search. J Biol Chem (2012) 1.19
Rhes, a physiologic regulator of sumoylation, enhances cross-sumoylation between the basic sumoylation enzymes E1 and Ubc9. J Biol Chem (2010) 1.19
Comparative analysis of yeast PIAS-type SUMO ligases in vivo and in vitro. J Biochem (2003) 1.19
Cell-cycle-dependent localisation of Ulp1, a Schizosaccharomyces pombe Pmt3 (SUMO)-specific protease. J Cell Sci (2002) 1.18
The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome. Blood (2009) 1.18
Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases. J Cell Biol (2008) 1.18
Expression analysis of Ubc9, the single small ubiquitin-like modifier (SUMO) E2 conjugating enzyme, in normal and malignant tissues. Hum Pathol (2010) 1.16
Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner. J Biol Chem (2011) 1.13
Targeting Ubc9 for cancer therapy. Expert Opin Ther Targets (2005) 1.12
Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90. EMBO J (2010) 1.11
NF-κB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress. Mol Cell (2011) 1.09
SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis. Cell Death Differ (2008) 1.09
Ube2W conjugates ubiquitin to α-amino groups of protein N-termini. Biochem J (2013) 1.07
Ubc9 sumoylation controls SUMO chain formation and meiotic synapsis in Saccharomyces cerevisiae. Mol Cell (2013) 1.05
PIAS1 is increased in human prostate cancer and enhances proliferation through inhibition of p21. Am J Pathol (2012) 1.02
Functional analysis of the SUMOylation pathway in Drosophila. Biochem Soc Trans (2008) 1.02
Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation. Mol Cell Biol (2013) 0.99
Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response. EMBO J (2013) 0.99
A novel mechanism for SUMO system control: regulated Ulp1 nucleolar sequestration. Mol Cell Biol (2010) 0.97
Functional modulation of parkin through physical interaction with SUMO-1. J Neurosci Res (2006) 0.97
Phosphorylation of SUMO-1 occurs in vivo and is conserved through evolution. J Proteome Res (2008) 0.96
An acetylation switch regulates SUMO-dependent protein interaction networks. Mol Cell (2012) 0.95
Small ubiquitin-like modifier (SUMO) modification of E1 Cys domain inhibits E1 Cys domain enzymatic activity. J Biol Chem (2012) 0.94
The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex. Mol Biol Cell (2011) 0.93
UBC9 autosumoylation negatively regulates sumoylation of septins in Saccharomyces cerevisiae. J Biol Chem (2011) 0.90
Identification and developmental expression of Xenopus laevis SUMO proteases. PLoS One (2009) 0.90
Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1. FEBS Lett (2005) 0.90
SUMO2 and SUMO3 transcription is differentially regulated by oxidative stress in an Sp1-dependent manner. Biochem J (2011) 0.89
Two distinct sites in Nup153 mediate interaction with the SUMO proteases SENP1 and SENP2. Nucleus (2012) 0.89
Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitin-conjugating enzyme 9. J Biol Chem (1996) 0.89